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Protein

Azole resistance protein 1

Gene

AZR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transporter protein required for adaptation to high stress imposed by low-chain organic acids, in particular by acetic acid, and for resistance to azoles, especially to ketoconazole and fluconazole.1 Publication

GO - Molecular functioni

  • azole transporter activity Source: SGD

GO - Biological processi

  • azole transport Source: SGD
  • transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30905-MONOMER.

Protein family/group databases

TCDBi2.A.1.3.53. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Azole resistance protein 1
Gene namesi
Name:AZR1
Ordered Locus Names:YGR224W
ORF Names:G8537
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR224W.
SGDiS000003456. AZR1.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 70ExtracellularSequence analysisAdd BLAST70
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Topological domaini92 – 102CytoplasmicSequence analysisAdd BLAST11
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 134ExtracellularSequence analysisAdd BLAST11
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 163CytoplasmicSequence analysis8
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 189ExtracellularSequence analysis5
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 221CytoplasmicSequence analysisAdd BLAST11
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 298ExtracellularSequence analysisAdd BLAST56
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 329CytoplasmicSequence analysis10
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 375ExtracellularSequence analysisAdd BLAST25
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 414CytoplasmicSequence analysisAdd BLAST18
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 443ExtracellularSequence analysis8
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 472CytoplasmicSequence analysis8
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 581ExtracellularSequence analysisAdd BLAST88
Transmembranei582 – 602HelicalSequence analysisAdd BLAST21
Topological domaini603 – 613CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734261 – 613Azole resistance protein 1Add BLAST613

Proteomic databases

PRIDEiP50080.

Expressioni

Inductioni

Transcriptionally regulated by PDR8.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi33477. 15 interactors.
DIPiDIP-7543N.
IntActiP50080. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliP50080.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000006559.
HOGENOMiHOG000247960.
InParanoidiP50080.
OMAiCVVIFEA.
OrthoDBiEOG092C1LCH.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGEPKTYSM SDLSYYGEKA QQQNEKQQKQ YVVRRNSTQS TSKQNVSVVL
60 70 80 90 100
EDNASESNEL PKGFILYASL IALALSLFLA ALDIMIVSTI IEEVAKQFGS
110 120 130 140 150
YSEIGWLFTG YSLPNALLAL IWGRIATPIG FKETMLFAIV IFEIGSLISA
160 170 180 190 200
LANSMSMLIG GRVIAGVGGC GIQSLSFVIG STLVEESQRG ILIAVLSCSF
210 220 230 240 250
AIASVVGPFL GGVFTSSVTW RWCFYVNLPI GGLAFFLFLF FYNPGLSTFQ
260 270 280 290 300
ETMDNIRKFP SQFIEIVRNV AYHLLKIKGF SKLNGWRKPF MELIFMYDII
310 320 330 340 350
EFVFCSAGFT CILLAFTFGG NRYAWNSASI IILFIIGIVL VVLAGIYDFL
360 370 380 390 400
VFPKFNIVKA TPHYQPLMSW TNIKKPGIFT VNIALFLTCA GYISQFTYIV
410 420 430 440 450
QYFQLIYNDS AWRAAVHLVA CIISTVVTAI LCGAITDKTR QIKPIIVISS
460 470 480 490 500
IFGVVGAGIL TLLNNNANNS AHIGLLILPG VAFGGLAQSS MLASQIQLDK
510 520 530 540 550
KSPTFRSDFV SITTFNTFCK NLGQALGGVI SNTVFSAAAI KKLTKANIQL
560 570 580 590 600
PDGTTVDNLV IYRQTNFDGS HSKLGNIISE SLTDVFYMAL GFYALSLIFA
610
VFASNKKVTA SLR
Length:613
Mass (Da):67,169
Last modified:October 1, 1996 - v1
Checksum:iCF65C211E81D3FFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87941 Genomic DNA. Translation: CAA61172.1.
Z73009 Genomic DNA. Translation: CAA97252.1.
BK006941 Genomic DNA. Translation: DAA08317.1.
PIRiS57687.
RefSeqiNP_011740.3. NM_001181353.3.

Genome annotation databases

EnsemblFungiiYGR224W; YGR224W; YGR224W.
GeneIDi853139.
KEGGisce:YGR224W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87941 Genomic DNA. Translation: CAA61172.1.
Z73009 Genomic DNA. Translation: CAA97252.1.
BK006941 Genomic DNA. Translation: DAA08317.1.
PIRiS57687.
RefSeqiNP_011740.3. NM_001181353.3.

3D structure databases

ProteinModelPortaliP50080.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33477. 15 interactors.
DIPiDIP-7543N.
IntActiP50080. 2 interactors.

Protein family/group databases

TCDBi2.A.1.3.53. the major facilitator superfamily (mfs).

Proteomic databases

PRIDEiP50080.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR224W; YGR224W; YGR224W.
GeneIDi853139.
KEGGisce:YGR224W.

Organism-specific databases

EuPathDBiFungiDB:YGR224W.
SGDiS000003456. AZR1.

Phylogenomic databases

GeneTreeiENSGT00390000006559.
HOGENOMiHOG000247960.
InParanoidiP50080.
OMAiCVVIFEA.
OrthoDBiEOG092C1LCH.

Enzyme and pathway databases

BioCyciYEAST:G3O-30905-MONOMER.

Miscellaneous databases

PROiP50080.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAZR1_YEAST
AccessioniPrimary (citable) accession number: P50080
Secondary accession number(s): D6VV06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.