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P50153

- GBG4_MOUSE

UniProt

P50153 - GBG4_MOUSE

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Gene

Gng4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GO - Molecular functioni

    1. GTPase activity Source: MGI
    2. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: MGI
    2. GTP catabolic process Source: GOC
    3. negative regulation of cell growth Source: Ensembl

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_221970. Ca2+ pathway.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
    Gene namesi
    Name:Gng4
    Synonyms:Gngt4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:102703. Gng4.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7272Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4PRO_0000012623Add
    BLAST
    Propeptidei73 – 753Removed in mature formBy similarityPRO_0000012624

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei72 – 721Cysteine methyl esterBy similarity
    Lipidationi72 – 721S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiP50153.
    PRIDEiP50153.

    PTM databases

    PhosphoSiteiP50153.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    BgeeiP50153.
    GenevestigatoriP50153.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3 By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-494N.
    IntActiP50153. 1 interaction.
    STRINGi10090.ENSMUSP00000021734.

    Structurei

    3D structure databases

    ProteinModelPortaliP50153.
    SMRiP50153. Positions 12-71.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG319015.
    GeneTreeiENSGT00740000115378.
    HOGENOMiHOG000231034.
    HOVERGENiHBG014983.
    InParanoidiP50153.
    KOiK04541.
    OMAiNATQPRP.
    OrthoDBiEOG7H1JP7.
    PhylomeDBiP50153.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P50153-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAASD LLAYCEAHVR   50
    EDPLIIPVPA SENPFREKKF FCTIL 75
    Length:75
    Mass (Da):8,405
    Last modified:October 1, 1996 - v1
    Checksum:i42FAEF47311FA195
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37527 mRNA. Translation: AAB93460.1.
    AF038594, AF038593 Genomic DNA. Translation: AAC40090.1.
    BC016506 mRNA. Translation: AAH16506.1.
    CCDSiCCDS36598.1.
    PIRiJC4339.
    RefSeqiNP_034447.1. NM_010317.2.
    XP_006516618.1. XM_006516555.1.
    UniGeneiMm.215394.

    Genome annotation databases

    EnsembliENSMUST00000021734; ENSMUSP00000021734; ENSMUSG00000021303.
    GeneIDi14706.
    KEGGimmu:14706.
    UCSCiuc007pml.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37527 mRNA. Translation: AAB93460.1 .
    AF038594 , AF038593 Genomic DNA. Translation: AAC40090.1 .
    BC016506 mRNA. Translation: AAH16506.1 .
    CCDSi CCDS36598.1.
    PIRi JC4339.
    RefSeqi NP_034447.1. NM_010317.2.
    XP_006516618.1. XM_006516555.1.
    UniGenei Mm.215394.

    3D structure databases

    ProteinModelPortali P50153.
    SMRi P50153. Positions 12-71.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-494N.
    IntActi P50153. 1 interaction.
    STRINGi 10090.ENSMUSP00000021734.

    PTM databases

    PhosphoSitei P50153.

    Proteomic databases

    PaxDbi P50153.
    PRIDEi P50153.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021734 ; ENSMUSP00000021734 ; ENSMUSG00000021303 .
    GeneIDi 14706.
    KEGGi mmu:14706.
    UCSCi uc007pml.1. mouse.

    Organism-specific databases

    CTDi 2786.
    MGIi MGI:102703. Gng4.

    Phylogenomic databases

    eggNOGi NOG319015.
    GeneTreei ENSGT00740000115378.
    HOGENOMi HOG000231034.
    HOVERGENi HBG014983.
    InParanoidi P50153.
    KOi K04541.
    OMAi NATQPRP.
    OrthoDBi EOG7H1JP7.
    PhylomeDBi P50153.
    TreeFami TF319909.

    Enzyme and pathway databases

    Reactomei REACT_208837. Activation of G protein gated Potassium channels.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_221970. Ca2+ pathway.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Miscellaneous databases

    NextBioi 286687.
    PROi P50153.
    SOURCEi Search...

    Gene expression databases

    Bgeei P50153.
    Genevestigatori P50153.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Structure and chromosomal localization of mouse G protein subunit gamma4 gene."
      Kalyanaraman S., Copeland N.G., Gilbert D.G., Jenkins N.A., Gautam N.
      Genomics 49:147-151(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiGBG4_MOUSE
    AccessioniPrimary (citable) accession number: P50153
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3