P50150 (GBG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Gene names

Name:	GNG4
Synonyms:	GNGT4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	75 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subunit structure	G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Tissue specificity	Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle.
Sequence similarities	Belongs to the G protein gamma family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Molecular function	Transducer
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro cellular response to glucagon stimulus Traceable author statement. Source: Reactome energy reserve metabolic process Traceable author statement. Source: Reactome negative regulation of cell growth Inferred from mutant phenotype PubMed 15824735. Source: BHF-UCL regulation of G-protein coupled receptor protein signaling pathway Traceable author statement Ref.1. Source: ProtInc small molecule metabolic process Traceable author statement. Source: Reactome synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro plasma membrane Traceable author statement. Source: Reactome
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Kcnk2	Q3MMY3	3	EBI-6395970,EBI-6530063	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 72	72	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4		PRO_0000012621
	Propeptide	73 – 75	3	Removed in mature form		PRO_0000012622
Amino acid modifications
	Modified residue	72	1	Cysteine methyl ester Ref.1
	Lipidation	72	1	S-geranylgeranyl cysteine Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P50150 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 42FAEF4728F83FF5	FASTA	75	8,389
	10 20 30 40 50 60 MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAAAD LLAYCEAHVR EDPLIIPVPA 70 SENPFREKKF FCTIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits." Ray K., Kunsch C., Bonner L.M., Robishaw J.D. J. Biol. Chem. 270:21765-21771(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ISOPRENYLATION AT CYS-72, METHYLATION AT CYS-72.
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U31382 mRNA. Translation: AAC50204.1. AF493872 mRNA. Translation: AAM12586.1. BC022485 mRNA. Translation: AAH22485.1.
IPI	IPI00030058.
PIR	I39157.
RefSeq	NP_001092191.1. NM_001098721.1. NP_001092192.1. NM_001098722.1. NP_004476.1. NM_004485.3.
UniGene	Hs.159711.
3D structure databases
ProteinModelPortal	P50150.
ModBase	Search...
Protein-protein interaction databases
IntAct	P50150. 1 interaction.
MINT	MINT-5004317.
STRING	9606.ENSP00000355556.
PTM databases
PhosphoSite	P50150.
Polymorphism databases
DMDM	1730219.
Proteomic databases
PaxDb	P50150.
PeptideAtlas	P50150.
PRIDE	P50150.
Protocols and materials databases
DNASU	2786.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000366597; ENSP00000355556; ENSG00000168243. ENST00000366598; ENSP00000355557; ENSG00000168243. ENST00000391854; ENSP00000375727; ENSG00000168243. ENST00000450593; ENSP00000398629; ENSG00000168243.
GeneID	2786.
KEGG	hsa:2786.
UCSC	uc001hxe.4. human.
Organism-specific databases
CTD	2786.
GeneCards	GC01M235710.
HGNC	HGNC:4407. GNG4.
MIM	604388. gene.
neXtProt	NX_P50150.
PharmGKB	PA28786.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG319015.
HOVERGEN	HBG014983.
InParanoid	P50150.
KO	K04541.
OMA	EVMSNNS.
OrthoDB	EOG47WNQC.
PhylomeDB	P50150.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_111217. Metabolism. REACT_13685. Neuronal System. REACT_15518. Transmembrane transport of small molecules. REACT_604. Hemostasis.
SignaLink	P50150.
Gene expression databases
ArrayExpress	P50150.
Bgee	P50150.
CleanEx	HS_GNG4.
Genevestigator	P50150.
GermOnline	ENSG00000168243. Homo sapiens.
Family and domain databases
Gene3D	4.10.260.10. 1 hit.
InterPro	IPR015898. G-protein_gamma-like_dom. IPR001770. Gprotein-gamma. [Graphical view]
PANTHER	PTHR13809. PTHR13809. 1 hit.
Pfam	PF00631. G-gamma. 1 hit. [Graphical view]
PRINTS	PR00321. GPROTEING.
SMART	SM00224. GGL. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit.
PROSITE	PS50058. G_PROTEIN_GAMMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GNG4. human.
GenomeRNAi	2786.
NextBio	10975.
SOURCE	Search...

Entry information

Entry name

GBG4_HUMAN

Accession

Primary (citable) accession number: P50150

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 124 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.