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P50091 (PEX21_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal membrane protein PEX21
Alternative name(s):
Peroxin-21
Gene names
Name:PEX21
Ordered Locus Names:YGR239C
ORF Names:G8593
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate. Acts as an activator of the seryl-tRNA synthetase SES1 by increasing its binding to tRNA. Ref.6 Ref.7 Ref.8 Ref.10

Subunit structure

Interacts with PEX7, PEX13 and SES1. Ref.6 Ref.7 Ref.8 Ref.10

Subcellular location

Cytoplasm. Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side Ref.9.

Sequence similarities

Belongs to the peroxin-21 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PEX7P391086EBI-23549,EBI-13183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Peroxisomal membrane protein PEX21
PRO_0000202855

Secondary structure

.............. 288
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P50091 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 0197257317ADE4FF

FASTA28833,050
        10         20         30         40         50         60 
MPSVCHTSPI EKIIQQGHRI QNDSLIPSKR TKLAHTELTA HYATEDSHVE KHFLHNGSNF 

        70         80         90        100        110        120 
DGIDNVRYQN QPSPLTFITP NNTVDSSDWV PQFSSMKIDD SLEFSSEYKR LYSNYESQQR 

       130        140        150        160        170        180 
LNSSRQHLPF KNCMIRKTSC TYPPQKTLRQ QRQGNRDNPT DAFQFDAEFQ VLEREIQKER 

       190        200        210        220        230        240 
YEPITRRDEK WFDQDQSELQ RIATDIVKCC TPPPSSASSS STLSSSVESK LSESKFIQLM 

       250        260        270        280 
RNISSGDVTL KKNADGNSAS ELFSSNNGEL VGNRHIFVKD EIHKDILD 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the 43 kb CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm of Saccharomyces cerevisiae chromosome VII."
van der Aart Q.J.M., Kleine K., Steensma H.Y.
Yeast 12:385-390(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Sequencing of a 9.9 kb segment on the right arm of yeast chromosome VII reveals four open reading frames, including PFK1, the gene coding for succinyl-CoA synthetase (beta-chain) and two ORFs sharing homology with ORFs of the yeast chromosome VIII."
Guerreiro P., Azevedo D., Barreiros T., Rodrigues-Pousada C.
Yeast 13:275-280(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 123-288.
Strain: ATCC 204508 / S288c.
[6]"Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway."
Purdue P.E., Yang X., Lazarow P.B.
J. Cell Biol. 143:1859-1869(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH PEX7.
[7]"Identifying Pex21p as a protein that specifically interacts with yeast seryl-tRNA synthetase."
Rocak S., Landeka I., Weygand-Durasevic I.
FEMS Microbiol. Lett. 214:101-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SES1.
[8]"Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import."
Stein K., Schell-Steven A., Erdmann R., Rottensteiner H.
Mol. Cell. Biol. 22:6056-6069(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH PEX7 AND PEX13.
[9]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[10]"Peroxin Pex21p interacts with the C-terminal noncatalytic domain of yeast seryl-tRNA synthetase and forms a specific ternary complex with tRNA(Ser)."
Godinic V., Mocibob M., Rocak S., Ibba M., Weygand-Durasevic I.
FEBS J. 274:2788-2799(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SES1.
[11]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X87941 Genomic DNA. Translation: CAA61191.1.
Z73024 Genomic DNA. Translation: CAA97267.1.
Z73025 Genomic DNA. Translation: CAA97269.1.
AY558277 Genomic DNA. Translation: AAS56603.1.
BK006941 Genomic DNA. Translation: DAA08330.1.
PIRS57706.
RefSeqNP_011755.3. NM_001181368.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3W15X-ray1.80B190-288[»]
ProteinModelPortalP50091.
SMRP50091. Positions 197-288.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33491. 16 interactions.
DIPDIP-1503N.
IntActP50091. 6 interactions.
MINTMINT-410398.

Protein family/group databases

TCDB3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGR239C; YGR239C; YGR239C.
GeneID853154.
KEGGsce:YGR239C.

Organism-specific databases

CYGDYGR239c.
SGDS000003471. PEX21.

Phylogenomic databases

eggNOGNOG70678.
OMAYATEDSH.
OrthoDBEOG71GB7H.

Enzyme and pathway databases

BioCycYEAST:G3O-30917-MONOMER.

Gene expression databases

GenevestigatorP50091.

Family and domain databases

ProtoNetSearch...

Other

NextBio973246.

Entry information

Entry namePEX21_YEAST
AccessionPrimary (citable) accession number: P50091
Secondary accession number(s): D6VV19, O11855, Q6Q597
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references