Skip Header

Contribute Send feedback
Read comments (?) or add your own

P49991 (DNAA_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chromosomal replication initiator protein DnaA
Gene names
Name:dnaA
Ordered Locus Names:Mb0001
OrganismMycobacterium bovis [Complete proteome] [HAMAP]
Taxonomic identifier1765 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377

Subcellular location

Cytoplasm By similarity HAMAP MF_00377.

Sequence similarities

Belongs to the DnaA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Chromosomal replication initiator protein DnaA HAMAP MF_00377
PRO_0000114210

Regions

Nucleotide binding208 – 2158ATP Potential

Experimental info

Sequence conflict2881H → R in AAA85542. Ref.2
Sequence conflict3211R → D in AAA85542. Ref.2
Sequence conflict3531I → V in AAA85542. Ref.2
Sequence conflict3561D → G in AAA85542. Ref.2
Sequence conflict3711E → V in AAA85542. Ref.2
Sequence conflict3811A → P in AAA85542. Ref.2
Sequence conflict4071N → S in AAA85542. Ref.2
Sequence conflict429 – 4302EE → GR in AAA85542. Ref.2
Sequence conflict4371T → P in AAA85542. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P49991 [UniParc].

Last modified July 11, 2003. Version 2.
Checksum: 3935A335D413AADE

FASTA50756,600
        10         20         30         40         50         60 
MTDDPGSGFT TVWNAVVSEL NGDPKVDDGP SSDANLSAPL TPQQRAWLNL VQPLTIVEGF 

        70         80         90        100        110        120 
ALLSVPSSFV QNEIERHLRA PITDALSRRL GHQIQLGVRI APPATDEADD TTVPPSENPA 

       130        140        150        160        170        180 
TTSPDTTTDN DEIDDSAAAR GDNQHSWPSY FTERPRNTDS ATAGVTSLNR RYTFDTFVIG 

       190        200        210        220        230        240 
ASNRFAHAAA LAIAEAPARA YNPLFIWGES GLGKTHLLHA AGNYAQRLFP GMRVKYVSTE 

       250        260        270        280        290        300 
EFTNDFINSL RDDRKVAFKR SYRDVDVLLV DDIQFIEGKE GIQEEFFHTF NTLHNANKQI 

       310        320        330        340        350        360 
VISSDRPPKQ LATLEDRLRT RFEWGLITDV QPPELETRIA ILRKKAQMER LAIPDDVLEL 

       370        380        390        400        410        420 
IASSIERNIR ELEGALIRVT AFASLNKTPI DKALAEIVLR DLIADANTMQ ISAATIMAAT 

       430        440        450        460        470        480 
AEYFDTTVEE LRGPGKTRAL AQSRQIAMYL CRELTDLSLP KIGQAFGRDH TTVMYAQRKI 

       490        500 
LSEMAERREV FDHVKELTTR IRQRSKR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX248334 Genomic DNA. Translation: CAD92863.1.
U19186 Genomic DNA. Translation: AAA85542.1.
PIRPC4084.
RefSeqNP_853671.1. NC_002945.3.

3D structure databases

ProteinModelPortalP49991.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000017759; EBMYCP00000017594; EBMYCG00000017754.
GeneID1090743.
GenomeReviewsGene locus Mb0001 in contig BX248333_GR.
KEGGmbo:Mb0001.
PATRIC18001659. VBIMycBov88188_0001.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017320.
HOGENOMHBG695666.
OMAASVHESW.
ProtClustDBPRK00149.

Enzyme and pathway databases

BioCycMBOV233413:MB0001-MONOMER.

Family and domain databases

HAMAPMF_00377. DnaA_bact.
[Tree]
InterProIPR003593. ATPase_AAA+_core.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013159. DnaA_C.
IPR013317. DnaA_Hda.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
Gene3DG3DSA:1.10.1750.10. DnaA_C. 1 hit.
KOK02313.
PfamPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSPR00051. DNAA.
SMARTSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMSSF48295. Trp_repress_rep. 1 hit.
TIGRFAMsTIGR00362. DnaA. 1 hit.
PROSITEPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNAA_MYCBO
AccessionPrimary (citable) accession number: P49991
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 11, 2003
Last modified: January 25, 2012
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents