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Protein

SVP1-like protein 2

Gene

HSV2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in piecemeal microautophagy of the nucleus (micronucleophagy).2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30904-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SVP1-like protein 2
Gene namesi
Name:HSV2
Ordered Locus Names:YGR223C
ORF Names:G8530
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR223C.
SGDiS000003455. HSV2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • cytosol Source: GO_Central
  • endosome Source: SGD
  • extrinsic component of membrane Source: SGD
  • fungal-type vacuole Source: SGD
  • late endosome membrane Source: UniProtKB-SubCell
  • pre-autophagosomal structure membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448SVP1-like protein 2PRO_0000051034Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence analysis
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence analysis
Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence analysis
Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence analysis
Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP50079.

Interactioni

Protein-protein interaction databases

BioGridi33476. 45 interactions.
DIPiDIP-5556N.
IntActiP50079. 7 interactions.
MINTiMINT-507579.

Structurei

3D structure databases

ProteinModelPortaliP50079.
SMRiP50079. Positions 24-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati222 – 26241WD 1Add
BLAST
Repeati267 – 30640WD 2Add
BLAST

Domaini

Contains a beta-propeller domain involved in specific binding of phosphatidylinositol 3,5-bisphosphate.

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated
Contains 2 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00730000110940.
HOGENOMiHOG000217543.
InParanoidiP50079.
OMAiCEMFRRY.
OrthoDBiEOG092C3UKJ.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

P50079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVRRPIREA VNNRRKPKFL SVSFNQDDSC FSVALENGFR IFNTDPLTSK
60 70 80 90 100
LSKTFKESAT NQSRGTGIGY TRMLYRTNYI ALVGGGKRPR HALNKLIIWD
110 120 130 140 150
DLLQKETITL KFMSSIKDVF LSRIHIVVVL ENTIEIFQFQ TNPQRICPIL
160 170 180 190 200
DIPPNGSVDY VVCSSKHLQS QASQSQSKIL EIIAFPSNKC VGQIQVADLS
210 220 230 240 250
QIKYNSQNPK ESALLPTSII KAHKNPIKLV RLNRQGTMVA TCSVQGTLIR
260 270 280 290 300
IFSTHNGTLI KEFRRGVDKA DIYEMSFSPN GSKLAVLSNK QTLHIFQIFE
310 320 330 340 350
TTNTETNTPD HSRANGSSHP LKNYIPKGLW RPKYLDSVWS ICNAHLKNPI
360 370 380 390 400
FDAHRNDNSG DVTHDNEFYK DRCRIGWCQD SNNREQDDSL VLVWQNSGIW
410 420 430 440
EKFVILEKEQ QDSSKTHYSL NESLRNEDTK SAGEPTRWEL VRESWREL
Length:448
Mass (Da):51,235
Last modified:October 1, 1996 - v1
Checksum:iA4287FAB80AA68DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87941 Genomic DNA. Translation: CAA61171.1.
Z73008 Genomic DNA. Translation: CAA97251.1.
BK006941 Genomic DNA. Translation: DAA08316.1.
PIRiS57686.
RefSeqiNP_011739.1. NM_001181352.1.

Genome annotation databases

EnsemblFungiiYGR223C; YGR223C; YGR223C.
GeneIDi853138.
KEGGisce:YGR223C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87941 Genomic DNA. Translation: CAA61171.1.
Z73008 Genomic DNA. Translation: CAA97251.1.
BK006941 Genomic DNA. Translation: DAA08316.1.
PIRiS57686.
RefSeqiNP_011739.1. NM_001181352.1.

3D structure databases

ProteinModelPortaliP50079.
SMRiP50079. Positions 24-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33476. 45 interactions.
DIPiDIP-5556N.
IntActiP50079. 7 interactions.
MINTiMINT-507579.

Proteomic databases

MaxQBiP50079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR223C; YGR223C; YGR223C.
GeneIDi853138.
KEGGisce:YGR223C.

Organism-specific databases

EuPathDBiFungiDB:YGR223C.
SGDiS000003455. HSV2.

Phylogenomic databases

GeneTreeiENSGT00730000110940.
HOGENOMiHOG000217543.
InParanoidiP50079.
OMAiCEMFRRY.
OrthoDBiEOG092C3UKJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-30904-MONOMER.

Miscellaneous databases

PROiP50079.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHSV2_YEAST
AccessioniPrimary (citable) accession number: P50079
Secondary accession number(s): D6VV05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.