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P50090 (KEL2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kelch repeat-containing protein 2
Gene names
Name:KEL2
Ordered Locus Names:YGR238C
ORF Names:G8585
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length882 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with KEL1.

Miscellaneous

Present with 468 molecules/cell in log phase SD medium.

Sequence similarities

Contains 6 Kelch repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

KEL1P388534EBI-9630,EBI-9619

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 882882Kelch repeat-containing protein 2
PRO_0000119097

Regions

Repeat99 – 14345Kelch 1
Repeat153 – 20755Kelch 2
Repeat213 – 26755Kelch 3
Repeat268 – 31750Kelch 4
Repeat319 – 36951Kelch 5
Repeat371 – 41747Kelch 6
Coiled coil550 – 685136 Potential
Coiled coil728 – 881154 Potential

Amino acid modifications

Modified residue4551Phosphothreonine Ref.7
Modified residue5091Phosphoserine Ref.7

Sequences

Sequence LengthMass (Da)Tools
P50090 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 63B9772FF017E6D9

FASTA88299,975
        10         20         30         40         50         60 
MVPFKLTNKV PTDTGPSLIS AQSVPRPIVF MDNRNNTRIV TPTLPPNQHR GISGASTALP 

        70         80         90        100        110        120 
WSPESKNTGK YIWNRVKLKN SPFPRYRHSS SFIVTNDNRI FVTGGLHDQS VYGDVWQIAA 

       130        140        150        160        170        180 
NADGTSFTSK RIDIDQNTPP PRVGHASTIC GNAYVVFGGD THKLNKNGLL DDDLYLFNIN 

       190        200        210        220        230        240 
SYKWTIPQPI GRRPLGRYGH KISIIASNPM QTKLYLFGGQ VDETYFNDLV VFDLSSFRRP 

       250        260        270        280        290        300 
NSHWEFLEPV GDLPPPLTNH TMVAYDNKLW VFGGETPKTI SNDTYRYDPA QSEWSKVKTT 

       310        320        330        340        350        360 
GEKPPPIQEH ASVVYKHLMC VLGGKDTHNA YSNDVYFLNL LSLKWYKLPR MKEGIPQERS 

       370        380        390        400        410        420 
GHSLTLMKNE KLLIMGGDKT DYASPNIHDL QTSETDQGEG TLLYTLDLSS LNELCPGIMC 

       430        440        450        460        470        480 
ESLHAGESFS NSLSGGFTPS KSTESENQEI INILTPRLPD SKVLSYNDID EGAGSYSSAL 

       490        500        510        520        530        540 
DDKAFERKSD REEKKPQSSK VDSSINKESP GTGIKVSKKN FPVLRGLTVD SEEYGSSSYK 

       550        560        570        580        590        600 
DTSCQKGIPK NLFDDLNLNL QTLRLEAQQK ELETARHISQ LEKEVQRLMV IKEASKDSNF 

       610        620        630        640        650        660 
QTARLKNLEI QKTFLESRIN DLKNLLMVKL SQASKLCDQI TIQNNGLKTC SEHVTIKRDI 

       670        680        690        700        710        720 
IDLENKCDVL KRQNEILVNN MQKITPELHT YLNESSCYLG KLLKSYPTSA RPPSSEKDNQ 

       730        740        750        760        770        780 
IYEKDSLNKI EKVINEMHET VRAKEKLHLE TQKLNDERDS LRANLLDNNN KLDALRKLSD 

       790        800        810        820        830        840 
GSSKSMDLTK KAIHLSQSEL EKYRKNNDDL QKEIDRIKTE QAEQDDKQEQ RGAITHGNFD 

       850        860        870        880 
AFHRMKINNL KAELYMSKEN RDSLKDELLA LKKKLYTLEQ KK 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the 43 kb CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm of Saccharomyces cerevisiae chromosome VII."
van der Aart Q.J.M., Kleine K., Steensma H.Y.
Yeast 12:385-390(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae."
Philips J., Herskowitz I.
J. Cell Biol. 143:375-389(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-455 AND SER-509, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X87941 Genomic DNA. Translation: CAA61189.1.
Z73023 Genomic DNA. Translation: CAA97266.1.
AY693035 Genomic DNA. Translation: AAT93054.1.
BK006941 Genomic DNA. Translation: DAA08329.1.
PIRS57704.
RefSeqNP_011754.3. NM_001181367.3.

3D structure databases

ProteinModelPortalP50090.
SMRP50090. Positions 268-379.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33490. 67 interactions.
DIPDIP-4229N.
IntActP50090. 9 interactions.
MINTMINT-542042.
STRING4932.YGR238C.

Proteomic databases

MaxQBP50090.
PaxDbP50090.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGR238C; YGR238C; YGR238C.
GeneID853153.
KEGGsce:YGR238C.

Organism-specific databases

CYGDYGR238c.
SGDS000003470. KEL2.

Phylogenomic databases

eggNOGNOG145020.
GeneTreeENSGT00720000108564.
HOGENOMHOG000000942.
OMAGHASTIC.
OrthoDBEOG7008HF.

Enzyme and pathway databases

BioCycYEAST:G3O-30916-MONOMER.

Gene expression databases

GenevestigatorP50090.

Family and domain databases

Gene3D2.120.10.80. 2 hits.
InterProIPR015915. Kelch-typ_b-propeller.
[Graphical view]
ProtoNetSearch...

Other

NextBio973243.

Entry information

Entry nameKEL2_YEAST
AccessionPrimary (citable) accession number: P50090
Secondary accession number(s): D6VV18
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families