Reviewed, UniProtKB/Swiss-Prot P50121 (RET2_PIG)

Names and origin

Protein names

Recommended name:
Retinol-binding protein 2

Alternative name(s):
Cellular retinol-binding protein II
Short name=CRBP-II

Gene names

Name:

RBP2

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	134 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Intracellular transport of retinol.
Subcellular location	Cytoplasm.
Domain	Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.
Sequence similarities	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm
Ligand	Retinol-binding Vitamin A
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	retinal binding Inferred from electronic annotation. Source: UniProtKB-KW retinol binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 134	133	Retinol-binding protein 2		PRO_0000067397
Sites
	Binding site	41	1	Retinoic acid By similarity
	Binding site	109	1	Retinoic acid By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50121-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 7701B7EBD5EF61A6	FASTA	134	15,638
	10 20 30 40 50 60 MTRDQNGTWE MESNDNFEGY MKALDIDFAT RKIAVALTQT KIIEQDGDKF KTKTNSTFRN 70 80 90 100 110 120 YDLDFTVGVE FDEYTKGLDN RNVKTLIIWE GDALVCVQKG EKENRGWKQW VEGDKLYLEL 130 TCGDQVCRQV FKKK

References

[1]	"Expression of differentiated functions in the developing porcine small intestine." Perozzi G., Baril D., Murgia C., Kelly D., Begbie R., King T.P. J. Nutr. Biochem. 4:699-705(1993) [Agricola: IND20415199] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Large white X Landrace. Tissue: Jejunum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X77639 mRNA. Translation: CAA54729.1.
PIR	S45378.
RefSeq	NP_999616.1.
UniGene	Ssc.42472
3D structure databases
SMR	P50121. Positions 2-134.
ModBase	Search...
Genome annotation databases
Ensembl	ENSSSCT00000012768; ENSSSCP00000012433; ENSSSCG00000011663; Sus scrofa. [Genome view]
GeneID	407611.
KEGG	ssc:407611.
Organism-specific databases
CTD	407611.
Phylogenomic databases
HOVERGEN	HBG005633.
Family and domain databases
InterPro	IPR012674. Calycin. IPR011038. Calycin-like. IPR000463. Fatty_acid_bd. IPR000566. Lipocln_cytosolic_FA_bd. [Graphical view]
Gene3D	G3DSA:2.40.128.20. Calycin. 1 hit.
PANTHER	PTHR11955. Fatty_acid_bd. 1 hit.
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PRINTS	PR00178. FATTYACIDBP.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00214. FABP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RET2_PIG

Accession

Primary (citable) accession number: P50121

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	March 2, 2010
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)