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P50175

- PENK_MESAU

UniProt

P50175 - PENK_MESAU

Protein

Proenkephalin-A

Gene

PENK

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(238-259) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endorphin, Neuropeptide, Opioid peptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proenkephalin-A
    Cleaved into the following 8 chains:
    Gene namesi
    Name:PENK
    Synonyms:ENK
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Peptidei25 – 9773SynenkephalinPRO_0000008255Add
    BLAST
    Peptidei100 – 1045Met-enkephalinPRO_0000008256
    Peptidei107 – 1115Met-enkephalinPRO_0000008257
    Peptidei114 – 13320PENK(114-133)By similarityPRO_0000377688Add
    BLAST
    Peptidei136 – 1405Met-enkephalinPRO_0000008259
    Peptidei143 – 18442PENK(143-184)By similarityPRO_0000377689Add
    BLAST
    Peptidei187 – 1948Met-enkephalin-Arg-Gly-LeuPRO_0000008261
    Propeptidei197 – 20812PRO_0000008262Add
    BLAST
    Peptidei211 – 2155Met-enkephalinPRO_0000008263
    Propeptidei218 – 22811PRO_0000008264Add
    BLAST
    Peptidei231 – 2355Leu-enkephalinPRO_0000008265
    Peptidei238 – 25922PENK(238-259)By similarityPRO_0000377690Add
    BLAST
    Peptidei262 – 2687Met-enkephalin-Arg-PhePRO_0000008267

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 ↔ 48By similarity
    Disulfide bondi30 ↔ 52By similarity
    Disulfide bondi33 ↔ 65By similarity

    Post-translational modificationi

    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG000063.

    Family and domain databases

    InterProiIPR006024. Opioid_neupept.
    IPR000703. Proenkphlin_A.
    [Graphical view]
    PANTHERiPTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF3. PTHR11438:SF3. 1 hit.
    PfamiPF01160. Opiods_neuropep. 1 hit.
    [Graphical view]
    PRINTSiPR01028. OPIOIDPRCRSR.
    PR01029. PENKAPRCRSR.
    PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P50175-1 [UniParc]FASTAAdd to Basket

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    MARFLRLCTW LLVLGSCLLA TVQAECSQDC AKCSYHLVSP GDINFLACTL    50
    ECEGQMPSHK IWETCKDLLQ VSKPEFPCDS INMFKDSNKQ DESHLLAKKY 100
    GGFMKRYGGF MKKMDELYPV EPEEEANGGE ILAKKYGGFM KKDADEGDTL 150
    ANSSDLLKEL LGTGDNRARE GRHQESTDND DNMSKRYGGF MRGLKRSPQV 200
    EDEAKELQKR YGGFMRRVGR PEWWMDYQKR YGGFLKRFAE SLPSDEEAES 250
    YSKEVPEIEK RYGGFMRF 268
    Length:268
    Mass (Da):30,733
    Last modified:October 1, 1996 - v1
    Checksum:i9670D1DEEA936725
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781C → W in AAB32115. (PubMed:7917015)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09941 Genomic DNA. Translation: AAA63650.1.
    S74095 mRNA. Translation: AAB32115.1.
    PIRiI53029.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09941 Genomic DNA. Translation: AAA63650.1 .
    S74095 mRNA. Translation: AAB32115.1 .
    PIRi I53029.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG000063.

    Family and domain databases

    InterProi IPR006024. Opioid_neupept.
    IPR000703. Proenkphlin_A.
    [Graphical view ]
    PANTHERi PTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF3. PTHR11438:SF3. 1 hit.
    Pfami PF01160. Opiods_neuropep. 1 hit.
    [Graphical view ]
    PRINTSi PR01028. OPIOIDPRCRSR.
    PR01029. PENKAPRCRSR.
    PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of hamster proenkephalin gene."
      Zhu Y.S., Branch A.D., Robertson H.D., Inturrisi C.E.
      DNA Cell Biol. 13:25-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Syrian.
      Tissue: Liver.
    2. "Molecular cloning and characterization of the hamster preproenkephalin A cDNA."
      Beaulieu M., Ouellette M., Desgroseillers L., Brakier-Gingras L.
      DNA Cell Biol. 13:933-940(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Syrian.
      Tissue: Adrenal gland.

    Entry informationi

    Entry nameiPENK_MESAU
    AccessioniPrimary (citable) accession number: P50175
    Secondary accession number(s): Q64030
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3