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P49995

- DNAA_SYNY3

UniProt

P49995 - DNAA_SYNY3

Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi147 – 1548ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA replication origin binding Source: UniProtKB-HAMAP
    3. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. DNA replication initiation Source: UniProtKB-HAMAP
    2. regulation of DNA replication Source: UniProtKB-HAMAP

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chromosomal replication initiator protein DnaA
    Gene namesi
    Name:dnaA
    Ordered Locus Names:sll0848
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 447447Chromosomal replication initiator protein DnaAPRO_0000114285Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiP49995. 2 interactions.
    STRINGi1148.sll0848.

    Structurei

    3D structure databases

    ProteinModelPortaliP49995.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DnaA family.Curated

    Phylogenomic databases

    eggNOGiCOG0593.
    HOGENOMiHOG000235658.
    KOiK02313.
    OMAiTEFSMWV.
    OrthoDBiEOG689HR1.
    PhylomeDBiP49995.

    Family and domain databases

    Gene3Di1.10.1750.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00377. DnaA_bact.
    InterProiIPR003593. AAA+_ATPase.
    IPR001957. Chromosome_initiator_DnaA.
    IPR020591. Chromosome_initiator_DnaA-like.
    IPR018312. Chromosome_initiator_DnaA_CS.
    IPR013159. DnaA_C.
    IPR013317. DnaA_Hda.
    IPR024633. DnaA_N_dom.
    IPR027417. P-loop_NTPase.
    IPR010921. Trp_repressor/repl_initiator.
    [Graphical view]
    PfamiPF00308. Bac_DnaA. 1 hit.
    PF08299. Bac_DnaA_C. 1 hit.
    PF11638. DnaA_N. 1 hit.
    [Graphical view]
    PRINTSiPR00051. DNAA.
    SMARTiSM00382. AAA. 1 hit.
    SM00760. Bac_DnaA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48295. SSF48295. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00362. DnaA. 1 hit.
    PROSITEiPS01008. DNAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49995-1 [UniParc]FASTAAdd to Basket

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    MVSCENLWQQ ALAILATQLT KPAFDTWIKA SVLISLGDGV ATIQVENGFV    50
    LNHLQKSYGP LLMEVLTDLT GQEITVKLIT DGLEPHSLIG QESSLPMETT 100
    PKNATALNGK YTFSRFVVGP TNRMAHAASL AVAESPGREF NPLFLCGGVG 150
    LGKTHLMQAI AHYRLEMYPN AKVYYVSTER FTNDLITAIR QDNMEDFRSY 200
    YRSADFLLID DIQFIKGKEY TQEEFFHTFN SLHEAGKQVV VASDRAPQRI 250
    PGLQDRLISR FSMGLIADIQ VPDLETRMAI LQKKAEYDRI RLPKEVIEYI 300
    ASHYTSNIRE LEGALIRAIA YTSLSNVAMT VENIAPVLNP PVEKVAAAPE 350
    TIITIVAQHY QLKVEELLSN SRRREVSLAR QVGMYLMRQH TDLSLPRIGE 400
    AFGGKDHTTV MYSCDKITQL QQKDWETSQT LTSLSHRINI AGQAPES 447
    Length:447
    Mass (Da):50,050
    Last modified:November 1, 1997 - v2
    Checksum:i8ACA68D6CC38D3BF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti118 – 1258VGPTNRMA → WAHQSHG in AAA85913. (PubMed:7635812)Curated
    Sequence conflicti297 – 2971I → M in AAA85913. (PubMed:7635812)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36958 Genomic DNA. Translation: AAA85913.1.
    BA000022 Genomic DNA. Translation: BAA17801.1.
    PIRiS74840.
    RefSeqiNP_441121.1. NC_000911.1.
    YP_005651178.1. NC_017277.1.
    YP_007451003.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17801; BAA17801; BAA17801.
    GeneIDi954435.
    KEGGisyn:sll0848.
    syy:SYNGTS_1225.
    syz:MYO_112360.
    PATRICi23839547. VBISynSp132158_1336.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36958 Genomic DNA. Translation: AAA85913.1 .
    BA000022 Genomic DNA. Translation: BAA17801.1 .
    PIRi S74840.
    RefSeqi NP_441121.1. NC_000911.1.
    YP_005651178.1. NC_017277.1.
    YP_007451003.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P49995.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P49995. 2 interactions.
    STRINGi 1148.sll0848.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17801 ; BAA17801 ; BAA17801 .
    GeneIDi 954435.
    KEGGi syn:sll0848.
    syy:SYNGTS_1225.
    syz:MYO_112360.
    PATRICi 23839547. VBISynSp132158_1336.

    Phylogenomic databases

    eggNOGi COG0593.
    HOGENOMi HOG000235658.
    KOi K02313.
    OMAi TEFSMWV.
    OrthoDBi EOG689HR1.
    PhylomeDBi P49995.

    Family and domain databases

    Gene3Di 1.10.1750.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00377. DnaA_bact.
    InterProi IPR003593. AAA+_ATPase.
    IPR001957. Chromosome_initiator_DnaA.
    IPR020591. Chromosome_initiator_DnaA-like.
    IPR018312. Chromosome_initiator_DnaA_CS.
    IPR013159. DnaA_C.
    IPR013317. DnaA_Hda.
    IPR024633. DnaA_N_dom.
    IPR027417. P-loop_NTPase.
    IPR010921. Trp_repressor/repl_initiator.
    [Graphical view ]
    Pfami PF00308. Bac_DnaA. 1 hit.
    PF08299. Bac_DnaA_C. 1 hit.
    PF11638. DnaA_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00051. DNAA.
    SMARTi SM00382. AAA. 1 hit.
    SM00760. Bac_DnaA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48295. SSF48295. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00362. DnaA. 1 hit.
    PROSITEi PS01008. DNAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic structure of the dnaA region of the cyanobacterium Synechocystis sp. strain PCC6803."
      Richter S., Messer W.
      J. Bacteriol. 177:4245-4251(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiDNAA_SYNY3
    AccessioniPrimary (citable) accession number: P49995
    Secondary accession number(s): P73750
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3