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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Gene

Gng4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_272374. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_286837. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_297430. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_308732. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_339334. Activation of G protein gated Potassium channels.
REACT_339920. Glucagon-type ligand receptors.
REACT_345203. Glucagon signaling in metabolic regulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Gene namesi
Name:Gng4
Synonyms:Gngt4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:102703. Gng4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7272Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4PRO_0000012623Add
BLAST
Propeptidei73 – 753Removed in mature formBy similarityPRO_0000012624

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei72 – 721Cysteine methyl esterBy similarity
Lipidationi72 – 721S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP50153.
PaxDbiP50153.
PRIDEiP50153.

PTM databases

PhosphoSiteiP50153.

Expressioni

Tissue specificityi

Brain.1 Publication

Gene expression databases

BgeeiP50153.
GenevisibleiP50153. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3 (By similarity). Interacts with KCNK1.By similarity1 Publication

Protein-protein interaction databases

DIPiDIP-494N.
IntActiP50153. 1 interaction.
STRINGi10090.ENSMUSP00000021734.

Structurei

3D structure databases

ProteinModelPortaliP50153.
SMRiP50153. Positions 12-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG319015.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP50153.
KOiK04541.
OMAiAYCEAHI.
OrthoDBiEOG7H1JP7.
PhylomeDBiP50153.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAASD LLAYCEAHVR
60 70
EDPLIIPVPA SENPFREKKF FCTIL
Length:75
Mass (Da):8,405
Last modified:October 1, 1996 - v1
Checksum:i42FAEF47311FA195
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37527 mRNA. Translation: AAB93460.1.
AF038594, AF038593 Genomic DNA. Translation: AAC40090.1.
BC016506 mRNA. Translation: AAH16506.1.
CCDSiCCDS36598.1.
PIRiJC4339.
RefSeqiNP_001289926.1. NM_001302997.1.
NP_034447.1. NM_010317.3.
UniGeneiMm.215394.

Genome annotation databases

EnsembliENSMUST00000021734; ENSMUSP00000021734; ENSMUSG00000021303.
GeneIDi14706.
KEGGimmu:14706.
UCSCiuc007pml.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37527 mRNA. Translation: AAB93460.1.
AF038594, AF038593 Genomic DNA. Translation: AAC40090.1.
BC016506 mRNA. Translation: AAH16506.1.
CCDSiCCDS36598.1.
PIRiJC4339.
RefSeqiNP_001289926.1. NM_001302997.1.
NP_034447.1. NM_010317.3.
UniGeneiMm.215394.

3D structure databases

ProteinModelPortaliP50153.
SMRiP50153. Positions 12-71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-494N.
IntActiP50153. 1 interaction.
STRINGi10090.ENSMUSP00000021734.

PTM databases

PhosphoSiteiP50153.

Proteomic databases

MaxQBiP50153.
PaxDbiP50153.
PRIDEiP50153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021734; ENSMUSP00000021734; ENSMUSG00000021303.
GeneIDi14706.
KEGGimmu:14706.
UCSCiuc007pml.2. mouse.

Organism-specific databases

CTDi2786.
MGIiMGI:102703. Gng4.

Phylogenomic databases

eggNOGiNOG319015.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP50153.
KOiK04541.
OMAiAYCEAHI.
OrthoDBiEOG7H1JP7.
PhylomeDBiP50153.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiREACT_272374. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_286837. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_297430. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_308732. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_339334. Activation of G protein gated Potassium channels.
REACT_339920. Glucagon-type ligand receptors.
REACT_345203. Glucagon signaling in metabolic regulation.

Miscellaneous databases

NextBioi286687.
PROiP50153.
SOURCEiSearch...

Gene expression databases

BgeeiP50153.
GenevisibleiP50153. MM.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Structure and chromosomal localization of mouse G protein subunit gamma4 gene."
    Kalyanaraman S., Copeland N.G., Gilbert D.G., Jenkins N.A., Gautam N.
    Genomics 49:147-151(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. "A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes."
    Hwang E.M., Kim E., Yarishkin O., Woo D.H., Han K.S., Park N., Bae Y., Woo J., Kim D., Park M., Lee C.J., Park J.Y.
    Nat. Commun. 5:3227-3227(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KCNK1.

Entry informationi

Entry nameiGBG4_MOUSE
AccessioniPrimary (citable) accession number: P50153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 22, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.