Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P50153 (GBG4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Gene names
Name:Gng4
Synonyms:Gngt4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length75 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3 By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Brain.

Sequence similarities

Belongs to the G protein gamma family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7272Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
PRO_0000012623
Propeptide73 – 753Removed in mature form By similarity
PRO_0000012624

Amino acid modifications

Modified residue721Cysteine methyl ester By similarity
Lipidation721S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P50153 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 42FAEF47311FA195

FASTA758,405
        10         20         30         40         50         60 
MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAASD LLAYCEAHVR EDPLIIPVPA 

        70 
SENPFREKKF FCTIL 

« Hide

References

« Hide 'large scale' references
[1]"A brain-specific G protein gamma subunit."
Kalyanaraman S., Kalyanaraman V., Gautam N.
Biochem. Biophys. Res. Commun. 216:126-132(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Structure and chromosomal localization of mouse G protein subunit gamma4 gene."
Kalyanaraman S., Copeland N.G., Gilbert D.G., Jenkins N.A., Gautam N.
Genomics 49:147-151(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U37527 mRNA. Translation: AAB93460.1.
AF038594, AF038593 Genomic DNA. Translation: AAC40090.1.
BC016506 mRNA. Translation: AAH16506.1.
PIRJC4339.
RefSeqNP_034447.1. NM_010317.2.
XP_006516618.1. XM_006516555.1.
UniGeneMm.215394.

3D structure databases

ProteinModelPortalP50153.
SMRP50153. Positions 12-71.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-494N.
IntActP50153. 1 interaction.
STRING10090.ENSMUSP00000021734.

PTM databases

PhosphoSiteP50153.

Proteomic databases

PaxDbP50153.
PRIDEP50153.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021734; ENSMUSP00000021734; ENSMUSG00000021303.
GeneID14706.
KEGGmmu:14706.
UCSCuc007pml.1. mouse.

Organism-specific databases

CTD2786.
MGIMGI:102703. Gng4.

Phylogenomic databases

eggNOGNOG319015.
GeneTreeENSGT00740000115378.
HOGENOMHOG000231034.
HOVERGENHBG014983.
InParanoidP50153.
KOK04541.
OMAAYCEAHI.
OrthoDBEOG7H1JP7.
PhylomeDBP50153.
TreeFamTF319909.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

BgeeP50153.
GenevestigatorP50153.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. PTHR13809. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286687.
PROP50153.
SOURCESearch...

Entry information

Entry nameGBG4_MOUSE
AccessionPrimary (citable) accession number: P50153
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot