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Protein

Retinol dehydrogenase 2

Gene

Rdh2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts on retinol bound on cellular retinol-binding protein (CRBP). Has higher activity with NADP rather than NAD.

Catalytic activityi

All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164SubstrateBy similarity1
Active sitei176Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 57NADPBy similarityAdd BLAST25

GO - Molecular functioni

  • protein homodimerization activity Source: RGD
  • retinol dehydrogenase activity Source: RGD

GO - Biological processi

  • 9-cis-retinoic acid biosynthetic process Source: RGD
  • retinoic acid metabolic process Source: RGD
  • retinol metabolic process Source: RGD

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 2 (EC:1.1.1.105)
Alternative name(s):
29 kDa protein
Retinol dehydrogenase type II
Short name:
RODH II
Gene namesi
Name:Rdh2
Synonyms:Rodhii
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735050. Rdh2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547591 – 317Retinol dehydrogenase 2Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei189PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP50170.
PRIDEiP50170.

Expressioni

Tissue specificityi

Liver > kidney > brain > lung > testis.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-4576403.
STRINGi10116.ENSRNOP00000035423.

Structurei

3D structure databases

ProteinModelPortaliP50170.
SMRiP50170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
HOVERGENiHBG005482.
InParanoidiP50170.
KOiK11154.
PhylomeDBiP50170.

Family and domain databases

InterProiView protein in InterPro
IPR036291. NAD(P)-bd_dom_sf.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

P50170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLYLLALVG LWNLLRLFRE RKVVSHLQDK YVFITGCDSG FGNLLARQLD
60 70 80 90 100
RRGMRVLAAC LTEKGAEQLR SKTSDRLETV ILDVTKTESI VAATQWVKER
110 120 130 140 150
VGNTGLWGLV NNAGISGHLG PNEWMNKQNI ASVLDVNLLG MIEVTLSTVP
160 170 180 190 200
LVRKARGRVV NVASIAGRLS FCGGGYCISK YGVEAFSDSL RRELSYFGVK
210 220 230 240 250
VAIVEPGFFR TDVTNGVTLS SNFQMLWDQT SSEVREVYGE NYLASYLKML
260 270 280 290 300
NGLDQRCNKD LSLVTDCMEH ALTSCHPRTR YSAGWDAKFF YLPMSYLPTF
310
LVDALFYWTS PKPEKAL
Length:317
Mass (Da):35,597
Last modified:October 1, 1996 - v1
Checksum:i13BF030FFC17BCB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33500 mRNA. Translation: AAC52316.1.
BC079153 mRNA. Translation: AAH79153.1.
PIRiI55462.
RefSeqiNP_954678.1. NM_199208.1.
UniGeneiRn.94108.

Genome annotation databases

GeneIDi299511.
KEGGirno:299511.
UCSCiRGD:735050. rat.

Similar proteinsi

Entry informationi

Entry nameiRDH2_RAT
AccessioniPrimary (citable) accession number: P50170
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families