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P50052

- AGTR2_HUMAN

UniProt

P50052 - AGTR2_HUMAN

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Protein
Type-2 angiotensin II receptor
Gene
AGTR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.1 Publication

GO - Molecular functioni

  1. angiotensin type II receptor activity Source: BHF-UCL
  2. peptide hormone binding Source: Ensembl
  3. protein binding Source: IntAct
  4. receptor antagonist activity Source: BHF-UCL

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: BHF-UCL
  2. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: BHF-UCL
  3. aldosterone secretion Source: Ensembl
  4. angiotensin-activated signaling pathway Source: GOC
  5. behavior Source: Ensembl
  6. blood vessel remodeling Source: BHF-UCL
  7. brain development Source: BHF-UCL
  8. brain renin-angiotensin system Source: Ensembl
  9. cell growth involved in cardiac muscle cell development Source: Ensembl
  10. cell surface receptor signaling pathway Source: BHF-UCL
  11. cellular response to dexamethasone stimulus Source: Ensembl
  12. cellular sodium ion homeostasis Source: Ensembl
  13. cerebellar cortex development Source: Ensembl
  14. dopamine biosynthetic process Source: Ensembl
  15. extracellular negative regulation of signal transduction Source: GOC
  16. inflammatory response Source: Ensembl
  17. intracellular signal transduction Source: BHF-UCL
  18. negative regulation of blood vessel endothelial cell migration Source: BHF-UCL
  19. negative regulation of cell growth Source: BHF-UCL
  20. negative regulation of fibroblast proliferation Source: Ensembl
  21. negative regulation of heart rate Source: BHF-UCL
  22. negative regulation of icosanoid secretion Source: Ensembl
  23. negative regulation of neurotrophin TRK receptor signaling pathway Source: BHF-UCL
  24. negative regulation of norepinephrine secretion Source: Ensembl
  25. nitric oxide mediated signal transduction Source: BHF-UCL
  26. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
  27. positive regulation of cell proliferation Source: Ensembl
  28. positive regulation of cytokine secretion Source: Ensembl
  29. positive regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
  30. positive regulation of metanephric glomerulus development Source: Ensembl
  31. positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
  32. positive regulation of nitric-oxide synthase activity Source: BHF-UCL
  33. positive regulation of phosphoprotein phosphatase activity Source: BHF-UCL
  34. positive regulation of renal sodium excretion Source: Ensembl
  35. positive regulation of transcription, DNA-templated Source: Ensembl
  36. positive regulation of vasodilation Source: BHF-UCL
  37. regulation of blood pressure Source: ProtInc
  38. regulation of metanephros size Source: Ensembl
  39. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: BHF-UCL
  40. regulation of transcription factor import into nucleus Source: Ensembl
  41. renin-angiotensin regulation of aldosterone production Source: Ensembl
  42. response to organonitrogen compound Source: Ensembl
  43. vasodilation by angiotensin involved in regulation of systemic arterial blood pressure Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 angiotensin II receptor
Alternative name(s):
Angiotensin II type-2 receptor
Short name:
AT2
Gene namesi
Name:AGTR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:338. AGTR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545Extracellular Reviewed prediction
Add
BLAST
Transmembranei46 – 7126Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini72 – 809Cytoplasmic Reviewed prediction
Transmembranei81 – 10222Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini103 – 11917Extracellular Reviewed prediction
Add
BLAST
Transmembranei120 – 14021Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini141 – 16020Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei161 – 17919Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini180 – 20829Extracellular Reviewed prediction
Add
BLAST
Transmembranei209 – 23426Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini235 – 25622Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei257 – 27822Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini279 – 29719Extracellular Reviewed prediction
Add
BLAST
Transmembranei298 – 31821Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini319 – 36345Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular region Source: GOC
  2. integral component of plasma membrane Source: BHF-UCL
  3. perinuclear region of cytoplasm Source: Ensembl
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti777. X-linked non-syndromic intellectual disability.
PharmGKBiPA44.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Type-2 angiotensin II receptor
PRO_0000069167Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13 – 131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi24 – 241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi34 – 341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi35 ↔ 290 By similarity
Disulfide bondi117 ↔ 195 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP50052.
PRIDEiP50052.

PTM databases

PhosphoSiteiP50052.

Expressioni

Tissue specificityi

In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.1 Publication

Gene expression databases

ArrayExpressiP50052.
BgeeiP50052.
CleanExiHS_AGTR2.
GenevestigatoriP50052.

Organism-specific databases

HPAiHPA029592.

Interactioni

Subunit structurei

Interacts with MTUS1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTP010192EBI-1748067,EBI-2927577
TIMP3P356257EBI-1748067,EBI-1748085

Protein-protein interaction databases

BioGridi106692. 5 interactions.
IntActiP50052. 3 interactions.
STRINGi9606.ENSP00000360973.

Structurei

3D structure databases

ProteinModelPortaliP50052.
SMRiP50052. Positions 46-336.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311643.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP50052.
KOiK04167.
OMAiNCSHKPS.
OrthoDBiEOG7TQV1F.
PhylomeDBiP50052.
TreeFamiTF330024.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50052-1 [UniParc]FASTAAdd to Basket

« Hide

MKGNSTLATT SKNITSGLHF GLVNISGNNE STLNCSQKPS DKHLDAIPIL    50
YYIIFVIGFL VNIVVVTLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW 100
ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF 150
LSQRRNPWQA SYIVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP 200
PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT 250
RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LAWMGVINSC EVIAVIDLAL 300
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRESMSCR 350
KSSSLREMET FVS 363
Length:363
Mass (Da):41,184
Last modified:October 1, 1996 - v1
Checksum:iFDD7D4E6F9B43E60
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211G → V Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 2 Publications
Corresponds to variant rs121917810 [ dbSNP | Ensembl ].
VAR_065946
Natural varianti231 – 2311Y → H.
Corresponds to variant rs3729977 [ dbSNP | Ensembl ].
VAR_049374
Natural varianti248 – 2481R → K.1 Publication
Corresponds to variant rs5191 [ dbSNP | Ensembl ].
VAR_011849
Natural varianti268 – 2681C → W.
Corresponds to variant rs1042860 [ dbSNP | Ensembl ].
VAR_011850
Natural varianti324 – 3241R → Q Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 2 Publications
Corresponds to variant rs35474657 [ dbSNP | Ensembl ].
VAR_065947
Natural varianti337 – 3371I → V Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 2 Publications
VAR_065948

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti269 – 2691W → C1 Publication
Sequence conflicti272 – 2721F → L in AAA50762. 1 Publication
Sequence conflicti323 – 3231N → G in AAA50762. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20860 Genomic DNA. Translation: AAA85851.1.
L34579 Genomic DNA. Translation: AAA98990.1.
U10273 Genomic DNA. Translation: AAA61794.1.
U15592 Genomic DNA. Translation: AAA50762.1.
U16957 mRNA. Translation: AAA67753.1.
U27478 Genomic DNA. Translation: AAA84900.1.
AY536522 Genomic DNA. Translation: AAS45437.1.
AY322542 Genomic DNA. Translation: AAP84355.1.
AY324607 Genomic DNA. Translation: AAP72969.1.
CR541969 mRNA. Translation: CAG46767.1.
AK313927 mRNA. Translation: BAG36648.1.
AL732602 Genomic DNA. Translation: CAI40984.1.
CH471234 Genomic DNA. Translation: EAW51502.1.
BC095504 mRNA. Translation: AAH95504.1.
X87723 mRNA. Translation: CAA61022.1.
CCDSiCCDS14569.1.
PIRiJC2543.
RefSeqiNP_000677.2. NM_000686.4.
UniGeneiHs.405348.

Genome annotation databases

EnsembliENST00000371906; ENSP00000360973; ENSG00000180772.
ENST00000601039; ENSP00000470282; ENSG00000269602.
GeneIDi186.
KEGGihsa:186.
UCSCiuc004eqh.4. human.

Polymorphism databases

DMDMi1703214.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20860 Genomic DNA. Translation: AAA85851.1 .
L34579 Genomic DNA. Translation: AAA98990.1 .
U10273 Genomic DNA. Translation: AAA61794.1 .
U15592 Genomic DNA. Translation: AAA50762.1 .
U16957 mRNA. Translation: AAA67753.1 .
U27478 Genomic DNA. Translation: AAA84900.1 .
AY536522 Genomic DNA. Translation: AAS45437.1 .
AY322542 Genomic DNA. Translation: AAP84355.1 .
AY324607 Genomic DNA. Translation: AAP72969.1 .
CR541969 mRNA. Translation: CAG46767.1 .
AK313927 mRNA. Translation: BAG36648.1 .
AL732602 Genomic DNA. Translation: CAI40984.1 .
CH471234 Genomic DNA. Translation: EAW51502.1 .
BC095504 mRNA. Translation: AAH95504.1 .
X87723 mRNA. Translation: CAA61022.1 .
CCDSi CCDS14569.1.
PIRi JC2543.
RefSeqi NP_000677.2. NM_000686.4.
UniGenei Hs.405348.

3D structure databases

ProteinModelPortali P50052.
SMRi P50052. Positions 46-336.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106692. 5 interactions.
IntActi P50052. 3 interactions.
STRINGi 9606.ENSP00000360973.

Chemistry

BindingDBi P50052.
ChEMBLi CHEMBL4607.
GuidetoPHARMACOLOGYi 35.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P50052.

Polymorphism databases

DMDMi 1703214.

Proteomic databases

PaxDbi P50052.
PRIDEi P50052.

Protocols and materials databases

DNASUi 186.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371906 ; ENSP00000360973 ; ENSG00000180772 .
ENST00000601039 ; ENSP00000470282 ; ENSG00000269602 .
GeneIDi 186.
KEGGi hsa:186.
UCSCi uc004eqh.4. human.

Organism-specific databases

CTDi 186.
GeneCardsi GC0XP115216.
H-InvDB HIX0213472.
HGNCi HGNC:338. AGTR2.
HPAi HPA029592.
MIMi 300034. gene.
neXtProti NX_P50052.
Orphaneti 777. X-linked non-syndromic intellectual disability.
PharmGKBi PA44.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG311643.
HOGENOMi HOG000234122.
HOVERGENi HBG104998.
InParanoidi P50052.
KOi K04167.
OMAi NCSHKPS.
OrthoDBi EOG7TQV1F.
PhylomeDBi P50052.
TreeFami TF330024.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Angiotensin_II_receptor_type_2.
GenomeRNAii 186.
NextBioi 764.
PROi P50052.
SOURCEi Search...

Gene expression databases

ArrayExpressi P50052.
Bgeei P50052.
CleanExi HS_AGTR2.
Genevestigatori P50052.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence and genomic organization of the human type 2 angiotensin II receptor."
    Martin M.M., Elton T.S.
    Biochem. Biophys. Res. Commun. 209:554-562(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization."
    Chassagne C., Beatty B.G., Meloche S.
    Genomics 25:601-603(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  3. "Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung."
    Koike G., Horiuchi M., Yamada T., Szpirer C., Jacob H.J., Dzau V.J.
    Biochem. Biophys. Res. Commun. 203:1842-1850(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  4. "Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor."
    Tsuzuki S., Ichiki T., Nakakubo H., Kitami Y., Guo D.F., Shirai H., Inagami T.
    Biochem. Biophys. Res. Commun. 200:1449-1454(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  5. "Molecular cloning of the human angiotensin II type 2 receptor cDNA."
    Martin M.M., Su B., Elton T.S.
    Biochem. Biophys. Res. Commun. 205:645-651(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  6. "Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues."
    Lazard D., Briend-Sutren M.M., Villageois P., Mattei M.-G., Strosberg A.D., Nahmias C.
    Recept. Channels 2:271-280(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  7. "Sequence of the AGTR2 gene in Cantonese."
    Zhang M., Ma H., Wang B., Zhao Y.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  8. "Isolation of complete coding sequence for angiotensin II receptor, type 2 (AGTR2)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  9. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  10. Rieder M.J., da Ponte S.H., Kuldanek S.A., Rajkumar N., Smith J.D., Toth E.J., Nickerson D.A.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  11. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  12. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  14. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  15. Katsuya T., Dzau V.J.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 1-22.
    Tissue: Blood.
  16. Warnecke C.H., Holzmeister J., Regitz-Zagrosek V., Fleck E.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 1-16.
    Tissue: Uterus.
  17. Cited for: TISSUE SPECIFICITY, VARIANTS VAL-21; LYS-248; GLN-324 AND VAL-337, POSSIBLE ASSOCIATION OF VARIANTS VAL-21; GLN-324 AND VAL-337 WITH X-LINKED MENTAL RETARDATION.
  18. "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP."
    Nouet S., Amzallag N., Li J.-M., Louis S., Seitz I., Cui T.-X., Alleaume A.-M., Di Benedetto M., Boden C., Masson M., Strosberg A.D., Horiuchi M., Couraud P.-O., Nahmias C.
    J. Biol. Chem. 279:28989-28997(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MTUS1, FUNCTION.
  19. "XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing."
    Piton A., Redin C., Mandel J.L.
    Am. J. Hum. Genet. 93:368-383(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF ASSOCIATION VARIANTS VAL-21; GLN-324 AND VAL-337 WITH X-LINKED MENTAL RETARDATION.

Entry informationi

Entry nameiAGTR2_HUMAN
AccessioniPrimary (citable) accession number: P50052
Secondary accession number(s): B2R9V1, Q13016, Q6FGY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although AGTR2 has been reported to be involved in X-linked mental retardation (1 Publication), its pathological role is questionable (1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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