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P50090

- KEL2_YEAST

UniProt

P50090 - KEL2_YEAST

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Protein
Kelch repeat-containing protein 2
Gene
KEL2, YGR238C, G8585
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. conjugation with cellular fusion Source: SGD
  2. negative regulation of exit from mitosis Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30916-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat-containing protein 2
Gene namesi
Name:KEL2
Ordered Locus Names:YGR238C
ORF Names:G8585
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR238c.
SGDiS000003470. KEL2.

Subcellular locationi

GO - Cellular componenti

  1. cellular bud neck Source: SGD
  2. cellular bud tip Source: SGD
  3. mating projection tip Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 882882Kelch repeat-containing protein 2
PRO_0000119097Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei455 – 4551Phosphothreonine1 Publication
Modified residuei509 – 5091Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP50090.
PaxDbiP50090.

Expressioni

Gene expression databases

GenevestigatoriP50090.

Interactioni

Subunit structurei

Interacts with KEL1.

Binary interactionsi

WithEntry#Exp.IntActNotes
KEL1P388534EBI-9630,EBI-9619

Protein-protein interaction databases

BioGridi33490. 67 interactions.
DIPiDIP-4229N.
IntActiP50090. 9 interactions.
MINTiMINT-542042.
STRINGi4932.YGR238C.

Structurei

3D structure databases

ProteinModelPortaliP50090.
SMRiP50090. Positions 268-379.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati99 – 14345Kelch 1
Add
BLAST
Repeati153 – 20755Kelch 2
Add
BLAST
Repeati213 – 26755Kelch 3
Add
BLAST
Repeati268 – 31750Kelch 4
Add
BLAST
Repeati319 – 36951Kelch 5
Add
BLAST
Repeati371 – 41747Kelch 6
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili550 – 685136 Reviewed prediction
Add
BLAST
Coiled coili728 – 881154 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 6 Kelch repeats.

Keywords - Domaini

Coiled coil, Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG145020.
GeneTreeiENSGT00720000108564.
HOGENOMiHOG000000942.
OMAiGHASTIC.
OrthoDBiEOG7008HF.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50090-1 [UniParc]FASTAAdd to Basket

« Hide

MVPFKLTNKV PTDTGPSLIS AQSVPRPIVF MDNRNNTRIV TPTLPPNQHR    50
GISGASTALP WSPESKNTGK YIWNRVKLKN SPFPRYRHSS SFIVTNDNRI 100
FVTGGLHDQS VYGDVWQIAA NADGTSFTSK RIDIDQNTPP PRVGHASTIC 150
GNAYVVFGGD THKLNKNGLL DDDLYLFNIN SYKWTIPQPI GRRPLGRYGH 200
KISIIASNPM QTKLYLFGGQ VDETYFNDLV VFDLSSFRRP NSHWEFLEPV 250
GDLPPPLTNH TMVAYDNKLW VFGGETPKTI SNDTYRYDPA QSEWSKVKTT 300
GEKPPPIQEH ASVVYKHLMC VLGGKDTHNA YSNDVYFLNL LSLKWYKLPR 350
MKEGIPQERS GHSLTLMKNE KLLIMGGDKT DYASPNIHDL QTSETDQGEG 400
TLLYTLDLSS LNELCPGIMC ESLHAGESFS NSLSGGFTPS KSTESENQEI 450
INILTPRLPD SKVLSYNDID EGAGSYSSAL DDKAFERKSD REEKKPQSSK 500
VDSSINKESP GTGIKVSKKN FPVLRGLTVD SEEYGSSSYK DTSCQKGIPK 550
NLFDDLNLNL QTLRLEAQQK ELETARHISQ LEKEVQRLMV IKEASKDSNF 600
QTARLKNLEI QKTFLESRIN DLKNLLMVKL SQASKLCDQI TIQNNGLKTC 650
SEHVTIKRDI IDLENKCDVL KRQNEILVNN MQKITPELHT YLNESSCYLG 700
KLLKSYPTSA RPPSSEKDNQ IYEKDSLNKI EKVINEMHET VRAKEKLHLE 750
TQKLNDERDS LRANLLDNNN KLDALRKLSD GSSKSMDLTK KAIHLSQSEL 800
EKYRKNNDDL QKEIDRIKTE QAEQDDKQEQ RGAITHGNFD AFHRMKINNL 850
KAELYMSKEN RDSLKDELLA LKKKLYTLEQ KK 882
Length:882
Mass (Da):99,975
Last modified:October 1, 1996 - v1
Checksum:i63B9772FF017E6D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87941 Genomic DNA. Translation: CAA61189.1.
Z73023 Genomic DNA. Translation: CAA97266.1.
AY693035 Genomic DNA. Translation: AAT93054.1.
BK006941 Genomic DNA. Translation: DAA08329.1.
PIRiS57704.
RefSeqiNP_011754.3. NM_001181367.3.

Genome annotation databases

EnsemblFungiiYGR238C; YGR238C; YGR238C.
GeneIDi853153.
KEGGisce:YGR238C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87941 Genomic DNA. Translation: CAA61189.1 .
Z73023 Genomic DNA. Translation: CAA97266.1 .
AY693035 Genomic DNA. Translation: AAT93054.1 .
BK006941 Genomic DNA. Translation: DAA08329.1 .
PIRi S57704.
RefSeqi NP_011754.3. NM_001181367.3.

3D structure databases

ProteinModelPortali P50090.
SMRi P50090. Positions 268-379.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33490. 67 interactions.
DIPi DIP-4229N.
IntActi P50090. 9 interactions.
MINTi MINT-542042.
STRINGi 4932.YGR238C.

Proteomic databases

MaxQBi P50090.
PaxDbi P50090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR238C ; YGR238C ; YGR238C .
GeneIDi 853153.
KEGGi sce:YGR238C.

Organism-specific databases

CYGDi YGR238c.
SGDi S000003470. KEL2.

Phylogenomic databases

eggNOGi NOG145020.
GeneTreei ENSGT00720000108564.
HOGENOMi HOG000000942.
OMAi GHASTIC.
OrthoDBi EOG7008HF.

Enzyme and pathway databases

BioCyci YEAST:G3O-30916-MONOMER.

Miscellaneous databases

NextBioi 973243.

Gene expression databases

Genevestigatori P50090.

Family and domain databases

Gene3Di 2.120.10.80. 2 hits.
InterProi IPR015915. Kelch-typ_b-propeller.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the 43 kb CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm of Saccharomyces cerevisiae chromosome VII."
    van der Aart Q.J.M., Kleine K., Steensma H.Y.
    Yeast 12:385-390(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae."
    Philips J., Herskowitz I.
    J. Cell Biol. 143:375-389(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-455 AND SER-509, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKEL2_YEAST
AccessioniPrimary (citable) accession number: P50090
Secondary accession number(s): D6VV18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 468 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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