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Protein

D-arabinitol 2-dehydrogenase [ribulose-forming]

Gene

ARDH

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-arabinitol + NAD+ = D-ribulose + NADH.

Pathwayi: D-arabinitol metabolism

This protein is involved in the pathway D-arabinitol metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway D-arabinitol metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei166SubstrateBy similarity1
Active sitei181Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 44NADBy similarityAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00380.

Names & Taxonomyi

Protein namesi
Recommended name:
D-arabinitol 2-dehydrogenase [ribulose-forming] (EC:1.1.1.250)
Short name:
ARDH
Gene namesi
Name:ARDH
Synonyms:ARD2
ORF Names:PICST_65696
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
Proteomesi
  • UP000002258 Componenti: Chromosome 5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000545191 – 278D-arabinitol 2-dehydrogenase [ribulose-forming]Add BLAST278

Interactioni

Protein-protein interaction databases

STRINGi322104.XP_001385035.1.

Structurei

3D structure databases

ProteinModelPortaliP50167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
InParanoidiP50167.
KOiK17738.
OMAiINEHHGK.
OrthoDBiEOG092C3TSH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYSYANVVP NFRLDGRLAI ITGGSGGLAA VISRALLAQG ADVALIDMNL
60 70 80 90 100
ERTKSAAKEV LGWGEETLKG EHASAIGQVS AWSCNIGDAE AVDATFSSIN
110 120 130 140 150
EHHGKIADLL INTAGYCENF PAETYPATNA ESIMKVNGLG SFYVSQSFAR
160 170 180 190 200
PLIQNNLRGS IILIGSMSGT IVNDPQPQCM YNMSKAGVIH LVRSLACEWA
210 220 230 240 250
KYNIRVNTLS PGYILTPLTR NVISGHTEMK EAWESKIPMK RMAEPKEFVG
260 270
SILYLASETA SSYTTGHNLV VDGGYECW
Length:278
Mass (Da):30,003
Last modified:October 1, 1996 - v1
Checksum:i36869165F23964F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46866 mRNA. Translation: CAA86939.1.
CP000499 Genomic DNA. Translation: ABN67006.1.
PIRiS57351.
RefSeqiXP_001385035.1. XM_001384998.1.

Genome annotation databases

EnsemblFungiiABN67006; ABN67006; PICST_65696.
GeneIDi4839199.
KEGGipic:PICST_65696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46866 mRNA. Translation: CAA86939.1.
CP000499 Genomic DNA. Translation: ABN67006.1.
PIRiS57351.
RefSeqiXP_001385035.1. XM_001384998.1.

3D structure databases

ProteinModelPortaliP50167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322104.XP_001385035.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiABN67006; ABN67006; PICST_65696.
GeneIDi4839199.
KEGGipic:PICST_65696.

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
InParanoidiP50167.
KOiK17738.
OMAiINEHHGK.
OrthoDBiEOG092C3TSH.

Enzyme and pathway databases

UniPathwayiUPA00380.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARDH_PICST
AccessioniPrimary (citable) accession number: P50167
Secondary accession number(s): A3LUR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.