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Protein

Retinol dehydrogenase 2

Gene

Rdh2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts on retinol bound on cellular retinol-binding protein (CRBP). Has higher activity with NADP rather than NAD.

Catalytic activityi

All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

Pathway: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei164 – 1641SubstrateBy similarity
Active sitei176 – 1761Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 5725NADPBy similarityAdd
BLAST

GO - Molecular functioni

  • retinol dehydrogenase activity Source: RGD

GO - Biological processi

  • retinoic acid metabolic process Source: RGD
  • retinol metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 2 (EC:1.1.1.105)
Alternative name(s):
29 kDa protein
Retinol dehydrogenase type II
Short name:
RODH II
Gene namesi
Name:Rdh2
Synonyms:Rodhii
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735050. Rdh2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Retinol dehydrogenase 2PRO_0000054759Add
BLAST

Proteomic databases

PaxDbiP50170.
PRIDEiP50170.

Expressioni

Tissue specificityi

Liver > kidney > brain > lung > testis.

Gene expression databases

GenevisibleiP50170. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4576403.
STRINGi10116.ENSRNOP00000035423.

Structurei

3D structure databases

ProteinModelPortaliP50170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
HOVERGENiHBG005482.
InParanoidiP50170.
KOiK11154.
PhylomeDBiP50170.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLYLLALVG LWNLLRLFRE RKVVSHLQDK YVFITGCDSG FGNLLARQLD
60 70 80 90 100
RRGMRVLAAC LTEKGAEQLR SKTSDRLETV ILDVTKTESI VAATQWVKER
110 120 130 140 150
VGNTGLWGLV NNAGISGHLG PNEWMNKQNI ASVLDVNLLG MIEVTLSTVP
160 170 180 190 200
LVRKARGRVV NVASIAGRLS FCGGGYCISK YGVEAFSDSL RRELSYFGVK
210 220 230 240 250
VAIVEPGFFR TDVTNGVTLS SNFQMLWDQT SSEVREVYGE NYLASYLKML
260 270 280 290 300
NGLDQRCNKD LSLVTDCMEH ALTSCHPRTR YSAGWDAKFF YLPMSYLPTF
310
LVDALFYWTS PKPEKAL
Length:317
Mass (Da):35,597
Last modified:October 1, 1996 - v1
Checksum:i13BF030FFC17BCB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33500 mRNA. Translation: AAC52316.1.
BC079153 mRNA. Translation: AAH79153.1.
PIRiI55462.
RefSeqiNP_954678.1. NM_199208.1.
UniGeneiRn.94108.

Genome annotation databases

GeneIDi299511.
KEGGirno:299511.
UCSCiRGD:735050. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33500 mRNA. Translation: AAC52316.1.
BC079153 mRNA. Translation: AAH79153.1.
PIRiI55462.
RefSeqiNP_954678.1. NM_199208.1.
UniGeneiRn.94108.

3D structure databases

ProteinModelPortaliP50170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4576403.
STRINGi10116.ENSRNOP00000035423.

Proteomic databases

PaxDbiP50170.
PRIDEiP50170.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi299511.
KEGGirno:299511.
UCSCiRGD:735050. rat.

Organism-specific databases

CTDi8608.
RGDi735050. Rdh2.

Phylogenomic databases

eggNOGiCOG1028.
HOVERGENiHBG005482.
InParanoidiP50170.
KOiK11154.
PhylomeDBiP50170.

Enzyme and pathway databases

UniPathwayiUPA00912.

Miscellaneous databases

NextBioi645355.
PROiP50170.

Gene expression databases

GenevisibleiP50170. RN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a cDNA for a second retinol dehydrogenase type II. Expression of its mRNA relative to type I."
    Chai X., Zhai Y., Popescu G., Napoli J.L.
    J. Biol. Chem. 270:28408-28412(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "Characterization of two P-450 isozymes placed in the rat CYP2D subfamily."
    Ohishi N., Imaoka S., Suzuki T., Funae Y.
    Biochim. Biophys. Acta 1158:227-236(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-10.
    Tissue: Liver.

Entry informationi

Entry nameiRDH2_RAT
AccessioniPrimary (citable) accession number: P50170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.