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Protein

Tropinone reductase 1

Gene

TR1

Organism
Datura stramonium (Jimsonweed) (Common thornapple)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the stereospecific reduction of tropinone to tropine.1 Publication

Catalytic activityi

Tropine + NADP+ = tropinone + NADPH.1 Publication

Pathwayi: tropane alkaloid biosynthesis

This protein is involved in the pathway tropane alkaloid biosynthesis, which is part of Alkaloid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway tropane alkaloid biosynthesis and in Alkaloid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei158 – 1581Substrate1 Publication
Active sitei171 – 1711Proton acceptor1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi25 – 4925NADP1 PublicationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13848.
BRENDAi1.1.1.206. 1839.
SABIO-RKP50162.
UniPathwayiUPA00330.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropinone reductase 11 Publication (EC:1.1.1.2061 Publication)
Alternative name(s):
Tropine dehydrogenase
Tropinone reductase I
Short name:
TR-I
Gene namesi
Name:TR11 Publication
OrganismiDatura stramonium (Jimsonweed) (Common thornapple)
Taxonomic identifieri4076 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeDatureaeDatura

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Tropinone reductase 1PRO_0000054785Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1
273
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 286Combined sources
Helixi32 – 4312Combined sources
Beta strandi47 – 537Combined sources
Helixi55 – 6713Combined sources
Beta strandi72 – 765Combined sources
Helixi82 – 9514Combined sources
Beta strandi102 – 1054Combined sources
Turni115 – 1173Combined sources
Helixi120 – 13011Combined sources
Helixi132 – 14817Combined sources
Beta strandi150 – 1567Combined sources
Helixi159 – 1613Combined sources
Helixi169 – 18921Combined sources
Helixi190 – 1923Combined sources
Beta strandi194 – 2018Combined sources
Helixi207 – 2159Combined sources
Helixi220 – 22910Combined sources
Helixi238 – 24912Combined sources
Helixi251 – 2533Combined sources
Beta strandi260 – 2645Combined sources
Helixi267 – 2693Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AE1X-ray2.40A/B1-273[»]
ProteinModelPortaliP50162.
SMRiP50162. Positions 16-273.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50162.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK08081.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEESKVSMMN CNNEGRWSLK GTTALVTGGS KGIGYAIVEE LAGLGARVYT
60 70 80 90 100
CSRNEKELDE CLEIWREKGL NVEGSVCDLL SRTERDKLMQ TVAHVFDGKL
110 120 130 140 150
NILVNNAGVV IHKEAKDFTE KDYNIIMGTN FEAAYHLSQI AYPLLKASQN
160 170 180 190 200
GNVIFLSSIA GFSALPSVSL YSASKGAINQ MTKSLACEWA KDNIRVNSVA
210 220 230 240 250
PGVILTPLVE TAIKKNPHQK EEIDNFIVKT PMGRAGKPQE VSALIAFLCF
260 270
PAASYITGQI IWADGGFTAN GGF
Length:273
Mass (Da):29,617
Last modified:October 1, 1996 - v1
Checksum:i39A523EF04EA81F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20473 mRNA. Translation: AAA33281.1.
PIRiA48674.

Genome annotation databases

KEGGiag:AAA33281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20473 mRNA. Translation: AAA33281.1.
PIRiA48674.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AE1X-ray2.40A/B1-273[»]
ProteinModelPortaliP50162.
SMRiP50162. Positions 16-273.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAA33281.

Phylogenomic databases

KOiK08081.

Enzyme and pathway databases

UniPathwayiUPA00330.
BioCyciMetaCyc:MONOMER-13848.
BRENDAi1.1.1.206. 1839.
SABIO-RKP50162.

Miscellaneous databases

EvolutionaryTraceiP50162.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRN1_DATST
AccessioniPrimary (citable) accession number: P50162
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.