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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

Gene

GNG10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.

GO - Molecular functioni

  1. GTPase activity Source: ProtInc
  2. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to glucagon stimulus Source: Reactome
  2. energy reserve metabolic process Source: Reactome
  3. G-protein coupled receptor signaling pathway Source: InterPro
  4. signal transduction Source: ProtInc
  5. small molecule metabolic process Source: Reactome
  6. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_15457. G-protein activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_263982. Ca2+ pathway.
REACT_75831. Activation of G protein gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
Gene namesi
Name:GNG10
Synonyms:GNGT10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:4402. GNG10.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. heterotrimeric G-protein complex Source: InterPro
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28781.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10PRO_0000012655Add
BLAST
Propeptidei66 – 683Removed in mature formBy similarityPRO_0000012656

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei65 – 651Cysteine methyl esterBy similarity
Lipidationi65 – 651S-geranylgeranyl cysteine1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP50151.
PaxDbiP50151.
PRIDEiP50151.

PTM databases

PhosphoSiteiP50151.

Expressioni

Tissue specificityi

Abundantly and ubiquitously expressed.

Gene expression databases

BgeeiP50151.
CleanExiHS_GNG10.
ExpressionAtlasiP50151. baseline and differential.
GenevestigatoriP50151.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

BioGridi109052. 14 interactions.
MINTiMINT-87208.
STRINGi9606.ENSP00000363411.

Structurei

3D structure databases

ProteinModelPortaliP50151.
SMRiP50151. Positions 5-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG325983.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP50151.
KOiK04545.
OMAiQQYCLQN.
OrthoDBiEOG7H1JP7.
PhylomeDBiP50151.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGASASAL QRLVEQLKLE AGVERIKVSQ AAAELQQYCM QNACKDALLV
60
GVPAGSNPFR EPRSCALL
Length:68
Mass (Da):7,205
Last modified:September 30, 1996 - v1
Checksum:iE3EC3CEA0EB0BD5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31383 mRNA. Translation: AAC50205.1.
AF493877 mRNA. Translation: AAM12591.1.
AL135787 Genomic DNA. Translation: CAC22155.1.
BC010384 mRNA. Translation: AAH10384.1.
BC015206 mRNA. No translation available.
BC016319 mRNA. Translation: AAH16319.1.
BC072671 mRNA. Translation: AAH72671.1.
BC107574 mRNA. Translation: AAI07575.1.
CCDSiCCDS35107.1.
PIRiI39158.
RefSeqiNP_001017998.1. NM_001017998.3.
NP_001185593.1. NM_001198664.1.
UniGeneiHs.534196.
Hs.732002.

Genome annotation databases

EnsembliENST00000374293; ENSP00000363411; ENSG00000242616.
GeneIDi2790.
KEGGihsa:2790.
UCSCiuc004bfp.3. human.

Polymorphism databases

DMDMi1730222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31383 mRNA. Translation: AAC50205.1.
AF493877 mRNA. Translation: AAM12591.1.
AL135787 Genomic DNA. Translation: CAC22155.1.
BC010384 mRNA. Translation: AAH10384.1.
BC015206 mRNA. No translation available.
BC016319 mRNA. Translation: AAH16319.1.
BC072671 mRNA. Translation: AAH72671.1.
BC107574 mRNA. Translation: AAI07575.1.
CCDSiCCDS35107.1.
PIRiI39158.
RefSeqiNP_001017998.1. NM_001017998.3.
NP_001185593.1. NM_001198664.1.
UniGeneiHs.534196.
Hs.732002.

3D structure databases

ProteinModelPortaliP50151.
SMRiP50151. Positions 5-61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109052. 14 interactions.
MINTiMINT-87208.
STRINGi9606.ENSP00000363411.

PTM databases

PhosphoSiteiP50151.

Polymorphism databases

DMDMi1730222.

Proteomic databases

MaxQBiP50151.
PaxDbiP50151.
PRIDEiP50151.

Protocols and materials databases

DNASUi2790.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374293; ENSP00000363411; ENSG00000242616.
GeneIDi2790.
KEGGihsa:2790.
UCSCiuc004bfp.3. human.

Organism-specific databases

CTDi2790.
GeneCardsiGC09P114423.
H-InvDBHIX0201744.
HGNCiHGNC:4402. GNG10.
MIMi604389. gene.
neXtProtiNX_P50151.
PharmGKBiPA28781.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG325983.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP50151.
KOiK04545.
OMAiQQYCLQN.
OrthoDBiEOG7H1JP7.
PhylomeDBiP50151.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiREACT_15457. G-protein activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_263982. Ca2+ pathway.
REACT_75831. Activation of G protein gated Potassium channels.

Miscellaneous databases

GenomeRNAii2790.
NextBioi10993.
PROiP50151.
SOURCEiSearch...

Gene expression databases

BgeeiP50151.
CleanExiHS_GNG10.
ExpressionAtlasiP50151. baseline and differential.
GenevestigatoriP50151.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits."
    Ray K., Kunsch C., Bonner L.M., Robishaw J.D.
    J. Biol. Chem. 270:21765-21771(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ISOPRENYLATION AT CYS-65.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGBG10_HUMAN
AccessioniPrimary (citable) accession number: P50151
Secondary accession number(s): Q3B7K2, Q4VC27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 30, 1996
Last sequence update: September 30, 1996
Last modified: March 31, 2015
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.