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P49948 (FRIHA_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin heavy chain A

Short name=Ferritin H subunit A
Alternative name(s):
Ferritin heavy chain 2
EC=1.16.3.1
XL2-17
Gene names
Name:fth1-a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited By similarity.

Miscellaneous

There are three types of ferritin subunits in amphibia: L, M and H chains. M and H chains are fast mineralizing; the L chain is very slow mineralizing By similarity.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 176176Ferritin heavy chain A
PRO_0000201078

Regions

Domain7 – 156150Ferritin-like diiron

Sites

Metal binding241Iron 1 By similarity
Metal binding591Iron 1 By similarity
Metal binding591Iron 2 By similarity
Metal binding621Iron 1 By similarity
Metal binding1041Iron 2 By similarity
Metal binding1381Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P49948 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: A3C167469B3F3F74

FASTA17620,526
        10         20         30         40         50         60 
MQSQVRQNFH SDCEAAINRM VNMEMYASYV YLSMSYYFDR DDVALHHVAK FFKEQSHEER 

        70         80         90        100        110        120 
EHAEKFLKYQ NKRGGRVVLQ DIKKPERDEW GNTLEATQAA LQLEKTVNQA LLDLHKLASD 

       130        140        150        160        170 
KVDAHLCDFL ESEYLEEQVK AMKQLGDYIT NLKRLGVPQN GMGEYLFDKH TLGESS 

« Hide

References

[1]"Molecular cloning and expression of ferritin mRNA in heavy metal-poisoned Xenopus laevis cells."
Muller J.-P., Vedel M., Monnot M.-J., Touzet N., Wegnez M.
DNA Cell Biol. 10:571-579(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S64727 mRNA. Translation: AAB20316.1.
RefSeqNP_001084057.1. NM_001090588.1.
UniGeneXl.57150.

3D structure databases

ProteinModelPortalP49948.
SMRP49948. Positions 3-172.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID399281.
KEGGxla:399281.

Organism-specific databases

CTD399281.
XenbaseXB-GENE-5743368. fth1.

Phylogenomic databases

HOVERGENHBG000410.
KOK00522.

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRIHA_XENLA
AccessionPrimary (citable) accession number: P49948
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families