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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Gene

Gng4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Gene namesi
Name:Gng4
Synonyms:Gngt4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:102703. Gng4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7272Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4PRO_0000012623Add
BLAST
Propeptidei73 – 753Removed in mature formBy similarityPRO_0000012624

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei72 – 721Cysteine methyl esterBy similarity
Lipidationi72 – 721S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP50153.
PaxDbiP50153.
PeptideAtlasiP50153.
PRIDEiP50153.

PTM databases

iPTMnetiP50153.
PhosphoSiteiP50153.

Expressioni

Tissue specificityi

Brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000021303.
GenevisibleiP50153. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3 (By similarity). Interacts with KCNK1.By similarity1 Publication

Protein-protein interaction databases

DIPiDIP-494N.
IntActiP50153. 1 interaction.
STRINGi10090.ENSMUSP00000021734.

Structurei

3D structure databases

ProteinModelPortaliP50153.
SMRiP50153. Positions 12-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP50153.
KOiK04541.
OMAiKEGMSSN.
OrthoDBiEOG091G17J0.
PhylomeDBiP50153.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAASD LLAYCEAHVR
60 70
EDPLIIPVPA SENPFREKKF FCTIL
Length:75
Mass (Da):8,405
Last modified:October 1, 1996 - v1
Checksum:i42FAEF47311FA195
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37527 mRNA. Translation: AAB93460.1.
AF038594, AF038593 Genomic DNA. Translation: AAC40090.1.
BC016506 mRNA. Translation: AAH16506.1.
CCDSiCCDS36598.1.
PIRiJC4339.
RefSeqiNP_001289926.1. NM_001302997.1.
NP_034447.1. NM_010317.3.
UniGeneiMm.215394.

Genome annotation databases

EnsembliENSMUST00000021734; ENSMUSP00000021734; ENSMUSG00000021303.
GeneIDi14706.
KEGGimmu:14706.
UCSCiuc007pml.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37527 mRNA. Translation: AAB93460.1.
AF038594, AF038593 Genomic DNA. Translation: AAC40090.1.
BC016506 mRNA. Translation: AAH16506.1.
CCDSiCCDS36598.1.
PIRiJC4339.
RefSeqiNP_001289926.1. NM_001302997.1.
NP_034447.1. NM_010317.3.
UniGeneiMm.215394.

3D structure databases

ProteinModelPortaliP50153.
SMRiP50153. Positions 12-71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-494N.
IntActiP50153. 1 interaction.
STRINGi10090.ENSMUSP00000021734.

PTM databases

iPTMnetiP50153.
PhosphoSiteiP50153.

Proteomic databases

MaxQBiP50153.
PaxDbiP50153.
PeptideAtlasiP50153.
PRIDEiP50153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021734; ENSMUSP00000021734; ENSMUSG00000021303.
GeneIDi14706.
KEGGimmu:14706.
UCSCiuc007pml.2. mouse.

Organism-specific databases

CTDi2786.
MGIiMGI:102703. Gng4.

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP50153.
KOiK04541.
OMAiKEGMSSN.
OrthoDBiEOG091G17J0.
PhylomeDBiP50153.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

PROiP50153.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021303.
GenevisibleiP50153. MM.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBG4_MOUSE
AccessioniPrimary (citable) accession number: P50153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.