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Protein

Chaperonin homolog Hsp-60, mitochondrial

Gene

hsp-60

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • 'de novo' protein folding Source: GO_Central
  • apoptotic mitochondrial changes Source: GO_Central
  • chaperone-mediated protein folding Source: GO_Central
  • embryo development ending in birth or egg hatching Source: WormBase
  • mitochondrial unfolded protein response Source: WormBase
  • mitochondrion organization Source: WormBase
  • nematode larval development Source: WormBase
  • protein import into mitochondrial intermembrane space Source: GO_Central
  • protein refolding Source: InterPro

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperonin homolog Hsp-60, mitochondrial
Alternative name(s):
Heat shock protein 60
Short name:
HSP-60
Gene namesi
Name:hsp-60
Synonyms:hsp60
ORF Names:Y22D7AL.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiY22D7AL.5a ; CE27244 ; WBGene00002025 ; hsp-60

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000005030? – 568Chaperonin homolog Hsp-60, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiP50140
PaxDbiP50140
PeptideAtlasiP50140
PRIDEiP50140

2D gel databases

World-2DPAGEi0011:P50140

Expressioni

Inductioni

By mitochondrial stress.1 Publication

Gene expression databases

BgeeiWBGene00002025
ExpressionAtlasiP50140 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP50140, 3 interactors
STRINGi6239.Y22D7AL.5a.2

Structurei

3D structure databases

ProteinModelPortaliP50140
SMRiP50140
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi548 – 568Gly-richAdd BLAST21

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00390000005727
HOGENOMiHOG000076290
InParanoidiP50140
KOiK04077
OMAiTDTDKME
OrthoDBiEOG091G04JM
PhylomeDBiP50140

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLARKGLQ TAVVRSYAKD VKFGAEGRQA MLVGVNLLAD AVSVTMGPKG
60 70 80 90 100
RNVIIEQSWG SPKITKDGVT VAKSIDLKDK YQNLGAKLIQ DVANKANEEA
110 120 130 140 150
GDGTTCATVL ARAIAKEGFE SIRQGGNAVE IRRGVMNAVE VVVAELKKIS
160 170 180 190 200
KKVTTPEEIA QVATISANGD TVVGNLISDA MKKVGTTGVI TVKDGKTLND
210 220 230 240 250
ELELIEGMKF DRGYISPYFI TSAKGAKVEY EKALVLLSEK KISQVQDIVP
260 270 280 290 300
ALELANKLRR PLVIIAEDVD GEALTTLVLN RLKVGLQVVA IKAPGFGDNR
310 320 330 340 350
KNTLKDMGIA TGATIFGDDS NLIKIEDITA NDLGEVDEVT ITKDDTLLLR
360 370 380 390 400
GRGDQTEIEK RIEHITDEIE QSTSDYEKEK LNERLAKLSK GVAVLKIGGG
410 420 430 440 450
SEVEVGEKKD RVTDALCATR AAVEEGIVPG GGVALLRSLT ALKNYKAANE
460 470 480 490 500
DQQIGVNIVK KALTQPIATI VKNAGLEPSS IIDEVTGNSN TSYGYDALNG
510 520 530 540 550
KFVDMFEAGI IDPTKVVRTA LQDASGVASL LATTECVVTE IPKEEAVGGP
560
AGGMGGMGGM GGMGGMGF
Length:568
Mass (Da):60,101
Last modified:June 6, 2002 - v2
Checksum:i814E3D209961E8B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111A → T in AAA28077 (Ref. 1) Curated1
Sequence conflicti121 – 125SIRQG → RHSSR in AAA28077 (Ref. 1) Curated5
Sequence conflicti201E → Q in AAA28077 (Ref. 1) Curated1
Sequence conflicti303T → A in AAA28077 (Ref. 1) Curated1
Sequence conflicti314T → S in AAA28077 (Ref. 1) Curated1
Sequence conflicti319 – 325DSNLIKI → ETLDLRL in AAA28077 (Ref. 1) Curated7
Sequence conflicti364H → E in AAA28077 (Ref. 1) Curated1
Sequence conflicti371Q → R in AAA28077 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36035 mRNA Translation: AAA28077.1
FO081783 Genomic DNA Translation: CCD73746.1
RefSeqiNP_497429.1, NM_065028.7
UniGeneiCel.7829

Genome annotation databases

EnsemblMetazoaiY22D7AL.5a.1; Y22D7AL.5a.1; WBGene00002025
Y22D7AL.5a.2; Y22D7AL.5a.2; WBGene00002025
GeneIDi175316
KEGGicel:CELE_Y22D7AL.5

Similar proteinsi

Entry informationi

Entry nameiCH60_CAEEL
AccessioniPrimary (citable) accession number: P50140
Secondary accession number(s): Q965Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 6, 2002
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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