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P50128

- 5HT2A_MACMU

UniProt

P50128 - 5HT2A_MACMU

Protein

5-hydroxytryptamine receptor 2A

Gene

HTR2A

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction By similarity.By similarity

    GO - Molecular functioni

    1. serotonin receptor activity Source: InterPro

    GO - Biological processi

    1. behavior Source: UniProtKB-KW
    2. regulation of behavior Source: InterPro
    3. regulation of hormone secretion Source: InterPro
    4. smooth muscle contraction Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Behavior

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 2A
    Short name:
    5-HT-2
    Short name:
    5-HT-2A
    Alternative name(s):
    Serotonin receptor 2A
    Gene namesi
    Name:HTR2A
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell projectiondendrite By similarity. Cell projectionaxon By similarity. Cytoplasmic vesicle By similarity. Membranecaveola By similarity
    Note: Localizes to the postsynaptic thickening of axo-dendritic synapses.By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB-SubCell
    2. caveola Source: UniProtKB-SubCell
    3. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    4. dendritic shaft Source: InterPro
    5. integral component of plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4714715-hydroxytryptamine receptor 2APRO_0000068947Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi148 ↔ 227PROSITE-ProRule annotation
    Disulfide bondi349 ↔ 353PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. Interacts with GRM2 and DRD2; this may affect signaling By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9544.ENSMMUP00000036319.

    Structurei

    3D structure databases

    ProteinModelPortaliP50128.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7575ExtracellularBy similarityAdd
    BLAST
    Topological domaini100 – 11011CytoplasmicBy similarityAdd
    BLAST
    Topological domaini133 – 14816ExtracellularBy similarityAdd
    BLAST
    Topological domaini172 – 19120CytoplasmicBy similarityAdd
    BLAST
    Topological domaini216 – 23318ExtracellularBy similarityAdd
    BLAST
    Topological domaini255 – 32470CytoplasmicBy similarityAdd
    BLAST
    Topological domaini347 – 36216ExtracellularBy similarityAdd
    BLAST
    Topological domaini385 – 47187CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9924Helical; Name=1By similarityAdd
    BLAST
    Transmembranei111 – 13222Helical; Name=2By similarityAdd
    BLAST
    Transmembranei149 – 17123Helical; Name=3By similarityAdd
    BLAST
    Transmembranei192 – 21524Helical; Name=4By similarityAdd
    BLAST
    Transmembranei234 – 25421Helical; Name=5By similarityAdd
    BLAST
    Transmembranei325 – 34622Helical; Name=6By similarityAdd
    BLAST
    Transmembranei363 – 38422Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni155 – 1606Agonist bindingBy similarity
    Regioni336 – 3405Agonist bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi172 – 1743DRY motif; important for ligand-induced conformation changesBy similarity
    Motifi376 – 3805NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity
    Motifi469 – 4713PDZ-binding

    Domaini

    The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4.By similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG247243.
    HOGENOMiHOG000240378.
    HOVERGENiHBG107487.
    InParanoidiP50128.
    KOiK04157.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000455. 5HT2A_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24247:SF30. PTHR24247:SF30. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00516. 5HT2ARECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50128-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDILCEENTS LSSTTNSLMQ LNEDTRLYSN DFNSGEANTS DAFNWTVESE    50
    NRTNLSCEGC LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS 100
    LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV 150
    WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW 200
    TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VSFFIPLTIM 250
    VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH 300
    RDPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK 350
    ESCNEDVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK 400
    ENKKPLQLIL VNTIPALAYK SSQLQMGQKK NSKQDAKTTD NDCSMVALGK 450
    QHSEDASKDN SDGVNEKVSC V 471
    Length:471
    Mass (Da):52,603
    Last modified:October 1, 1996 - v1
    Checksum:i300FFC84DE03D462
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S78209 mRNA. Translation: AAB34691.1.
    RefSeqiNP_001028138.1. NM_001032966.1.
    UniGeneiMmu.3400.

    Genome annotation databases

    GeneIDi613032.
    KEGGimcc:613032.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S78209 mRNA. Translation: AAB34691.1 .
    RefSeqi NP_001028138.1. NM_001032966.1.
    UniGenei Mmu.3400.

    3D structure databases

    ProteinModelPortali P50128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9544.ENSMMUP00000036319.

    Chemistry

    BindingDBi P50128.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 613032.
    KEGGi mcc:613032.

    Organism-specific databases

    CTDi 3356.

    Phylogenomic databases

    eggNOGi NOG247243.
    HOGENOMi HOG000240378.
    HOVERGENi HBG107487.
    InParanoidi P50128.
    KOi K04157.

    Miscellaneous databases

    NextBioi 19979833.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000455. 5HT2A_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24247:SF30. PTHR24247:SF30. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00516. 5HT2ARECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Species differences in 5-HT2A receptors: cloned pig and rhesus monkey 5-HT2A receptors reveal conserved transmembrane homology to the human rather than rat sequence."
      Johnson M.P., Baez M., Kursar J.D., Nelson D.L.
      Biochim. Biophys. Acta 1236:201-206(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry namei5HT2A_MACMU
    AccessioniPrimary (citable) accession number: P50128
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3