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P50170 (RDH2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Retinol dehydrogenase 2

EC=1.1.1.105
Alternative name(s):
29 kDa protein
Retinol dehydrogenase type II
Short name=RODH II
Gene names
Name:Rdh2
Synonyms:Rodhii
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts on retinol bound on cellular retinol-binding protein (CRBP). Has higher activity with NADP rather than NAD.

Catalytic activity

All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

Pathway

Cofactor metabolism; retinol metabolism.

Subcellular location

Microsome. Endoplasmic reticulum Potential.

Tissue specificity

Liver > kidney > brain > lung > testis.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Retinol dehydrogenase 2
PRO_0000054759

Regions

Nucleotide binding33 – 5725NADP By similarity

Sites

Active site1761Proton acceptor By similarity
Binding site1641Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P50170 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 13BF030FFC17BCB8

FASTA31735,597
        10         20         30         40         50         60 
MWLYLLALVG LWNLLRLFRE RKVVSHLQDK YVFITGCDSG FGNLLARQLD RRGMRVLAAC 

        70         80         90        100        110        120 
LTEKGAEQLR SKTSDRLETV ILDVTKTESI VAATQWVKER VGNTGLWGLV NNAGISGHLG 

       130        140        150        160        170        180 
PNEWMNKQNI ASVLDVNLLG MIEVTLSTVP LVRKARGRVV NVASIAGRLS FCGGGYCISK 

       190        200        210        220        230        240 
YGVEAFSDSL RRELSYFGVK VAIVEPGFFR TDVTNGVTLS SNFQMLWDQT SSEVREVYGE 

       250        260        270        280        290        300 
NYLASYLKML NGLDQRCNKD LSLVTDCMEH ALTSCHPRTR YSAGWDAKFF YLPMSYLPTF 

       310 
LVDALFYWTS PKPEKAL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a cDNA for a second retinol dehydrogenase type II. Expression of its mRNA relative to type I."
Chai X., Zhai Y., Popescu G., Napoli J.L.
J. Biol. Chem. 270:28408-28412(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]"Characterization of two P-450 isozymes placed in the rat CYP2D subfamily."
Ohishi N., Imaoka S., Suzuki T., Funae Y.
Biochim. Biophys. Acta 1158:227-236(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-10.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U33500 mRNA. Translation: AAC52316.1.
BC079153 mRNA. Translation: AAH79153.1.
PIRI55462.
RefSeqNP_954678.1. NM_199208.1.
UniGeneRn.94108.

3D structure databases

ProteinModelPortalP50170.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4576403.
STRING10116.ENSRNOP00000039311.

Proteomic databases

PaxDbP50170.
PRIDEP50170.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID299511.
KEGGrno:299511.
UCSCRGD:735050. rat.

Organism-specific databases

CTD8608.
RGD735050. Rdh2.

Phylogenomic databases

eggNOGCOG1028.
HOVERGENHBG005482.
InParanoidP50170.
PhylomeDBP50170.

Enzyme and pathway databases

BRENDA1.1.1.105. 5301.
UniPathwayUPA00912.

Gene expression databases

GenevestigatorP50170.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio645355.

Entry information

Entry nameRDH2_RAT
AccessionPrimary (citable) accession number: P50170
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways