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Protein

Sorting assembly machinery 37 kDa subunit

Gene

SAM37

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which is required for the sorting of proteins with complicated topology, such as beta-barrel proteins, to the mitochondrial outer membrane after import by the TOM complex.1 Publication

GO - Biological processi

  • mitochondrial outer membrane translocase complex assembly Source: SGD
  • phospholipid transport Source: SGD
  • protein import into mitochondrial outer membrane Source: SGD
  • protein targeting to mitochondrion Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32763-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Protein family/group databases

TCDBi1.B.33.3.1. the outer membrane protein insertion porin (bam complex) (ompip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting assembly machinery 37 kDa subunit
Alternative name(s):
MAS37 protein
Mitochondrial 37 kDa outer membrane protein
Gene namesi
Name:SAM37
Synonyms:MAS37, PET3027, TOM37
Ordered Locus Names:YMR060C
ORF Names:YM9796.13C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR060C.
SGDiS000004664. SAM37.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3317HelicalSequence analysisAdd
BLAST
Transmembranei247 – 26519HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Sorting assembly machinery 37 kDa subunitPRO_0000072630Add
BLAST

Proteomic databases

MaxQBiP50110.
PRIDEiP50110.

Interactioni

Subunit structurei

Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which at least consists of SAM35, SAM37 and SAM50. SAM37 interacts with TOM70.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SAM35P146937EBI-2347180,EBI-24602
SAM50P539695EBI-2347180,EBI-28646

Protein-protein interaction databases

BioGridi35235. 187 interactions.
IntActiP50110. 9 interactions.
MINTiMINT-4497641.

Structurei

3D structure databases

ProteinModelPortaliP50110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000141704.
InParanoidiP50110.
KOiK17714.
OMAiESIALFW.
OrthoDBiEOG092C58SJ.

Family and domain databases

InterProiIPR019564. Sam37/metaxin_N.
IPR031317. Tom37_C.
[Graphical view]
PfamiPF10568. Tom37. 1 hit.
PF11801. Tom37_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKGSVHLWG KDGKASLISV DSIALVWFIK LCTSEEAKSM VAGLQIVFSN
60 70 80 90 100
NTDLSSDGKL PVLILDNGTK VSGYVNIVQF LHKNICTSKY EKGTDYEEDL
110 120 130 140 150
AIVRKKDRLL EYSLLNYVDV EISRLTDYQL FLNTKNYNEY TKKLFSKLLY
160 170 180 190 200
FPMWYNTPLQ LRSQARENCE EIIGSLTLED DEEFVESKAM ESASQLAQSK
210 220 230 240 250
TFKIAHKNKI KGKQELQQVK YNLQFDNRLQ SCVSNWLAAR KKLDDSVILS
260 270 280 290 300
SDLLFLANLY VQLGLPDGNR IRSKLEQTFG SELLNSMSNK IDDFVHRPSN
310 320
NLEQRDPQFR EQGNVVMSLY NLACKYI
Length:327
Mass (Da):37,493
Last modified:October 1, 1996 - v1
Checksum:iD4ABA929CE5CAD16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62565 Genomic DNA. Translation: CAA44438.1.
Z49703 Genomic DNA. Translation: CAA89770.1.
AY557989 Genomic DNA. Translation: AAS56315.1.
BK006946 Genomic DNA. Translation: DAA09958.1.
PIRiS54560.
RefSeqiNP_013776.1. NM_001182558.1.

Genome annotation databases

EnsemblFungiiYMR060C; YMR060C; YMR060C.
GeneIDi855082.
KEGGisce:YMR060C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62565 Genomic DNA. Translation: CAA44438.1.
Z49703 Genomic DNA. Translation: CAA89770.1.
AY557989 Genomic DNA. Translation: AAS56315.1.
BK006946 Genomic DNA. Translation: DAA09958.1.
PIRiS54560.
RefSeqiNP_013776.1. NM_001182558.1.

3D structure databases

ProteinModelPortaliP50110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35235. 187 interactions.
IntActiP50110. 9 interactions.
MINTiMINT-4497641.

Protein family/group databases

TCDBi1.B.33.3.1. the outer membrane protein insertion porin (bam complex) (ompip) family.

Proteomic databases

MaxQBiP50110.
PRIDEiP50110.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR060C; YMR060C; YMR060C.
GeneIDi855082.
KEGGisce:YMR060C.

Organism-specific databases

EuPathDBiFungiDB:YMR060C.
SGDiS000004664. SAM37.

Phylogenomic databases

HOGENOMiHOG000141704.
InParanoidiP50110.
KOiK17714.
OMAiESIALFW.
OrthoDBiEOG092C58SJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-32763-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Miscellaneous databases

PROiP50110.

Family and domain databases

InterProiIPR019564. Sam37/metaxin_N.
IPR031317. Tom37_C.
[Graphical view]
PfamiPF10568. Tom37. 1 hit.
PF11801. Tom37_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAM37_YEAST
AccessioniPrimary (citable) accession number: P50110
Secondary accession number(s): D6VZN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1580 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.