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P50153

- GBG4_MOUSE

UniProt

P50153 - GBG4_MOUSE

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Protein
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Gene
Gng4, Gngt4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. GTPase activity Source: MGI
  2. signal transducer activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: MGI
  2. GTP catabolic process Source: GOC
  3. negative regulation of cell growth Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Gene namesi
Name:Gng4
Synonyms:Gngt4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:102703. Gng4.

Subcellular locationi

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7272Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
PRO_0000012623Add
BLAST
Propeptidei73 – 753Removed in mature form By similarity
PRO_0000012624

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei72 – 721Cysteine methyl ester By similarity
Lipidationi72 – 721S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP50153.
PRIDEiP50153.

PTM databases

PhosphoSiteiP50153.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiP50153.
GenevestigatoriP50153.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3 By similarity.

Protein-protein interaction databases

DIPiDIP-494N.
IntActiP50153. 1 interaction.
STRINGi10090.ENSMUSP00000021734.

Structurei

3D structure databases

ProteinModelPortaliP50153.
SMRiP50153. Positions 12-71.

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.

Phylogenomic databases

eggNOGiNOG319015.
GeneTreeiENSGT00740000115378.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP50153.
KOiK04541.
OMAiNATQPRP.
OrthoDBiEOG7H1JP7.
PhylomeDBiP50153.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50153-1 [UniParc]FASTAAdd to Basket

« Hide

MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAASD LLAYCEAHVR   50
EDPLIIPVPA SENPFREKKF FCTIL 75
Length:75
Mass (Da):8,405
Last modified:October 1, 1996 - v1
Checksum:i42FAEF47311FA195
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37527 mRNA. Translation: AAB93460.1.
AF038594, AF038593 Genomic DNA. Translation: AAC40090.1.
BC016506 mRNA. Translation: AAH16506.1.
CCDSiCCDS36598.1.
PIRiJC4339.
RefSeqiNP_034447.1. NM_010317.2.
XP_006516618.1. XM_006516555.1.
UniGeneiMm.215394.

Genome annotation databases

EnsembliENSMUST00000021734; ENSMUSP00000021734; ENSMUSG00000021303.
GeneIDi14706.
KEGGimmu:14706.
UCSCiuc007pml.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37527 mRNA. Translation: AAB93460.1 .
AF038594 , AF038593 Genomic DNA. Translation: AAC40090.1 .
BC016506 mRNA. Translation: AAH16506.1 .
CCDSi CCDS36598.1.
PIRi JC4339.
RefSeqi NP_034447.1. NM_010317.2.
XP_006516618.1. XM_006516555.1.
UniGenei Mm.215394.

3D structure databases

ProteinModelPortali P50153.
SMRi P50153. Positions 12-71.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-494N.
IntActi P50153. 1 interaction.
STRINGi 10090.ENSMUSP00000021734.

PTM databases

PhosphoSitei P50153.

Proteomic databases

PaxDbi P50153.
PRIDEi P50153.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021734 ; ENSMUSP00000021734 ; ENSMUSG00000021303 .
GeneIDi 14706.
KEGGi mmu:14706.
UCSCi uc007pml.1. mouse.

Organism-specific databases

CTDi 2786.
MGIi MGI:102703. Gng4.

Phylogenomic databases

eggNOGi NOG319015.
GeneTreei ENSGT00740000115378.
HOGENOMi HOG000231034.
HOVERGENi HBG014983.
InParanoidi P50153.
KOi K04541.
OMAi NATQPRP.
OrthoDBi EOG7H1JP7.
PhylomeDBi P50153.
TreeFami TF319909.

Enzyme and pathway databases

Reactomei REACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

NextBioi 286687.
PROi P50153.
SOURCEi Search...

Gene expression databases

Bgeei P50153.
Genevestigatori P50153.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Structure and chromosomal localization of mouse G protein subunit gamma4 gene."
    Kalyanaraman S., Copeland N.G., Gilbert D.G., Jenkins N.A., Gautam N.
    Genomics 49:147-151(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiGBG4_MOUSE
AccessioniPrimary (citable) accession number: P50153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi