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P49995 (DNAA_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chromosomal replication initiator protein DnaA
Gene names
Name:dnaA
Ordered Locus Names:sll0848
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP-Rule MF_00377

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00377.

Sequence similarities

Belongs to the DnaA family.

Ontologies

Keywords
   Biological processDNA replication
   Cellular componentCytoplasm
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication initiation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

regulation of DNA replication

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

DNA replication origin binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Chromosomal replication initiator protein DnaA HAMAP-Rule MF_00377
PRO_0000114285

Regions

Nucleotide binding147 – 1548ATP Potential

Experimental info

Sequence conflict118 – 1258VGPTNRMA → WAHQSHG in AAA85913. Ref.1
Sequence conflict2971I → M in AAA85913. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P49995 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 8ACA68D6CC38D3BF

FASTA44750,050
        10         20         30         40         50         60 
MVSCENLWQQ ALAILATQLT KPAFDTWIKA SVLISLGDGV ATIQVENGFV LNHLQKSYGP 

        70         80         90        100        110        120 
LLMEVLTDLT GQEITVKLIT DGLEPHSLIG QESSLPMETT PKNATALNGK YTFSRFVVGP 

       130        140        150        160        170        180 
TNRMAHAASL AVAESPGREF NPLFLCGGVG LGKTHLMQAI AHYRLEMYPN AKVYYVSTER 

       190        200        210        220        230        240 
FTNDLITAIR QDNMEDFRSY YRSADFLLID DIQFIKGKEY TQEEFFHTFN SLHEAGKQVV 

       250        260        270        280        290        300 
VASDRAPQRI PGLQDRLISR FSMGLIADIQ VPDLETRMAI LQKKAEYDRI RLPKEVIEYI 

       310        320        330        340        350        360 
ASHYTSNIRE LEGALIRAIA YTSLSNVAMT VENIAPVLNP PVEKVAAAPE TIITIVAQHY 

       370        380        390        400        410        420 
QLKVEELLSN SRRREVSLAR QVGMYLMRQH TDLSLPRIGE AFGGKDHTTV MYSCDKITQL 

       430        440 
QQKDWETSQT LTSLSHRINI AGQAPES 

« Hide

References

« Hide 'large scale' references
[1]"Genetic structure of the dnaA region of the cyanobacterium Synechocystis sp. strain PCC6803."
Richter S., Messer W.
J. Bacteriol. 177:4245-4251(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L36958 Genomic DNA. Translation: AAA85913.1.
BA000022 Genomic DNA. Translation: BAA17801.1.
PIRS74840.
RefSeqNP_441121.1. NC_000911.1.
YP_005651178.1. NC_017277.1.
YP_007451003.1. NC_020286.1.

3D structure databases

ProteinModelPortalP49995.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP49995. 2 interactions.
STRING1148.sll0848.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17801; BAA17801; BAA17801.
GeneID12255505.
14616658.
954435.
KEGGsyn:sll0848.
syy:SYNGTS_1225.
syz:MYO_112360.
PATRIC23839547. VBISynSp132158_1336.

Phylogenomic databases

eggNOGCOG0593.
HOGENOMHOG000235658.
KOK02313.
OMASWFARMD.
OrthoDBEOG689HR1.
PhylomeDBP49995.
ProtClustDBPRK00149.

Family and domain databases

Gene3D1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00377. DnaA_bact.
InterProIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013159. DnaA_C.
IPR013317. DnaA_Hda.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSPR00051. DNAA.
SMARTSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00362. DnaA. 1 hit.
PROSITEPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNAA_SYNY3
AccessionPrimary (citable) accession number: P49995
Secondary accession number(s): P73750
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families