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P50052 (AGTR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type-2 angiotensin II receptor
Alternative name(s):
Angiotensin II type-2 receptor
Short name=AT2
Gene names
Name:AGTR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. Ref.18

Subunit structure

Interacts with MTUS1. Ref.18

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine. Ref.17

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

Although AGTR2 has been reported to be involved in X-linked mental retardation (Ref.17), its pathological role is questionable (Ref.19).

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred by curator PubMed 10406457. Source: BHF-UCL

G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger

Inferred from sequence or structural similarity PubMed 17000928. Source: BHF-UCL

aldosterone secretion

Inferred from electronic annotation. Source: Ensembl

angiotensin-activated signaling pathway

Inferred from physical interaction PubMed 10406457. Source: GOC

behavior

Inferred from electronic annotation. Source: Ensembl

blood vessel remodeling

Traceable author statement PubMed 17159080. Source: BHF-UCL

brain development

Non-traceable author statement Ref.17. Source: BHF-UCL

brain renin-angiotensin system

Inferred from electronic annotation. Source: Ensembl

cell growth involved in cardiac muscle cell development

Inferred from electronic annotation. Source: Ensembl

cell surface receptor signaling pathway

Inferred from direct assay PubMed 10406457. Source: BHF-UCL

cellular response to dexamethasone stimulus

Inferred from electronic annotation. Source: Ensembl

cellular sodium ion homeostasis

Inferred from electronic annotation. Source: Ensembl

cerebellar cortex development

Inferred from electronic annotation. Source: Ensembl

dopamine biosynthetic process

Inferred from electronic annotation. Source: Ensembl

extracellular negative regulation of signal transduction

Traceable author statement PubMed 17159079. Source: GOC

inflammatory response

Inferred from electronic annotation. Source: Ensembl

intracellular signal transduction

Inferred from sequence or structural similarity PubMed 17000928. Source: BHF-UCL

negative regulation of blood vessel endothelial cell migration

Non-traceable author statement PubMed 15710780. Source: BHF-UCL

negative regulation of cell growth

Traceable author statement PubMed 17159080. Source: BHF-UCL

negative regulation of fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of heart rate

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of icosanoid secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of neurotrophin TRK receptor signaling pathway

Inferred from mutant phenotype PubMed 10406457. Source: BHF-UCL

negative regulation of norepinephrine secretion

Inferred from electronic annotation. Source: Ensembl

nitric oxide mediated signal transduction

Traceable author statement PubMed 17159080. Source: BHF-UCL

positive regulation of branching involved in ureteric bud morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytokine secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of extrinsic apoptotic signaling pathway

Inferred from mutant phenotype PubMed 10406457. Source: BHF-UCL

positive regulation of metanephric glomerulus development

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric oxide biosynthetic process

Inferred by curator PubMed 17000928. Source: BHF-UCL

positive regulation of nitric-oxide synthase activity

Inferred from sequence or structural similarity PubMed 17000928. Source: BHF-UCL

positive regulation of phosphoprotein phosphatase activity

Inferred from direct assay PubMed 10406457. Source: BHF-UCL

positive regulation of renal sodium excretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasodilation

Inferred from direct assay PubMed 15117835PubMed 17159079. Source: BHF-UCL

regulation of blood pressure

Traceable author statement PubMed 7477266. Source: ProtInc

regulation of metanephros size

Inferred from electronic annotation. Source: Ensembl

regulation of systemic arterial blood pressure by circulatory renin-angiotensin

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of transcription factor import into nucleus

Inferred from electronic annotation. Source: Ensembl

renin-angiotensin regulation of aldosterone production

Inferred from electronic annotation. Source: Ensembl

response to organonitrogen compound

Inferred from electronic annotation. Source: Ensembl

vasodilation by angiotensin involved in regulation of systemic arterial blood pressure

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Traceable author statement PubMed 17159079. Source: GOC

integral component of plasma membrane

Inferred by curator PubMed 10406457. Source: BHF-UCL

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionangiotensin type II receptor activity

Inferred from physical interaction PubMed 10406457. Source: BHF-UCL

peptide hormone binding

Inferred from electronic annotation. Source: Ensembl

receptor antagonist activity

Traceable author statement PubMed 17159079. Source: BHF-UCL

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Type-2 angiotensin II receptor
PRO_0000069167

Regions

Topological domain1 – 4545Extracellular Potential
Transmembrane46 – 7126Helical; Name=1; Potential
Topological domain72 – 809Cytoplasmic Potential
Transmembrane81 – 10222Helical; Name=2; Potential
Topological domain103 – 11917Extracellular Potential
Transmembrane120 – 14021Helical; Name=3; Potential
Topological domain141 – 16020Cytoplasmic Potential
Transmembrane161 – 17919Helical; Name=4; Potential
Topological domain180 – 20829Extracellular Potential
Transmembrane209 – 23426Helical; Name=5; Potential
Topological domain235 – 25622Cytoplasmic Potential
Transmembrane257 – 27822Helical; Name=6; Potential
Topological domain279 – 29719Extracellular Potential
Transmembrane298 – 31821Helical; Name=7; Potential
Topological domain319 – 36345Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation131N-linked (GlcNAc...) Potential
Glycosylation241N-linked (GlcNAc...) Potential
Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation341N-linked (GlcNAc...) Potential
Disulfide bond35 ↔ 290 By similarity
Disulfide bond117 ↔ 195 By similarity

Natural variations

Natural variant211G → V Rare variant found in patients with X-linked mental retardation; unknown pathological significance. Ref.17 Ref.19
Corresponds to variant rs121917810 [ dbSNP | Ensembl ].
VAR_065946
Natural variant2311Y → H.
Corresponds to variant rs3729977 [ dbSNP | Ensembl ].
VAR_049374
Natural variant2481R → K. Ref.17
Corresponds to variant rs5191 [ dbSNP | Ensembl ].
VAR_011849
Natural variant2681C → W.
Corresponds to variant rs1042860 [ dbSNP | Ensembl ].
VAR_011850
Natural variant3241R → Q Rare variant found in patients with X-linked mental retardation; unknown pathological significance. Ref.17 Ref.19
Corresponds to variant rs35474657 [ dbSNP | Ensembl ].
VAR_065947
Natural variant3371I → V Rare variant found in patients with X-linked mental retardation; unknown pathological significance. Ref.17 Ref.19
VAR_065948

Experimental info

Sequence conflict2691W → C Ref.5
Sequence conflict2721F → L in AAA50762. Ref.4
Sequence conflict3231N → G in AAA50762. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P50052 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: FDD7D4E6F9B43E60

FASTA36341,184
        10         20         30         40         50         60 
MKGNSTLATT SKNITSGLHF GLVNISGNNE STLNCSQKPS DKHLDAIPIL YYIIFVIGFL 

        70         80         90        100        110        120 
VNIVVVTLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW ATYYSYRYDW LFGPVMCKVF 

       130        140        150        160        170        180 
GSFLTLNMFA SIFFITCMSV DRYQSVIYPF LSQRRNPWQA SYIVPLVWCM ACLSSLPTFY 

       190        200        210        220        230        240 
FRDVRTIEYL GVNACIMAFP PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK 

       250        260        270        280        290        300 
TNSYGKNRIT RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LAWMGVINSC EVIAVIDLAL 

       310        320        330        340        350        360 
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRESMSCR KSSSLREMET 


FVS 

« Hide

References

« Hide 'large scale' references
[1]"The sequence and genomic organization of the human type 2 angiotensin II receptor."
Martin M.M., Elton T.S.
Biochem. Biophys. Res. Commun. 209:554-562(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[2]"Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization."
Chassagne C., Beatty B.G., Meloche S.
Genomics 25:601-603(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[3]"Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung."
Koike G., Horiuchi M., Yamada T., Szpirer C., Jacob H.J., Dzau V.J.
Biochem. Biophys. Res. Commun. 203:1842-1850(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Blood.
[4]"Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor."
Tsuzuki S., Ichiki T., Nakakubo H., Kitami Y., Guo D.F., Shirai H., Inagami T.
Biochem. Biophys. Res. Commun. 200:1449-1454(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[5]"Molecular cloning of the human angiotensin II type 2 receptor cDNA."
Martin M.M., Su B., Elton T.S.
Biochem. Biophys. Res. Commun. 205:645-651(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[6]"Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues."
Lazard D., Briend-Sutren M.M., Villageois P., Mattei M.-G., Strosberg A.D., Nahmias C.
Recept. Channels 2:271-280(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[7]"Sequence of the AGTR2 gene in Cantonese."
Zhang M., Ma H., Wang B., Zhao Y.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]"Isolation of complete coding sequence for angiotensin II receptor, type 2 (AGTR2)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[9]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[10]Rieder M.J., da Ponte S.H., Kuldanek S.A., Rajkumar N., Smith J.D., Toth E.J., Nickerson D.A.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[11]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[12]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[13]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[14]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[15]Katsuya T., Dzau V.J.
Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 1-22.
Tissue: Blood.
[16]Warnecke C.H., Holzmeister J., Regitz-Zagrosek V., Fleck E.
Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 1-16.
Tissue: Uterus.
[17]"AGTR2 mutations in X-linked mental retardation."
Vervoort V.S., Beachem M.A., Edwards P.S., Ladd S., Miller K.E., de Mollerat X., Clarkson K., DuPont B., Schwartz C.E., Stevenson R.E., Boyd E., Srivastava A.K.
Science 296:2401-2403(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, VARIANTS VAL-21; LYS-248; GLN-324 AND VAL-337, POSSIBLE ASSOCIATION OF VARIANTS VAL-21; GLN-324 AND VAL-337 WITH X-LINKED MENTAL RETARDATION.
[18]"Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP."
Nouet S., Amzallag N., Li J.-M., Louis S., Seitz I., Cui T.-X., Alleaume A.-M., Di Benedetto M., Boden C., Masson M., Strosberg A.D., Horiuchi M., Couraud P.-O., Nahmias C.
J. Biol. Chem. 279:28989-28997(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MTUS1, FUNCTION.
[19]"XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing."
Piton A., Redin C., Mandel J.L.
Am. J. Hum. Genet. 93:368-383(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: LACK OF ASSOCIATION VARIANTS VAL-21; GLN-324 AND VAL-337 WITH X-LINKED MENTAL RETARDATION.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U20860 Genomic DNA. Translation: AAA85851.1.
L34579 Genomic DNA. Translation: AAA98990.1.
U10273 Genomic DNA. Translation: AAA61794.1.
U15592 Genomic DNA. Translation: AAA50762.1.
U16957 mRNA. Translation: AAA67753.1.
U27478 Genomic DNA. Translation: AAA84900.1.
AY536522 Genomic DNA. Translation: AAS45437.1.
AY322542 Genomic DNA. Translation: AAP84355.1.
AY324607 Genomic DNA. Translation: AAP72969.1.
CR541969 mRNA. Translation: CAG46767.1.
AK313927 mRNA. Translation: BAG36648.1.
AL732602 Genomic DNA. Translation: CAI40984.1.
CH471234 Genomic DNA. Translation: EAW51502.1.
BC095504 mRNA. Translation: AAH95504.1.
X87723 mRNA. Translation: CAA61022.1.
PIRJC2543.
RefSeqNP_000677.2. NM_000686.4.
UniGeneHs.405348.

3D structure databases

ProteinModelPortalP50052.
SMRP50052. Positions 46-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106692. 5 interactions.
IntActP50052. 3 interactions.
STRING9606.ENSP00000360973.

Chemistry

BindingDBP50052.
ChEMBLCHEMBL2094256.
GuidetoPHARMACOLOGY35.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP50052.

Polymorphism databases

DMDM1703214.

Proteomic databases

PaxDbP50052.
PRIDEP50052.

Protocols and materials databases

DNASU186.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371906; ENSP00000360973; ENSG00000180772.
ENST00000601039; ENSP00000470282; ENSG00000269602.
GeneID186.
KEGGhsa:186.
UCSCuc004eqh.4. human.

Organism-specific databases

CTD186.
GeneCardsGC0XP115216.
H-InvDBHIX0213472.
HGNCHGNC:338. AGTR2.
HPAHPA029592.
MIM300034. gene.
neXtProtNX_P50052.
Orphanet777. X-linked non-syndromic intellectual deficit.
PharmGKBPA44.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG311643.
HOGENOMHOG000234122.
HOVERGENHBG104998.
InParanoidP50052.
KOK04167.
OMANCSHKPS.
OrthoDBEOG7TQV1F.
PhylomeDBP50052.
TreeFamTF330024.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP50052.
BgeeP50052.
CleanExHS_AGTR2.
GenevestigatorP50052.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiAngiotensin_II_receptor_type_2.
GenomeRNAi186.
NextBio764.
PROP50052.
SOURCESearch...

Entry information

Entry nameAGTR2_HUMAN
AccessionPrimary (citable) accession number: P50052
Secondary accession number(s): B2R9V1, Q13016, Q6FGY7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries