P50145 (CCKNB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cholecystokinin B

Alternative name(s):
Cholecystokinin type 2

Cleaved into the following chain:

1. Cholecystokinin
   Short name=CCK

Gene names

Name:

cck-b

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted By similarity.
Tissue specificity	Brain and gastrointestinal tract.
Post-translational modification	The precursor is cleaved by proteases to produce a number of active cholecystokinins By similarity.
Sequence similarities	Belongs to the gastrin/cholecystokinin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Sulfation
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 108	88	Potential		PRO_0000010606
	Peptide	109 – 116	8	Cholecystokinin		PRO_0000010607
	Propeptide	120 – 128	9	Potential		PRO_0000010608
Amino acid modifications
	Modified residue	110	1	Sulfotyrosine By similarity
	Modified residue	116	1	Phenylalanine amide By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50145 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: EA984DFECADFEDA7	FASTA	128	14,201
	10 20 30 40 50 60 MCSGVCICLL LAMLSASSKA HQATGSLGED AVGTEMDQLN LSQLPRYARA SSAGQKKSFQ 70 80 90 100 110 120 RTDGDQRSNI GNALVKYLQQ SRKAGPSGRY VVLPNRPIFD QSHRINDRDY MGWMDFGRRS AEEYEYSS

References

[1]	"Structure of two cDNAs encoding cholecystokinin precursors from the brain of Xenopus laevis." Wechselberger C., Kreil G. J. Mol. Endocrinol. 14:357-364(1995) [PubMed: 7669225] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z47558 mRNA. Translation: CAA87639.1.
PIR	I51605.
RefSeq	NP_001079304.1. NM_001085835.1.
UniGene	Xl.1147.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	378612.
KEGG	xla:378612.
Organism-specific databases
CTD	378612.
Xenbase	XB-GENE-865926. cck.
Phylogenomic databases
HOVERGEN	HBG005806.
Family and domain databases
InterPro	IPR015499. CCK. IPR001651. Gastrin. IPR013152. Gastrin/cholecystokinin_CS. [Graphical view]
KO	K05226.
PANTHER	PTHR10786. CCK. 1 hit.
Pfam	PF00918. Gastrin. 1 hit. [Graphical view]
SMART	SM00029. GASTRIN. 1 hit. [Graphical view]
PROSITE	PS00259. GASTRIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCKNB_XENLA

Accession

Primary (citable) accession number: P50145

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 16, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program