ID   ARDH_CANTR              Reviewed;         282 AA.
AC   P50166;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 50.
DE   RecName: Full=D-arabinitol 2-dehydrogenase [ribulose-forming];
DE            Short=ARDH;
DE            EC=1.1.1.250;
GN   Name=ARD;
OS   Candida tropicalis (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales;
OC   Candida.
OX   NCBI_TaxID=5482;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=ATCC 750 / CBS 94 / DSM 11953 / JCM 1541;
RX   MEDLINE=95212917; PubMed=7698655; DOI=10.1016/0378-1119(94)00900-D;
RA   Murray J.S., Wong M.L., Miyada C.G., Switchenko A.C., Goodman T.C.,
RA   Wong B.;
RT   "Isolation, characterization and expression of the gene that encodes
RT   D-arabinitol dehydrogenase in Candida tropicalis.";
RL   Gene 155:123-128(1995).
RN   [2]
RP   CHARACTERIZATION.
RX   MEDLINE=94071892; PubMed=8250887; DOI=10.1006/bbrc.1993.2397;
RA   Quong M.W., Miyada C.G., Switchenko A.C., Goodman T.C.;
RT   "Identification, purification, and characterization of a D-arabinitol-
RT   specific dehydrogenase from Candida tropicalis.";
RL   Biochem. Biophys. Res. Commun. 196:1323-1329(1993).
CC   -!- CATALYTIC ACTIVITY: D-arabinitol + NAD(+) = D-ribulose + NADH.
CC   -!- PATHWAY: Carbohydrate metabolism; D-arabinitol metabolism.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
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DR   EMBL; U00675; AAA66355.1; -; Genomic_DNA.
DR   PIR; JC4041; JC4041.
DR   HSSP; Q9ZFY9; 1FK8.
DR   BRENDA; 1.1.1.250; 1242.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0047038; F:D-arabinitol 2-dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR002347; Glc/ribitol_DH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; NAD; Oxidoreductase.
FT   CHAIN         1    282       D-arabinitol 2-dehydrogenase [ribulose-
FT                                forming].
FT                                /FTId=PRO_0000054518.
FT   NP_BIND      26     48       NAD (By similarity).
FT   ACT_SITE    185    185       Proton acceptor (By similarity).
FT   BINDING     170    170       Substrate (By similarity).
SQ   SEQUENCE   282 AA;  30748 MW;  A82A3DA4E771EF0D CRC64;
     MDSSSYWSYD NIVPSFRLDG KLVIITGGSG GLSAVVSRAL LAKGADIALI DMNLERTQQA
     ARDVLQWGEE QMKGKHESPI GQVSAWSCNI GDAEAVELTF KAINEHHGKV ASVLINTAGY
     AENFPAEEYP AKNAENIMKV NGLGSFYVSQ AFARPLIQNN MTGSIILIGS MSGTIVNDPQ
     PQCMYNMSKA GVIHLARSLA CEWAKYNIRV NTLSPGYILT PLTRNVISGH TEMKTEWESK
     IPMKRMAEPK EFVGSILYLA SDSASSYTTG HNLVVDGGYE CW
//