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Protein

Protein S100-B

Gene

S100b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi19 – 321; low affinityAdd BLAST14
Calcium bindingi62 – 732; high affinityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • astrocyte differentiation Source: Ensembl
  • cellular calcium ion homeostasis Source: UniProtKB
  • cellular response to hypoxia Source: Ensembl
  • energy reserve metabolic process Source: UniProtKB
  • learning or memory Source: UniProtKB
  • long-term synaptic potentiation Source: Ensembl
  • memory Source: MGI
  • negative regulation of skeletal muscle cell differentiation Source: Ensembl
  • positive regulation of apoptotic process Source: Ensembl
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  • positive regulation of myelination Source: Ensembl
  • regulation of cell shape Source: Ensembl
  • regulation of cytokine biosynthetic process Source: UniProtKB
  • regulation of long-term neuronal synaptic plasticity Source: UniProtKB
  • regulation of neuronal synaptic plasticity Source: MGI
  • response to glucocorticoid Source: Ensembl
  • response to methylmercury Source: Ensembl

Keywordsi

LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1810476 RIP-mediated NFkB activation via ZBP1
R-MMU-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-MMU-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-879415 Advanced glycosylation endproduct receptor signaling
R-MMU-933542 TRAF6 mediated NF-kB activation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-B
Alternative name(s):
S-100 protein beta chain
S-100 protein subunit beta
S100 calcium-binding protein B
Gene namesi
Name:S100b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:98217 S100b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001439672 – 92Protein S100-BAdd BLAST91

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP50114
PeptideAtlasiP50114
PRIDEiP50114

PTM databases

PhosphoSitePlusiP50114

Expressioni

Tissue specificityi

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

Gene expression databases

BgeeiENSMUSG00000033208
CleanExiMM_S100B
ExpressionAtlasiP50114 baseline and differential
GenevisibleiP50114 MM

Interactioni

Subunit structurei

Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with CACYBP in a calcium-dependent manner. Interacts with ATAD3A; this interaction probably occurs in the cytosol prior to ATAD3A mitochondrial targeting. Interacts with S100A6. The S100B dimer interacts with two molecules of CAPZA1. Interacts with AGER. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203058, 1 interactor
IntActiP50114, 2 interactors
MINTiP50114
STRINGi10090.ENSMUSP00000047968

Structurei

3D structure databases

ProteinModelPortaliP50114
SMRiP50114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini49 – 84EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYFX Eukaryota
ENOG41127J0 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP50114
OMAiCCHEFFE
OrthoDBiEOG091G13Z2
PhylomeDBiP50114
TreeFamiTF332727

Family and domain databases

CDDicd05027 S-100B, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR028481 S100-B
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF17 PTHR11639:SF17, 1 hit
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE
60 70 80 90
QEVVDKVMET LDEDGDGECD FQEFMAFVAM VTTACHEFFE HE
Length:92
Mass (Da):10,728
Last modified:January 23, 2007 - v2
Checksum:i43815AC212A81DD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22144 Unassigned DNA Translation: AAA03075.1
BC061178 mRNA Translation: AAH61178.1
CCDSiCCDS35943.1
PIRiA48015
RefSeqiNP_033141.1, NM_009115.3
UniGeneiMm.235998

Genome annotation databases

EnsembliENSMUST00000036387; ENSMUSP00000047968; ENSMUSG00000033208
GeneIDi20203
KEGGimmu:20203
UCSCiuc007fuc.2 mouse

Similar proteinsi

Entry informationi

Entry nameiS100B_MOUSE
AccessioniPrimary (citable) accession number: P50114
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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