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Protein

Zinc-containing ferredoxin

Gene

zfx

Organism
Acidianus ambivalens (Desulfurolobus ambivalens)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. The 3Fe-4S cluster is reduced by a flavoprotein with NADH oxidase activity from the same organism.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi16ZincBy similarity1
Metal bindingi19ZincBy similarity1
Metal bindingi34ZincBy similarity1
Metal bindingi45Iron-sulfur 1 (3Fe-4S)By similarity1
Metal bindingi51Iron-sulfur 1 (3Fe-4S)By similarity1
Metal bindingi55Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi83Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi86Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi89Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi93Iron-sulfur 1 (3Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-containing ferredoxin
Alternative name(s):
Seven-iron ferredoxin
Gene namesi
Name:zfx
OrganismiAcidianus ambivalens (Desulfurolobus ambivalens)
Taxonomic identifieri2283 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeAcidianus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001591731 – 103Zinc-containing ferredoxinAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29N6-methyllysine; partial1 Publication1
Modified residuei101N6-methyllysine; partial1 Publication1

Post-translational modificationi

Lys-29 was found to be 95% monomethylated and Lys-101 was found to be 10% monomethylated.

Keywords - PTMi

Methylation

Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 9Combined sources4
Beta strandi12 – 16Combined sources5
Beta strandi19 – 23Combined sources5
Turni27 – 29Combined sources3
Beta strandi36 – 41Combined sources6
Turni42 – 44Combined sources3
Helixi50 – 54Combined sources5
Beta strandi61 – 64Combined sources4
Beta strandi72 – 76Combined sources5
Helixi80 – 82Combined sources3
Helixi88 – 92Combined sources5
Beta strandi98 – 100Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VKRX-ray2.01A/B/C/D/E/F/G1-103[»]
ProteinModelPortaliP49949.
SMRiP49949.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49949.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 654Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST29
Domaini74 – 1034Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 36N-terminal extensionAdd BLAST36

Sequence similaritiesi

Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009157. Fd_Zn-bd.
[Graphical view]
PfamiPF13187. Fer4_9. 1 hit.
[Graphical view]
PIRSFiPIRSF000068. Zn_Fdx_Sulfol. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GIDPNYRTSR QVVGEHQGHK VYGPVDPPKV LGIHGTIVGV DFDLCIADGS
60 70 80 90 100
CITACPVNVF QWYDTPGHPA SEKKADPINE QACIFCMACV NVCPVAAIDV

KPP
Length:103
Mass (Da):11,004
Last modified:May 30, 2000 - v2
Checksum:iF2504DB8AAC2DD17
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VKRX-ray2.01A/B/C/D/E/F/G1-103[»]
ProteinModelPortaliP49949.
SMRiP49949.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP49949.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009157. Fd_Zn-bd.
[Graphical view]
PfamiPF13187. Fer4_9. 1 hit.
[Graphical view]
PIRSFiPIRSF000068. Zn_Fdx_Sulfol. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFER_ACIAM
AccessioniPrimary (citable) accession number: P49949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.