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P50150 (GBG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Gene names
Name:GNG4
Synonyms:GNGT4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length75 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle.

Sequence similarities

Belongs to the G protein gamma family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Kcnk2Q3MMY33EBI-6395970,EBI-6530063From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7272Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
PRO_0000012621
Propeptide73 – 753Removed in mature form
PRO_0000012622

Amino acid modifications

Modified residue721Cysteine methyl ester Ref.1
Lipidation721S-geranylgeranyl cysteine Ref.1

Sequences

Sequence LengthMass (Da)Tools
P50150 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 42FAEF4728F83FF5

FASTA758,389
        10         20         30         40         50         60 
MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAAAD LLAYCEAHVR EDPLIIPVPA 

        70 
SENPFREKKF FCTIL 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits."
Ray K., Kunsch C., Bonner L.M., Robishaw J.D.
J. Biol. Chem. 270:21765-21771(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ISOPRENYLATION AT CYS-72, METHYLATION AT CYS-72.
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U31382 mRNA. Translation: AAC50204.1.
AF493872 mRNA. Translation: AAM12586.1.
BC022485 mRNA. Translation: AAH22485.1.
PIRI39157.
RefSeqNP_001092191.1. NM_001098721.1.
NP_001092192.1. NM_001098722.1.
NP_004476.1. NM_004485.3.
UniGeneHs.159711.

3D structure databases

ProteinModelPortalP50150.
SMRP50150. Positions 12-71.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109048. 7 interactions.
IntActP50150. 1 interaction.
MINTMINT-5004317.
STRING9606.ENSP00000355556.

PTM databases

PhosphoSiteP50150.

Polymorphism databases

DMDM1730219.

Proteomic databases

PaxDbP50150.
PeptideAtlasP50150.
PRIDEP50150.

Protocols and materials databases

DNASU2786.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000366597; ENSP00000355556; ENSG00000168243.
ENST00000366598; ENSP00000355557; ENSG00000168243.
ENST00000391854; ENSP00000375727; ENSG00000168243.
ENST00000450593; ENSP00000398629; ENSG00000168243.
GeneID2786.
KEGGhsa:2786.
UCSCuc001hxe.4. human.

Organism-specific databases

CTD2786.
GeneCardsGC01M235710.
HGNCHGNC:4407. GNG4.
MIM604388. gene.
neXtProtNX_P50150.
PharmGKBPA28786.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG319015.
HOVERGENHBG014983.
InParanoidP50150.
KOK04541.
OMAAYCEAHI.
OrthoDBEOG7H1JP7.
PhylomeDBP50150.
TreeFamTF319909.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_111217. Metabolism.
REACT_13685. Neuronal System.
REACT_15518. Transmembrane transport of small molecules.
REACT_604. Hemostasis.
SignaLinkP50150.

Gene expression databases

ArrayExpressP50150.
BgeeP50150.
CleanExHS_GNG4.
GenevestigatorP50150.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. PTHR13809. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGNG4. human.
GenomeRNAi2786.
NextBio10975.
PROP50150.
SOURCESearch...

Entry information

Entry nameGBG4_HUMAN
AccessionPrimary (citable) accession number: P50150
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM