P50134 (DCOR_DATST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ornithine decarboxylase Short name=ODC EC=4.1.1.17
Organism	Datura stramonium (Jimsonweed) (Common thornapple)
Taxonomic identifier	4076 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Datureae › Datura

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-ornithine = putrescine + CO2.
Cofactor	Pyridoxal phosphate.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	polyamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ornithine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 431	431	Ornithine decarboxylase		PRO_0000149904
Sites
	Active site	376	1	Proton donor; shared with dimeric partner By similarity
Amino acid modifications
	Modified residue	94	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50134 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 8168064D8CC1C9F8	FASTA	431	46,659
	10 20 30 40 50 60 MAGQTVIVSG LNPAAILQST IGGATPAPAA ENDHTRKVVP LSRDALQDFM VSIITQKLQD 70 80 90 100 110 120 EKQPFYVLDL GEVVSLMDQW NAGLPNIRPF YAVKCNPEPS FLSMLSAMGS NFDCASRAEI 130 140 150 160 170 180 EYVLSLGISP DRIVFANPCK PESDIIFAAK VGVNLTTFDS EDEVYKIRKH HPKCELLLRI 190 200 210 220 230 240 KPMDDGNARC PMGPKYGALP EEVEPLLRTA QAARLTVSGV SFHIGSGDAD SKAYLGAIAA 250 260 270 280 290 300 AKGVFETAAR FGMSKMTVLD IGGGFTSGHQ FTTASAAVRS ALEQHFHDEQ ELTIIAEPGR 310 320 330 340 350 360 FFAETAFTLA TTIIGKRVRG ELREYWINDG LYGSMNCVLY DHATVNATPL ACMSNRSNLN 370 380 390 400 410 420 CGGSKTFPST VFGPTCDALD TVLRDYQLPE LQVNDWLIFP NMGAYTKAAG SNFNGFNTSA 430 IVTHLAYAYP S

References

[1]	"Molecular cloning and functional identification of a plant ornithine decarboxylase cDNA." Michael A.J., Furze J.M., Rhodes M.J.C., Burtin D. Biochem. J. 314:241-248(1996) [PubMed: 8660289] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. D15/5. Tissue: Root.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X87847 mRNA. Translation: CAA61121.1.
PIR	S64704.
3D structure databases
ProteinModelPortal	P50134.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-14990.
Family and domain databases
InterPro	IPR009006. Ala_racemase/Decarboxylase_C. IPR022643. De-COase2_C. IPR022657. De-COase2_CS. IPR022644. De-COase2_N. IPR022653. De-COase2_pyr-phos_BS. IPR000183. Orn/DAP/Arg_de-COase. IPR002433. Orn_de-COase. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PRINTS	PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE.
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCOR_DATST

Accession

Primary (citable) accession number: P50134

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	September 21, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program