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Protein

Type-2 angiotensin II receptor

Gene

AGTR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.1 Publication

GO - Molecular functioni

  • angiotensin type II receptor activity Source: BHF-UCL
  • peptide hormone binding Source: Ensembl
  • receptor antagonist activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180772-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP50052.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 angiotensin II receptor
Alternative name(s):
Angiotensin II type-2 receptor
Short name:
AT2
Gene namesi
Name:AGTR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:338. AGTR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularSequence analysisAdd BLAST45
Transmembranei46 – 71Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini72 – 80CytoplasmicSequence analysis9
Transmembranei81 – 102Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini103 – 119ExtracellularSequence analysisAdd BLAST17
Transmembranei120 – 140Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini141 – 160CytoplasmicSequence analysisAdd BLAST20
Transmembranei161 – 179Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini180 – 208ExtracellularSequence analysisAdd BLAST29
Transmembranei209 – 234Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini235 – 256CytoplasmicSequence analysisAdd BLAST22
Transmembranei257 – 278Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini279 – 297ExtracellularSequence analysisAdd BLAST19
Transmembranei298 – 318Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini319 – 363CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi186.
MalaCardsiAGTR2.
OpenTargetsiENSG00000180772.
Orphaneti777. X-linked non-syndromic intellectual disability.
PharmGKBiPA44.

Chemistry databases

ChEMBLiCHEMBL4607.
DrugBankiDB01349. Tasosartan.
GuidetoPHARMACOLOGYi35.

Polymorphism and mutation databases

BioMutaiAGTR2.
DMDMi1703214.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691671 – 363Type-2 angiotensin II receptorAdd BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi13N-linked (GlcNAc...)Sequence analysis1
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi35 ↔ 290PROSITE-ProRule annotation
Disulfide bondi117 ↔ 195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP50052.
PRIDEiP50052.

PTM databases

iPTMnetiP50052.
PhosphoSitePlusiP50052.

Expressioni

Tissue specificityi

In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.1 Publication

Gene expression databases

BgeeiENSG00000180772.
CleanExiHS_AGTR2.
GenevisibleiP50052. HS.

Interactioni

Subunit structurei

Interacts with MTUS1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTP010192EBI-1748067,EBI-2927577
TIMP3P356257EBI-1748067,EBI-1748085

GO - Molecular functioni

  • receptor antagonist activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi106692. 6 interactors.
IntActiP50052. 3 interactors.
STRINGi9606.ENSP00000360973.

Chemistry databases

BindingDBiP50052.

Structurei

3D structure databases

ProteinModelPortaliP50052.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP50052.
KOiK04167.
OMAiNCSHKPS.
OrthoDBiEOG091G0HEN.
PhylomeDBiP50052.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGNSTLATT SKNITSGLHF GLVNISGNNE STLNCSQKPS DKHLDAIPIL
60 70 80 90 100
YYIIFVIGFL VNIVVVTLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW
110 120 130 140 150
ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF
160 170 180 190 200
LSQRRNPWQA SYIVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP
210 220 230 240 250
PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT
260 270 280 290 300
RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LAWMGVINSC EVIAVIDLAL
310 320 330 340 350
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRESMSCR
360
KSSSLREMET FVS
Length:363
Mass (Da):41,184
Last modified:October 1, 1996 - v1
Checksum:iFDD7D4E6F9B43E60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti269W → C (PubMed:7999093).Curated1
Sequence conflicti272F → L in AAA50762 (PubMed:8185599).Curated1
Sequence conflicti323N → G in AAA50762 (PubMed:8185599).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06594621G → V Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 2 PublicationsCorresponds to variant rs121917810dbSNPEnsembl.1
Natural variantiVAR_049374231Y → H.Corresponds to variant rs3729977dbSNPEnsembl.1
Natural variantiVAR_011849248R → K.1 PublicationCorresponds to variant rs5191dbSNPEnsembl.1
Natural variantiVAR_011850268C → W.Corresponds to variant rs1042860dbSNPEnsembl.1
Natural variantiVAR_065947324R → Q Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 2 PublicationsCorresponds to variant rs35474657dbSNPEnsembl.1
Natural variantiVAR_065948337I → V Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 1 PublicationCorresponds to variant rs121917811dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20860 Genomic DNA. Translation: AAA85851.1.
L34579 Genomic DNA. Translation: AAA98990.1.
U10273 Genomic DNA. Translation: AAA61794.1.
U15592 Genomic DNA. Translation: AAA50762.1.
U16957 mRNA. Translation: AAA67753.1.
U27478 Genomic DNA. Translation: AAA84900.1.
AY536522 Genomic DNA. Translation: AAS45437.1.
AY322542 Genomic DNA. Translation: AAP84355.1.
AY324607 Genomic DNA. Translation: AAP72969.1.
CR541969 mRNA. Translation: CAG46767.1.
AK313927 mRNA. Translation: BAG36648.1.
AL732602 Genomic DNA. Translation: CAI40984.1.
CH471234 Genomic DNA. Translation: EAW51502.1.
BC095504 mRNA. Translation: AAH95504.1.
X87723 mRNA. Translation: CAA61022.1.
CCDSiCCDS14569.1.
PIRiJC2543.
RefSeqiNP_000677.2. NM_000686.4.
XP_011535835.1. XM_011537533.1.
UniGeneiHs.405348.

Genome annotation databases

EnsembliENST00000371906; ENSP00000360973; ENSG00000180772.
GeneIDi186.
KEGGihsa:186.
UCSCiuc004eqh.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20860 Genomic DNA. Translation: AAA85851.1.
L34579 Genomic DNA. Translation: AAA98990.1.
U10273 Genomic DNA. Translation: AAA61794.1.
U15592 Genomic DNA. Translation: AAA50762.1.
U16957 mRNA. Translation: AAA67753.1.
U27478 Genomic DNA. Translation: AAA84900.1.
AY536522 Genomic DNA. Translation: AAS45437.1.
AY322542 Genomic DNA. Translation: AAP84355.1.
AY324607 Genomic DNA. Translation: AAP72969.1.
CR541969 mRNA. Translation: CAG46767.1.
AK313927 mRNA. Translation: BAG36648.1.
AL732602 Genomic DNA. Translation: CAI40984.1.
CH471234 Genomic DNA. Translation: EAW51502.1.
BC095504 mRNA. Translation: AAH95504.1.
X87723 mRNA. Translation: CAA61022.1.
CCDSiCCDS14569.1.
PIRiJC2543.
RefSeqiNP_000677.2. NM_000686.4.
XP_011535835.1. XM_011537533.1.
UniGeneiHs.405348.

3D structure databases

ProteinModelPortaliP50052.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106692. 6 interactors.
IntActiP50052. 3 interactors.
STRINGi9606.ENSP00000360973.

Chemistry databases

BindingDBiP50052.
ChEMBLiCHEMBL4607.
DrugBankiDB01349. Tasosartan.
GuidetoPHARMACOLOGYi35.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP50052.
PhosphoSitePlusiP50052.

Polymorphism and mutation databases

BioMutaiAGTR2.
DMDMi1703214.

Proteomic databases

PaxDbiP50052.
PRIDEiP50052.

Protocols and materials databases

DNASUi186.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371906; ENSP00000360973; ENSG00000180772.
GeneIDi186.
KEGGihsa:186.
UCSCiuc004eqh.5. human.

Organism-specific databases

CTDi186.
DisGeNETi186.
GeneCardsiAGTR2.
H-InvDBHIX0213472.
HGNCiHGNC:338. AGTR2.
MalaCardsiAGTR2.
MIMi300034. gene.
neXtProtiNX_P50052.
OpenTargetsiENSG00000180772.
Orphaneti777. X-linked non-syndromic intellectual disability.
PharmGKBiPA44.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP50052.
KOiK04167.
OMAiNCSHKPS.
OrthoDBiEOG091G0HEN.
PhylomeDBiP50052.
TreeFamiTF330024.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180772-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP50052.

Miscellaneous databases

GeneWikiiAngiotensin_II_receptor_type_2.
GenomeRNAii186.
PROiP50052.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180772.
CleanExiHS_AGTR2.
GenevisibleiP50052. HS.

Family and domain databases

InterProiIPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGTR2_HUMAN
AccessioniPrimary (citable) accession number: P50052
Secondary accession number(s): B2R9V1, Q13016, Q6FGY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although AGTR2 has been reported to be involved in X-linked mental retardation (PubMed:12089445), its pathological role is questionable (PubMed:23871722).2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.