P49948 (FRIHA_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferritin heavy chain A
Short name=Ferritin H subunit A

Alternative name(s):
Ferritin heavy chain 2
EC=1.16.3.1
XL2-17

Gene names

Name:

fth1-a

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.
Catalytic activity	4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
Subunit structure	Oligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited By similarity.
Miscellaneous	There are three types of ferritin subunits in amphibia: L, M and H chains. M and H chains are fast mineralizing; the L chain is very slow mineralizing By similarity.
Sequence similarities	Belongs to the ferritin family. Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
Biological process	Iron storage
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW iron ion transport Inferred from electronic annotation. Source: InterPro
Molecular_function	ferric iron binding Inferred from electronic annotation. Source: InterPro ferroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	Ferritin heavy chain A		PRO_0000201078
Regions
	Domain	7 – 156	150	Ferritin-like diiron
Sites
	Metal binding	24	1	Iron 1 By similarity
	Metal binding	59	1	Iron 1 By similarity
	Metal binding	59	1	Iron 2 By similarity
	Metal binding	62	1	Iron 1 By similarity
	Metal binding	104	1	Iron 2 By similarity
	Metal binding	138	1	Iron 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49948 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: A3C167469B3F3F74	FASTA	176	20,526
	10 20 30 40 50 60 MQSQVRQNFH SDCEAAINRM VNMEMYASYV YLSMSYYFDR DDVALHHVAK FFKEQSHEER 70 80 90 100 110 120 EHAEKFLKYQ NKRGGRVVLQ DIKKPERDEW GNTLEATQAA LQLEKTVNQA LLDLHKLASD 130 140 150 160 170 KVDAHLCDFL ESEYLEEQVK AMKQLGDYIT NLKRLGVPQN GMGEYLFDKH TLGESS

References

[1]	"Molecular cloning and expression of ferritin mRNA in heavy metal-poisoned Xenopus laevis cells." Muller J.-P., Vedel M., Monnot M.-J., Touzet N., Wegnez M. DNA Cell Biol. 10:571-579(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	S64727 mRNA. Translation: AAB20316.1.
RefSeq	NP_001084057.1. NM_001090588.1.
UniGene	Xl.57150.
3D structure databases
ProteinModelPortal	P49948.
SMR	P49948. Positions 3-172.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	399281.
KEGG	xla:399281.
Organism-specific databases
CTD	399281.
Xenbase	XB-GENE-5743368. fth1.
Phylogenomic databases
HOVERGEN	HBG000410.
KO	K00522.
Family and domain databases
Gene3D	1.20.1260.10. 1 hit.
InterPro	IPR001519. Ferritin. IPR009040. Ferritin-like_diiron. IPR009078. Ferritin-like_SF. IPR012347. Ferritin-rel. IPR014034. Ferritin_CS. IPR008331. Ferritin_DPS_dom. [Graphical view]
PANTHER	PTHR11431. PTHR11431. 1 hit.
Pfam	PF00210. Ferritin. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
PROSITE	PS00540. FERRITIN_1. 1 hit. PS00204. FERRITIN_2. 1 hit. PS50905. FERRITIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FRIHA_XENLA

Accession

Primary (citable) accession number: P49948

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program