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Reviewed, UniProtKB/Swiss-Prot P50145 (CCKN2_XENLA)

Last modified November 25, 2008. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cholecystokinin type 2
Cleaved into the following chain:
    1- Recommended name:
            Cholecystokinin
                Short name=CCK
Gene names
Name: cck-B
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraMesobatrachiaPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length128 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Subcellular location

SecretedBy similarity.

Tissue specificity

Brain and gastrointestinal tract.

Post-translational modification

The precursor is cleaved by proteases to produce a number of active cholecystokinins By similarity.

Sequence similarities

Belongs to the gastrin/cholecystokinin family.

Ontologies

Keywords

   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Sulfation

Gene Ontology (GO)

   Cellular componentextracellular region

Inferred from electronic annotation. Source: InterPro

   Molecular functionhormone activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 10888 Potential
PRO_0000010606
Peptide109 – 1168Cholecystokinin
PRO_0000010607
Propeptide120 – 1289 Potential
PRO_0000010608

Amino acid modifications

Modified residue1101Sulfotyrosine By similarity
Modified residue1161Phenylalanine amide By similarity

Sequences

Sequence LengthMass (Da)Tools
P50145-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: EA984DFECADFEDA7

FASTA12814,201
        10         20         30         40         50         60 
MCSGVCICLL LAMLSASSKA HQATGSLGED AVGTEMDQLN LSQLPRYARA SSAGQKKSFQ 

        70         80         90        100        110        120 
RTDGDQRSNI GNALVKYLQQ SRKAGPSGRY VVLPNRPIFD QSHRINDRDY MGWMDFGRRS 


AEEYEYSS 

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References

[1]"Structure of two cDNAs encoding cholecystokinin precursors from the brain of Xenopus laevis."
Wechselberger C., Kreil G.
J. Mol. Endocrinol. 14:357-364(1995) [PubMed: 7669225] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

Z47558 mRNA. Translation: CAA87639.1.
PIRI51605.
RefSeqNP_001079304.1.
UniGeneXl.1147

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID378612.
KEGGxla:378612.

Organism-specific databases

XenbaseXB-FEAT-495438. cck.

Phylogenomic databases

HOVERGENP50145.

Family and domain databases

InterProIPR015499. CCK.
IPR001651. Gastrin.
IPR013152. Gastrin_CCK_CS.
[Graphical view]
PANTHERPTHR10786. CCK. 1 hit.
PfamPF00918. Gastrin. 1 hit.
[Graphical view]
SMARTSM00029. GASTRIN. 1 hit.
[Graphical view]
PROSITEPS00259. GASTRIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCKN2_XENLA
AccessionPrimary (citable) accession number: P50145
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 25, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectXenopus annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents