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Protein

SVP1-like protein 2

Gene

HSV2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in piecemeal microautophagy of the nucleus (micronucleophagy).2 Publications

GO - Molecular functioni

  • phosphatidylinositol-3,5-bisphosphate binding Source: SGD
  • phosphatidylinositol-3-phosphate binding Source: SGD
  • phosphatidylinositol-4-phosphate binding Source: SGD
  • phosphatidylinositol-5-phosphate binding Source: SGD

GO - Biological processi

Enzyme and pathway databases

BioCyciYEAST:G3O-30904-MONOMER
ReactomeiR-SCE-1632852 Macroautophagy

Names & Taxonomyi

Protein namesi
Recommended name:
SVP1-like protein 2
Gene namesi
Name:HSV2
Ordered Locus Names:YGR223C
ORF Names:G8530
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR223C
SGDiS000003455 HSV2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510341 – 448SVP1-like protein 2Add BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP50079
PaxDbiP50079
PRIDEiP50079

Interactioni

Protein-protein interaction databases

BioGridi33476, 105 interactors
DIPiDIP-5556N
IntActiP50079, 8 interactors
MINTiP50079
STRINGi4932.YGR223C

Structurei

3D structure databases

ProteinModelPortaliP50079
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati222 – 262WD 1Add BLAST41
Repeati267 – 306WD 2Add BLAST40

Domaini

Contains a beta-propeller domain involved in specific binding of phosphatidylinositol 3,5-bisphosphate.

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00730000110940
HOGENOMiHOG000217543
InParanoidiP50079
OMAiYCINFNH
OrthoDBiEOG092C3UKJ

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 2 hits
SUPFAMiSSF50978 SSF50978, 1 hit

Sequencei

Sequence statusi: Complete.

P50079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVRRPIREA VNNRRKPKFL SVSFNQDDSC FSVALENGFR IFNTDPLTSK
60 70 80 90 100
LSKTFKESAT NQSRGTGIGY TRMLYRTNYI ALVGGGKRPR HALNKLIIWD
110 120 130 140 150
DLLQKETITL KFMSSIKDVF LSRIHIVVVL ENTIEIFQFQ TNPQRICPIL
160 170 180 190 200
DIPPNGSVDY VVCSSKHLQS QASQSQSKIL EIIAFPSNKC VGQIQVADLS
210 220 230 240 250
QIKYNSQNPK ESALLPTSII KAHKNPIKLV RLNRQGTMVA TCSVQGTLIR
260 270 280 290 300
IFSTHNGTLI KEFRRGVDKA DIYEMSFSPN GSKLAVLSNK QTLHIFQIFE
310 320 330 340 350
TTNTETNTPD HSRANGSSHP LKNYIPKGLW RPKYLDSVWS ICNAHLKNPI
360 370 380 390 400
FDAHRNDNSG DVTHDNEFYK DRCRIGWCQD SNNREQDDSL VLVWQNSGIW
410 420 430 440
EKFVILEKEQ QDSSKTHYSL NESLRNEDTK SAGEPTRWEL VRESWREL
Length:448
Mass (Da):51,235
Last modified:October 1, 1996 - v1
Checksum:iA4287FAB80AA68DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87941 Genomic DNA Translation: CAA61171.1
Z73008 Genomic DNA Translation: CAA97251.1
BK006941 Genomic DNA Translation: DAA08316.1
PIRiS57686
RefSeqiNP_011739.1, NM_001181352.1

Genome annotation databases

EnsemblFungiiYGR223C; YGR223C; YGR223C
GeneIDi853138
KEGGisce:YGR223C

Similar proteinsi

Entry informationi

Entry nameiHSV2_YEAST
AccessioniPrimary (citable) accession number: P50079
Secondary accession number(s): D6VV05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health