P50052 (AGTR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type-2 angiotensin II receptor

Alternative name(s):
Angiotensin II type-2 receptor
Short name=AT2

Gene names

Name:

AGTR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. Ref.18
Subunit structure	Interacts with MTUS1. Ref.18
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine. Ref.17
Involvement in disease	Mental retardation, X-linked 88 (MRX88) [MIM:300852]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.17
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Disease	Disease mutation Mental retardation
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Inferred from sequence or structural similarity PubMed 17000928. Source: BHF-UCL aldosterone secretion Inferred from electronic annotation. Source: Compara behavior Inferred from mutant phenotype Ref.17. Source: BHF-UCL blood vessel remodeling Traceable author statement PubMed 17159080. Source: BHF-UCL brain development Non-traceable author statement Ref.17. Source: BHF-UCL brain renin-angiotensin system Inferred from electronic annotation. Source: Compara cell growth involved in cardiac muscle cell development Inferred from electronic annotation. Source: Compara cellular response to dexamethasone stimulus Inferred from electronic annotation. Source: Compara cellular sodium ion homeostasis Inferred from electronic annotation. Source: Compara cerebellar cortex development Inferred from electronic annotation. Source: Compara dopamine biosynthetic process Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: Compara intracellular protein kinase cascade Inferred from sequence or structural similarity PubMed 17000928. Source: BHF-UCL negative regulation of blood vessel endothelial cell migration Non-traceable author statement PubMed 15710780. Source: BHF-UCL negative regulation of cell growth Traceable author statement PubMed 17159080. Source: BHF-UCL negative regulation of fibroblast proliferation Inferred from electronic annotation. Source: Compara negative regulation of heart rate Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of nerve growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 10406457. Source: BHF-UCL negative regulation of norepinephrine secretion Inferred from electronic annotation. Source: Compara nitric oxide mediated signal transduction Traceable author statement PubMed 17159080. Source: BHF-UCL positive regulation of apoptotic process Inferred from mutant phenotype PubMed 10406457. Source: BHF-UCL positive regulation of branching involved in ureteric bud morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of cytokine secretion Inferred from electronic annotation. Source: Compara positive regulation of metanephric glomerulus development Inferred from electronic annotation. Source: Compara positive regulation of nitric oxide biosynthetic process Inferred by curator PubMed 17000928. Source: BHF-UCL positive regulation of nitric-oxide synthase activity Inferred from sequence or structural similarity PubMed 17000928. Source: BHF-UCL positive regulation of phosphoprotein phosphatase activity Inferred from direct assay PubMed 10406457. Source: BHF-UCL positive regulation of renal sodium excretion Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara positive regulation of vasodilation Inferred from direct assay PubMed 15117835PubMed 17159079. Source: BHF-UCL regulation of metanephros size Inferred from electronic annotation. Source: Compara regulation of systemic arterial blood pressure by circulatory renin-angiotensin Inferred from sequence or structural similarity. Source: BHF-UCL regulation of transcription factor import into nucleus Inferred from electronic annotation. Source: Compara renin-angiotensin regulation of aldosterone production Inferred from electronic annotation. Source: Compara response to organic nitrogen Inferred from electronic annotation. Source: Compara vasodilation by angiotensin involved in regulation of systemic arterial blood pressure Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular region Traceable author statement PubMed 17159079. Source: GOC integral to plasma membrane Inferred by curator PubMed 10406457. Source: BHF-UCL perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara
Molecular_function	angiotensin type II receptor activity Inferred from physical interaction PubMed 10406457. Source: BHF-UCL peptide hormone binding Inferred from electronic annotation. Source: Compara receptor antagonist activity Traceable author statement PubMed 17159079. Source: BHF-UCL
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TIMP3	P35625	7	EBI-1748067,EBI-1748085

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Type-2 angiotensin II receptor		PRO_0000069167
Regions
	Topological domain	1 – 45	45	Extracellular Potential
	Transmembrane	46 – 71	26	Helical; Name=1; Potential
	Topological domain	72 – 80	9	Cytoplasmic Potential
	Transmembrane	81 – 102	22	Helical; Name=2; Potential
	Topological domain	103 – 119	17	Extracellular Potential
	Transmembrane	120 – 140	21	Helical; Name=3; Potential
	Topological domain	141 – 160	20	Cytoplasmic Potential
	Transmembrane	161 – 179	19	Helical; Name=4; Potential
	Topological domain	180 – 208	29	Extracellular Potential
	Transmembrane	209 – 234	26	Helical; Name=5; Potential
	Topological domain	235 – 256	22	Cytoplasmic Potential
	Transmembrane	257 – 278	22	Helical; Name=6; Potential
	Topological domain	279 – 297	19	Extracellular Potential
	Transmembrane	298 – 318	21	Helical; Name=7; Potential
	Topological domain	319 – 363	45	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	13	1	N-linked (GlcNAc...) Potential
	Glycosylation	24	1	N-linked (GlcNAc...) Potential
	Glycosylation	29	1	N-linked (GlcNAc...) Potential
	Glycosylation	34	1	N-linked (GlcNAc...) Potential
	Disulfide bond	35 ↔ 290		By similarity
	Disulfide bond	117 ↔ 195		By similarity
Natural variations
	Natural variant	21	1	G → V in MRX88. Ref.17		VAR_065946
	Natural variant	231	1	Y → H. Corresponds to variant rs3729977 [ dbSNP | Ensembl ].		VAR_049374
	Natural variant	248	1	R → K. Ref.17 Corresponds to variant rs5191 [ dbSNP | Ensembl ].		VAR_011849
	Natural variant	268	1	C → W. Corresponds to variant rs1042860 [ dbSNP | Ensembl ].		VAR_011850
	Natural variant	324	1	R → Q in MRX88. Ref.17		VAR_065947
	Natural variant	337	1	I → V in MRX88. Ref.17		VAR_065948
Experimental info
	Sequence conflict	269	1	W → C Ref.5
	Sequence conflict	272	1	F → L in AAA50762. Ref.4
	Sequence conflict	323	1	N → G in AAA50762. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P50052 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: FDD7D4E6F9B43E60	FASTA	363	41,184
	10 20 30 40 50 60 MKGNSTLATT SKNITSGLHF GLVNISGNNE STLNCSQKPS DKHLDAIPIL YYIIFVIGFL 70 80 90 100 110 120 VNIVVVTLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW ATYYSYRYDW LFGPVMCKVF 130 140 150 160 170 180 GSFLTLNMFA SIFFITCMSV DRYQSVIYPF LSQRRNPWQA SYIVPLVWCM ACLSSLPTFY 190 200 210 220 230 240 FRDVRTIEYL GVNACIMAFP PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK 250 260 270 280 290 300 TNSYGKNRIT RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LAWMGVINSC EVIAVIDLAL 310 320 330 340 350 360 PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRESMSCR KSSSLREMET FVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence and genomic organization of the human type 2 angiotensin II receptor." Martin M.M., Elton T.S. Biochem. Biophys. Res. Commun. 209:554-562(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver.
[2]	"Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization." Chassagne C., Beatty B.G., Meloche S. Genomics 25:601-603(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[3]	"Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung." Koike G., Horiuchi M., Yamada T., Szpirer C., Jacob H.J., Dzau V.J. Biochem. Biophys. Res. Commun. 203:1842-1850(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood.
[4]	"Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor." Tsuzuki S., Ichiki T., Nakakubo H., Kitami Y., Guo D.F., Shirai H., Inagami T. Biochem. Biophys. Res. Commun. 200:1449-1454(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[5]	"Molecular cloning of the human angiotensin II type 2 receptor cDNA." Martin M.M., Su B., Elton T.S. Biochem. Biophys. Res. Commun. 205:645-651(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[6]	"Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues." Lazard D., Briend-Sutren M.M., Villageois P., Mattei M.-G., Strosberg A.D., Nahmias C. Recept. Channels 2:271-280(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[7]	"Sequence of the AGTR2 gene in Cantonese." Zhang M., Ma H., Wang B., Zhao Y. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]	"Isolation of complete coding sequence for angiotensin II receptor, type 2 (AGTR2)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[9]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[10]	Rieder M.J., da Ponte S.H., Kuldanek S.A., Rajkumar N., Smith J.D., Toth E.J., Nickerson D.A. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[11]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[12]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[13]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[14]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[15]	Katsuya T., Dzau V.J. Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-22. Tissue: Blood.
[16]	Warnecke C.H., Holzmeister J., Regitz-Zagrosek V., Fleck E. Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-16. Tissue: Uterus.
[17]	"AGTR2 mutations in X-linked mental retardation." Vervoort V.S., Beachem M.A., Edwards P.S., Ladd S., Miller K.E., de Mollerat X., Clarkson K., DuPont B., Schwartz C.E., Stevenson R.E., Boyd E., Srivastava A.K. Science 296:2401-2403(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, VARIANTS MRX88 VAL-21; GLN-324 AND VAL-337, VARIANT LYS-248.
[18]	"Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP." Nouet S., Amzallag N., Li J.-M., Louis S., Seitz I., Cui T.-X., Alleaume A.-M., Di Benedetto M., Boden C., Masson M., Strosberg A.D., Horiuchi M., Couraud P.-O., Nahmias C. J. Biol. Chem. 279:28989-28997(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MTUS1, FUNCTION.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	U20860 Genomic DNA. Translation: AAA85851.1. L34579 Genomic DNA. Translation: AAA98990.1. U10273 Genomic DNA. Translation: AAA61794.1. U15592 Genomic DNA. Translation: AAA50762.1. U16957 mRNA. Translation: AAA67753.1. U27478 Genomic DNA. Translation: AAA84900.1. AY536522 Genomic DNA. Translation: AAS45437.1. AY322542 Genomic DNA. Translation: AAP84355.1. AY324607 Genomic DNA. Translation: AAP72969.1. CR541969 mRNA. Translation: CAG46767.1. AK313927 mRNA. Translation: BAG36648.1. AL732602 Genomic DNA. Translation: CAI40984.1. CH471234 Genomic DNA. Translation: EAW51502.1. BC095504 mRNA. Translation: AAH95504.1. X87723 mRNA. Translation: CAA61022.1.
IPI	IPI00029486.
PIR	JC2543.
RefSeq	NP_000677.2. NM_000686.4.
UniGene	Hs.405348.
3D structure databases
ProteinModelPortal	P50052.
ModBase	Search...
Protein-protein interaction databases
IntAct	P50052. 1 interaction.
STRING	9606.ENSP00000360973.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P50052.
Polymorphism databases
DMDM	1703214.
Proteomic databases
PaxDb	P50052.
PRIDE	P50052.
Protocols and materials databases
DNASU	186.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371906; ENSP00000360973; ENSG00000180772. ENST00000601039; ENSP00000470282; ENSG00000269602.
GeneID	186.
KEGG	hsa:186.
UCSC	uc004eqh.4. human.
Organism-specific databases
CTD	186.
GeneCards	GC0XP115216.
H-InvDB	HIX0213472.
HGNC	HGNC:338. AGTR2.
HPA	HPA029592.
MIM	300034. gene. 300852. phenotype.
neXtProt	NX_P50052.
Orphanet	777. X-linked nonsyndromic intellectual deficit.
PharmGKB	PA44.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG311643.
HOGENOM	HOG000234122.
HOVERGEN	HBG104998.
InParanoid	P50052.
KO	K04167.
OMA	NCSHKPS.
OrthoDB	EOG4SXND6.
PhylomeDB	P50052.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P50052.
Bgee	P50052.
CleanEx	HS_AGTR2.
Genevestigator	P50052.
GermOnline	ENSG00000180772. Homo sapiens.
Family and domain databases
InterPro	IPR000147. ATII_AT2_rcpt. IPR000248. ATII_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00241. ANGIOTENSINR. PR00636. ANGIOTENSN2R. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P50052.
ChEMBL	CHEMBL4607.
GenomeRNAi	186.
NextBio	764.
SOURCE	Search...

Entry information

Entry name

AGTR2_HUMAN

Accession

Primary (citable) accession number: P50052
Secondary accession number(s): B2R9V1, Q13016, Q6FGY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 120 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.