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Protein

Tropinone reductase 1

Gene

TR1

Organism
Datura stramonium (Jimsonweed) (Common thornapple)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the stereospecific reduction of tropinone to tropine.1 Publication

Catalytic activityi

Tropine + NADP+ = tropinone + NADPH.1 Publication

Pathwayi: tropane alkaloid biosynthesis

This protein is involved in the pathway tropane alkaloid biosynthesis, which is part of Alkaloid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway tropane alkaloid biosynthesis and in Alkaloid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei158Substrate1 Publication1
Active sitei171Proton acceptor1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi25 – 49NADP1 PublicationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13848.
BRENDAi1.1.1.206. 1839.
SABIO-RKP50162.
UniPathwayiUPA00330.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropinone reductase 11 Publication (EC:1.1.1.2061 Publication)
Alternative name(s):
Tropine dehydrogenase
Tropinone reductase I
Short name:
TR-I
Gene namesi
Name:TR11 Publication
OrganismiDatura stramonium (Jimsonweed) (Common thornapple)
Taxonomic identifieri4076 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeDatureaeDatura

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547851 – 273Tropinone reductase 1Add BLAST273

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 28Combined sources6
Helixi32 – 43Combined sources12
Beta strandi47 – 53Combined sources7
Helixi55 – 67Combined sources13
Beta strandi72 – 76Combined sources5
Helixi82 – 95Combined sources14
Beta strandi102 – 105Combined sources4
Turni115 – 117Combined sources3
Helixi120 – 130Combined sources11
Helixi132 – 148Combined sources17
Beta strandi150 – 156Combined sources7
Helixi159 – 161Combined sources3
Helixi169 – 189Combined sources21
Helixi190 – 192Combined sources3
Beta strandi194 – 201Combined sources8
Helixi207 – 215Combined sources9
Helixi220 – 229Combined sources10
Helixi238 – 249Combined sources12
Helixi251 – 253Combined sources3
Beta strandi260 – 264Combined sources5
Helixi267 – 269Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AE1X-ray2.40A/B1-273[»]
ProteinModelPortaliP50162.
SMRiP50162.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50162.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK08081.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEESKVSMMN CNNEGRWSLK GTTALVTGGS KGIGYAIVEE LAGLGARVYT
60 70 80 90 100
CSRNEKELDE CLEIWREKGL NVEGSVCDLL SRTERDKLMQ TVAHVFDGKL
110 120 130 140 150
NILVNNAGVV IHKEAKDFTE KDYNIIMGTN FEAAYHLSQI AYPLLKASQN
160 170 180 190 200
GNVIFLSSIA GFSALPSVSL YSASKGAINQ MTKSLACEWA KDNIRVNSVA
210 220 230 240 250
PGVILTPLVE TAIKKNPHQK EEIDNFIVKT PMGRAGKPQE VSALIAFLCF
260 270
PAASYITGQI IWADGGFTAN GGF
Length:273
Mass (Da):29,617
Last modified:October 1, 1996 - v1
Checksum:i39A523EF04EA81F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20473 mRNA. Translation: AAA33281.1.
PIRiA48674.

Genome annotation databases

KEGGiag:AAA33281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20473 mRNA. Translation: AAA33281.1.
PIRiA48674.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AE1X-ray2.40A/B1-273[»]
ProteinModelPortaliP50162.
SMRiP50162.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAA33281.

Phylogenomic databases

KOiK08081.

Enzyme and pathway databases

UniPathwayiUPA00330.
BioCyciMetaCyc:MONOMER-13848.
BRENDAi1.1.1.206. 1839.
SABIO-RKP50162.

Miscellaneous databases

EvolutionaryTraceiP50162.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRN1_DATST
AccessioniPrimary (citable) accession number: P50162
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.