Reviewed, UniProtKB/Swiss-Prot P50144 (CCKN1_XENLA)

Names and origin

Protein names

Recommended name:
    Cholecystokinin type 1
Cleaved into the following chain:
    1- Recommended name:
            Cholecystokinin
                Short name=CCK

Gene names

Name:

cck-A

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	123 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Secreted By similarity.
Tissue specificity	Brain, gastrointestinal tract and lung.
Post-translational modification	The precursor is cleaved by proteases to produce a number of active cholecystokinins By similarity.
Sequence similarities	Belongs to the gastrin/cholecystokinin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Sulfation
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 103	83	Potential		PRO_0000010603
	Peptide	104 – 111	8	Cholecystokinin		PRO_0000010604
	Propeptide	115 – 123	9	Potential		PRO_0000010605
Amino acid modifications
	Modified residue	105	1	Sulfotyrosine By similarity
	Modified residue	111	1	Phenylalanine amide By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50144-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: FBDCC9E150A98540	FASTA	123	13,943
	10 20 30 40 50 60 MYSGICICLL LAMLSASSKA HQSEDAVVTE MDQLTLSQLP RYARASSAGQ KKSFQRTDGD 70 80 90 100 110 120 QRSNIGNVLV KYLQQSRKAG PSGRYVVLPN RPIFDQPHRI NDRDYMGWMD FGRRSAEEYE YSS

References

[1]	"Structure of two cDNAs encoding cholecystokinin precursors from the brain of Xenopus laevis." Wechselberger C., Kreil G. J. Mol. Endocrinol. 14:357-364(1995) [PubMed: 7669225] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z47557 mRNA. Translation: CAA87638.1.
PIR	I51604.
RefSeq	NP_001079303.1.
UniGene	Xl.1146
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	378611.
KEGG	xla:378611.
Phylogenomic databases
HOVERGEN	P50144.
Family and domain databases
InterPro	IPR015499. CCK. IPR001651. Gastrin. IPR013152. Gastrin/cholecystokinin_CS. [Graphical view]
PANTHER	PTHR10786. CCK. 1 hit.
Pfam	PF00918. Gastrin. 1 hit. [Graphical view]
SMART	SM00029. GASTRIN. 1 hit. [Graphical view]
PROSITE	PS00259. GASTRIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCKN1_XENLA

Accession

Primary (citable) accession number: P50144

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project