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Protein

Chaperonin homolog Hsp-60, mitochondrial

Gene

hsp-60

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • transcription factor binding Source: WormBase

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: WormBase
  • mitochondrial unfolded protein response Source: WormBase
  • mitochondrion organization Source: WormBase
  • nematode larval development Source: WormBase
  • protein refolding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperonin homolog Hsp-60, mitochondrial
Alternative name(s):
Heat shock protein 60
Short name:
HSP-60
Gene namesi
Name:hsp-60
Synonyms:hsp60
ORF Names:Y22D7AL.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiY22D7AL.5a; CE27244; WBGene00002025; hsp-60.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000005030? – 568Chaperonin homolog Hsp-60, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiP50140.
PaxDbiP50140.
PeptideAtlasiP50140.
PRIDEiP50140.

2D gel databases

World-2DPAGE0011:P50140.

Expressioni

Gene expression databases

BgeeiWBGene00002025.
ExpressionAtlasiP50140. differential.

Interactioni

GO - Molecular functioni

  • transcription factor binding Source: WormBase

Protein-protein interaction databases

IntActiP50140. 3 interactors.
STRINGi6239.Y22D7AL.5a.2.

Structurei

3D structure databases

ProteinModelPortaliP50140.
SMRiP50140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi548 – 568Gly-richAdd BLAST21

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00390000005727.
HOGENOMiHOG000076290.
InParanoidiP50140.
KOiK04077.
OMAiKDPAMGG.
OrthoDBiEOG091G04JM.
PhylomeDBiP50140.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLARKGLQ TAVVRSYAKD VKFGAEGRQA MLVGVNLLAD AVSVTMGPKG
60 70 80 90 100
RNVIIEQSWG SPKITKDGVT VAKSIDLKDK YQNLGAKLIQ DVANKANEEA
110 120 130 140 150
GDGTTCATVL ARAIAKEGFE SIRQGGNAVE IRRGVMNAVE VVVAELKKIS
160 170 180 190 200
KKVTTPEEIA QVATISANGD TVVGNLISDA MKKVGTTGVI TVKDGKTLND
210 220 230 240 250
ELELIEGMKF DRGYISPYFI TSAKGAKVEY EKALVLLSEK KISQVQDIVP
260 270 280 290 300
ALELANKLRR PLVIIAEDVD GEALTTLVLN RLKVGLQVVA IKAPGFGDNR
310 320 330 340 350
KNTLKDMGIA TGATIFGDDS NLIKIEDITA NDLGEVDEVT ITKDDTLLLR
360 370 380 390 400
GRGDQTEIEK RIEHITDEIE QSTSDYEKEK LNERLAKLSK GVAVLKIGGG
410 420 430 440 450
SEVEVGEKKD RVTDALCATR AAVEEGIVPG GGVALLRSLT ALKNYKAANE
460 470 480 490 500
DQQIGVNIVK KALTQPIATI VKNAGLEPSS IIDEVTGNSN TSYGYDALNG
510 520 530 540 550
KFVDMFEAGI IDPTKVVRTA LQDASGVASL LATTECVVTE IPKEEAVGGP
560
AGGMGGMGGM GGMGGMGF
Length:568
Mass (Da):60,101
Last modified:June 6, 2002 - v2
Checksum:i814E3D209961E8B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111A → T in AAA28077 (Ref. 1) Curated1
Sequence conflicti121 – 125SIRQG → RHSSR in AAA28077 (Ref. 1) Curated5
Sequence conflicti201E → Q in AAA28077 (Ref. 1) Curated1
Sequence conflicti303T → A in AAA28077 (Ref. 1) Curated1
Sequence conflicti314T → S in AAA28077 (Ref. 1) Curated1
Sequence conflicti319 – 325DSNLIKI → ETLDLRL in AAA28077 (Ref. 1) Curated7
Sequence conflicti364H → E in AAA28077 (Ref. 1) Curated1
Sequence conflicti371Q → R in AAA28077 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36035 mRNA. Translation: AAA28077.1.
FO081783 Genomic DNA. Translation: CCD73746.1.
RefSeqiNP_497429.1. NM_065028.7.
UniGeneiCel.7829.

Genome annotation databases

EnsemblMetazoaiY22D7AL.5a.1; Y22D7AL.5a.1; WBGene00002025.
Y22D7AL.5a.2; Y22D7AL.5a.2; WBGene00002025.
GeneIDi175316.
KEGGicel:CELE_Y22D7AL.5.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36035 mRNA. Translation: AAA28077.1.
FO081783 Genomic DNA. Translation: CCD73746.1.
RefSeqiNP_497429.1. NM_065028.7.
UniGeneiCel.7829.

3D structure databases

ProteinModelPortaliP50140.
SMRiP50140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP50140. 3 interactors.
STRINGi6239.Y22D7AL.5a.2.

2D gel databases

World-2DPAGE0011:P50140.

Proteomic databases

EPDiP50140.
PaxDbiP50140.
PeptideAtlasiP50140.
PRIDEiP50140.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY22D7AL.5a.1; Y22D7AL.5a.1; WBGene00002025.
Y22D7AL.5a.2; Y22D7AL.5a.2; WBGene00002025.
GeneIDi175316.
KEGGicel:CELE_Y22D7AL.5.

Organism-specific databases

CTDi175316.
WormBaseiY22D7AL.5a; CE27244; WBGene00002025; hsp-60.

Phylogenomic databases

eggNOGiKOG0356. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00390000005727.
HOGENOMiHOG000076290.
InParanoidiP50140.
KOiK04077.
OMAiKDPAMGG.
OrthoDBiEOG091G04JM.
PhylomeDBiP50140.

Miscellaneous databases

PROiP50140.

Gene expression databases

BgeeiWBGene00002025.
ExpressionAtlasiP50140. differential.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH60_CAEEL
AccessioniPrimary (citable) accession number: P50140
Secondary accession number(s): Q965Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 6, 2002
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.