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P50087

- MIC26_YEAST

UniProt

P50087 - MIC26_YEAST

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Protein

MICOS subunit MIC26

Gene

MIC26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.2 Publications

GO - Biological processi

  1. cristae formation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30913-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS subunit MIC26
Alternative name(s):
Mitochondrial contact site complex 29 kDa subunit
Mitochondrial inner membrane organization component of 27 kDa
Mitochondrial organizing structure protein 2
Short name:
MitOS2
Gene namesi
Name:MIC26
Synonyms:MCS29, MIO27, MOS2
Ordered Locus Names:YGR235C
ORF Names:G8575
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR235c.
SGDiS000003467. MIC26.

Subcellular locationi

Mitochondrion inner membrane Curated; Multi-pass membrane protein Curated
Note: Enriched at crista junctions.3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 119119Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei120 – 13718HelicalSequence AnalysisAdd
BLAST
Topological domaini138 – 1414Mitochondrial matrixSequence Analysis
Transmembranei142 – 16423HelicalSequence AnalysisAdd
BLAST
Topological domaini165 – 23369Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. MICOS complex Source: SGD
  2. mitochondrial crista junction Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Moderate changes in the mitochondrial morphology.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233MICOS subunit MIC26PRO_0000202852Add
BLAST

Proteomic databases

MaxQBiP50087.
PaxDbiP50087.

Expressioni

Gene expression databases

GenevestigatoriP50087.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex.1 Publication

Protein-protein interaction databases

BioGridi33487. 19 interactions.
DIPiDIP-4903N.
IntActiP50087. 5 interactions.
MINTiMINT-564115.
STRINGi4932.YGR235C.

Structurei

3D structure databases

ProteinModelPortaliP50087.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42638.
HOGENOMiHOG000000941.
InParanoidiP50087.
KOiK17786.
OMAiPTTFRNT.
OrthoDBiEOG7966V9.

Family and domain databases

InterProiIPR019166. Apolipoprotein_O.
[Graphical view]
PfamiPF09769. ApoO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50087-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKDFYRQLD PVEEKIVPPE NAIVISSEAK EATVNEKEAK QGVLSQRVMK
60 70 80 90 100
YIGENELVDG ISVRDPDYLK RFFNERRKQF SAKWDKVTNK IDDIAGRYYA
110 120 130 140 150
REESFTSTIA SLHTDPNERL IPGLLSILVA SMTGSVLARR RTWLLRATMP
160 170 180 190 200
IILGSCCFAY AMPTTFRNTM GLIHNLEMNT FPHFTERQDR VWKETKRLST
210 220 230
ASVQYYYDAK KWLNKDVEKT GNAIKNWTGV NVK
Length:233
Mass (Da):26,912
Last modified:October 1, 1996 - v1
Checksum:iD72E346FE810DF99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87941 Genomic DNA. Translation: CAA61185.1.
Z73020 Genomic DNA. Translation: CAA97263.1.
AY558276 Genomic DNA. Translation: AAS56602.1.
BK006941 Genomic DNA. Translation: DAA08326.1.
PIRiS57700.
RefSeqiNP_011751.1. NM_001181364.1.

Genome annotation databases

EnsemblFungiiYGR235C; YGR235C; YGR235C.
GeneIDi853150.
KEGGisce:YGR235C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87941 Genomic DNA. Translation: CAA61185.1 .
Z73020 Genomic DNA. Translation: CAA97263.1 .
AY558276 Genomic DNA. Translation: AAS56602.1 .
BK006941 Genomic DNA. Translation: DAA08326.1 .
PIRi S57700.
RefSeqi NP_011751.1. NM_001181364.1.

3D structure databases

ProteinModelPortali P50087.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33487. 19 interactions.
DIPi DIP-4903N.
IntActi P50087. 5 interactions.
MINTi MINT-564115.
STRINGi 4932.YGR235C.

Proteomic databases

MaxQBi P50087.
PaxDbi P50087.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR235C ; YGR235C ; YGR235C .
GeneIDi 853150.
KEGGi sce:YGR235C.

Organism-specific databases

CYGDi YGR235c.
SGDi S000003467. MIC26.

Phylogenomic databases

eggNOGi NOG42638.
HOGENOMi HOG000000941.
InParanoidi P50087.
KOi K17786.
OMAi PTTFRNT.
OrthoDBi EOG7966V9.

Enzyme and pathway databases

BioCyci YEAST:G3O-30913-MONOMER.

Miscellaneous databases

NextBioi 973234.

Gene expression databases

Genevestigatori P50087.

Family and domain databases

InterProi IPR019166. Apolipoprotein_O.
[Graphical view ]
Pfami PF09769. ApoO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the 43 kb CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm of Saccharomyces cerevisiae chromosome VII."
    van der Aart Q.J.M., Kleine K., Steensma H.Y.
    Yeast 12:385-390(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: FUNCTION, COMPOSITION OF THE MICOS COMPLEX, SUBCELLULAR LOCATION.
  7. "The mitochondrial contact site complex, a determinant of mitochondrial architecture."
    Harner M., Korner C., Walther D., Mokranjac D., Kaesmacher J., Welsch U., Griffith J., Mann M., Reggiori F., Neupert W.
    EMBO J. 30:4356-4370(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MICOS COMPLEX, MASS SPECTROMETRY, SUBCELLULAR LOCATION, TOPOLOGY.
  8. "A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria."
    Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.
    J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, COMPOSITION OF THE MICOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  9. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiMIC26_YEAST
AccessioniPrimary (citable) accession number: P50087
Secondary accession number(s): D6VV15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5220 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3