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P50175

- PENK_MESAU

UniProt

P50175 - PENK_MESAU

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Protein

Proenkephalin-A

Gene

PENK

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(238-259) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-A
Cleaved into the following 8 chains:
Gene namesi
Name:PENK
Synonyms:ENK
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Peptidei25 – 9773SynenkephalinPRO_0000008255Add
BLAST
Peptidei100 – 1045Met-enkephalinPRO_0000008256
Peptidei107 – 1115Met-enkephalinPRO_0000008257
Peptidei114 – 13320PENK(114-133)By similarityPRO_0000377688Add
BLAST
Peptidei136 – 1405Met-enkephalinPRO_0000008259
Peptidei143 – 18442PENK(143-184)By similarityPRO_0000377689Add
BLAST
Peptidei187 – 1948Met-enkephalin-Arg-Gly-LeuPRO_0000008261
Propeptidei197 – 20812PRO_0000008262Add
BLAST
Peptidei211 – 2155Met-enkephalinPRO_0000008263
Propeptidei218 – 22811PRO_0000008264Add
BLAST
Peptidei231 – 2355Leu-enkephalinPRO_0000008265
Peptidei238 – 25922PENK(238-259)By similarityPRO_0000377690Add
BLAST
Peptidei262 – 2687Met-enkephalin-Arg-PhePRO_0000008267

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 48By similarity
Disulfide bondi30 ↔ 52By similarity
Disulfide bondi33 ↔ 65By similarity

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000063.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50175-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARFLRLCTW LLVLGSCLLA TVQAECSQDC AKCSYHLVSP GDINFLACTL
60 70 80 90 100
ECEGQMPSHK IWETCKDLLQ VSKPEFPCDS INMFKDSNKQ DESHLLAKKY
110 120 130 140 150
GGFMKRYGGF MKKMDELYPV EPEEEANGGE ILAKKYGGFM KKDADEGDTL
160 170 180 190 200
ANSSDLLKEL LGTGDNRARE GRHQESTDND DNMSKRYGGF MRGLKRSPQV
210 220 230 240 250
EDEAKELQKR YGGFMRRVGR PEWWMDYQKR YGGFLKRFAE SLPSDEEAES
260
YSKEVPEIEK RYGGFMRF
Length:268
Mass (Da):30,733
Last modified:October 1, 1996 - v1
Checksum:i9670D1DEEA936725
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781C → W in AAB32115. (PubMed:7917015)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09941 Genomic DNA. Translation: AAA63650.1.
S74095 mRNA. Translation: AAB32115.1.
PIRiI53029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09941 Genomic DNA. Translation: AAA63650.1 .
S74095 mRNA. Translation: AAB32115.1 .
PIRi I53029.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000063.

Family and domain databases

InterProi IPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view ]
PANTHERi PTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
Pfami PF01160. Opiods_neuropep. 1 hit.
[Graphical view ]
PRINTSi PR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of hamster proenkephalin gene."
    Zhu Y.S., Branch A.D., Robertson H.D., Inturrisi C.E.
    DNA Cell Biol. 13:25-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Syrian.
    Tissue: Liver.
  2. "Molecular cloning and characterization of the hamster preproenkephalin A cDNA."
    Beaulieu M., Ouellette M., Desgroseillers L., Brakier-Gingras L.
    DNA Cell Biol. 13:933-940(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Syrian.
    Tissue: Adrenal gland.

Entry informationi

Entry nameiPENK_MESAU
AccessioniPrimary (citable) accession number: P50175
Secondary accession number(s): Q64030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3