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Protein

Calcium-channel protein CCH1

Gene

CCH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-gated, high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones. Functions together with MID1 to ensure that adequate levels of Ca2+ are supplied to PMR1 to sustain secretion and growth. Required for growth in low-calcium environments.2 Publications

GO - Molecular functioni

  • calcium channel activity Source: SGD
  • calcium ion binding Source: InterPro
  • voltage-gated calcium channel activity Source: SGD

GO - Biological processi

  • calcium ion transport Source: SGD
  • membrane depolarization during action potential Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Stress response, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciYEAST:G3O-30899-MONOMER.

Protein family/group databases

TCDBi1.A.1.11.10. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-channel protein CCH1
Gene namesi
Name:CCH1
Ordered Locus Names:YGR217W
ORF Names:G8501
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR217W.
SGDiS000003449. CCH1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei346 – 36621HelicalSequence analysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence analysisAdd
BLAST
Transmembranei563 – 58321HelicalSequence analysisAdd
BLAST
Transmembranei658 – 67821HelicalSequence analysisAdd
BLAST
Transmembranei691 – 71121HelicalSequence analysisAdd
BLAST
Transmembranei766 – 78621HelicalSequence analysisAdd
BLAST
Transmembranei809 – 82921HelicalSequence analysisAdd
BLAST
Transmembranei841 – 86121HelicalSequence analysisAdd
BLAST
Transmembranei904 – 92421HelicalSequence analysisAdd
BLAST
Transmembranei942 – 96221HelicalSequence analysisAdd
BLAST
Transmembranei978 – 99821HelicalSequence analysisAdd
BLAST
Transmembranei1207 – 122721HelicalSequence analysisAdd
BLAST
Transmembranei1247 – 126721HelicalSequence analysisAdd
BLAST
Transmembranei1277 – 129721HelicalSequence analysisAdd
BLAST
Transmembranei1340 – 136021HelicalSequence analysisAdd
BLAST
Transmembranei1408 – 142821HelicalSequence analysisAdd
BLAST
Transmembranei1452 – 147221HelicalSequence analysisAdd
BLAST
Transmembranei1529 – 154921HelicalSequence analysisAdd
BLAST
Transmembranei1554 – 157421HelicalSequence analysisAdd
BLAST
Transmembranei1596 – 161621HelicalSequence analysisAdd
BLAST
Transmembranei1618 – 163821HelicalSequence analysisAdd
BLAST
Transmembranei1654 – 167421HelicalSequence analysisAdd
BLAST
Transmembranei1748 – 176821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20392039Calcium-channel protein CCH1PRO_0000054106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei284 – 2841PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP50077.

PTM databases

iPTMnetiP50077.

Interactioni

Subunit structurei

Interacts with MID1 to form a Ca2+ influx channel.1 Publication

Protein-protein interaction databases

BioGridi33470. 55 interactions.
IntActiP50077. 14 interactions.
MINTiMINT-4487826.

Structurei

3D structure databases

ProteinModelPortaliP50077.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1787 – 182236EF-handPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 EF-hand domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00830000128247.
HOGENOMiHOG000111448.
InParanoidiP50077.
OMAiEIANEEY.
OrthoDBiEOG092C00XX.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR005821. Ion_trans_dom.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGRKRTLTE PFEPNTNPFG DNAAVMTENV EDNSETDGNR LESKPQALVP
60 70 80 90 100
PALNIVPPES SIHSTEEKKG DEYNGNDKDS SLISNIFRTR VGRSSHENLS
110 120 130 140 150
RPKLSLKTAS FGAAESSRRN VSPSTKSAKS SSQYIDLNDE RLRRRSFSSY
160 170 180 190 200
SRSSSRRVSN SPSSTDRPPR SAKVLSLIAA DDMDDFEDLQ KGFKSAIDEE
210 220 230 240 250
GLTWLPQLKS EKSRPVSDVG EDRGEGEQES IPDVHTPNVG ASATPGSIHL
260 270 280 290 300
TPEPAQNGSV SEGLEGSINN SRKKPSPKFF HHLSPQKEDK DQTEVIEYAE
310 320 330 340 350
DILDFETLQR KLESRPFVLY GHSLGVFSPT NPLRIKIARF LLHRRYSLLY
360 370 380 390 400
NTLLTFYAIL LAIRTYNPHN VVFLYRFSNW TDYFIFILSA CFTGNDIAKI
410 420 430 440 450
IAFGFWDDSE MFKAYGREYK SILQRSGIMK LYIYLREKYG RKLIDFIIPF
460 470 480 490 500
RIISPGEETK YQRSSLSTSL TKPYGAKENQ RPFGTPRAFA RSSWNRIDLV
510 520 530 540 550
SSVSFWLGMF LSIKSYDTKT GIRIFKPLAI LRILRLVNVD TGMPSILRGL
560 570 580 590 600
KYGIPQLVNV SSMLVYFWIF FGILGVQIFQ GSFRRQCVWF NPEDPTDTYQ
610 620 630 640 650
YDMQFCGGYL DPVTKRKQNY IYEDGSEGSV SKGFLCPQYS KCVSNANPYN
660 670 680 690 700
GRISFDNIVN SMELVFVIMS ANTFTDLMYY TMDSDEMAAC LFFIVCIFVL
710 720 730 740 750
TIWLLNLLIA VLVSSFEIAN EEYKKKKFIY GSRKTGYVAR IVTGYWKYFK
760 770 780 790 800
LKANQTKFPN WSQKGLAIYS HVEFIFVILI ICDIGMRASV KVSTSANCNN
810 820 830 840 850
ILLKTDRGIS IVLFIESLAR LVLYLPNMWK FLTKPSYVYD FIISIITLVI
860 870 880 890 900
SCLAVEGVLG HMYAWLSIFH ISRFYRVIIS FNLTKKLWKQ ILSNGVMIWN
910 920 930 940 950
LSSFYFFFTF LVAIIMAVYF EGVIPPEEMA DQPFGMYSLP NSFLSLFIIG
960 970 980 990 1000
STENWTDILY ALQKHSPNIS STFFCSVFFI IWFLLSNSVI LNIFIALISE
1010 1020 1030 1040 1050
SMEVKEEEKR PQQIKHYLKF VYPQKIQEYT HASLVARIRK KFFGGHRNED
1060 1070 1080 1090 1100
TRDFKQFLMR GTAIMNIAQN MGELADEFKE PPSENLFKKG LSKLTIGVPS
1110 1120 1130 1140 1150
LKRLRMFANN PFYKNSDVVF TETNDINGRT YILELNEYED EKLDYLKKYP
1160 1170 1180 1190 1200
LFNYSYYFFS PQHRFRRFCQ RLVPPSTGKR TDGSRFFEDS TDLYNKRSYF
1210 1220 1230 1240 1250
HHIERDVFVF IFALATILLI VCSCYVTPLY RMHHKMGTWN WSSALDCAFI
1260 1270 1280 1290 1300
GAFSIEFIVK TVADGFIYSP NAYLRNPWNF IDFCVLISMW INLIAYLKNN
1310 1320 1330 1340 1350
GNLSRIFKGL TALRALRCLT ISNTARQTFN LVMFDGLNKI FEAGLISLSL
1360 1370 1380 1390 1400
LFPFTVWGLS IFKGRLGTCN DGSLGRADCY NEYSNSVFQW DIMSPRVYQQ
1410 1420 1430 1440 1450
PYLHLDSFAS AFSSLYQIIS LEGWVDLLEN MMNSSGIGTP ATVMGSAGNA
1460 1470 1480 1490 1500
LFLVLFNFLS MVFILNLFVS FIVNNQARTT GSAYFTIEEK AWLESQKLLS
1510 1520 1530 1540 1550
QAKPKAIPNL IELSRVRQFF YQLAVEKKNF YYASFLQVVL YLHIIMLLSR
1560 1570 1580 1590 1600
SYNPGNLIGY QGVYFMFSTS VFLIQEALHM CGEGPRLYFR QKWNSIRLSI
1610 1620 1630 1640 1650
IIIAFIMNAV AFHVPASHYW FHNIKGFFLL VIFLFIIPQN DTLTELLETA
1660 1670 1680 1690 1700
MASLPPILSL TYTWGVLFLV YAIALNQIFG LTRLGSNTTD NINFRTVIKS
1710 1720 1730 1740 1750
MIVLFRCSFG EGWNYIMADL TVSEPYCSSD DNSTYTDCGS ETYAYLLLMS
1760 1770 1780 1790 1800
WNIISMYIFV NMFVSLIIGN FSYVYRSGGS RSGINRSEIK KYIEAWSKFD
1810 1820 1830 1840 1850
TDGTGELELS YLPRIMHSFD GPLSFKIWEG RLTIKSLVEN YMEVNPDDPY
1860 1870 1880 1890 1900
DVKIDLIGLN KELNTIDKAK IIQRKLQYRR FVQSIHYTNA YNGCIRFSDL
1910 1920 1930 1940 1950
LLQIPLYTAY SARECLGIDQ YVHHLYILGK VDKYLENQRN FDVLEMVVTR
1960 1970 1980 1990 2000
WKFHCRMKRT IEPEWDVKDP TVSSHISNIN VNLEPAPGIL EREPIATPRM
2010 2020 2030
DYGVNNFMWS PRMNQDSTME PPEEPIDNND DSANDLIDR
Length:2,039
Mass (Da):234,599
Last modified:October 1, 1996 - v1
Checksum:i800B3825D6C6E527
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1185 – 11851R → Q in CAA61165 (PubMed:9290212).Curated
Sequence conflicti1203 – 12031I → N in CAA61165 (PubMed:9290212).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73002 Genomic DNA. Translation: CAA97244.1.
Z73003 Genomic DNA. Translation: CAA97245.1.
X87941 Genomic DNA. Translation: CAA61165.1.
BK006941 Genomic DNA. Translation: DAA08311.1.
PIRiS64540.
RefSeqiNP_011733.3. NM_001181346.3.

Genome annotation databases

EnsemblFungiiYGR217W; YGR217W; YGR217W.
GeneIDi853131.
KEGGisce:YGR217W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73002 Genomic DNA. Translation: CAA97244.1.
Z73003 Genomic DNA. Translation: CAA97245.1.
X87941 Genomic DNA. Translation: CAA61165.1.
BK006941 Genomic DNA. Translation: DAA08311.1.
PIRiS64540.
RefSeqiNP_011733.3. NM_001181346.3.

3D structure databases

ProteinModelPortaliP50077.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33470. 55 interactions.
IntActiP50077. 14 interactions.
MINTiMINT-4487826.

Protein family/group databases

TCDBi1.A.1.11.10. the voltage-gated ion channel (vic) superfamily.

PTM databases

iPTMnetiP50077.

Proteomic databases

MaxQBiP50077.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR217W; YGR217W; YGR217W.
GeneIDi853131.
KEGGisce:YGR217W.

Organism-specific databases

EuPathDBiFungiDB:YGR217W.
SGDiS000003449. CCH1.

Phylogenomic databases

GeneTreeiENSGT00830000128247.
HOGENOMiHOG000111448.
InParanoidiP50077.
OMAiEIANEEY.
OrthoDBiEOG092C00XX.

Enzyme and pathway databases

BioCyciYEAST:G3O-30899-MONOMER.

Miscellaneous databases

PROiP50077.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR005821. Ion_trans_dom.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCH1_YEAST
AccessioniPrimary (citable) accession number: P50077
Secondary accession number(s): D6VV00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.