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P50052

- AGTR2_HUMAN

UniProt

P50052 - AGTR2_HUMAN

Protein

Type-2 angiotensin II receptor

Gene

AGTR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.1 Publication

    GO - Molecular functioni

    1. angiotensin type II receptor activity Source: BHF-UCL
    2. peptide hormone binding Source: Ensembl
    3. protein binding Source: IntAct
    4. receptor antagonist activity Source: BHF-UCL

    GO - Biological processi

    1. aldosterone secretion Source: Ensembl
    2. angiotensin-activated signaling pathway Source: GOC
    3. behavior Source: Ensembl
    4. blood vessel remodeling Source: BHF-UCL
    5. brain development Source: BHF-UCL
    6. brain renin-angiotensin system Source: Ensembl
    7. cell growth involved in cardiac muscle cell development Source: Ensembl
    8. cell surface receptor signaling pathway Source: BHF-UCL
    9. cellular response to dexamethasone stimulus Source: Ensembl
    10. cellular sodium ion homeostasis Source: Ensembl
    11. cerebellar cortex development Source: Ensembl
    12. dopamine biosynthetic process Source: Ensembl
    13. extracellular negative regulation of signal transduction Source: GOC
    14. G-protein coupled receptor signaling pathway Source: BHF-UCL
    15. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: BHF-UCL
    16. inflammatory response Source: Ensembl
    17. intracellular signal transduction Source: BHF-UCL
    18. negative regulation of blood vessel endothelial cell migration Source: BHF-UCL
    19. negative regulation of cell growth Source: BHF-UCL
    20. negative regulation of fibroblast proliferation Source: Ensembl
    21. negative regulation of heart rate Source: BHF-UCL
    22. negative regulation of icosanoid secretion Source: Ensembl
    23. negative regulation of neurotrophin TRK receptor signaling pathway Source: BHF-UCL
    24. negative regulation of norepinephrine secretion Source: Ensembl
    25. nitric oxide mediated signal transduction Source: BHF-UCL
    26. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
    27. positive regulation of cell proliferation Source: Ensembl
    28. positive regulation of cytokine secretion Source: Ensembl
    29. positive regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
    30. positive regulation of metanephric glomerulus development Source: Ensembl
    31. positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
    32. positive regulation of nitric-oxide synthase activity Source: BHF-UCL
    33. positive regulation of phosphoprotein phosphatase activity Source: BHF-UCL
    34. positive regulation of renal sodium excretion Source: Ensembl
    35. positive regulation of transcription, DNA-templated Source: Ensembl
    36. positive regulation of vasodilation Source: BHF-UCL
    37. regulation of blood pressure Source: ProtInc
    38. regulation of metanephros size Source: Ensembl
    39. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: BHF-UCL
    40. regulation of transcription factor import into nucleus Source: Ensembl
    41. renin-angiotensin regulation of aldosterone production Source: Ensembl
    42. response to organonitrogen compound Source: Ensembl
    43. vasodilation by angiotensin involved in regulation of systemic arterial blood pressure Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-2 angiotensin II receptor
    Alternative name(s):
    Angiotensin II type-2 receptor
    Short name:
    AT2
    Gene namesi
    Name:AGTR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:338. AGTR2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: GOC
    2. integral component of plasma membrane Source: BHF-UCL
    3. perinuclear region of cytoplasm Source: Ensembl
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti777. X-linked non-syndromic intellectual disability.
    PharmGKBiPA44.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Type-2 angiotensin II receptorPRO_0000069167Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi35 ↔ 290PROSITE-ProRule annotation
    Disulfide bondi117 ↔ 195PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP50052.
    PRIDEiP50052.

    PTM databases

    PhosphoSiteiP50052.

    Expressioni

    Tissue specificityi

    In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.1 Publication

    Gene expression databases

    ArrayExpressiP50052.
    BgeeiP50052.
    CleanExiHS_AGTR2.
    GenevestigatoriP50052.

    Organism-specific databases

    HPAiHPA029592.

    Interactioni

    Subunit structurei

    Interacts with MTUS1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AGTP010192EBI-1748067,EBI-2927577
    TIMP3P356257EBI-1748067,EBI-1748085

    Protein-protein interaction databases

    BioGridi106692. 5 interactions.
    IntActiP50052. 3 interactions.
    STRINGi9606.ENSP00000360973.

    Structurei

    3D structure databases

    ProteinModelPortaliP50052.
    SMRiP50052. Positions 46-336.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini72 – 809CytoplasmicSequence Analysis
    Topological domaini103 – 11917ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini141 – 16020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 20829ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini235 – 25622CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini279 – 29719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini319 – 36345CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 7126Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 10222Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei161 – 17919Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 23426Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27822Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311643.
    HOGENOMiHOG000234122.
    HOVERGENiHBG104998.
    InParanoidiP50052.
    KOiK04167.
    OMAiNCSHKPS.
    OrthoDBiEOG7TQV1F.
    PhylomeDBiP50052.
    TreeFamiTF330024.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000147. ATII_AT2_rcpt.
    IPR000248. ATII_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00241. ANGIOTENSINR.
    PR00636. ANGIOTENSN2R.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50052-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGNSTLATT SKNITSGLHF GLVNISGNNE STLNCSQKPS DKHLDAIPIL    50
    YYIIFVIGFL VNIVVVTLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW 100
    ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF 150
    LSQRRNPWQA SYIVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP 200
    PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT 250
    RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LAWMGVINSC EVIAVIDLAL 300
    PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRESMSCR 350
    KSSSLREMET FVS 363
    Length:363
    Mass (Da):41,184
    Last modified:October 1, 1996 - v1
    Checksum:iFDD7D4E6F9B43E60
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti269 – 2691W → C(PubMed:7999093)Curated
    Sequence conflicti272 – 2721F → L in AAA50762. (PubMed:8185599)Curated
    Sequence conflicti323 – 3231N → G in AAA50762. (PubMed:8185599)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211G → V Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 1 Publication
    Corresponds to variant rs121917810 [ dbSNP | Ensembl ].
    VAR_065946
    Natural varianti231 – 2311Y → H.
    Corresponds to variant rs3729977 [ dbSNP | Ensembl ].
    VAR_049374
    Natural varianti248 – 2481R → K.1 Publication
    Corresponds to variant rs5191 [ dbSNP | Ensembl ].
    VAR_011849
    Natural varianti268 – 2681C → W.
    Corresponds to variant rs1042860 [ dbSNP | Ensembl ].
    VAR_011850
    Natural varianti324 – 3241R → Q Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 1 Publication
    Corresponds to variant rs35474657 [ dbSNP | Ensembl ].
    VAR_065947
    Natural varianti337 – 3371I → V Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 1 Publication
    VAR_065948

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20860 Genomic DNA. Translation: AAA85851.1.
    L34579 Genomic DNA. Translation: AAA98990.1.
    U10273 Genomic DNA. Translation: AAA61794.1.
    U15592 Genomic DNA. Translation: AAA50762.1.
    U16957 mRNA. Translation: AAA67753.1.
    U27478 Genomic DNA. Translation: AAA84900.1.
    AY536522 Genomic DNA. Translation: AAS45437.1.
    AY322542 Genomic DNA. Translation: AAP84355.1.
    AY324607 Genomic DNA. Translation: AAP72969.1.
    CR541969 mRNA. Translation: CAG46767.1.
    AK313927 mRNA. Translation: BAG36648.1.
    AL732602 Genomic DNA. Translation: CAI40984.1.
    CH471234 Genomic DNA. Translation: EAW51502.1.
    BC095504 mRNA. Translation: AAH95504.1.
    X87723 mRNA. Translation: CAA61022.1.
    CCDSiCCDS14569.1.
    PIRiJC2543.
    RefSeqiNP_000677.2. NM_000686.4.
    UniGeneiHs.405348.

    Genome annotation databases

    EnsembliENST00000371906; ENSP00000360973; ENSG00000180772.
    GeneIDi186.
    KEGGihsa:186.
    UCSCiuc004eqh.4. human.

    Polymorphism databases

    DMDMi1703214.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20860 Genomic DNA. Translation: AAA85851.1 .
    L34579 Genomic DNA. Translation: AAA98990.1 .
    U10273 Genomic DNA. Translation: AAA61794.1 .
    U15592 Genomic DNA. Translation: AAA50762.1 .
    U16957 mRNA. Translation: AAA67753.1 .
    U27478 Genomic DNA. Translation: AAA84900.1 .
    AY536522 Genomic DNA. Translation: AAS45437.1 .
    AY322542 Genomic DNA. Translation: AAP84355.1 .
    AY324607 Genomic DNA. Translation: AAP72969.1 .
    CR541969 mRNA. Translation: CAG46767.1 .
    AK313927 mRNA. Translation: BAG36648.1 .
    AL732602 Genomic DNA. Translation: CAI40984.1 .
    CH471234 Genomic DNA. Translation: EAW51502.1 .
    BC095504 mRNA. Translation: AAH95504.1 .
    X87723 mRNA. Translation: CAA61022.1 .
    CCDSi CCDS14569.1.
    PIRi JC2543.
    RefSeqi NP_000677.2. NM_000686.4.
    UniGenei Hs.405348.

    3D structure databases

    ProteinModelPortali P50052.
    SMRi P50052. Positions 46-336.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106692. 5 interactions.
    IntActi P50052. 3 interactions.
    STRINGi 9606.ENSP00000360973.

    Chemistry

    BindingDBi P50052.
    ChEMBLi CHEMBL4607.
    GuidetoPHARMACOLOGYi 35.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P50052.

    Polymorphism databases

    DMDMi 1703214.

    Proteomic databases

    PaxDbi P50052.
    PRIDEi P50052.

    Protocols and materials databases

    DNASUi 186.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371906 ; ENSP00000360973 ; ENSG00000180772 .
    GeneIDi 186.
    KEGGi hsa:186.
    UCSCi uc004eqh.4. human.

    Organism-specific databases

    CTDi 186.
    GeneCardsi GC0XP115216.
    H-InvDB HIX0213472.
    HGNCi HGNC:338. AGTR2.
    HPAi HPA029592.
    MIMi 300034. gene.
    neXtProti NX_P50052.
    Orphaneti 777. X-linked non-syndromic intellectual disability.
    PharmGKBi PA44.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311643.
    HOGENOMi HOG000234122.
    HOVERGENi HBG104998.
    InParanoidi P50052.
    KOi K04167.
    OMAi NCSHKPS.
    OrthoDBi EOG7TQV1F.
    PhylomeDBi P50052.
    TreeFami TF330024.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Angiotensin_II_receptor_type_2.
    GenomeRNAii 186.
    NextBioi 764.
    PROi P50052.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50052.
    Bgeei P50052.
    CleanExi HS_AGTR2.
    Genevestigatori P50052.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000147. ATII_AT2_rcpt.
    IPR000248. ATII_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00241. ANGIOTENSINR.
    PR00636. ANGIOTENSN2R.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence and genomic organization of the human type 2 angiotensin II receptor."
      Martin M.M., Elton T.S.
      Biochem. Biophys. Res. Commun. 209:554-562(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    2. "Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization."
      Chassagne C., Beatty B.G., Meloche S.
      Genomics 25:601-603(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    3. "Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung."
      Koike G., Horiuchi M., Yamada T., Szpirer C., Jacob H.J., Dzau V.J.
      Biochem. Biophys. Res. Commun. 203:1842-1850(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    4. "Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor."
      Tsuzuki S., Ichiki T., Nakakubo H., Kitami Y., Guo D.F., Shirai H., Inagami T.
      Biochem. Biophys. Res. Commun. 200:1449-1454(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    5. "Molecular cloning of the human angiotensin II type 2 receptor cDNA."
      Martin M.M., Su B., Elton T.S.
      Biochem. Biophys. Res. Commun. 205:645-651(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    6. "Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues."
      Lazard D., Briend-Sutren M.M., Villageois P., Mattei M.-G., Strosberg A.D., Nahmias C.
      Recept. Channels 2:271-280(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    7. "Sequence of the AGTR2 gene in Cantonese."
      Zhang M., Ma H., Wang B., Zhao Y.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    8. "Isolation of complete coding sequence for angiotensin II receptor, type 2 (AGTR2)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    9. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    10. Rieder M.J., da Ponte S.H., Kuldanek S.A., Rajkumar N., Smith J.D., Toth E.J., Nickerson D.A.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    11. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    12. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    14. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    15. Katsuya T., Dzau V.J.
      Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 1-22.
      Tissue: Blood.
    16. Warnecke C.H., Holzmeister J., Regitz-Zagrosek V., Fleck E.
      Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 1-16.
      Tissue: Uterus.
    17. Cited for: TISSUE SPECIFICITY, VARIANTS VAL-21; LYS-248; GLN-324 AND VAL-337, POSSIBLE ASSOCIATION OF VARIANTS VAL-21; GLN-324 AND VAL-337 WITH X-LINKED MENTAL RETARDATION.
    18. "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP."
      Nouet S., Amzallag N., Li J.-M., Louis S., Seitz I., Cui T.-X., Alleaume A.-M., Di Benedetto M., Boden C., Masson M., Strosberg A.D., Horiuchi M., Couraud P.-O., Nahmias C.
      J. Biol. Chem. 279:28989-28997(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MTUS1, FUNCTION.
    19. "XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing."
      Piton A., Redin C., Mandel J.L.
      Am. J. Hum. Genet. 93:368-383(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF ASSOCIATION VARIANTS VAL-21; GLN-324 AND VAL-337 WITH X-LINKED MENTAL RETARDATION.

    Entry informationi

    Entry nameiAGTR2_HUMAN
    AccessioniPrimary (citable) accession number: P50052
    Secondary accession number(s): B2R9V1, Q13016, Q6FGY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 136 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Although AGTR2 has been reported to be involved in X-linked mental retardation (PubMed:12089445), its pathological role is questionable (PubMed:23871722).2 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3