SVP1-like protein 2 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P50079 (HSV2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 79. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
SVP1-like protein 2

Gene names

Name:	HSV2
Ordered Locus Names:	YGR223C
ORF Names:	G8530

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in piecemeal microautophagy of the nucleus (micronucleophagy). Ref.4 Ref.6
Subcellular location	Endosome membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein. Note: Recruitment to endosomes depends on binding to phosphatidylinositol 3-phosphate. Ref.5 Ref.6
Domain	Contains a beta-propeller domain involved in specific binding of phosphatidylinositol 3,5-biphosphate.
Post-translational modification	N-glycosylated. Ref.7
Sequence similarities	Belongs to the WD repeat SVP1 family. Contains 2 WD repeats.

Ontologies

Keywords
Cellular component	Endosome Membrane
Domain	Repeat WD repeat
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	piecemeal microautophagy of nucleus Inferred from mutant phenotype Ref.6. Source: SGD response to starvation Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular component	fungal-type vacuole Inferred from direct assay. Source: SGD late endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell peripheral to membrane of membrane fraction Inferred from direct assay Ref.6. Source: SGD
Molecular function	phosphatidylinositol-3,5-bisphosphate binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

448

SVP1-like protein 2

PRO_0000051034

Regions

Repeat

41

WD 1

Repeat

40

WD 2

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P50079 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: A4287FAB80AA68DF
Show »

448

51,235

        10         20         30         40         50         60 
MDVRRPIREA VNNRRKPKFL SVSFNQDDSC FSVALENGFR IFNTDPLTSK LSKTFKESAT 

        70         80         90        100        110        120 
NQSRGTGIGY TRMLYRTNYI ALVGGGKRPR HALNKLIIWD DLLQKETITL KFMSSIKDVF 

       130        140        150        160        170        180 
LSRIHIVVVL ENTIEIFQFQ TNPQRICPIL DIPPNGSVDY VVCSSKHLQS QASQSQSKIL 

       190        200        210        220        230        240 
EIIAFPSNKC VGQIQVADLS QIKYNSQNPK ESALLPTSII KAHKNPIKLV RLNRQGTMVA 

       250        260        270        280        290        300 
TCSVQGTLIR IFSTHNGTLI KEFRRGVDKA DIYEMSFSPN GSKLAVLSNK QTLHIFQIFE 

       310        320        330        340        350        360 
TTNTETNTPD HSRANGSSHP LKNYIPKGLW RPKYLDSVWS ICNAHLKNPI FDAHRNDNSG 

       370        380        390        400        410        420 
DVTHDNEFYK DRCRIGWCQD SNNREQDDSL VLVWQNSGIW EKFVILEKEQ QDSSKTHYSL 

       430        440 
NESLRNEDTK SAGEPTRWEL VRESWREL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of the 43 kb CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm of Saccharomyces cerevisiae chromosome VII." van der Aart Q.J.M., Kleine K., Steensma H.Y. Yeast 12:385-390(1996) [PubMed: 8701610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Functional analysis of the Saccharomyces cerevisiae YFR021w/YGR223c/YPL100w ORF family suggests relations to mitochondrial/peroxisomal functions and amino acid signalling pathways." Georgakopoulos T., Koutroubas G., Vakonakis I., Tzermia M., Prokova V., Voutsina A., Alexandraki D. Yeast 18:1155-1171(2001) [PubMed: 11536337] [Abstract] Cited for: FUNCTION.
[5]	"Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors." Dove S.K., Piper R.C., McEwen R.K., Yu J.W., King M.C., Hughes D.C., Thuring J., Holmes A.B., Cooke F.T., Michell R.H., Parker P.J., Lemmon M.A. EMBO J. 23:1922-1933(2004) [PubMed: 15103325] [Abstract] Cited for: INTERACTION WITH PIP2, SUBCELLULAR LOCATION.
[6]	"Dissecting the localization and function of Atg18, Atg21 and Ygr223c." Krick R., Henke S., Tolstrup J., Thumm M. Autophagy 4:896-910(2008) [PubMed: 18769150] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[7]	"Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes." Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H. Mol. Syst. Biol. 5:308-308(2009) [PubMed: 19756047] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X87941 Genomic DNA. Translation: CAA61171.1. Z73008 Genomic DNA. Translation: CAA97251.1. BK006941 Genomic DNA. Translation: DAA08316.1.
PIR	S57686.
RefSeq	NP_011739.1. NM_001181352.1.
3D structure databases
ProteinModelPortal	P50079.
SMR	P50079. Positions 94-140, 220-297.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5556N.
IntAct	P50079. 6 interactions.
MINT	MINT-507579.
STRING	P50079.
Proteomic databases
PeptideAtlas	P50079.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGR223C; YGR223C; YGR223C.
GeneID	853138.
KEGG	sce:YGR223C.
NMPDR	fig\|4932.3.peg.2867.
Organism-specific databases
CYGD	YGR223c.
SGD	S000003455. HSV2.
Phylogenomic databases
eggNOG	fuNOG08128.
GeneTree	EFGT00050000004137.
HOGENOM	HBG443829.
OMA	HQKNTIV.
OrthoDB	EOG4PK5HQ.
Gene expression databases
ArrayExpress	P50079.
Genevestigator	P50079.
GermOnline	YGR223C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
SMART	SM00320. WD40. 2 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	973204.

Entry information

Entry name

HSV2_YEAST

Accession

Primary (citable) accession number: P50079
Secondary accession number(s): D6VV05

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents