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P50101

- UBP15_YEAST

UniProt

P50101 - UBP15_YEAST

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Protein
Ubiquitin carboxyl-terminal hydrolase 15
Gene
UBP15, YMR304W, YM9952.06
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei214 – 2141Nucleophile By similarity
Active sitei465 – 4651Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: SGD

GO - Biological processi

  1. protein deubiquitination Source: SGD
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-32969-MONOMER.

Protein family/group databases

MEROPSiC19.099.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 15 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 15
Ubiquitin thioesterase 15
Ubiquitin-specific-processing protease 15
Gene namesi
Name:UBP15
Ordered Locus Names:YMR304W
ORF Names:YM9952.06
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR304w.
SGDiS000004920. UBP15.

Subcellular locationi

GO - Cellular componenti

  1. peroxisome Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12301230Ubiquitin carboxyl-terminal hydrolase 15
PRO_0000080600Add
BLAST

Proteomic databases

MaxQBiP50101.
PaxDbiP50101.
PeptideAtlasiP50101.

Expressioni

Gene expression databases

GenevestigatoriP50101.

Interactioni

Protein-protein interaction databases

BioGridi35484. 118 interactions.
DIPiDIP-6313N.
IntActiP50101. 32 interactions.
MINTiMINT-618224.
STRINGi4932.YMR304W.

Structurei

3D structure databases

ProteinModelPortaliP50101.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 179141MATH
Add
BLAST
Domaini205 – 536332USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 MATH domain.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00740000115066.
HOGENOMiHOG000160240.
KOiK11838.
OMAiFDDERVW.
OrthoDBiEOG7C2R8P.

Family and domain databases

InterProiIPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view]
PfamiPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50101-1 [UniParc]FASTAAdd to Basket

« Hide

MSSEDELGSI GTVFPGSPID KSIGSILPQF DEEVETLLED SFTWNIPDWN     50
ELTNPKYNSP RFRIGDFEWD ILLFPQGNHN KGVAVYLEPH PEEKLDETTG 100
EMVPVDPDWY CCAQFAIGIS RPGNGDTINL INKSHHRFNA LDTDWGFANL 150
IDLNNLKHPS KGRPLSFLNE GTLNITAYVR ILKDPTGVLW HNFLNYDSKK 200
VTGYVGFRNQ GATCYLNSLL QSYFFTKYFR KLVYEIPTEH ESPNNSVPLA 250
LQRAFYQLQV SDIPLDTLEL TRSFGWDTAE SFTQHDVQEL NRILMDRLEN 300
NMKGTPVEGK LNEIFVGKMK SYIKCINVDY ESARVEDFWD LQLNVKNFKN 350
LQESFDNYIE MELMNGENQY AAQDYGLQDA QKGVIFESFP PVLHLQLKRF 400
EYDFNYDQMV KVNDKYEFPE TIDLSPFVDK DVLKKTLDSE NKDKNPYVYN 450
LHGVLVHSGD ISTGHYYTLI KPGVEDQWYR FDDERVWRVT KKQVFQENFG 500
CDRLPDEKVR TMTRGEYQNY IIQRHTSAYM LVYIRQEQEE DLLRPVLESD 550
VPKHVITRVR EEIKERETKE KEIREAHLYV TLRLHSIKEF IHYEGFDYFA 600
HDGFRLFAEE LNDSGLQQIN LKVLRTTKLS DIFASIKETM NIPQERDVKY 650
WKMDYRRNST LRLTQPINFE SVNITLQEAL KKEKKRTMQT QYGEEGVAST 700
EEDDKALLET VSFLDLFIEE PYLELQFLNK LKEASLISKA QLDDELISTI 750
RTNLPELTKG GIEPVFATDN KSNLLFVKSY DPHTQKLLGF GHFAVNQLQQ 800
LSDISAIIED SISSNEKLTF YEEVQPGTIN EIYMKETIYD ADIDTGDIVS 850
FEVPGAVLPD TFPVYATIKD FYSYLRYRVK LKFSKFDGSS EEYGVSNEIP 900
ESFEFWISAY APYDDLARMV SKYAHVKPEY LKIIALYSNG RFVLKSTSLL 950
NDYLLKDFNC DQIPPFAFEV LSVPLKELER LRPIKLYWLK NSYIHYQCFE 1000
FEVANDYTES QFLEKVQHKI GFTDEEKENI LLWTNTNFQF QGLLSDQNTF 1050
KDVSKHSLLF GRILPEESKL FKELNRLENV QTSSLEDFMD DENATDRPMD 1100
DEQDLGMAIE HSEDMKGRIV VVQQYFKDLE NRHGISFLFN LIPDETFPKT 1150
KDRLHAKFGL GQKEFSKIKL SIGYSTEEGT VFRSLQGFSD EELDKVILYD 1200
IMSNLDYIYM DHPDRLRSHS SYDRPMIIKN 1230
Length:1,230
Mass (Da):143,564
Last modified:October 1, 1996 - v1
Checksum:iBEB8F6E3DD71A0CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49212 Genomic DNA. Translation: CAA89137.1.
BK006946 Genomic DNA. Translation: DAA10205.1.
PIRiS53974.
RefSeqiNP_014033.1. NM_001182814.1.

Genome annotation databases

EnsemblFungiiYMR304W; YMR304W; YMR304W.
GeneIDi855350.
KEGGisce:YMR304W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49212 Genomic DNA. Translation: CAA89137.1 .
BK006946 Genomic DNA. Translation: DAA10205.1 .
PIRi S53974.
RefSeqi NP_014033.1. NM_001182814.1.

3D structure databases

ProteinModelPortali P50101.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35484. 118 interactions.
DIPi DIP-6313N.
IntActi P50101. 32 interactions.
MINTi MINT-618224.
STRINGi 4932.YMR304W.

Protein family/group databases

MEROPSi C19.099.

Proteomic databases

MaxQBi P50101.
PaxDbi P50101.
PeptideAtlasi P50101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR304W ; YMR304W ; YMR304W .
GeneIDi 855350.
KEGGi sce:YMR304W.

Organism-specific databases

CYGDi YMR304w.
SGDi S000004920. UBP15.

Phylogenomic databases

eggNOGi COG5077.
GeneTreei ENSGT00740000115066.
HOGENOMi HOG000160240.
KOi K11838.
OMAi FDDERVW.
OrthoDBi EOG7C2R8P.

Enzyme and pathway databases

BioCyci YEAST:G3O-32969-MONOMER.

Miscellaneous databases

NextBioi 979106.
PROi P50101.

Gene expression databases

Genevestigatori P50101.

Family and domain databases

InterProi IPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view ]
Pfami PF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view ]
SMARTi SM00061. MATH. 1 hit.
[Graphical view ]
SUPFAMi SSF49599. SSF49599. 1 hit.
PROSITEi PS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUBP15_YEAST
AccessioniPrimary (citable) accession number: P50101
Secondary accession number(s): D6W0D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2810 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi