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Protein

Signal recognition particle 9 kDa protein

Gene

Srp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle 9 kDa protein
Short name:
SRP9
Gene namesi
Name:Srp9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1350930 Srp9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Signal recognition particle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001351831 – 86Signal recognition particle 9 kDa proteinAdd BLAST86

Proteomic databases

EPDiP49962
PaxDbiP49962
PeptideAtlasiP49962
PRIDEiP49962

PTM databases

iPTMnetiP49962
PhosphoSitePlusiP49962
SwissPalmiP49962

Expressioni

Gene expression databases

BgeeiENSMUSG00000026511
CleanExiMM_SRP9
ExpressionAtlasiP49962 baseline and differential
GenevisibleiP49962 MM

Interactioni

Subunit structurei

Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.1 Publication

Protein-protein interaction databases

BioGridi205113, 1 interactor
STRINGi10090.ENSMUSP00000027792

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1914X-ray2.53A1-86[»]
ProteinModelPortaliP49962
SMRiP49962
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49962

Family & Domainsi

Sequence similaritiesi

Belongs to the SRP9 family.Curated

Phylogenomic databases

eggNOGiKOG3465 Eukaryota
ENOG41123E8 LUCA
GeneTreeiENSGT00390000018505
HOGENOMiHOG000283871
HOVERGENiHBG055306
InParanoidiP49962
KOiK03109
OMAiVCLQYKT
OrthoDBiEOG091G15XS
PhylomeDBiP49962
TreeFamiTF106246

Family and domain databases

Gene3Di3.30.720.10, 1 hit
InterProiView protein in InterPro
IPR008832 Signal_recog_particle_SRP9
IPR009018 Signal_recog_particle_SRP9/14
PIRSFiPIRSF017029 Signal_recog_particle_SRP9, 1 hit
SUPFAMiSSF54762 SSF54762, 1 hit

Sequencei

Sequence statusi: Complete.

P49962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQFQTWEEF SRAAEKLYLA DPMKVRVVLK YRHVDGNLCI KVTDDLVCLV
60 70 80
YRTDQAQDVK KIEKFHSQLM RLMVAKESRN VTMETE
Length:86
Mass (Da):10,194
Last modified:January 23, 2007 - v2
Checksum:i655860497132AD2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22P → S in BAB27800 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78304 mRNA Translation: CAA55114.1
AK011720 mRNA Translation: BAB27800.1
AK020583 mRNA Translation: BAB32138.1
AK020620 mRNA Translation: BAB32151.1
BC039648 mRNA Translation: AAH39648.1
CCDSiCCDS35812.1
PIRiS57500
RefSeqiNP_036188.1, NM_012058.3
UniGeneiMm.273196
Mm.303071

Genome annotation databases

EnsembliENSMUST00000027792; ENSMUSP00000027792; ENSMUSG00000026511
GeneIDi27058
KEGGimmu:27058
UCSCiuc007dxu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSRP09_MOUSE
AccessioniPrimary (citable) accession number: P49962
Secondary accession number(s): Q9D085
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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