P50167 (ARDH_PICST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-arabinitol 2-dehydrogenase [ribulose-forming]
Short name=ARDH
EC=1.1.1.250

Gene names

Name:	ARDH
Synonyms:	ARD2
ORF Names:	PICST_65696

Organism

Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis) [Complete proteome]

Taxonomic identifier

322104 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Scheffersomyces

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	D-arabinitol + NAD+ = D-ribulose + NADH.
Pathway	Carbohydrate metabolism; D-arabinitol metabolism.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	D-arabinitol 2-dehydrogenase activity Inferred from sequence or structural similarity. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	D-arabinitol 2-dehydrogenase [ribulose-forming]		PRO_0000054519
Regions
	Nucleotide binding	22 – 44	23	NAD By similarity
Sites
	Active site	181	1	Proton acceptor By similarity
	Binding site	166	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50167 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 36869165F23964F6	FASTA	278	30,003
	10 20 30 40 50 60 MDYSYANVVP NFRLDGRLAI ITGGSGGLAA VISRALLAQG ADVALIDMNL ERTKSAAKEV 70 80 90 100 110 120 LGWGEETLKG EHASAIGQVS AWSCNIGDAE AVDATFSSIN EHHGKIADLL INTAGYCENF 130 140 150 160 170 180 PAETYPATNA ESIMKVNGLG SFYVSQSFAR PLIQNNLRGS IILIGSMSGT IVNDPQPQCM 190 200 210 220 230 240 YNMSKAGVIH LVRSLACEWA KYNIRVNTLS PGYILTPLTR NVISGHTEMK EAWESKIPMK 250 260 270 RMAEPKEFVG SILYLASETA SSYTTGHNLV VDGGYECW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A short-chain dehydrogenase gene from Pichia stipitis having D-arabinitol dehydrogenase activity." Hallborn J., Walfridsson M., Penttilae M., Keraenen S., Hahn-Haegerdal B. Yeast 11:839-847(1995) [PubMed: 7483848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.
[2]	"Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis." Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A., Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S., Passoth V., Richardson P.M. Nat. Biotechnol. 25:319-326(2007) [PubMed: 17334359] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46866 mRNA. Translation: CAA86939.1. CP000499 Genomic DNA. Translation: ABN67006.1.
PIR	S57351.
RefSeq	XP_001385035.1. XM_001384998.1.
3D structure databases
ProteinModelPortal	P50167.
ModBase	Search...
Protein-protein interaction databases
STRING	P50167.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4839199.
GenomeReviews	Gene locus ARDH in contig CP000499_GR.
KEGG	pic:PICST_65696.
Phylogenomic databases
eggNOG	fuNOG07335.
HOGENOM	HBG750976.
OMA	IVNDPQP.
OrthoDB	EOG4XD70T.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARDH_PICST

Accession

Primary (citable) accession number: P50167
Secondary accession number(s): A3LUR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program