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P50090

- KEL2_YEAST

UniProt

P50090 - KEL2_YEAST

Protein

Kelch repeat-containing protein 2

Gene

KEL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. conjugation with cellular fusion Source: SGD
    2. negative regulation of exit from mitosis Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30916-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kelch repeat-containing protein 2
    Gene namesi
    Name:KEL2
    Ordered Locus Names:YGR238C
    ORF Names:G8585
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR238c.
    SGDiS000003470. KEL2.

    Subcellular locationi

    GO - Cellular componenti

    1. cellular bud neck Source: SGD
    2. cellular bud tip Source: SGD
    3. mating projection tip Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 882882Kelch repeat-containing protein 2PRO_0000119097Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei455 – 4551Phosphothreonine1 Publication
    Modified residuei509 – 5091Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP50090.
    PaxDbiP50090.

    Expressioni

    Gene expression databases

    GenevestigatoriP50090.

    Interactioni

    Subunit structurei

    Interacts with KEL1.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KEL1P388534EBI-9630,EBI-9619

    Protein-protein interaction databases

    BioGridi33490. 70 interactions.
    DIPiDIP-4229N.
    IntActiP50090. 9 interactions.
    MINTiMINT-542042.
    STRINGi4932.YGR238C.

    Structurei

    3D structure databases

    ProteinModelPortaliP50090.
    SMRiP50090. Positions 268-379.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati99 – 14345Kelch 1Add
    BLAST
    Repeati153 – 20755Kelch 2Add
    BLAST
    Repeati213 – 26755Kelch 3Add
    BLAST
    Repeati268 – 31750Kelch 4Add
    BLAST
    Repeati319 – 36951Kelch 5Add
    BLAST
    Repeati371 – 41747Kelch 6Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili550 – 685136Sequence AnalysisAdd
    BLAST
    Coiled coili728 – 881154Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 6 Kelch repeats.Curated

    Keywords - Domaini

    Coiled coil, Kelch repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG145020.
    GeneTreeiENSGT00720000108564.
    HOGENOMiHOG000000942.
    OMAiGHASTIC.
    OrthoDBiEOG7008HF.

    Family and domain databases

    Gene3Di2.120.10.80. 2 hits.
    InterProiIPR015915. Kelch-typ_b-propeller.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50090-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPFKLTNKV PTDTGPSLIS AQSVPRPIVF MDNRNNTRIV TPTLPPNQHR    50
    GISGASTALP WSPESKNTGK YIWNRVKLKN SPFPRYRHSS SFIVTNDNRI 100
    FVTGGLHDQS VYGDVWQIAA NADGTSFTSK RIDIDQNTPP PRVGHASTIC 150
    GNAYVVFGGD THKLNKNGLL DDDLYLFNIN SYKWTIPQPI GRRPLGRYGH 200
    KISIIASNPM QTKLYLFGGQ VDETYFNDLV VFDLSSFRRP NSHWEFLEPV 250
    GDLPPPLTNH TMVAYDNKLW VFGGETPKTI SNDTYRYDPA QSEWSKVKTT 300
    GEKPPPIQEH ASVVYKHLMC VLGGKDTHNA YSNDVYFLNL LSLKWYKLPR 350
    MKEGIPQERS GHSLTLMKNE KLLIMGGDKT DYASPNIHDL QTSETDQGEG 400
    TLLYTLDLSS LNELCPGIMC ESLHAGESFS NSLSGGFTPS KSTESENQEI 450
    INILTPRLPD SKVLSYNDID EGAGSYSSAL DDKAFERKSD REEKKPQSSK 500
    VDSSINKESP GTGIKVSKKN FPVLRGLTVD SEEYGSSSYK DTSCQKGIPK 550
    NLFDDLNLNL QTLRLEAQQK ELETARHISQ LEKEVQRLMV IKEASKDSNF 600
    QTARLKNLEI QKTFLESRIN DLKNLLMVKL SQASKLCDQI TIQNNGLKTC 650
    SEHVTIKRDI IDLENKCDVL KRQNEILVNN MQKITPELHT YLNESSCYLG 700
    KLLKSYPTSA RPPSSEKDNQ IYEKDSLNKI EKVINEMHET VRAKEKLHLE 750
    TQKLNDERDS LRANLLDNNN KLDALRKLSD GSSKSMDLTK KAIHLSQSEL 800
    EKYRKNNDDL QKEIDRIKTE QAEQDDKQEQ RGAITHGNFD AFHRMKINNL 850
    KAELYMSKEN RDSLKDELLA LKKKLYTLEQ KK 882
    Length:882
    Mass (Da):99,975
    Last modified:October 1, 1996 - v1
    Checksum:i63B9772FF017E6D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87941 Genomic DNA. Translation: CAA61189.1.
    Z73023 Genomic DNA. Translation: CAA97266.1.
    AY693035 Genomic DNA. Translation: AAT93054.1.
    BK006941 Genomic DNA. Translation: DAA08329.1.
    PIRiS57704.
    RefSeqiNP_011754.3. NM_001181367.3.

    Genome annotation databases

    EnsemblFungiiYGR238C; YGR238C; YGR238C.
    GeneIDi853153.
    KEGGisce:YGR238C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87941 Genomic DNA. Translation: CAA61189.1 .
    Z73023 Genomic DNA. Translation: CAA97266.1 .
    AY693035 Genomic DNA. Translation: AAT93054.1 .
    BK006941 Genomic DNA. Translation: DAA08329.1 .
    PIRi S57704.
    RefSeqi NP_011754.3. NM_001181367.3.

    3D structure databases

    ProteinModelPortali P50090.
    SMRi P50090. Positions 268-379.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33490. 70 interactions.
    DIPi DIP-4229N.
    IntActi P50090. 9 interactions.
    MINTi MINT-542042.
    STRINGi 4932.YGR238C.

    Proteomic databases

    MaxQBi P50090.
    PaxDbi P50090.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR238C ; YGR238C ; YGR238C .
    GeneIDi 853153.
    KEGGi sce:YGR238C.

    Organism-specific databases

    CYGDi YGR238c.
    SGDi S000003470. KEL2.

    Phylogenomic databases

    eggNOGi NOG145020.
    GeneTreei ENSGT00720000108564.
    HOGENOMi HOG000000942.
    OMAi GHASTIC.
    OrthoDBi EOG7008HF.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30916-MONOMER.

    Miscellaneous databases

    NextBioi 973243.

    Gene expression databases

    Genevestigatori P50090.

    Family and domain databases

    Gene3Di 2.120.10.80. 2 hits.
    InterProi IPR015915. Kelch-typ_b-propeller.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the 43 kb CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm of Saccharomyces cerevisiae chromosome VII."
      van der Aart Q.J.M., Kleine K., Steensma H.Y.
      Yeast 12:385-390(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae."
      Philips J., Herskowitz I.
      J. Cell Biol. 143:375-389(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-455 AND SER-509, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKEL2_YEAST
    AccessioniPrimary (citable) accession number: P50090
    Secondary accession number(s): D6VV18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 468 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3