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Protein

Peroxisomal membrane protein PEX21

Gene

PEX21

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate. Acts as an activator of the seryl-tRNA synthetase SES1 by increasing its binding to tRNA.4 Publications

GO - Biological processi

  • positive regulation of binding Source: SGD
  • protein import into peroxisome matrix Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30917-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX21
Alternative name(s):
Peroxin-21
Gene namesi
Name:PEX21
Ordered Locus Names:YGR239C
ORF Names:G8593
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR239C.
SGDiS000003471. PEX21.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • peroxisomal membrane Source: UniProtKB-SubCell
  • peroxisome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002028551 – 288Peroxisomal membrane protein PEX21Add BLAST288

Proteomic databases

PRIDEiP50091.

PTM databases

iPTMnetiP50091.

Interactioni

Subunit structurei

Interacts with PEX7, PEX13 and SES1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX7P391086EBI-23549,EBI-13183

Protein-protein interaction databases

BioGridi33491. 17 interactors.
DIPiDIP-1503N.
IntActiP50091. 7 interactors.
MINTiMINT-410398.

Structurei

Secondary structure

1288
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi198 – 209Combined sources12
Helixi225 – 232Combined sources8
Helixi235 – 244Combined sources10
Beta strandi247 – 250Combined sources4
Beta strandi262 – 264Combined sources3
Turni265 – 267Combined sources3
Beta strandi269 – 272Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3W15X-ray1.80B190-288[»]
ProteinModelPortaliP50091.
SMRiP50091.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-21 family.Curated

Phylogenomic databases

InParanoidiP50091.
OMAiYATEDSH.
OrthoDBiEOG092C45XF.

Sequencei

Sequence statusi: Complete.

P50091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSVCHTSPI EKIIQQGHRI QNDSLIPSKR TKLAHTELTA HYATEDSHVE
60 70 80 90 100
KHFLHNGSNF DGIDNVRYQN QPSPLTFITP NNTVDSSDWV PQFSSMKIDD
110 120 130 140 150
SLEFSSEYKR LYSNYESQQR LNSSRQHLPF KNCMIRKTSC TYPPQKTLRQ
160 170 180 190 200
QRQGNRDNPT DAFQFDAEFQ VLEREIQKER YEPITRRDEK WFDQDQSELQ
210 220 230 240 250
RIATDIVKCC TPPPSSASSS STLSSSVESK LSESKFIQLM RNISSGDVTL
260 270 280
KKNADGNSAS ELFSSNNGEL VGNRHIFVKD EIHKDILD
Length:288
Mass (Da):33,050
Last modified:October 1, 1996 - v1
Checksum:i0197257317ADE4FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87941 Genomic DNA. Translation: CAA61191.1.
Z73024 Genomic DNA. Translation: CAA97267.1.
Z73025 Genomic DNA. Translation: CAA97269.1.
AY558277 Genomic DNA. Translation: AAS56603.1.
BK006941 Genomic DNA. Translation: DAA08330.1.
PIRiS57706.
RefSeqiNP_011755.3. NM_001181368.3.

Genome annotation databases

EnsemblFungiiYGR239C; YGR239C; YGR239C.
GeneIDi853154.
KEGGisce:YGR239C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87941 Genomic DNA. Translation: CAA61191.1.
Z73024 Genomic DNA. Translation: CAA97267.1.
Z73025 Genomic DNA. Translation: CAA97269.1.
AY558277 Genomic DNA. Translation: AAS56603.1.
BK006941 Genomic DNA. Translation: DAA08330.1.
PIRiS57706.
RefSeqiNP_011755.3. NM_001181368.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3W15X-ray1.80B190-288[»]
ProteinModelPortaliP50091.
SMRiP50091.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33491. 17 interactors.
DIPiDIP-1503N.
IntActiP50091. 7 interactors.
MINTiMINT-410398.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

PTM databases

iPTMnetiP50091.

Proteomic databases

PRIDEiP50091.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR239C; YGR239C; YGR239C.
GeneIDi853154.
KEGGisce:YGR239C.

Organism-specific databases

EuPathDBiFungiDB:YGR239C.
SGDiS000003471. PEX21.

Phylogenomic databases

InParanoidiP50091.
OMAiYATEDSH.
OrthoDBiEOG092C45XF.

Enzyme and pathway databases

BioCyciYEAST:G3O-30917-MONOMER.

Miscellaneous databases

PROiP50091.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiPEX21_YEAST
AccessioniPrimary (citable) accession number: P50091
Secondary accession number(s): D6VV19, O11855, Q6Q597
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.