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Protein

Tropinone reductase 2

Gene

TR2

Organism
Hyoscyamus niger (Black henbane)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the stereospecific reduction of tropinone to pseudotropine.

Catalytic activityi

Pseudotropine + NADP+ = tropinone + NADPH.

Pathwayi: tropane alkaloid biosynthesis

This protein is involved in the pathway tropane alkaloid biosynthesis, which is part of Alkaloid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway tropane alkaloid biosynthesis and in Alkaloid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei146SubstrateBy similarity1
Active sitei159Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 37NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00330

Names & Taxonomyi

Protein namesi
Recommended name:
Tropinone reductase 2 (EC:1.1.1.236)
Alternative name(s):
Tropinone reductase II
Short name:
TR-II
Gene namesi
Name:TR2
OrganismiHyoscyamus niger (Black henbane)
Taxonomic identifieri4079 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeHyoscyameaeHyoscyamus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547871 – 260Tropinone reductase 2Add BLAST260

Proteomic databases

PRIDEiP50164

Structurei

3D structure databases

ProteinModelPortaliP50164
SMRiP50164
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

P50164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRWNLEGC TALVTGGSRG IGYGIVEELA NLGASVYTCS RNQKELDECL
60 70 80 90 100
TQWRSKGFNV EASVCDLSSR SEREEFMKTV SNHFHGKLNI LVNNAGIVIY
110 120 130 140 150
KEAKDYTMED YSHIMSINFE AAYHLSVLAH PFLKASERGN VVFISSISGA
160 170 180 190 200
SALPYEAVYG ATKGAMDQLT RCLAFEWAKD NIRVNGVGPG VIATSMVEMT
210 220 230 240 250
IQDPEQKENL DKLIDRCALR RMGEPKELAA VVAFLCFPAA SYVTGQIIYV
260
DGGFMANGGF
Length:260
Mass (Da):28,437
Last modified:October 1, 1996 - v1
Checksum:i6CA7AF85CAA128FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20485 mRNA Translation: AAB09776.1
AB026545 Genomic DNA Translation: BAA85845.1

Similar proteinsi

Entry informationi

Entry nameiTRN2_HYONI
AccessioniPrimary (citable) accession number: P50164
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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