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Protein

Signal recognition particle 54 kDa protein 2

Gene

SRP-54B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi108 – 117GTPBy similarity10
Nucleotide bindingi192 – 196GTPBy similarity5
Nucleotide bindingi250 – 253GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-1799339 SRP-dependent cotranslational protein targeting to membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle 54 kDa protein 2
Short name:
SRP54
Gene namesi
Name:SRP-54B
Ordered Locus Names:At5g49500
ORF Names:K6M13.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G49500
TAIRilocus:2157809 AT5G49500

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Signal recognition particle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012051 – 497Signal recognition particle 54 kDa protein 2Add BLAST497

Proteomic databases

PaxDbiP49966
PRIDEiP49966

Expressioni

Gene expression databases

ExpressionAtlasiP49966 baseline and differential
GenevisibleiP49966 AT

Interactioni

Subunit structurei

Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

Protein-protein interaction databases

BioGridi20256, 2 interactors
IntActiP49966, 1 interactor
STRINGi3702.AT5G49500.1

Structurei

3D structure databases

ProteinModelPortaliP49966
SMRiP49966
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 297G-domainAdd BLAST297
Regioni298 – 497M-domainAdd BLAST200

Domaini

Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.

Sequence similaritiesi

Belongs to the GTP-binding SRP family. SRP54 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0780 Eukaryota
COG0541 LUCA
HOGENOMiHOG000036165
InParanoidiP49966
KOiK03106
OrthoDBiEOG09360AIV

Family and domain databases

Gene3Di1.10.260.30, 1 hit
HAMAPiMF_00306 SRP54, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR036891 Signal_recog_part_SRP54_M_sf
IPR013822 Signal_recog_particl_SRP54_hlx
IPR004125 Signal_recog_particle_SRP54_M
IPR036225 SRP/SRP_N
IPR022941 SRP54
IPR006325 SRP54_euk
IPR000897 SRP54_GTPase_dom
PANTHERiPTHR11564 PTHR11564, 1 hit
PfamiView protein in Pfam
PF00448 SRP54, 1 hit
PF02881 SRP54_N, 1 hit
PF02978 SRP_SPB, 1 hit
SMARTiView protein in SMART
SM00962 SRP54, 1 hit
SM00963 SRP54_N, 1 hit
SUPFAMiSSF47364 SSF47364, 1 hit
SSF47446 SSF47446, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01425 SRP54_euk, 1 hit
PROSITEiView protein in PROSITE
PS00300 SRP54, 1 hit

Sequencei

Sequence statusi: Complete.

P49966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLAELGGRI MSAIQKMNNV TIIDEKALND CLNEITRALL QSDVSFPLVK
60 70 80 90 100
EMQTNIKKIV NLEDLAAGHN KRRIIEQAIF SELCKMLDPG KSAFAPKKAK
110 120 130 140 150
PSVVMFVGLQ GEVLEKPQLV PSMLIIIRRK GYKPALVCAD TFRAGAFDQL
160 170 180 190 200
KQNATKSKIP YYGSYTGSDP VKIAVEGVDR FKKENCDLII VDTSGRHKQQ
210 220 230 240 250
ASLFEEMRQI SEATKPDLVI FVMDSSIGQT AFEQARAFKQ TVAVGAVIIT
260 270 280 290 300
KMDGHAKGGG TLSAVAATKS PVIFIGTGEH MDEFEVFDAK PFVSRLLGNG
310 320 330 340 350
DMSGFVNKLQ EVVPKDQQPE LLEMLSHGKF TLRIMYDQFQ NMLNMGPLKE
360 370 380 390 400
VFSMLPGMRA EMMPEGHEKE SQAKIKRYMT MMDSMTNEEL DSSNPKVFNE
410 420 430 440 450
SRIMRIARGS GRIVREVMEM LEEYKRLTTM WGKVKGLKNL EKGNMSALSK
460 470 480 490
NKNSQQLSKV LPAQMLKQIG GMSGLQSLMK QMGSGKDLMG MFGGRDE
Length:497
Mass (Da):55,263
Last modified:July 27, 2011 - v2
Checksum:iA84627610B7B75A2
GO

Sequence cautioni

The sequence AAA66199 differs from that shown. Sequencing errors.Curated
The sequence AAA66199 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12126 Genomic DNA Translation: AAA66199.1 Sequence problems.
AB023033 Genomic DNA Translation: BAB10763.1
CP002688 Genomic DNA Translation: AED95821.1
RefSeqiNP_199761.1, NM_124327.2
UniGeneiAt.29781

Genome annotation databases

EnsemblPlantsiAT5G49500.1; AT5G49500.1; AT5G49500
GeneIDi835010
GrameneiAT5G49500.1; AT5G49500.1; AT5G49500
KEGGiath:AT5G49500

Similar proteinsi

Entry informationi

Entry nameiSR542_ARATH
AccessioniPrimary (citable) accession number: P49966
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health