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P50169

- RDH3_RAT

UniProt

P50169 - RDH3_RAT

Protein

Retinol dehydrogenase 3

Gene

Rdh3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Acts on retinol bound on cellular retinol-binding protein (CRBP). Has higher activity with NADP rather than NAD.

    Catalytic activityi

    All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei164 – 1641SubstrateBy similarity
    Active sitei176 – 1761Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi33 – 5725NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. retinol dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. retinol metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00912.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinol dehydrogenase 3 (EC:1.1.1.105)
    Alternative name(s):
    Retinol dehydrogenase type I
    Short name:
    RODH I
    Gene namesi
    Name:Rdh3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi631370. Rdh3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Retinol dehydrogenase 3PRO_0000054760Add
    BLAST

    Proteomic databases

    PaxDbiP50169.
    PRIDEiP50169.

    Expressioni

    Tissue specificityi

    Liver >> lung > testis > brain > kidney.

    Gene expression databases

    GenevestigatoriP50169.

    Interactioni

    Protein-protein interaction databases

    IntActiP50169. 1 interaction.
    MINTiMINT-4565884.

    Structurei

    3D structure databases

    ProteinModelPortaliP50169.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    HOVERGENiHBG005482.
    InParanoidiP50169.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50169-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWLYLLALVG LWNLLRLFRE RKVVSHLQDK YVFITGCDSG FGNLLARQLD    50
    RRGMRVLAAC LTEKGAEQLR SKTSDRLETV ILDVTKTESI VAATQWVKER 100
    VGNRGLWGLV NNAGISVPVG PNEWMRKKDF ASVLDVNLLG VIEVTLNMLP 150
    LVRKARGRVV NIASTMGRMS LVGGGYCISK YGVEAFSDSL RRELTYFGVK 200
    VAIIEPGGFK TNVTNMERLS DNLKKLWDQT TEEVKEIYGE KFQDSYMKAM 250
    ESLVNTCSGD LSLVTDCMEH ALTSCHPRTR YSPGWDAKFF YLPMSYLPTF 300
    LSDAVIHWGS VKPARAL 317
    Length:317
    Mass (Da):35,662
    Last modified:October 1, 1996 - v1
    Checksum:i59B66DDC92E4E24D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 182LF → FL in AAB07997. (PubMed:7876135)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18762 mRNA. Translation: AAB07997.1.
    PIRiA55884.
    UniGeneiRn.31786.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18762 mRNA. Translation: AAB07997.1 .
    PIRi A55884.
    UniGenei Rn.31786.

    3D structure databases

    ProteinModelPortali P50169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P50169. 1 interaction.
    MINTi MINT-4565884.

    Proteomic databases

    PaxDbi P50169.
    PRIDEi P50169.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 631370. Rdh3.

    Phylogenomic databases

    eggNOGi COG1028.
    HOVERGENi HBG005482.
    InParanoidi P50169.

    Enzyme and pathway databases

    UniPathwayi UPA00912 .

    Gene expression databases

    Genevestigatori P50169.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a cDNA for liver microsomal retinol dehydrogenase. A tissue-specific, short-chain alcohol dehydrogenase."
      Chai X., Boerman M.H.E.M., Zhai Y., Napoli J.L.
      J. Biol. Chem. 270:3900-3904(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: Sprague-Dawley.
      Tissue: Liver.

    Entry informationi

    Entry nameiRDH3_RAT
    AccessioniPrimary (citable) accession number: P50169
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3