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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Gene

GNG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.Curated

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: InterPro
  • negative regulation of cell growth Source: BHF-UCL
  • regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SignaLinkiP50150

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Gene namesi
Name:GNG4
Synonyms:GNGT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000168243.10
HGNCiHGNC:4407 GNG4
MIMi604388 gene
neXtProtiNX_P50150

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2786
OpenTargetsiENSG00000168243
PharmGKBiPA28786

Polymorphism and mutation databases

BioMutaiGNG4
DMDMi1730219

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126211 – 72Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4Add BLAST72
PropeptideiPRO_000001262273 – 75Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72Cysteine methyl ester1 Publication1
Lipidationi72S-geranylgeranyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP50150
MaxQBiP50150
PaxDbiP50150
PeptideAtlasiP50150
PRIDEiP50150

PTM databases

PhosphoSitePlusiP50150

Expressioni

Tissue specificityi

Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle.

Gene expression databases

BgeeiENSG00000168243
CleanExiHS_GNG4
ExpressionAtlasiP50150 baseline and differential
GenevisibleiP50150 HS

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3 (PubMed:7665596). Interacts with KCNK1 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnk2Q920B63EBI-6395970,EBI-6530063From Rattus norvegicus.

Protein-protein interaction databases

BioGridi109048, 19 interactors
IntActiP50150, 1 interactor
STRINGi9606.ENSP00000355556

Structurei

3D structure databases

ProteinModelPortaliP50150
SMRiP50150
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOVERGENiHBG014983
InParanoidiP50150
KOiK04541
OMAiAHTREDP
OrthoDBiEOG091G17J0
PhylomeDBiP50150
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50150-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAAAD LLAYCEAHVR
60 70
EDPLIIPVPA SENPFREKKF FCTIL
Length:75
Mass (Da):8,389
Last modified:October 1, 1996 - v1
Checksum:i42FAEF4728F83FF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31382 mRNA Translation: AAC50204.1
AF493872 mRNA Translation: AAM12586.1
BC022485 mRNA Translation: AAH22485.1
CCDSiCCDS1607.1
PIRiI39157
RefSeqiNP_001092191.1, NM_001098721.1
NP_001092192.1, NM_001098722.1
NP_004476.1, NM_004485.3
XP_006711824.1, XM_006711761.2
XP_011542469.1, XM_011544167.2
UniGeneiHs.159711

Genome annotation databases

EnsembliENST00000366597; ENSP00000355556; ENSG00000168243
ENST00000366598; ENSP00000355557; ENSG00000168243
ENST00000391854; ENSP00000375727; ENSG00000168243
ENST00000450593; ENSP00000398629; ENSG00000168243
ENST00000484517; ENSP00000482192; ENSG00000168243
ENST00000634574; ENSP00000489027; ENSG00000282972
ENST00000635006; ENSP00000489228; ENSG00000282972
ENST00000635235; ENSP00000489454; ENSG00000282972
ENST00000635387; ENSP00000489307; ENSG00000282972
ENST00000635595; ENSP00000489194; ENSG00000282972
GeneIDi2786
KEGGihsa:2786
UCSCiuc001hxe.5 human

Entry informationi

Entry nameiGBG4_HUMAN
AccessioniPrimary (citable) accession number: P50150
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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