ID   CCKN1_XENLA             Reviewed;         123 AA.
AC   P50144;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 48.
DE   RecName: Full=Cholecystokinin type 1;
DE   Contains:
DE     RecName: Full=Cholecystokinin;
DE              Short=CCK;
DE   Flags: Precursor;
GN   Name=cck-A;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=95398816; PubMed=7669225;
RA   Wechselberger C., Kreil G.;
RT   "Structure of two cDNAs encoding cholecystokinin precursors from the
RT   brain of Xenopus laevis.";
RL   J. Mol. Endocrinol. 14:357-364(1995).
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- TISSUE SPECIFICITY: Brain, gastrointestinal tract and lung.
CC   -!- PTM: The precursor is cleaved by proteases to produce a number of
CC       active cholecystokinins (By similarity).
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; Z47557; CAA87638.1; -; mRNA.
DR   PIR; I51604; I51604.
DR   RefSeq; NP_001079303.1; -.
DR   UniGene; Xl.1146; -.
DR   GeneID; 378611; -.
DR   KEGG; xla:378611; -.
DR   HOVERGEN; P50144; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015499; CCK.
DR   InterPro; IPR001651; Gastrin.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PANTHER; PTHR10786; CCK; 1.
DR   Pfam; PF00918; Gastrin; 1.
DR   SMART; SM00029; GASTRIN; 1.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Secreted;
KW   Signal; Sulfation.
FT   SIGNAL        1     20       Potential.
FT   PROPEP       21    103       Potential.
FT                                /FTId=PRO_0000010603.
FT   PEPTIDE     104    111       Cholecystokinin.
FT                                /FTId=PRO_0000010604.
FT   PROPEP      115    123       Potential.
FT                                /FTId=PRO_0000010605.
FT   MOD_RES     105    105       Sulfotyrosine (By similarity).
FT   MOD_RES     111    111       Phenylalanine amide (By similarity).
SQ   SEQUENCE   123 AA;  13943 MW;  FBDCC9E150A98540 CRC64;
     MYSGICICLL LAMLSASSKA HQSEDAVVTE MDQLTLSQLP RYARASSAGQ KKSFQRTDGD
     QRSNIGNVLV KYLQQSRKAG PSGRYVVLPN RPIFDQPHRI NDRDYMGWMD FGRRSAEEYE
     YSS
//