Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Retinol dehydrogenase 3

Gene

Rdh3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts on retinol bound on cellular retinol-binding protein (CRBP). Has higher activity with NADP rather than NAD.

Catalytic activityi

All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei164 – 1641SubstrateBy similarity
Active sitei176 – 1761Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 5725NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. retinol dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. retinol metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 3 (EC:1.1.1.105)
Alternative name(s):
Retinol dehydrogenase type I
Short name:
RODH I
Gene namesi
Name:Rdh3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631370. Rdh3.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Retinol dehydrogenase 3PRO_0000054760Add
BLAST

Proteomic databases

PaxDbiP50169.
PRIDEiP50169.

Expressioni

Tissue specificityi

Liver >> lung > testis > brain > kidney.

Gene expression databases

GenevestigatoriP50169.

Interactioni

Protein-protein interaction databases

IntActiP50169. 1 interaction.
MINTiMINT-4565884.

Structurei

3D structure databases

ProteinModelPortaliP50169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
HOVERGENiHBG005482.
InParanoidiP50169.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLYLLALVG LWNLLRLFRE RKVVSHLQDK YVFITGCDSG FGNLLARQLD
60 70 80 90 100
RRGMRVLAAC LTEKGAEQLR SKTSDRLETV ILDVTKTESI VAATQWVKER
110 120 130 140 150
VGNRGLWGLV NNAGISVPVG PNEWMRKKDF ASVLDVNLLG VIEVTLNMLP
160 170 180 190 200
LVRKARGRVV NIASTMGRMS LVGGGYCISK YGVEAFSDSL RRELTYFGVK
210 220 230 240 250
VAIIEPGGFK TNVTNMERLS DNLKKLWDQT TEEVKEIYGE KFQDSYMKAM
260 270 280 290 300
ESLVNTCSGD LSLVTDCMEH ALTSCHPRTR YSPGWDAKFF YLPMSYLPTF
310
LSDAVIHWGS VKPARAL
Length:317
Mass (Da):35,662
Last modified:September 30, 1996 - v1
Checksum:i59B66DDC92E4E24D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 182LF → FL in AAB07997 (PubMed:7876135).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18762 mRNA. Translation: AAB07997.1.
PIRiA55884.
UniGeneiRn.31786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18762 mRNA. Translation: AAB07997.1.
PIRiA55884.
UniGeneiRn.31786.

3D structure databases

ProteinModelPortaliP50169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP50169. 1 interaction.
MINTiMINT-4565884.

Proteomic databases

PaxDbiP50169.
PRIDEiP50169.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi631370. Rdh3.

Phylogenomic databases

eggNOGiCOG1028.
HOVERGENiHBG005482.
InParanoidiP50169.

Enzyme and pathway databases

UniPathwayiUPA00912.

Gene expression databases

GenevestigatoriP50169.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of a cDNA for liver microsomal retinol dehydrogenase. A tissue-specific, short-chain alcohol dehydrogenase."
    Chai X., Boerman M.H.E.M., Zhai Y., Napoli J.L.
    J. Biol. Chem. 270:3900-3904(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiRDH3_RAT
AccessioniPrimary (citable) accession number: P50169
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 30, 1996
Last sequence update: September 30, 1996
Last modified: January 6, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.