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P50087

- MIC26_YEAST

UniProt

P50087 - MIC26_YEAST

Protein

MICOS subunit MIC26

Gene

MIC26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.2 Publications

    GO - Biological processi

    1. cristae formation Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30913-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MICOS subunit MIC26
    Alternative name(s):
    Mitochondrial contact site complex 29 kDa subunit
    Mitochondrial inner membrane organization component of 27 kDa
    Mitochondrial organizing structure protein 2
    Short name:
    MitOS2
    Gene namesi
    Name:MIC26
    Synonyms:MCS29, MIO27, MOS2
    Ordered Locus Names:YGR235C
    ORF Names:G8575
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR235c.
    SGDiS000003467. MIC26.

    Subcellular locationi

    Mitochondrion inner membrane Curated; Multi-pass membrane protein Curated
    Note: Enriched at crista junctions.3 Publications

    GO - Cellular componenti

    1. MICOS complex Source: SGD
    2. mitochondrial crista junction Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Disruption phenotypei

    Moderate changes in the mitochondrial morphology.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233MICOS subunit MIC26PRO_0000202852Add
    BLAST

    Proteomic databases

    MaxQBiP50087.
    PaxDbiP50087.

    Expressioni

    Gene expression databases

    GenevestigatoriP50087.

    Interactioni

    Subunit structurei

    Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex.1 Publication

    Protein-protein interaction databases

    BioGridi33487. 17 interactions.
    DIPiDIP-4903N.
    IntActiP50087. 5 interactions.
    MINTiMINT-564115.
    STRINGi4932.YGR235C.

    Structurei

    3D structure databases

    ProteinModelPortaliP50087.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 119119Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini138 – 1414Mitochondrial matrixSequence Analysis
    Topological domaini165 – 23369Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei120 – 13718HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16423HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42638.
    HOGENOMiHOG000000941.
    KOiK17786.
    OMAiPTTFRNT.
    OrthoDBiEOG7966V9.

    Family and domain databases

    InterProiIPR019166. Apolipoprotein_O.
    [Graphical view]
    PfamiPF09769. ApoO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50087-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKDFYRQLD PVEEKIVPPE NAIVISSEAK EATVNEKEAK QGVLSQRVMK    50
    YIGENELVDG ISVRDPDYLK RFFNERRKQF SAKWDKVTNK IDDIAGRYYA 100
    REESFTSTIA SLHTDPNERL IPGLLSILVA SMTGSVLARR RTWLLRATMP 150
    IILGSCCFAY AMPTTFRNTM GLIHNLEMNT FPHFTERQDR VWKETKRLST 200
    ASVQYYYDAK KWLNKDVEKT GNAIKNWTGV NVK 233
    Length:233
    Mass (Da):26,912
    Last modified:October 1, 1996 - v1
    Checksum:iD72E346FE810DF99
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87941 Genomic DNA. Translation: CAA61185.1.
    Z73020 Genomic DNA. Translation: CAA97263.1.
    AY558276 Genomic DNA. Translation: AAS56602.1.
    BK006941 Genomic DNA. Translation: DAA08326.1.
    PIRiS57700.
    RefSeqiNP_011751.1. NM_001181364.1.

    Genome annotation databases

    EnsemblFungiiYGR235C; YGR235C; YGR235C.
    GeneIDi853150.
    KEGGisce:YGR235C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87941 Genomic DNA. Translation: CAA61185.1 .
    Z73020 Genomic DNA. Translation: CAA97263.1 .
    AY558276 Genomic DNA. Translation: AAS56602.1 .
    BK006941 Genomic DNA. Translation: DAA08326.1 .
    PIRi S57700.
    RefSeqi NP_011751.1. NM_001181364.1.

    3D structure databases

    ProteinModelPortali P50087.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33487. 17 interactions.
    DIPi DIP-4903N.
    IntActi P50087. 5 interactions.
    MINTi MINT-564115.
    STRINGi 4932.YGR235C.

    Proteomic databases

    MaxQBi P50087.
    PaxDbi P50087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR235C ; YGR235C ; YGR235C .
    GeneIDi 853150.
    KEGGi sce:YGR235C.

    Organism-specific databases

    CYGDi YGR235c.
    SGDi S000003467. MIC26.

    Phylogenomic databases

    eggNOGi NOG42638.
    HOGENOMi HOG000000941.
    KOi K17786.
    OMAi PTTFRNT.
    OrthoDBi EOG7966V9.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30913-MONOMER.

    Miscellaneous databases

    NextBioi 973234.

    Gene expression databases

    Genevestigatori P50087.

    Family and domain databases

    InterProi IPR019166. Apolipoprotein_O.
    [Graphical view ]
    Pfami PF09769. ApoO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the 43 kb CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm of Saccharomyces cerevisiae chromosome VII."
      van der Aart Q.J.M., Kleine K., Steensma H.Y.
      Yeast 12:385-390(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. Cited for: FUNCTION, COMPOSITION OF THE MICOS COMPLEX, SUBCELLULAR LOCATION.
    7. "The mitochondrial contact site complex, a determinant of mitochondrial architecture."
      Harner M., Korner C., Walther D., Mokranjac D., Kaesmacher J., Welsch U., Griffith J., Mann M., Reggiori F., Neupert W.
      EMBO J. 30:4356-4370(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE MICOS COMPLEX, MASS SPECTROMETRY, SUBCELLULAR LOCATION, TOPOLOGY.
    8. "A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria."
      Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.
      J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, COMPOSITION OF THE MICOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    9. Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiMIC26_YEAST
    AccessioniPrimary (citable) accession number: P50087
    Secondary accession number(s): D6VV15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 5220 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3