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P50169

- RDH3_RAT

UniProt

P50169 - RDH3_RAT

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Protein
Retinol dehydrogenase 3
Gene
Rdh3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Acts on retinol bound on cellular retinol-binding protein (CRBP). Has higher activity with NADP rather than NAD.

Catalytic activityi

All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei164 – 1641Substrate By similarity
Active sitei176 – 1761Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 5725NADP By similarity
Add
BLAST

GO - Molecular functioni

  1. retinol dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. retinol metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 3 (EC:1.1.1.105)
Alternative name(s):
Retinol dehydrogenase type I
Short name:
RODH I
Gene namesi
Name:Rdh3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi631370. Rdh3.

Subcellular locationi

Microsome. Endoplasmic reticulum Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Retinol dehydrogenase 3
PRO_0000054760Add
BLAST

Proteomic databases

PaxDbiP50169.
PRIDEiP50169.

Expressioni

Tissue specificityi

Liver >> lung > testis > brain > kidney.

Gene expression databases

GenevestigatoriP50169.

Interactioni

Protein-protein interaction databases

IntActiP50169. 1 interaction.
MINTiMINT-4565884.

Structurei

3D structure databases

ProteinModelPortaliP50169.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
HOVERGENiHBG005482.
InParanoidiP50169.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50169-1 [UniParc]FASTAAdd to Basket

« Hide

MWLYLLALVG LWNLLRLFRE RKVVSHLQDK YVFITGCDSG FGNLLARQLD    50
RRGMRVLAAC LTEKGAEQLR SKTSDRLETV ILDVTKTESI VAATQWVKER 100
VGNRGLWGLV NNAGISVPVG PNEWMRKKDF ASVLDVNLLG VIEVTLNMLP 150
LVRKARGRVV NIASTMGRMS LVGGGYCISK YGVEAFSDSL RRELTYFGVK 200
VAIIEPGGFK TNVTNMERLS DNLKKLWDQT TEEVKEIYGE KFQDSYMKAM 250
ESLVNTCSGD LSLVTDCMEH ALTSCHPRTR YSPGWDAKFF YLPMSYLPTF 300
LSDAVIHWGS VKPARAL 317
Length:317
Mass (Da):35,662
Last modified:October 1, 1996 - v1
Checksum:i59B66DDC92E4E24D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 182LF → FL in AAB07997. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18762 mRNA. Translation: AAB07997.1.
PIRiA55884.
UniGeneiRn.31786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18762 mRNA. Translation: AAB07997.1 .
PIRi A55884.
UniGenei Rn.31786.

3D structure databases

ProteinModelPortali P50169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P50169. 1 interaction.
MINTi MINT-4565884.

Proteomic databases

PaxDbi P50169.
PRIDEi P50169.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 631370. Rdh3.

Phylogenomic databases

eggNOGi COG1028.
HOVERGENi HBG005482.
InParanoidi P50169.

Enzyme and pathway databases

UniPathwayi UPA00912 .

Gene expression databases

Genevestigatori P50169.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of a cDNA for liver microsomal retinol dehydrogenase. A tissue-specific, short-chain alcohol dehydrogenase."
    Chai X., Boerman M.H.E.M., Zhai Y., Napoli J.L.
    J. Biol. Chem. 270:3900-3904(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiRDH3_RAT
AccessioniPrimary (citable) accession number: P50169
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 22, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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