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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi147 – 1548ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA replication origin binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication initiation Source: UniProtKB-HAMAP
  2. regulation of DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:sll0848
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Chromosomal replication initiator protein DnaAPRO_0000114285Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP49995. 2 interactions.
STRINGi1148.sll0848.

Structurei

3D structure databases

ProteinModelPortaliP49995.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiCOG0593.
HOGENOMiHOG000235658.
InParanoidiP49995.
KOiK02313.
OMAiSWFARMD.
OrthoDBiEOG689HR1.
PhylomeDBiP49995.

Family and domain databases

Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013159. DnaA_C.
IPR013317. DnaA_Hda.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49995-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSCENLWQQ ALAILATQLT KPAFDTWIKA SVLISLGDGV ATIQVENGFV
60 70 80 90 100
LNHLQKSYGP LLMEVLTDLT GQEITVKLIT DGLEPHSLIG QESSLPMETT
110 120 130 140 150
PKNATALNGK YTFSRFVVGP TNRMAHAASL AVAESPGREF NPLFLCGGVG
160 170 180 190 200
LGKTHLMQAI AHYRLEMYPN AKVYYVSTER FTNDLITAIR QDNMEDFRSY
210 220 230 240 250
YRSADFLLID DIQFIKGKEY TQEEFFHTFN SLHEAGKQVV VASDRAPQRI
260 270 280 290 300
PGLQDRLISR FSMGLIADIQ VPDLETRMAI LQKKAEYDRI RLPKEVIEYI
310 320 330 340 350
ASHYTSNIRE LEGALIRAIA YTSLSNVAMT VENIAPVLNP PVEKVAAAPE
360 370 380 390 400
TIITIVAQHY QLKVEELLSN SRRREVSLAR QVGMYLMRQH TDLSLPRIGE
410 420 430 440
AFGGKDHTTV MYSCDKITQL QQKDWETSQT LTSLSHRINI AGQAPES
Length:447
Mass (Da):50,050
Last modified:November 1, 1997 - v2
Checksum:i8ACA68D6CC38D3BF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1258VGPTNRMA → WAHQSHG in AAA85913 (PubMed:7635812).Curated
Sequence conflicti297 – 2971I → M in AAA85913 (PubMed:7635812).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36958 Genomic DNA. Translation: AAA85913.1.
BA000022 Genomic DNA. Translation: BAA17801.1.
PIRiS74840.
RefSeqiNP_441121.1. NC_000911.1.
YP_005651178.1. NC_017277.1.
YP_007451003.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17801; BAA17801; BAA17801.
KEGGisyn:sll0848.
PATRICi23839547. VBISynSp132158_1336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36958 Genomic DNA. Translation: AAA85913.1.
BA000022 Genomic DNA. Translation: BAA17801.1.
PIRiS74840.
RefSeqiNP_441121.1. NC_000911.1.
YP_005651178.1. NC_017277.1.
YP_007451003.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP49995.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP49995. 2 interactions.
STRINGi1148.sll0848.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17801; BAA17801; BAA17801.
KEGGisyn:sll0848.
PATRICi23839547. VBISynSp132158_1336.

Phylogenomic databases

eggNOGiCOG0593.
HOGENOMiHOG000235658.
InParanoidiP49995.
KOiK02313.
OMAiSWFARMD.
OrthoDBiEOG689HR1.
PhylomeDBiP49995.

Family and domain databases

Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013159. DnaA_C.
IPR013317. DnaA_Hda.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic structure of the dnaA region of the cyanobacterium Synechocystis sp. strain PCC6803."
    Richter S., Messer W.
    J. Bacteriol. 177:4245-4251(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiDNAA_SYNY3
AccessioniPrimary (citable) accession number: P49995
Secondary accession number(s): P73750
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: April 1, 2015
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.