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P50134 (DCOR_DATST) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ornithine decarboxylase

Short name=ODC
EC=4.1.1.17
OrganismDatura stramonium (Jimsonweed) (Common thornapple)
Taxonomic identifier4076 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsasteridslamiidsSolanalesSolanaceaeSolanoideaeDatureaeDatura

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-ornithine = putrescine + CO2.

Cofactor

Pyridoxal phosphate.

Pathway

Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
   Biological processPolyamine biosynthesis
   LigandPyridoxal phosphate
   Molecular functionDecarboxylase
Lyase
Gene Ontology (GO)
   Biological processpolyamine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionornithine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431Ornithine decarboxylase
PRO_0000149904

Sites

Active site3761Proton donor; shared with dimeric partner By similarity

Amino acid modifications

Modified residue941N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P50134 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 8168064D8CC1C9F8

FASTA43146,659
        10         20         30         40         50         60 
MAGQTVIVSG LNPAAILQST IGGATPAPAA ENDHTRKVVP LSRDALQDFM VSIITQKLQD 

        70         80         90        100        110        120 
EKQPFYVLDL GEVVSLMDQW NAGLPNIRPF YAVKCNPEPS FLSMLSAMGS NFDCASRAEI 

       130        140        150        160        170        180 
EYVLSLGISP DRIVFANPCK PESDIIFAAK VGVNLTTFDS EDEVYKIRKH HPKCELLLRI 

       190        200        210        220        230        240 
KPMDDGNARC PMGPKYGALP EEVEPLLRTA QAARLTVSGV SFHIGSGDAD SKAYLGAIAA 

       250        260        270        280        290        300 
AKGVFETAAR FGMSKMTVLD IGGGFTSGHQ FTTASAAVRS ALEQHFHDEQ ELTIIAEPGR 

       310        320        330        340        350        360 
FFAETAFTLA TTIIGKRVRG ELREYWINDG LYGSMNCVLY DHATVNATPL ACMSNRSNLN 

       370        380        390        400        410        420 
CGGSKTFPST VFGPTCDALD TVLRDYQLPE LQVNDWLIFP NMGAYTKAAG SNFNGFNTSA 

       430 
IVTHLAYAYP S 

« Hide

References

[1]"Molecular cloning and functional identification of a plant ornithine decarboxylase cDNA."
Michael A.J., Furze J.M., Rhodes M.J.C., Burtin D.
Biochem. J. 314:241-248(1996) [PubMed: 8660289] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. D15/5.
Tissue: Root.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X87847 mRNA. Translation: CAA61121.1.
PIRS64704.

3D structure databases

ProteinModelPortalP50134.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-14990.

Family and domain databases

InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
[Graphical view]
Gene3DG3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCOR_DATST
AccessionPrimary (citable) accession number: P50134
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 21, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families