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Protein

Type-2 angiotensin II receptor

Gene

AGTR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.1 Publication

Caution

Although AGTR2 has been reported to be involved in X-linked mental retardation (PubMed:12089445), its pathological role is questionable (PubMed:23871722).2 Publications

GO - Molecular functioni

  • angiotensin type II receptor activity Source: BHF-UCL
  • peptide hormone binding Source: Ensembl
  • receptor antagonist activity Source: BHF-UCL
  • transcription factor binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP50052

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 angiotensin II receptor
Alternative name(s):
Angiotensin II type-2 receptor
Short name:
AT2
Gene namesi
Name:AGTR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000180772.6
HGNCiHGNC:338 AGTR2
MIMi300034 gene
neXtProtiNX_P50052

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularSequence analysisAdd BLAST45
Transmembranei46 – 71Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini72 – 80CytoplasmicSequence analysis9
Transmembranei81 – 102Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini103 – 119ExtracellularSequence analysisAdd BLAST17
Transmembranei120 – 140Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini141 – 160CytoplasmicSequence analysisAdd BLAST20
Transmembranei161 – 179Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini180 – 208ExtracellularSequence analysisAdd BLAST29
Transmembranei209 – 234Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini235 – 256CytoplasmicSequence analysisAdd BLAST22
Transmembranei257 – 278Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini279 – 297ExtracellularSequence analysisAdd BLAST19
Transmembranei298 – 318Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini319 – 363CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi186
MalaCardsiAGTR2
OpenTargetsiENSG00000180772
Orphaneti777 X-linked non-syndromic intellectual disability
PharmGKBiPA44

Chemistry databases

ChEMBLiCHEMBL4607
DrugBankiDB05739 CYT006-AngQb
DB01349 Tasosartan
GuidetoPHARMACOLOGYi35

Polymorphism and mutation databases

BioMutaiAGTR2
DMDMi1703214

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691671 – 363Type-2 angiotensin II receptorAdd BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi35 ↔ 290PROSITE-ProRule annotation
Disulfide bondi117 ↔ 195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP50052
PRIDEiP50052
ProteomicsDBi56191

PTM databases

iPTMnetiP50052
PhosphoSitePlusiP50052

Expressioni

Tissue specificityi

In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.1 Publication

Gene expression databases

BgeeiENSG00000180772
CleanExiHS_AGTR2
GenevisibleiP50052 HS

Interactioni

Subunit structurei

Interacts with MTUS1.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • receptor antagonist activity Source: BHF-UCL
  • transcription factor binding Source: Ensembl

Protein-protein interaction databases

BioGridi106692, 6 interactors
IntActiP50052, 3 interactors
STRINGi9606.ENSP00000360973

Chemistry databases

BindingDBiP50052

Structurei

Secondary structure

1363
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni39 – 42Combined sources4
Helixi46 – 71Combined sources26
Helixi79 – 94Combined sources16
Helixi97 – 105Combined sources9
Helixi113 – 147Combined sources35
Helixi149 – 151Combined sources3
Helixi159 – 174Combined sources16
Helixi176 – 181Combined sources6
Beta strandi182 – 186Combined sources5
Turni188 – 190Combined sources3
Beta strandi193 – 197Combined sources5
Helixi201 – 203Combined sources3
Helixi205 – 219Combined sources15
Helixi221 – 240Combined sources20
Helixi246 – 283Combined sources38
Helixi290 – 318Combined sources29
Turni319 – 321Combined sources3
Helixi322 – 333Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UNFX-ray2.80A/B35-335[»]
5UNGX-ray2.80B35-335[»]
5UNHX-ray2.90A/B35-335[»]
ProteinModelPortaliP50052
SMRiP50052
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000234122
HOVERGENiHBG104998
InParanoidiP50052
KOiK04167
OMAiNCSHKPS
OrthoDBiEOG091G0HEN
PhylomeDBiP50052
TreeFamiTF330024

Family and domain databases

CDDicd15191 7tmA_AT2R, 1 hit
InterProiView protein in InterPro
IPR000147 ATII_AT2_rcpt
IPR000248 ATII_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00241 ANGIOTENSINR
PR00636 ANGIOTENSN2R
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P50052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGNSTLATT SKNITSGLHF GLVNISGNNE STLNCSQKPS DKHLDAIPIL
60 70 80 90 100
YYIIFVIGFL VNIVVVTLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW
110 120 130 140 150
ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF
160 170 180 190 200
LSQRRNPWQA SYIVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP
210 220 230 240 250
PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT
260 270 280 290 300
RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LAWMGVINSC EVIAVIDLAL
310 320 330 340 350
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRESMSCR
360
KSSSLREMET FVS
Length:363
Mass (Da):41,184
Last modified:October 1, 1996 - v1
Checksum:iFDD7D4E6F9B43E60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti269W → C (PubMed:7999093).Curated1
Sequence conflicti272F → L in AAA50762 (PubMed:8185599).Curated1
Sequence conflicti323N → G in AAA50762 (PubMed:8185599).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06594621G → V Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs121917810EnsemblClinVar.1
Natural variantiVAR_049374231Y → H. Corresponds to variant dbSNP:rs3729977Ensembl.1
Natural variantiVAR_011849248R → K1 PublicationCorresponds to variant dbSNP:rs5191EnsemblClinVar.1
Natural variantiVAR_011850268C → W. Corresponds to variant dbSNP:rs1042860Ensembl.1
Natural variantiVAR_065947324R → Q Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs35474657EnsemblClinVar.1
Natural variantiVAR_065948337I → V Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121917811EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20860 Genomic DNA Translation: AAA85851.1
L34579 Genomic DNA Translation: AAA98990.1
U10273 Genomic DNA Translation: AAA61794.1
U15592 Genomic DNA Translation: AAA50762.1
U16957 mRNA Translation: AAA67753.1
U27478 Genomic DNA Translation: AAA84900.1
AY536522 Genomic DNA Translation: AAS45437.1
AY322542 Genomic DNA Translation: AAP84355.1
AY324607 Genomic DNA Translation: AAP72969.1
CR541969 mRNA Translation: CAG46767.1
AK313927 mRNA Translation: BAG36648.1
AL732602 Genomic DNA No translation available.
CH471234 Genomic DNA Translation: EAW51502.1
BC095504 mRNA Translation: AAH95504.1
X87723 mRNA Translation: CAA61022.1
CCDSiCCDS14569.1
PIRiJC2543
RefSeqiNP_000677.2, NM_000686.4
XP_011535835.1, XM_011537533.1
UniGeneiHs.405348

Genome annotation databases

EnsembliENST00000371906; ENSP00000360973; ENSG00000180772
GeneIDi186
KEGGihsa:186
UCSCiuc004eqh.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAGTR2_HUMAN
AccessioniPrimary (citable) accession number: P50052
Secondary accession number(s): B2R9V1, Q13016, Q6FGY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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