Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prohibitin-2

Gene

PHB2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.1 Publication

Miscellaneous

Present with 2850 molecules/cell in log phase SD medium.1 Publication
Mitochondrial targeting of PHB2 is ensured by a bipartite non-cleavable presequence at the N-terminus.

GO - Biological processi

  • mitochondrion inheritance Source: SGD
  • negative regulation of proteolysis Source: SGD
  • protein folding Source: SGD
  • replicative cell aging Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-30909-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin-2
Gene namesi
Name:PHB2
Ordered Locus Names:YGR231C
ORF Names:G8561
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR231C
SGDiS000003463 PHB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 58Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138881 – 310Prohibitin-2Add BLAST310

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

MaxQBiP50085
PaxDbiP50085
PRIDEiP50085

Interactioni

Subunit structurei

The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2), assembled into a membrane-associated ring-shaped supercomplex of approximately 1 mDa.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PHB1P409613EBI-23530,EBI-13360

Protein-protein interaction databases

BioGridi33483, 482 interactors
IntActiP50085, 42 interactors
MINTiP50085
STRINGi4932.YGR231C

Structurei

3D structure databases

ProteinModelPortaliP50085
SMRiP50085
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili212 – 2531 PublicationAdd BLAST42

Sequence similaritiesi

Belongs to the prohibitin family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000075076
HOGENOMiHOG000205692
InParanoidiP50085
KOiK17081
OMAiELGTDYD
OrthoDBiEOG092C43I2

Family and domain databases

CDDicd03401 SPFH_prohibitin, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR000163 Prohibitin
PANTHERiPTHR23222 PTHR23222, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00679 PROHIBITIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequencei

Sequence statusi: Complete.

P50085-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRSPGEFQR YAKAFQKQLS KVQQTGGRGQ VPSPRGAFAG LGGLLLLGGG
60 70 80 90 100
ALFINNALFN VDGGHRAIVY SRIHGVSSRI FNEGTHFIFP WLDTPIIYDV
110 120 130 140 150
RAKPRNVASL TGTKDLQMVN ITCRVLSRPD VVQLPTIYRT LGQDYDERVL
160 170 180 190 200
PSIVNEVLKA VVAQFNASQL ITQREKVSRL IRENLVRRAS KFNILLDDVS
210 220 230 240 250
ITYMTFSPEF TNAVEAKQIA QQDAQRAAFV VDKARQEKQG MVVRAQGEAK
260 270 280 290 300
SAELIGEAIK KSRDYVELKR LDTARDIAKI LASSPNRVIL DNEALLLNTV
310
VDARIDGRGK
Length:310
Mass (Da):34,407
Last modified:October 3, 2006 - v2
Checksum:i3526D9690F39B493
GO

Sequence cautioni

The sequence CAA61181 differs from that shown. Reason: Frameshift at position 310.Curated
The sequence CAA97259 differs from that shown. Reason: Frameshift at position 310.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87941 Genomic DNA Translation: CAA61181.1 Frameshift.
Z73016 Genomic DNA Translation: CAA97259.1 Frameshift.
BK006941 Genomic DNA Translation: DAA08322.1
PIRiS57696
RefSeqiNP_011747.2, NM_001181360.1

Genome annotation databases

EnsemblFungiiYGR231C; YGR231C; YGR231C
GeneIDi853146
KEGGisce:YGR231C

Similar proteinsi

Entry informationi

Entry nameiPHB2_YEAST
AccessioniPrimary (citable) accession number: P50085
Secondary accession number(s): D6VV11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2006
Last modified: May 23, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health