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Protein

D-arabinitol 2-dehydrogenase [ribulose-forming]

Gene

ARD

Organism
Candida tropicalis (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-arabinitol + NAD+ = D-ribulose + NADH.

Pathwayi: D-arabinitol metabolism

This protein is involved in the pathway D-arabinitol metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway D-arabinitol metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei170SubstrateBy similarity1
Active sitei185Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 48NADBy similarityAdd BLAST23

GO - Molecular functioni

  • D-arabinitol 2-dehydrogenase activity Source: UniProtKB

GO - Biological processi

  • arabitol metabolic process Source: UniProtKB-UniPathway
  • carbohydrate metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00380.

Names & Taxonomyi

Protein namesi
Recommended name:
D-arabinitol 2-dehydrogenase [ribulose-forming] (EC:1.1.1.250)
Short name:
ARDH
Gene namesi
Name:ARD
OrganismiCandida tropicalis (Yeast)
Taxonomic identifieri5482 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000545181 – 282D-arabinitol 2-dehydrogenase [ribulose-forming]Add BLAST282

Interactioni

Protein-protein interaction databases

STRINGi294747.XP_002548729.1.

Structurei

3D structure databases

ProteinModelPortaliP50166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSSYWSYD NIVPSFRLDG KLVIITGGSG GLSAVVSRAL LAKGADIALI
60 70 80 90 100
DMNLERTQQA ARDVLQWGEE QMKGKHESPI GQVSAWSCNI GDAEAVELTF
110 120 130 140 150
KAINEHHGKV ASVLINTAGY AENFPAEEYP AKNAENIMKV NGLGSFYVSQ
160 170 180 190 200
AFARPLIQNN MTGSIILIGS MSGTIVNDPQ PQCMYNMSKA GVIHLARSLA
210 220 230 240 250
CEWAKYNIRV NTLSPGYILT PLTRNVISGH TEMKTEWESK IPMKRMAEPK
260 270 280
EFVGSILYLA SDSASSYTTG HNLVVDGGYE CW
Length:282
Mass (Da):30,748
Last modified:October 1, 1996 - v1
Checksum:iA82A3DA4E771EF0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00675 Genomic DNA. Translation: AAA66355.1.
PIRiJC4041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00675 Genomic DNA. Translation: AAA66355.1.
PIRiJC4041.

3D structure databases

ProteinModelPortaliP50166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi294747.XP_002548729.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00380.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARDH_CANTR
AccessioniPrimary (citable) accession number: P50166
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.