ID   CCKN2_XENLA             Reviewed;         128 AA.
AC   P50145;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 52.
DE   RecName: Full=Cholecystokinin type 2;
DE   Contains:
DE     RecName: Full=Cholecystokinin;
DE              Short=CCK;
DE   Flags: Precursor;
GN   Name=cck-B;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=95398816; PubMed=7669225;
RA   Wechselberger C., Kreil G.;
RT   "Structure of two cDNAs encoding cholecystokinin precursors from the
RT   brain of Xenopus laevis.";
RL   J. Mol. Endocrinol. 14:357-364(1995).
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- TISSUE SPECIFICITY: Brain and gastrointestinal tract.
CC   -!- PTM: The precursor is cleaved by proteases to produce a number of
CC       active cholecystokinins (By similarity).
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
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DR   EMBL; Z47558; CAA87639.1; -; mRNA.
DR   PIR; I51605; I51605.
DR   RefSeq; NP_001079304.1; -.
DR   UniGene; Xl.1147; -.
DR   GeneID; 378612; -.
DR   KEGG; xla:378612; -.
DR   Xenbase; XB-FEAT-495438; cck.
DR   HOVERGEN; P50145; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015499; CCK.
DR   InterPro; IPR001651; Gastrin.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PANTHER; PTHR10786; CCK; 1.
DR   Pfam; PF00918; Gastrin; 1.
DR   SMART; SM00029; GASTRIN; 1.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Secreted;
KW   Signal; Sulfation.
FT   SIGNAL        1     20       Potential.
FT   PROPEP       21    108       Potential.
FT                                /FTId=PRO_0000010606.
FT   PEPTIDE     109    116       Cholecystokinin.
FT                                /FTId=PRO_0000010607.
FT   PROPEP      120    128       Potential.
FT                                /FTId=PRO_0000010608.
FT   MOD_RES     110    110       Sulfotyrosine (By similarity).
FT   MOD_RES     116    116       Phenylalanine amide (By similarity).
SQ   SEQUENCE   128 AA;  14201 MW;  EA984DFECADFEDA7 CRC64;
     MCSGVCICLL LAMLSASSKA HQATGSLGED AVGTEMDQLN LSQLPRYARA SSAGQKKSFQ
     RTDGDQRSNI GNALVKYLQQ SRKAGPSGRY VVLPNRPIFD QSHRINDRDY MGWMDFGRRS
     AEEYEYSS
//