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Protein

Zinc-containing ferredoxin

Gene

zfx

Organism
Acidianus ambivalens (Desulfurolobus ambivalens)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. The 3Fe-4S cluster is reduced by a flavoprotein with NADH oxidase activity from the same organism.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi16 – 161ZincBy similarity
Metal bindingi19 – 191ZincBy similarity
Metal bindingi34 – 341ZincBy similarity
Metal bindingi45 – 451Iron-sulfur 1 (3Fe-4S)By similarity
Metal bindingi51 – 511Iron-sulfur 1 (3Fe-4S)By similarity
Metal bindingi55 – 551Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi83 – 831Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi86 – 861Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi89 – 891Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi93 – 931Iron-sulfur 1 (3Fe-4S)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-containing ferredoxin
Alternative name(s):
Seven-iron ferredoxin
Gene namesi
Name:zfx
OrganismiAcidianus ambivalens (Desulfurolobus ambivalens)
Taxonomic identifieri2283 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeAcidianus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 103103Zinc-containing ferredoxinPRO_0000159173Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291N6-methyllysine; partial1 Publication
Modified residuei101 – 1011N6-methyllysine; partial1 Publication

Post-translational modificationi

Lys-29 was found to be 95% monomethylated and Lys-101 was found to be 10% monomethylated.

Keywords - PTMi

Methylation

Structurei

Secondary structure

1
103
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 94Combined sources
Beta strandi12 – 165Combined sources
Beta strandi19 – 235Combined sources
Turni27 – 293Combined sources
Beta strandi36 – 416Combined sources
Turni42 – 443Combined sources
Helixi50 – 545Combined sources
Beta strandi61 – 644Combined sources
Beta strandi72 – 765Combined sources
Helixi80 – 823Combined sources
Helixi88 – 925Combined sources
Beta strandi98 – 1003Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VKRX-ray2.01A/B/C/D/E/F/G1-103[»]
ProteinModelPortaliP49949.
SMRiP49949. Positions 1-103.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49949.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 65294Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini74 – 103304Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3636N-terminal extensionAdd
BLAST

Sequence similaritiesi

Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009157. Fd_Zn-bd.
[Graphical view]
PfamiPF13187. Fer4_9. 1 hit.
[Graphical view]
PIRSFiPIRSF000068. Zn_Fdx_Sulfol. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GIDPNYRTSR QVVGEHQGHK VYGPVDPPKV LGIHGTIVGV DFDLCIADGS
60 70 80 90 100
CITACPVNVF QWYDTPGHPA SEKKADPINE QACIFCMACV NVCPVAAIDV

KPP
Length:103
Mass (Da):11,004
Last modified:May 30, 2000 - v2
Checksum:iF2504DB8AAC2DD17
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VKRX-ray2.01A/B/C/D/E/F/G1-103[»]
ProteinModelPortaliP49949.
SMRiP49949. Positions 1-103.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP49949.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009157. Fd_Zn-bd.
[Graphical view]
PfamiPF13187. Fer4_9. 1 hit.
[Graphical view]
PIRSFiPIRSF000068. Zn_Fdx_Sulfol. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFER_ACIAM
AccessioniPrimary (citable) accession number: P49949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: October 14, 2015
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.