Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P50150

- GBG4_HUMAN

UniProt

P50150 - GBG4_HUMAN

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Gene

GNG4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to glucagon stimulus Source: Reactome
    2. energy reserve metabolic process Source: Reactome
    3. G-protein coupled receptor signaling pathway Source: InterPro
    4. negative regulation of cell growth Source: BHF-UCL
    5. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
    6. small molecule metabolic process Source: Reactome
    7. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_15457. G-protein activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_172761. Ca2+ pathway.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18283. G alpha (q) signalling events.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
    REACT_18377. Glucagon-type ligand receptors.
    REACT_18407. G alpha (12/13) signalling events.
    REACT_19140. ADP signalling through P2Y purinoceptor 1.
    REACT_19145. G beta:gamma signalling through PLC beta.
    REACT_19231. G alpha (i) signalling events.
    REACT_19290. G beta:gamma signalling through PI3Kgamma.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_20647. Thromboxane signalling through TP receptor.
    REACT_20653. ADP signalling through P2Y purinoceptor 12.
    REACT_21254. Presynaptic function of Kainate receptors.
    REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_23946. Prostacyclin signalling through prostacyclin receptor.
    REACT_24023. Regulation of water balance by renal Aquaporins.
    REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75831. Activation of G protein gated Potassium channels.
    SignaLinkiP50150.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
    Gene namesi
    Name:GNG4
    Synonyms:GNGT4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:4407. GNG4.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: InterPro
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28786.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7272Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4PRO_0000012621Add
    BLAST
    Propeptidei73 – 753Removed in mature formPRO_0000012622

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei72 – 721Cysteine methyl ester1 Publication
    Lipidationi72 – 721S-geranylgeranyl cysteine1 Publication

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiP50150.
    PaxDbiP50150.
    PeptideAtlasiP50150.
    PRIDEiP50150.

    PTM databases

    PhosphoSiteiP50150.

    Expressioni

    Tissue specificityi

    Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle.

    Gene expression databases

    ArrayExpressiP50150.
    BgeeiP50150.
    CleanExiHS_GNG4.
    GenevestigatoriP50150.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Kcnk2Q920B63EBI-6395970,EBI-6530063From a different organism.

    Protein-protein interaction databases

    BioGridi109048. 7 interactions.
    IntActiP50150. 1 interaction.
    MINTiMINT-5004317.
    STRINGi9606.ENSP00000355556.

    Structurei

    3D structure databases

    ProteinModelPortaliP50150.
    SMRiP50150. Positions 12-71.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG319015.
    HOVERGENiHBG014983.
    InParanoidiP50150.
    KOiK04541.
    OMAiKEGMSSN.
    OrthoDBiEOG7H1JP7.
    PhylomeDBiP50150.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P50150-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAAAD LLAYCEAHVR   50
    EDPLIIPVPA SENPFREKKF FCTIL 75
    Length:75
    Mass (Da):8,389
    Last modified:October 1, 1996 - v1
    Checksum:i42FAEF4728F83FF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31382 mRNA. Translation: AAC50204.1.
    AF493872 mRNA. Translation: AAM12586.1.
    BC022485 mRNA. Translation: AAH22485.1.
    CCDSiCCDS1607.1.
    PIRiI39157.
    RefSeqiNP_001092191.1. NM_001098721.1.
    NP_001092192.1. NM_001098722.1.
    NP_004476.1. NM_004485.3.
    XP_006711824.1. XM_006711761.1.
    XP_006711825.1. XM_006711762.1.
    UniGeneiHs.159711.

    Genome annotation databases

    EnsembliENST00000366597; ENSP00000355556; ENSG00000168243.
    ENST00000366598; ENSP00000355557; ENSG00000168243.
    ENST00000391854; ENSP00000375727; ENSG00000168243.
    ENST00000450593; ENSP00000398629; ENSG00000168243.
    GeneIDi2786.
    KEGGihsa:2786.
    UCSCiuc001hxe.4. human.

    Polymorphism databases

    DMDMi1730219.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31382 mRNA. Translation: AAC50204.1 .
    AF493872 mRNA. Translation: AAM12586.1 .
    BC022485 mRNA. Translation: AAH22485.1 .
    CCDSi CCDS1607.1.
    PIRi I39157.
    RefSeqi NP_001092191.1. NM_001098721.1.
    NP_001092192.1. NM_001098722.1.
    NP_004476.1. NM_004485.3.
    XP_006711824.1. XM_006711761.1.
    XP_006711825.1. XM_006711762.1.
    UniGenei Hs.159711.

    3D structure databases

    ProteinModelPortali P50150.
    SMRi P50150. Positions 12-71.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109048. 7 interactions.
    IntActi P50150. 1 interaction.
    MINTi MINT-5004317.
    STRINGi 9606.ENSP00000355556.

    PTM databases

    PhosphoSitei P50150.

    Polymorphism databases

    DMDMi 1730219.

    Proteomic databases

    MaxQBi P50150.
    PaxDbi P50150.
    PeptideAtlasi P50150.
    PRIDEi P50150.

    Protocols and materials databases

    DNASUi 2786.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366597 ; ENSP00000355556 ; ENSG00000168243 .
    ENST00000366598 ; ENSP00000355557 ; ENSG00000168243 .
    ENST00000391854 ; ENSP00000375727 ; ENSG00000168243 .
    ENST00000450593 ; ENSP00000398629 ; ENSG00000168243 .
    GeneIDi 2786.
    KEGGi hsa:2786.
    UCSCi uc001hxe.4. human.

    Organism-specific databases

    CTDi 2786.
    GeneCardsi GC01M235710.
    HGNCi HGNC:4407. GNG4.
    MIMi 604388. gene.
    neXtProti NX_P50150.
    PharmGKBi PA28786.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG319015.
    HOVERGENi HBG014983.
    InParanoidi P50150.
    KOi K04541.
    OMAi KEGMSSN.
    OrthoDBi EOG7H1JP7.
    PhylomeDBi P50150.
    TreeFami TF319909.

    Enzyme and pathway databases

    Reactomei REACT_15457. G-protein activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_172761. Ca2+ pathway.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18283. G alpha (q) signalling events.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
    REACT_18377. Glucagon-type ligand receptors.
    REACT_18407. G alpha (12/13) signalling events.
    REACT_19140. ADP signalling through P2Y purinoceptor 1.
    REACT_19145. G beta:gamma signalling through PLC beta.
    REACT_19231. G alpha (i) signalling events.
    REACT_19290. G beta:gamma signalling through PI3Kgamma.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_20647. Thromboxane signalling through TP receptor.
    REACT_20653. ADP signalling through P2Y purinoceptor 12.
    REACT_21254. Presynaptic function of Kainate receptors.
    REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_23946. Prostacyclin signalling through prostacyclin receptor.
    REACT_24023. Regulation of water balance by renal Aquaporins.
    REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75831. Activation of G protein gated Potassium channels.
    SignaLinki P50150.

    Miscellaneous databases

    ChiTaRSi GNG4. human.
    GenomeRNAii 2786.
    NextBioi 10975.
    PROi P50150.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50150.
    Bgeei P50150.
    CleanExi HS_GNG4.
    Genevestigatori P50150.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits."
      Ray K., Kunsch C., Bonner L.M., Robishaw J.D.
      J. Biol. Chem. 270:21765-21771(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ISOPRENYLATION AT CYS-72, METHYLATION AT CYS-72.
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGBG4_HUMAN
    AccessioniPrimary (citable) accession number: P50150
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3