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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi147 – 154ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:sll0848
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001142851 – 447Chromosomal replication initiator protein DnaAAdd BLAST447

Proteomic databases

PaxDbiP49995
PRIDEiP49995

Interactioni

Protein-protein interaction databases

IntActiP49995, 2 interactors
STRINGi1148.SYNGTS_1225

Structurei

3D structure databases

ProteinModelPortaliP49995
SMRiP49995
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

HOGENOMiHOG000235658
InParanoidiP49995
KOiK02313
OMAiREFNPLF
PhylomeDBiP49995

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR024633 DnaA_N_dom
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PF11638 DnaA_N, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

P49995-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSCENLWQQ ALAILATQLT KPAFDTWIKA SVLISLGDGV ATIQVENGFV
60 70 80 90 100
LNHLQKSYGP LLMEVLTDLT GQEITVKLIT DGLEPHSLIG QESSLPMETT
110 120 130 140 150
PKNATALNGK YTFSRFVVGP TNRMAHAASL AVAESPGREF NPLFLCGGVG
160 170 180 190 200
LGKTHLMQAI AHYRLEMYPN AKVYYVSTER FTNDLITAIR QDNMEDFRSY
210 220 230 240 250
YRSADFLLID DIQFIKGKEY TQEEFFHTFN SLHEAGKQVV VASDRAPQRI
260 270 280 290 300
PGLQDRLISR FSMGLIADIQ VPDLETRMAI LQKKAEYDRI RLPKEVIEYI
310 320 330 340 350
ASHYTSNIRE LEGALIRAIA YTSLSNVAMT VENIAPVLNP PVEKVAAAPE
360 370 380 390 400
TIITIVAQHY QLKVEELLSN SRRREVSLAR QVGMYLMRQH TDLSLPRIGE
410 420 430 440
AFGGKDHTTV MYSCDKITQL QQKDWETSQT LTSLSHRINI AGQAPES
Length:447
Mass (Da):50,050
Last modified:November 1, 1997 - v2
Checksum:i8ACA68D6CC38D3BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118 – 125VGPTNRMA → WAHQSHG in AAA85913 (PubMed:7635812).Curated8
Sequence conflicti297I → M in AAA85913 (PubMed:7635812).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36958 Genomic DNA Translation: AAA85913.1
BA000022 Genomic DNA Translation: BAA17801.1
PIRiS74840

Genome annotation databases

EnsemblBacteriaiBAA17801; BAA17801; BAA17801
KEGGisyn:sll0848

Similar proteinsi

Entry informationi

Entry nameiDNAA_SYNY3
AccessioniPrimary (citable) accession number: P49995
Secondary accession number(s): P73750
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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