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P50182

- MTN4_NEILA

UniProt

P50182 - MTN4_NEILA

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Protein

Modification methylase NlaIV

Gene
nlaIVM
Organism
Neisseria lactamica
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GGNNCC, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the NlaIV endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801 By similarity

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3469. M.NlaIV.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase NlaIV (EC:2.1.1.37)
Short name:
M.NlaIV
Alternative name(s):
Cytosine-specific methyltransferase NlaIV
Gene namesi
Name:nlaIVM
OrganismiNeisseria lactamica
Taxonomic identifieri486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Modification methylase NlaIVPRO_0000087901Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP50182.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 423420SAM-dependent MTase C5-typeAdd
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS00094. C5_MTASE_1. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50182-1 [UniParc]FASTAAdd to Basket

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MQQIKFIDLF SGMSGIRKGF EQACRKQSVA CKCVFTSEIK PAALEVLKQN    50
YPDEVPYGDI TKIETGDIPD FDILLAGFPC QAFSFAGKRL GFEDTRGTLF 100
FDVARILKAK KPKGFILENV EGLVTHDRKD PTQKIGRTLT VILETLEALG 150
YYVSWKVLNA KDFGIPQNRK RIYLTGSLKS KPDLSFETTP SPKLKNILES 200
GLPTESSPFI KKLLKKFPPS ELYGKSVKDK RGGKNNIHSW DIELKGAVTE 250
EEKQLLNILL KERRKKKWAS EIGIDWMDGM PLTKAQISTF YKHPDLQNIL 300
DSLTDKGYLV LEHPKQKIGG QRIKDESLPK GYNIVSGKKS FEINKILDPN 350
DVAPTLVAMD MEHLFVVDNG GLRTLTGKEG LRLFGYPDDY SFDIPKKDKY 400
DLLGNTVAVP VIKAVSERLL HTL 423
Length:423
Mass (Da):47,615
Last modified:October 1, 1996 - v1
Checksum:i027E49558AEFDB19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06074 Genomic DNA. Translation: AAA53237.1.
PIRiS43886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06074 Genomic DNA. Translation: AAA53237.1 .
PIRi S43886.

3D structure databases

ProteinModelPortali P50182.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 3469. M.NlaIV.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 2 hits.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS00094. C5_MTASE_1. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The NlaIV restriction and modification genes of Neisseria lactamica are flanked by leucine biosynthesis genes."
    Lau P.C.K., Forghani F., Labbe D., Bergeron H., Brousseau R., Holtke H.J.
    Mol. Gen. Genet. 243:24-31(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 23970 / CCUG 5853 / DSM 4691 / NCDC A7515 / NCTC 10617.
  2. Erratum
    Lau P.C.K., Forghani F., Labbe D., Bergeron H., Brousseau R., Holtke H.J.
    Mol. Gen. Genet. 244:167-167(1994)

Entry informationi

Entry nameiMTN4_NEILA
AccessioniPrimary (citable) accession number: P50182
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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