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Protein

Signal recognition particle 9 kDa protein

Gene

Srp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle 9 kDa protein
Short name:
SRP9
Gene namesi
Name:Srp9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1350930. Srp9.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Signal recognition particle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001351832 – 86Signal recognition particle 9 kDa proteinAdd BLAST85

Proteomic databases

EPDiP49962.
PaxDbiP49962.
PeptideAtlasiP49962.
PRIDEiP49962.

PTM databases

iPTMnetiP49962.
PhosphoSitePlusiP49962.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026511.
CleanExiMM_SRP9.
ExpressionAtlasiP49962. baseline and differential.
GenevisibleiP49962. MM.

Interactioni

Subunit structurei

Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027792.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1914X-ray2.53A1-86[»]
ProteinModelPortaliP49962.
SMRiP49962.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49962.

Family & Domainsi

Sequence similaritiesi

Belongs to the SRP9 family.Curated

Phylogenomic databases

eggNOGiKOG3465. Eukaryota.
ENOG41123E8. LUCA.
GeneTreeiENSGT00390000018505.
HOGENOMiHOG000283871.
HOVERGENiHBG055306.
InParanoidiP49962.
KOiK03109.
OMAiVCLQYKT.
OrthoDBiEOG091G15XS.
PhylomeDBiP49962.
TreeFamiTF106246.

Family and domain databases

InterProiView protein in InterPro
IPR008832. Signal_recog_particle_SRP9.
IPR009018. Signal_recog_particle_SRP9/14.
PIRSFiPIRSF017029. Signal_recog_particle_SRP9. 1 hit.
SUPFAMiSSF54762. SSF54762. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQFQTWEEF SRAAEKLYLA DPMKVRVVLK YRHVDGNLCI KVTDDLVCLV
60 70 80
YRTDQAQDVK KIEKFHSQLM RLMVAKESRN VTMETE
Length:86
Mass (Da):10,194
Last modified:January 23, 2007 - v2
Checksum:i655860497132AD2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22P → S in BAB27800 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78304 mRNA. Translation: CAA55114.1.
AK011720 mRNA. Translation: BAB27800.1.
AK020583 mRNA. Translation: BAB32138.1.
AK020620 mRNA. Translation: BAB32151.1.
BC039648 mRNA. Translation: AAH39648.1.
CCDSiCCDS35812.1.
PIRiS57500.
RefSeqiNP_036188.1. NM_012058.3.
UniGeneiMm.273196.
Mm.303071.

Genome annotation databases

EnsembliENSMUST00000027792; ENSMUSP00000027792; ENSMUSG00000026511.
GeneIDi27058.
KEGGimmu:27058.
UCSCiuc007dxu.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSRP09_MOUSE
AccessioniPrimary (citable) accession number: P49962
Secondary accession number(s): Q9D085
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families