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P50087 (MOS2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial organizing structure protein 2

Short name=MitOS2
Alternative name(s):
Mitochondrial inner membrane organization component of 27 kDa
Gene names
Name:MOS2
Synonyms:MIO27
Ordered Locus Names:YGR235C
ORF Names:G8575
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

As a component of the mitochondrial inner membrane organizing system (MINOS/MitOS) complex, important for normal mitochondrial morphology. Ref.6 Ref.7

Subunit structure

Component of the MINOS/MitOS complex, that includes FCJ1, AIM5, AIM13, AIM37, MOS1 and MOS2.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Ref.6 Ref.7.

Disruption phenotype

Moderate changes in the mitochondrial morphology. Ref.7

Miscellaneous

Present with 5220 molecules/cell in log phase SD medium.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 233233Mitochondrial organizing structure protein 2
PRO_0000202852

Regions

Transmembrane120 – 13718Helical; Potential
Transmembrane142 – 16423Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P50087 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: D72E346FE810DF99

FASTA23326,912
        10         20         30         40         50         60 
MTKDFYRQLD PVEEKIVPPE NAIVISSEAK EATVNEKEAK QGVLSQRVMK YIGENELVDG 

        70         80         90        100        110        120 
ISVRDPDYLK RFFNERRKQF SAKWDKVTNK IDDIAGRYYA REESFTSTIA SLHTDPNERL 

       130        140        150        160        170        180 
IPGLLSILVA SMTGSVLARR RTWLLRATMP IILGSCCFAY AMPTTFRNTM GLIHNLEMNT 

       190        200        210        220        230 
FPHFTERQDR VWKETKRLST ASVQYYYDAK KWLNKDVEKT GNAIKNWTGV NVK 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the 43 kb CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm of Saccharomyces cerevisiae chromosome VII."
van der Aart Q.J.M., Kleine K., Steensma H.Y.
Yeast 12:385-390(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis."
von der Malsburg K., Muller J.M., Bohnert M., Oeljeklaus S., Kwiatkowska P., Becker T., Loniewska-Lwowska A., Wiese S., Rao S., Milenkovic D., Hutu D.P., Zerbes R.M., Schulze-Specking A., Meyer H.E., Martinou J.C., Rospert S., Rehling P., Meisinger C. expand/collapse author list , Veenhuis M., Warscheid B., van der Klei I.J., Pfanner N., Chacinska A., van der Laan M.
Dev. Cell 21:694-707(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, COMPOSITION OF THE MINOS COMPLEX, SUBCELLULAR LOCATION.
[7]"A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria."
Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.
J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, COMPOSITION OF THE MINOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X87941 Genomic DNA. Translation: CAA61185.1.
Z73020 Genomic DNA. Translation: CAA97263.1.
AY558276 Genomic DNA. Translation: AAS56602.1.
BK006941 Genomic DNA. Translation: DAA08326.1.
PIRS57700.
RefSeqNP_011751.1. NM_001181364.1.

3D structure databases

ProteinModelPortalP50087.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33487. 17 interactions.
DIPDIP-4903N.
IntActP50087. 5 interactions.
MINTMINT-564115.
STRING4932.YGR235C.

Proteomic databases

PaxDbP50087.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGR235C; YGR235C; YGR235C.
GeneID853150.
KEGGsce:YGR235C.

Organism-specific databases

CYGDYGR235c.
SGDS000003467. MOS2.

Phylogenomic databases

eggNOGNOG42638.
HOGENOMHOG000000941.
KOK17786.
OMAPTTFRNT.
OrthoDBEOG7966V9.

Enzyme and pathway databases

BioCycYEAST:G3O-30913-MONOMER.

Gene expression databases

GenevestigatorP50087.

Family and domain databases

InterProIPR019166. Apolipoprotein_O.
[Graphical view]
PfamPF09769. ApoO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio973234.

Entry information

Entry nameMOS2_YEAST
AccessionPrimary (citable) accession number: P50087
Secondary accession number(s): D6VV15
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD