Reviewed, UniProtKB/Swiss-Prot P50166 (ARDH_CANTR)

Names and origin

Protein names

Recommended name:
    D-arabinitol 2-dehydrogenase [ribulose-forming]
      Short name=ARDH
    EC=1.1.1.250

Gene names

Name:

ARD

Organism

Candida tropicalis (Yeast)

Taxonomic identifier

5482 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	D-arabinitol + NAD+ = D-ribulose + NADH.
Pathway	Carbohydrate metabolism; D-arabinitol metabolism.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	D-arabinitol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	D-arabinitol 2-dehydrogenase [ribulose-forming]		PRO_0000054518
Regions
	Nucleotide binding	26 – 48	23	NAD By similarity
Sites
	Active site	185	1	Proton acceptor By similarity
	Binding site	170	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50166-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: A82A3DA4E771EF0D	FASTA	282	30,748
	10 20 30 40 50 60 MDSSSYWSYD NIVPSFRLDG KLVIITGGSG GLSAVVSRAL LAKGADIALI DMNLERTQQA 70 80 90 100 110 120 ARDVLQWGEE QMKGKHESPI GQVSAWSCNI GDAEAVELTF KAINEHHGKV ASVLINTAGY 130 140 150 160 170 180 AENFPAEEYP AKNAENIMKV NGLGSFYVSQ AFARPLIQNN MTGSIILIGS MSGTIVNDPQ 190 200 210 220 230 240 PQCMYNMSKA GVIHLARSLA CEWAKYNIRV NTLSPGYILT PLTRNVISGH TEMKTEWESK 250 260 270 280 IPMKRMAEPK EFVGSILYLA SDSASSYTTG HNLVVDGGYE CW

References

[1]	"Isolation, characterization and expression of the gene that encodes D-arabinitol dehydrogenase in Candida tropicalis." Murray J.S., Wong M.L., Miyada C.G., Switchenko A.C., Goodman T.C., Wong B. Gene 155:123-128(1995) [PubMed: 7698655] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE. Strain: ATCC 750 / CBS 94 / DSM 11953 / JCM 1541.
[2]	"Identification, purification, and characterization of a D-arabinitol-specific dehydrogenase from Candida tropicalis." Quong M.W., Miyada C.G., Switchenko A.C., Goodman T.C. Biochem. Biophys. Res. Commun. 196:1323-1329(1993) [PubMed: 8250887] [Abstract] Cited for: CHARACTERIZATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00675 Genomic DNA. Translation: AAA66355.1.
PIR	JC4041.
3D structure databases
HSSP	HSSP built from PDB template 1FK8 based on UniProtKB Q9ZFY9.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.250. 1242.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARDH_CANTR

Accession

Primary (citable) accession number: P50166

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)