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P50148

- GNAQ_HUMAN

UniProt

P50148 - GNAQ_HUMAN

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Protein

Guanine nucleotide-binding protein G(q) subunit alpha

Gene
GNAQ, GAQ
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Magnesium By similarity
Metal bindingi186 – 1861Magnesium By similarity
Binding sitei331 – 3311GTP; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 538GTP By similarity
Nucleotide bindingi180 – 1867GTP By similarity
Nucleotide bindingi205 – 2095GTP By similarity
Nucleotide bindingi274 – 2774GTP By similarity

GO - Molecular functioni

  1. G-protein beta/gamma-subunit complex binding Source: RefGenome
  2. G-protein coupled receptor binding Source: RefGenome
  3. GTPase activator activity Source: UniProtKB
  4. GTPase activity Source: ProtInc
  5. GTP binding Source: UniProtKB-KW
  6. metal ion binding Source: UniProtKB-KW
  7. protein binding Source: UniProtKB
  8. signal transducer activity Source: RefGenome

GO - Biological processi

  1. action potential Source: RefGenome
  2. activation of phospholipase C activity Source: ProtInc
  3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RefGenome
  4. blood coagulation Source: Reactome
  5. developmental pigmentation Source: Ensembl
  6. embryonic digit morphogenesis Source: Ensembl
  7. forebrain neuron development Source: Ensembl
  8. glutamate receptor signaling pathway Source: RefGenome
  9. heart development Source: Ensembl
  10. maternal behavior Source: Ensembl
  11. negative regulation of protein kinase activity Source: BHF-UCL
  12. neuron remodeling Source: Ensembl
  13. phospholipase C-activating dopamine receptor signaling pathway Source: RefGenome
  14. platelet activation Source: Reactome
  15. positive regulation of GTPase activity Source: GOC
  16. post-embryonic development Source: Ensembl
  17. protein stabilization Source: BHF-UCL
  18. regulation of catenin import into nucleus Source: BHF-UCL
  19. regulation of melanocyte differentiation Source: Ensembl
  20. skeletal system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18405. Acetylcholine regulates insulin secretion.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19193. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
SignaLinkiP50148.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(q) subunit alpha
Alternative name(s):
Guanine nucleotide-binding protein alpha-q
Gene namesi
Name:GNAQ
Synonyms:GAQ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:4390. GNAQ.

Subcellular locationi

Nucleus By similarity. Membrane By similarity. Nucleus membrane By similarity
Note: Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes By similarity.

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. extracellular vesicular exosome Source: UniProt
  3. extrinsic component of cytoplasmic side of plasma membrane Source: RefGenome
  4. heterotrimeric G-protein complex Source: RefGenome
  5. lysosomal membrane Source: UniProtKB
  6. nuclear membrane Source: UniProtKB-SubCell
  7. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Capillary malformations, congenital (CMC) [MIM:163000]: A form of vascular malformations that are present from birth, tend to grow with the individual, do not regress spontaneously, and show normal rates of endothelial cell turnover. Capillary malformations are distinct from capillary hemangiomas, which are highly proliferative lesions that appear shortly after birth and show rapid growth, slow involution, and endothelial hypercellularity.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti183 – 1831R → Q in SWS; found as somatic mosaic mutation in CMC; also found in melanocytomas sample; somatic mutation; shows significant activation of EPHB2 compared to control. 2 Publications
VAR_067270
Sturge-Weber syndrome (SWS) [MIM:185300]: A syndrome characterized by an intracranial vascular anomaly, leptomeningeal angiomatosis, most often involving the occipital and posterior parietal lobes. The most common features are facial cutaneous vascular malformations (port-wine stains), seizures, and glaucoma. Stasis results in ischemia underlying the leptomeningeal angiomatosis, leading to calcification and laminar cortical necrosis. The clinical course is highly variable and some children experience intractable seizures, mental retardation, and recurrent stroke-like episodes.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti183 – 1831R → Q in SWS; found as somatic mosaic mutation in CMC; also found in melanocytomas sample; somatic mutation; shows significant activation of EPHB2 compared to control. 2 Publications
VAR_067270

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi163000. phenotype.
185300. phenotype.
Orphaneti624. Familial multiple nevi flammei.
3205. Sturge-Weber syndrome.
PharmGKBiPA174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Guanine nucleotide-binding protein G(q) subunit alphaPRO_0000203760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi9 – 91S-palmitoyl cysteine By similarity
Lipidationi10 – 101S-palmitoyl cysteine By similarity
Modified residuei183 – 1831ADP-ribosylarginine; by cholera toxin By similarity

Keywords - PTMi

ADP-ribosylation, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP50148.
PaxDbiP50148.
PRIDEiP50148.

PTM databases

PhosphoSiteiP50148.

Expressioni

Tissue specificityi

Predominantly expressed in ovary, prostate, testis and colon. Down-regulated in the peripheral blood lymphocytes (PBLs) of rheumatoid arthritis patients (at protein level).2 Publications

Gene expression databases

ArrayExpressiP50148.
BgeeiP50148.
CleanExiHS_GNAQ.
GenevestigatoriP50148.

Organism-specific databases

HPAiCAB010036.
HPA048886.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Binds SLC9A3R1. Forms a complex with PECAM1 and BDKRB2. Interacts with PECAM1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARRB1P494072EBI-3909604,EBI-743313
RARAP102764EBI-3909604,EBI-413374

Protein-protein interaction databases

BioGridi109038. 40 interactions.
IntActiP50148. 9 interactions.
MINTiMINT-262439.
STRINGi9606.ENSP00000286548.

Structurei

3D structure databases

ProteinModelPortaliP50148.
SMRiP50148. Positions 18-354.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG322962.
HOGENOMiHOG000038729.
HOVERGENiHBG063184.
InParanoidiP50148.
KOiK04634.
OMAiLKISYGV.
OrthoDBiEOG7ZWD1W.
PhylomeDBiP50148.
TreeFamiTF300673.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

P50148-1 [UniParc]FASTAAdd to Basket

« Hide

MTLESIMACC LSEEAKEARR INDEIERQLR RDKRDARREL KLLLLGTGES    50
GKSTFIKQMR IIHGSGYSDE DKRGFTKLVY QNIFTAMQAM IRAMDTLKIP 100
YKYEHNKAHA QLVREVDVEK VSAFENPYVD AIKSLWNDPG IQECYDRRRE 150
YQLSDSTKYY LNDLDRVADP AYLPTQQDVL RVRVPTTGII EYPFDLQSVI 200
FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE 250
SKALFRTIIT YPWFQNSSVI LFLNKKDLLE EKIMYSHLVD YFPEYDGPQR 300
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ 350
LNLKEYNLV 359
Length:359
Mass (Da):42,142
Last modified:July 7, 2009 - v4
Checksum:i6F69C4F617DFA7C7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti183 – 1831R → Q in SWS; found as somatic mosaic mutation in CMC; also found in melanocytomas sample; somatic mutation; shows significant activation of EPHB2 compared to control. 2 Publications
VAR_067270
Natural varianti209 – 2091Q → L Found in blue naevi and uveal melanoma samples; somatic mutation; constitutive activation. 1 Publication
VAR_067271
Natural varianti355 – 3551E → D.
Corresponds to variant rs1059531 [ dbSNP | Ensembl ].
VAR_059319

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41E → D in AAB64301. 1 Publication
Sequence conflicti28 – 292QL → HV in AAC50363. 1 Publication
Sequence conflicti92 – 921R → T in AAB64301. 1 Publication
Sequence conflicti103 – 1031Y → C in AAB64301. 1 Publication
Sequence conflicti324 – 3241I → N in AAB06875. 1 Publication
Sequence conflicti337 – 3371I → V in AAB64301. 1 Publication
Sequence conflicti358 – 3581L → A in AAB39498. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40038 mRNA. Translation: AAC50363.1.
U43083 mRNA. Translation: AAB06875.1.
L76256 mRNA. Translation: AAB39498.1.
AF329284 mRNA. Translation: AAG61117.1.
AF011496 mRNA. Translation: AAB64301.1.
AF493896 mRNA. Translation: AAM12610.1.
AL160268, AL160278, AL355535 Genomic DNA. Translation: CAI12198.1.
AL355535, AL160268, AL160278 Genomic DNA. Translation: CAI14669.1.
AL160278, AL160268, AL355535 Genomic DNA. Translation: CAI15999.1.
CH471089 Genomic DNA. Translation: EAW62607.1.
BC057777 mRNA. Translation: AAH57777.1.
BC067850 mRNA. Translation: AAH67850.1.
BC069520 mRNA. Translation: AAH69520.1.
BC075096 mRNA. Translation: AAH75096.1.
BC075097 mRNA. Translation: AAH75097.1.
L40629 mRNA. Translation: AAA99950.1.
CCDSiCCDS6658.1.
PIRiS59635.
S71963.
RefSeqiNP_002063.2. NM_002072.4.
UniGeneiHs.269782.
Hs.594695.

Genome annotation databases

EnsembliENST00000286548; ENSP00000286548; ENSG00000156052.
GeneIDi2776.
KEGGihsa:2776.
UCSCiuc004akw.3. human.

Polymorphism databases

DMDMi251757492.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40038 mRNA. Translation: AAC50363.1 .
U43083 mRNA. Translation: AAB06875.1 .
L76256 mRNA. Translation: AAB39498.1 .
AF329284 mRNA. Translation: AAG61117.1 .
AF011496 mRNA. Translation: AAB64301.1 .
AF493896 mRNA. Translation: AAM12610.1 .
AL160268 , AL160278 , AL355535 Genomic DNA. Translation: CAI12198.1 .
AL355535 , AL160268 , AL160278 Genomic DNA. Translation: CAI14669.1 .
AL160278 , AL160268 , AL355535 Genomic DNA. Translation: CAI15999.1 .
CH471089 Genomic DNA. Translation: EAW62607.1 .
BC057777 mRNA. Translation: AAH57777.1 .
BC067850 mRNA. Translation: AAH67850.1 .
BC069520 mRNA. Translation: AAH69520.1 .
BC075096 mRNA. Translation: AAH75096.1 .
BC075097 mRNA. Translation: AAH75097.1 .
L40629 mRNA. Translation: AAA99950.1 .
CCDSi CCDS6658.1.
PIRi S59635.
S71963.
RefSeqi NP_002063.2. NM_002072.4.
UniGenei Hs.269782.
Hs.594695.

3D structure databases

ProteinModelPortali P50148.
SMRi P50148. Positions 18-354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109038. 40 interactions.
IntActi P50148. 9 interactions.
MINTi MINT-262439.
STRINGi 9606.ENSP00000286548.

PTM databases

PhosphoSitei P50148.

Polymorphism databases

DMDMi 251757492.

Proteomic databases

MaxQBi P50148.
PaxDbi P50148.
PRIDEi P50148.

Protocols and materials databases

DNASUi 2776.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000286548 ; ENSP00000286548 ; ENSG00000156052 .
GeneIDi 2776.
KEGGi hsa:2776.
UCSCi uc004akw.3. human.

Organism-specific databases

CTDi 2776.
GeneCardsi GC09M080331.
HGNCi HGNC:4390. GNAQ.
HPAi CAB010036.
HPA048886.
MIMi 163000. phenotype.
185300. phenotype.
600998. gene.
neXtProti NX_P50148.
Orphaneti 624. Familial multiple nevi flammei.
3205. Sturge-Weber syndrome.
PharmGKBi PA174.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322962.
HOGENOMi HOG000038729.
HOVERGENi HBG063184.
InParanoidi P50148.
KOi K04634.
OMAi LKISYGV.
OrthoDBi EOG7ZWD1W.
PhylomeDBi P50148.
TreeFami TF300673.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_18405. Acetylcholine regulates insulin secretion.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19193. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
SignaLinki P50148.

Miscellaneous databases

ChiTaRSi GNAQ. human.
GeneWikii GNAQ.
GenomeRNAii 2776.
NextBioi 10922.
PROi P50148.
SOURCEi Search...

Gene expression databases

ArrayExpressi P50148.
Bgeei P50148.
CleanExi HS_GNAQ.
Genevestigatori P50148.

Family and domain databases

Gene3Di 1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10218. PTHR10218. 1 hit.
Pfami PF00503. G-alpha. 1 hit.
[Graphical view ]
PRINTSi PR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTi SM00275. G_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene."
    Dong Q., Shenker A., Way J., Haddad B.R., Lin K., Hughes M.R., McBride W.O., Spiegel A.M., Battey J.
    Genomics 30:470-475(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Prostate.
  3. "Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences."
    Johnson G.J., Leis L.A., Dunlop P.C.
    Biochem. J. 318:1023-1031(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "G alpha q cDNA sequence from human platelets."
    Gabbeta J., Dhanasekaran N., Rao A.K.
    Thromb. Res. 91:29-32(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Nucleotide sequence of human Gq guanine nucleotide binding protein."
    Bai X.H., Acharya R., Rivera C., Murtagh J.J.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Placenta.
  10. "Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain."
    Lesch K.-P., Manji H.K.
    Biol. Psychiatry 32:549-579(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-235.
    Tissue: Brain cortex.
  11. "Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways."
    Thomas C.P., Dunn M.J., Mattera R.
    Biochem. J. 312:151-158(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-337.
    Tissue: Hematopoietic.
  12. "Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50)."
    Rochdi M.D., Watier V., La Madeleine C., Nakata H., Kozasa T., Parent J.-L.
    J. Biol. Chem. 277:40751-40759(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SLC9A3R1.
  13. "Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1."
    Yeh J.C., Otte L.A., Frangos J.A.
    Biochemistry 47:9029-9039(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PECAM1.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Expression of G protein alphaq subunit is decreased in lymphocytes from rheumatoid arthritis patients and is correlated with disease activity."
    Wang Y., Li Y., He Y., Sun Y., Sun W., Xie Q., Yin G., Du Y., Wang L., Shi G.
    Scand. J. Immunol. 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  16. Cited for: INVOLVEMENT IN CMC, VARIANT SWS GLN-183, CHARACTERIZATION OF VARIANT SWS GLN-183.
  17. Cited for: CHARACTERIZATION OF VARIANT LEU-209.
  18. "GNAQ and GNA11 mutations in melanocytomas of the central nervous system."
    Murali R., Wiesner T., Rosenblum M.K., Bastian B.C.
    Acta Neuropathol. 123:457-459(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLN-183.

Entry informationi

Entry nameiGNAQ_HUMAN
AccessioniPrimary (citable) accession number: P50148
Secondary accession number(s): O15108
, Q13462, Q6NT27, Q92471, Q9BZB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: September 3, 2014
This is version 140 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi