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Protein

MICOS subunit MIC26

Gene

MIC26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.2 Publications

GO - Biological processi

  • cristae formation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30913-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS subunit MIC26
Alternative name(s):
Mitochondrial contact site complex 29 kDa subunit
Mitochondrial inner membrane organization component of 27 kDa
Mitochondrial organizing structure protein 2
Short name:
MitOS2
Gene namesi
Name:MIC26
Synonyms:MCS29, MIO27, MOS2
Ordered Locus Names:YGR235C
ORF Names:G8575
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VII

Organism-specific databases

CYGDiYGR235c.
EuPathDBiFungiDB:YGR235C.
SGDiS000003467. MIC26.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 119119Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei120 – 13718HelicalSequence AnalysisAdd
BLAST
Topological domaini138 – 1414Mitochondrial matrixSequence Analysis
Transmembranei142 – 16423HelicalSequence AnalysisAdd
BLAST
Topological domaini165 – 23369Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • MICOS complex Source: SGD
  • mitochondrial crista junction Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Moderate changes in the mitochondrial morphology.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233MICOS subunit MIC26PRO_0000202852Add
BLAST

Proteomic databases

MaxQBiP50087.
PaxDbiP50087.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex.1 Publication

Protein-protein interaction databases

BioGridi33487. 19 interactions.
DIPiDIP-4903N.
IntActiP50087. 5 interactions.
MINTiMINT-564115.

Structurei

3D structure databases

ProteinModelPortaliP50087.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42638.
HOGENOMiHOG000000941.
InParanoidiP50087.
KOiK17786.
OMAiPTTFRNT.
OrthoDBiEOG7966V9.

Family and domain databases

InterProiIPR019166. Apolipoprotein_O.
[Graphical view]
PfamiPF09769. ApoO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50087-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKDFYRQLD PVEEKIVPPE NAIVISSEAK EATVNEKEAK QGVLSQRVMK
60 70 80 90 100
YIGENELVDG ISVRDPDYLK RFFNERRKQF SAKWDKVTNK IDDIAGRYYA
110 120 130 140 150
REESFTSTIA SLHTDPNERL IPGLLSILVA SMTGSVLARR RTWLLRATMP
160 170 180 190 200
IILGSCCFAY AMPTTFRNTM GLIHNLEMNT FPHFTERQDR VWKETKRLST
210 220 230
ASVQYYYDAK KWLNKDVEKT GNAIKNWTGV NVK
Length:233
Mass (Da):26,912
Last modified:October 1, 1996 - v1
Checksum:iD72E346FE810DF99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87941 Genomic DNA. Translation: CAA61185.1.
Z73020 Genomic DNA. Translation: CAA97263.1.
AY558276 Genomic DNA. Translation: AAS56602.1.
BK006941 Genomic DNA. Translation: DAA08326.1.
PIRiS57700.
RefSeqiNP_011751.1. NM_001181364.1.

Genome annotation databases

EnsemblFungiiYGR235C; YGR235C; YGR235C.
GeneIDi853150.
KEGGisce:YGR235C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87941 Genomic DNA. Translation: CAA61185.1.
Z73020 Genomic DNA. Translation: CAA97263.1.
AY558276 Genomic DNA. Translation: AAS56602.1.
BK006941 Genomic DNA. Translation: DAA08326.1.
PIRiS57700.
RefSeqiNP_011751.1. NM_001181364.1.

3D structure databases

ProteinModelPortaliP50087.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33487. 19 interactions.
DIPiDIP-4903N.
IntActiP50087. 5 interactions.
MINTiMINT-564115.

Proteomic databases

MaxQBiP50087.
PaxDbiP50087.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR235C; YGR235C; YGR235C.
GeneIDi853150.
KEGGisce:YGR235C.

Organism-specific databases

CYGDiYGR235c.
EuPathDBiFungiDB:YGR235C.
SGDiS000003467. MIC26.

Phylogenomic databases

eggNOGiNOG42638.
HOGENOMiHOG000000941.
InParanoidiP50087.
KOiK17786.
OMAiPTTFRNT.
OrthoDBiEOG7966V9.

Enzyme and pathway databases

BioCyciYEAST:G3O-30913-MONOMER.

Miscellaneous databases

NextBioi973234.
PROiP50087.

Family and domain databases

InterProiIPR019166. Apolipoprotein_O.
[Graphical view]
PfamiPF09769. ApoO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the 43 kb CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm of Saccharomyces cerevisiae chromosome VII."
    van der Aart Q.J.M., Kleine K., Steensma H.Y.
    Yeast 12:385-390(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: FUNCTION, COMPOSITION OF THE MICOS COMPLEX, SUBCELLULAR LOCATION.
  7. "The mitochondrial contact site complex, a determinant of mitochondrial architecture."
    Harner M., Korner C., Walther D., Mokranjac D., Kaesmacher J., Welsch U., Griffith J., Mann M., Reggiori F., Neupert W.
    EMBO J. 30:4356-4370(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MICOS COMPLEX, MASS SPECTROMETRY, SUBCELLULAR LOCATION, TOPOLOGY.
  8. "A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria."
    Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.
    J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, COMPOSITION OF THE MICOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  9. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiMIC26_YEAST
AccessioniPrimary (citable) accession number: P50087
Secondary accession number(s): D6VV15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 22, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5220 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.