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Protein

Azole resistance protein 1

Gene

AZR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transporter protein required for adaptation to high stress imposed by low-chain organic acids, in particular by acetic acid, and for resistance to azoles, especially to ketoconazole and fluconazole.1 Publication

GO - Molecular functioni

  • azole transmembrane transporter activity Source: SGD
  • transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • azole transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-30905-MONOMER

Protein family/group databases

TCDBi2.A.1.3.53 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Azole resistance protein 1
Gene namesi
Name:AZR1
Ordered Locus Names:YGR224W
ORF Names:G8537
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR224W
SGDiS000003456 AZR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 70ExtracellularSequence analysisAdd BLAST70
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Topological domaini92 – 102CytoplasmicSequence analysisAdd BLAST11
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 134ExtracellularSequence analysisAdd BLAST11
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 163CytoplasmicSequence analysis8
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 189ExtracellularSequence analysis5
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 221CytoplasmicSequence analysisAdd BLAST11
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 298ExtracellularSequence analysisAdd BLAST56
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 329CytoplasmicSequence analysis10
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 375ExtracellularSequence analysisAdd BLAST25
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 414CytoplasmicSequence analysisAdd BLAST18
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 443ExtracellularSequence analysis8
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 472CytoplasmicSequence analysis8
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 581ExtracellularSequence analysisAdd BLAST88
Transmembranei582 – 602HelicalSequence analysisAdd BLAST21
Topological domaini603 – 613CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734261 – 613Azole resistance protein 1Add BLAST613

Proteomic databases

PaxDbiP50080
PRIDEiP50080

PTM databases

CarbonylDBiP50080

Expressioni

Inductioni

Transcriptionally regulated by PDR8.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi33477, 72 interactors
DIPiDIP-7543N
IntActiP50080, 2 interactors
STRINGi4932.YGR224W

Structurei

3D structure databases

ProteinModelPortaliP50080
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000006559
HOGENOMiHOG000247960
InParanoidiP50080
OMAiFMLPMAC
OrthoDBiEOG092C1LCH

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 3 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P50080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGEPKTYSM SDLSYYGEKA QQQNEKQQKQ YVVRRNSTQS TSKQNVSVVL
60 70 80 90 100
EDNASESNEL PKGFILYASL IALALSLFLA ALDIMIVSTI IEEVAKQFGS
110 120 130 140 150
YSEIGWLFTG YSLPNALLAL IWGRIATPIG FKETMLFAIV IFEIGSLISA
160 170 180 190 200
LANSMSMLIG GRVIAGVGGC GIQSLSFVIG STLVEESQRG ILIAVLSCSF
210 220 230 240 250
AIASVVGPFL GGVFTSSVTW RWCFYVNLPI GGLAFFLFLF FYNPGLSTFQ
260 270 280 290 300
ETMDNIRKFP SQFIEIVRNV AYHLLKIKGF SKLNGWRKPF MELIFMYDII
310 320 330 340 350
EFVFCSAGFT CILLAFTFGG NRYAWNSASI IILFIIGIVL VVLAGIYDFL
360 370 380 390 400
VFPKFNIVKA TPHYQPLMSW TNIKKPGIFT VNIALFLTCA GYISQFTYIV
410 420 430 440 450
QYFQLIYNDS AWRAAVHLVA CIISTVVTAI LCGAITDKTR QIKPIIVISS
460 470 480 490 500
IFGVVGAGIL TLLNNNANNS AHIGLLILPG VAFGGLAQSS MLASQIQLDK
510 520 530 540 550
KSPTFRSDFV SITTFNTFCK NLGQALGGVI SNTVFSAAAI KKLTKANIQL
560 570 580 590 600
PDGTTVDNLV IYRQTNFDGS HSKLGNIISE SLTDVFYMAL GFYALSLIFA
610
VFASNKKVTA SLR
Length:613
Mass (Da):67,169
Last modified:October 1, 1996 - v1
Checksum:iCF65C211E81D3FFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87941 Genomic DNA Translation: CAA61172.1
Z73009 Genomic DNA Translation: CAA97252.1
BK006941 Genomic DNA Translation: DAA08317.1
PIRiS57687
RefSeqiNP_011740.3, NM_001181353.3

Genome annotation databases

EnsemblFungiiYGR224W; YGR224W; YGR224W
GeneIDi853139
KEGGisce:YGR224W

Similar proteinsi

Entry informationi

Entry nameiAZR1_YEAST
AccessioniPrimary (citable) accession number: P50080
Secondary accession number(s): D6VV06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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