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P50183

- T2N4_NEILA

UniProt

P50183 - T2N4_NEILA

Protein

Type-2 restriction enzyme NlaIV

Gene

nlaIVR

Organism
Neisseria lactamica
Status
Reviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 45 (16 Apr 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Recognizes the double-stranded sequence GGNNCC and cleaves after N-3.

    Catalytic activityi

    Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

    GO - Molecular functioni

    1. Type II site-specific deoxyribonuclease activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    Restriction system

    Protein family/group databases

    REBASEi1342. NlaIV.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-2 restriction enzyme NlaIV (EC:3.1.21.4)
    Short name:
    R.NlaIV
    Alternative name(s):
    Endonuclease NlaIV
    Type II restriction enzyme NlaIV
    Gene namesi
    Name:nlaIVR
    OrganismiNeisseria lactamica
    Taxonomic identifieri486 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 243243Type-2 restriction enzyme NlaIVPRO_0000077350Add
    BLAST

    Proteomic databases

    PRIDEiP50183.

    Family & Domainsi

    Family and domain databases

    InterProiIPR019064. Restrct_endonuc_II_NlaIV.
    [Graphical view]
    PfamiPF09564. RE_NgoBV. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50183-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKLTAQQIF DKLLDEEKIL SANGQIRFFL GDVDIIVKQK DVVGNIIQEW    50
    LGGWLRKREI EFDVSTNTQM PPDFFLNKKD RSRELLEVKA FNRNASPGFD 100
    IADFKMYSDE IIHKPYMLDV DYLIFGYDMD DNGNVTIKDL WLKKVWQITR 150
    SMDGWAINLQ VKKGVVHKIR PGVWYSINKK NMPMFECLED FVSAIEETVY 200
    QNPATRHNAS LWKRKFEEAY KKHYNRSISI PRWHEIAHKY KKK 243
    Length:243
    Mass (Da):28,826
    Last modified:October 1, 1996 - v1
    Checksum:i3068E972D6736A49
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06074 Genomic DNA. Translation: AAA53238.1.
    PIRiS43887.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06074 Genomic DNA. Translation: AAA53238.1 .
    PIRi S43887.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 1342. NlaIV.

    Proteomic databases

    PRIDEi P50183.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR019064. Restrct_endonuc_II_NlaIV.
    [Graphical view ]
    Pfami PF09564. RE_NgoBV. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The NlaIV restriction and modification genes of Neisseria lactamica are flanked by leucine biosynthesis genes."
      Lau P.C.K., Forghani F., Labbe D., Bergeron H., Brousseau R., Holtke H.J.
      Mol. Gen. Genet. 243:24-31(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 23970 / CCUG 5853 / DSM 4691 / NCDC A7515 / NCTC 10617.
    2. Erratum
      Lau P.C.K., Forghani F., Labbe D., Bergeron H., Brousseau R., Holtke H.J.
      Mol. Gen. Genet. 244:167-167(1994)

    Entry informationi

    Entry nameiT2N4_NEILA
    AccessioniPrimary (citable) accession number: P50183
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: April 16, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries

    External Data

    Dasty 3