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Protein

MICOS subunit MIC26

Gene

MIC26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.2 Publications

Miscellaneous

Present with 5220 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • cristae formation Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-30913-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS subunit MIC26
Alternative name(s):
Mitochondrial contact site complex 29 kDa subunit
Mitochondrial inner membrane organization component of 27 kDa
Mitochondrial organizing structure protein 2
Short name:
MitOS2
Gene namesi
Name:MIC26
Synonyms:MCS29, MIO27, MOS2
Ordered Locus Names:YGR235C
ORF Names:G8575
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR235C
SGDiS000003467 MIC26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 119Mitochondrial intermembraneSequence analysisAdd BLAST119
Transmembranei120 – 137HelicalSequence analysisAdd BLAST18
Topological domaini138 – 141Mitochondrial matrixSequence analysis4
Transmembranei142 – 164HelicalSequence analysisAdd BLAST23
Topological domaini165 – 233Mitochondrial intermembraneSequence analysisAdd BLAST69

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Moderate changes in the mitochondrial morphology.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002028521 – 233MICOS subunit MIC26Add BLAST233

Proteomic databases

MaxQBiP50087
PaxDbiP50087
PRIDEiP50087

PTM databases

iPTMnetiP50087

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex.1 Publication

Protein-protein interaction databases

BioGridi33487, 33 interactors
DIPiDIP-4903N
IntActiP50087, 7 interactors
MINTiP50087
STRINGi4932.YGR235C

Structurei

3D structure databases

ProteinModelPortaliP50087
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000000941
InParanoidiP50087
KOiK17786
OMAiSAYNATH
OrthoDBiEOG092C39W3

Family and domain databases

InterProiView protein in InterPro
IPR019166 MIC26/MIC27
IPR033181 Mic26_fungi
PANTHERiPTHR28268 PTHR28268, 1 hit
PfamiView protein in Pfam
PF09769 ApoO, 1 hit

Sequencei

Sequence statusi: Complete.

P50087-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKDFYRQLD PVEEKIVPPE NAIVISSEAK EATVNEKEAK QGVLSQRVMK
60 70 80 90 100
YIGENELVDG ISVRDPDYLK RFFNERRKQF SAKWDKVTNK IDDIAGRYYA
110 120 130 140 150
REESFTSTIA SLHTDPNERL IPGLLSILVA SMTGSVLARR RTWLLRATMP
160 170 180 190 200
IILGSCCFAY AMPTTFRNTM GLIHNLEMNT FPHFTERQDR VWKETKRLST
210 220 230
ASVQYYYDAK KWLNKDVEKT GNAIKNWTGV NVK
Length:233
Mass (Da):26,912
Last modified:October 1, 1996 - v1
Checksum:iD72E346FE810DF99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87941 Genomic DNA Translation: CAA61185.1
Z73020 Genomic DNA Translation: CAA97263.1
AY558276 Genomic DNA Translation: AAS56602.1
BK006941 Genomic DNA Translation: DAA08326.1
PIRiS57700
RefSeqiNP_011751.1, NM_001181364.1

Genome annotation databases

EnsemblFungiiYGR235C; YGR235C; YGR235C
GeneIDi853150
KEGGisce:YGR235C

Similar proteinsi

Entry informationi

Entry nameiMIC26_YEAST
AccessioniPrimary (citable) accession number: P50087
Secondary accession number(s): D6VV15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health