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P50170

- RDH2_RAT

UniProt

P50170 - RDH2_RAT

Protein

Retinol dehydrogenase 2

Gene

Rdh2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Acts on retinol bound on cellular retinol-binding protein (CRBP). Has higher activity with NADP rather than NAD.

    Catalytic activityi

    All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei164 – 1641SubstrateBy similarity
    Active sitei176 – 1761Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi33 – 5725NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. retinol dehydrogenase activity Source: RGD

    GO - Biological processi

    1. retinoic acid metabolic process Source: RGD
    2. retinol metabolic process Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    BRENDAi1.1.1.105. 5301.
    UniPathwayiUPA00912.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinol dehydrogenase 2 (EC:1.1.1.105)
    Alternative name(s):
    29 kDa protein
    Retinol dehydrogenase type II
    Short name:
    RODH II
    Gene namesi
    Name:Rdh2
    Synonyms:Rodhii
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi735050. Rdh2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Retinol dehydrogenase 2PRO_0000054759Add
    BLAST

    Proteomic databases

    PaxDbiP50170.
    PRIDEiP50170.

    Expressioni

    Tissue specificityi

    Liver > kidney > brain > lung > testis.

    Gene expression databases

    GenevestigatoriP50170.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4576403.
    STRINGi10116.ENSRNOP00000039311.

    Structurei

    3D structure databases

    ProteinModelPortaliP50170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    HOVERGENiHBG005482.
    InParanoidiP50170.
    PhylomeDBiP50170.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50170-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWLYLLALVG LWNLLRLFRE RKVVSHLQDK YVFITGCDSG FGNLLARQLD    50
    RRGMRVLAAC LTEKGAEQLR SKTSDRLETV ILDVTKTESI VAATQWVKER 100
    VGNTGLWGLV NNAGISGHLG PNEWMNKQNI ASVLDVNLLG MIEVTLSTVP 150
    LVRKARGRVV NVASIAGRLS FCGGGYCISK YGVEAFSDSL RRELSYFGVK 200
    VAIVEPGFFR TDVTNGVTLS SNFQMLWDQT SSEVREVYGE NYLASYLKML 250
    NGLDQRCNKD LSLVTDCMEH ALTSCHPRTR YSAGWDAKFF YLPMSYLPTF 300
    LVDALFYWTS PKPEKAL 317
    Length:317
    Mass (Da):35,597
    Last modified:October 1, 1996 - v1
    Checksum:i13BF030FFC17BCB8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33500 mRNA. Translation: AAC52316.1.
    BC079153 mRNA. Translation: AAH79153.1.
    PIRiI55462.
    RefSeqiNP_954678.1. NM_199208.1.
    UniGeneiRn.94108.

    Genome annotation databases

    GeneIDi299511.
    KEGGirno:299511.
    UCSCiRGD:735050. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33500 mRNA. Translation: AAC52316.1 .
    BC079153 mRNA. Translation: AAH79153.1 .
    PIRi I55462.
    RefSeqi NP_954678.1. NM_199208.1.
    UniGenei Rn.94108.

    3D structure databases

    ProteinModelPortali P50170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4576403.
    STRINGi 10116.ENSRNOP00000039311.

    Proteomic databases

    PaxDbi P50170.
    PRIDEi P50170.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 299511.
    KEGGi rno:299511.
    UCSCi RGD:735050. rat.

    Organism-specific databases

    CTDi 8608.
    RGDi 735050. Rdh2.

    Phylogenomic databases

    eggNOGi COG1028.
    HOVERGENi HBG005482.
    InParanoidi P50170.
    PhylomeDBi P50170.

    Enzyme and pathway databases

    UniPathwayi UPA00912 .
    BRENDAi 1.1.1.105. 5301.

    Miscellaneous databases

    NextBioi 645355.

    Gene expression databases

    Genevestigatori P50170.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a cDNA for a second retinol dehydrogenase type II. Expression of its mRNA relative to type I."
      Chai X., Zhai Y., Popescu G., Napoli J.L.
      J. Biol. Chem. 270:28408-28412(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. "Characterization of two P-450 isozymes placed in the rat CYP2D subfamily."
      Ohishi N., Imaoka S., Suzuki T., Funae Y.
      Biochim. Biophys. Acta 1158:227-236(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-10.
      Tissue: Liver.

    Entry informationi

    Entry nameiRDH2_RAT
    AccessioniPrimary (citable) accession number: P50170
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3