Reviewed, UniProtKB/Swiss-Prot P50024 (DSBA_LEGPN)

Names and origin

Protein names

Recommended name:
    Thiol:disulfide interchange protein dsbA

Gene names

Name:

dsbA

Organism

Legionella pneumophila

Taxonomic identifier

446 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins By similarity.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 204	186	Thiol:disulfide interchange protein dsbA		PRO_0000034261
Regions
	Domain	19 – 146	128	Thioredoxin
Amino acid modifications
	Disulfide bond	53 ↔ 56		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	P50024-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 8234634690B147AE	FASTA	204	23,146
	10 20 30 40 50 60 MFKKLIGLLF LMPMTALATQ FIEGKDYQTV ASAQLSTNKD KTPLITEFFS YGCPWCYKID 70 80 90 100 110 120 APLNDWATRM GKGAHLERVP VVFKPNWDLY AKAYYTAKTL AMSDKMNPIL FKAIQEDKNP 130 140 150 160 170 180 LATKQSMVDF FVAHGVDREI AKSAFENSPT IDMRVNSGMS LMAHYQINAV PAFVVNNKYK 190 200 TDLQMAGSEE RLFEILNYLV RKSA

References

[1]	Sadosky A.B., Shuman H.A. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: JR32.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U15278 Genomic DNA. Translation: AAA67725.1.
3D structure databases
HSSP	HSSP built from PDB template 1BED based on UniProtKB P32557.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.8.4.2. 1454.
Family and domain databases
InterPro	IPR001853. OxRdtase_DSBA. IPR017936. Thioredoxin-like. IPR017937. Thioredoxin_CS. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF01323. DSBA. 1 hit. [Graphical view]
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBA_LEGPN

Accession

Primary (citable) accession number: P50024

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	March 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)