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P50151 (GBG10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
Gene names
Name:GNG10
Synonyms:GNGT10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length68 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Abundantly and ubiquitously expressed.

Sequence similarities

Belongs to the G protein gamma family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
PRO_0000012655
Propeptide66 – 683Removed in mature form By similarity
PRO_0000012656

Amino acid modifications

Modified residue21N-acetylserine Ref.5
Modified residue651Cysteine methyl ester By similarity
Lipidation651S-geranylgeranyl cysteine Ref.1

Sequences

Sequence LengthMass (Da)Tools
P50151 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E3EC3CEA0EB0BD5A

FASTA687,205
        10         20         30         40         50         60 
MSSGASASAL QRLVEQLKLE AGVERIKVSQ AAAELQQYCM QNACKDALLV GVPAGSNPFR 


EPRSCALL 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits."
Ray K., Kunsch C., Bonner L.M., Robishaw J.D.
J. Biol. Chem. 270:21765-21771(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ISOPRENYLATION AT CYS-65.
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Lung.
[5]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U31383 mRNA. Translation: AAC50205.1.
AF493877 mRNA. Translation: AAM12591.1.
AL135787 Genomic DNA. Translation: CAC22155.1.
BC010384 mRNA. Translation: AAH10384.1.
BC015206 mRNA. No translation available.
BC016319 mRNA. Translation: AAH16319.1.
BC072671 mRNA. Translation: AAH72671.1.
BC107574 mRNA. Translation: AAI07575.1.
CCDSCCDS35107.1.
PIRI39158.
RefSeqNP_001017998.1. NM_001017998.3.
NP_001185593.1. NM_001198664.1.
UniGeneHs.534196.
Hs.732002.

3D structure databases

ProteinModelPortalP50151.
SMRP50151. Positions 11-58.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109052. 4 interactions.
MINTMINT-87208.
STRING9606.ENSP00000363411.

PTM databases

PhosphoSiteP50151.

Polymorphism databases

DMDM1730222.

Proteomic databases

MaxQBP50151.
PaxDbP50151.
PRIDEP50151.

Protocols and materials databases

DNASU2790.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374293; ENSP00000363411; ENSG00000242616.
GeneID2790.
KEGGhsa:2790.
UCSCuc004bfp.3. human.

Organism-specific databases

CTD2790.
GeneCardsGC09P114423.
H-InvDBHIX0201744.
HGNCHGNC:4402. GNG10.
MIM604389. gene.
neXtProtNX_P50151.
PharmGKBPA28781.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG325983.
HOGENOMHOG000231034.
HOVERGENHBG014983.
KOK04545.
OMAYCLQNAG.
OrthoDBEOG7H1JP7.
PhylomeDBP50151.
TreeFamTF319909.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_111217. Metabolism.
REACT_13685. Neuronal System.
REACT_15518. Transmembrane transport of small molecules.
REACT_604. Hemostasis.

Gene expression databases

BgeeP50151.
CleanExHS_GNG10.
GenevestigatorP50151.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. PTHR13809. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi2790.
NextBio10993.
PROP50151.
SOURCESearch...

Entry information

Entry nameGBG10_HUMAN
AccessionPrimary (citable) accession number: P50151
Secondary accession number(s): Q3B7K2, Q4VC27
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM