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P49948

- FRIHA_XENLA

UniProt

P49948 - FRIHA_XENLA

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Protein

Ferritin heavy chain A

Gene
fth1-a
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi24 – 241Iron 1 By similarity
Metal bindingi59 – 591Iron 1 By similarity
Metal bindingi59 – 591Iron 2 By similarity
Metal bindingi62 – 621Iron 1 By similarity
Metal bindingi104 – 1041Iron 2 By similarity
Metal bindingi138 – 1381Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy chain A
Short name:
Ferritin H subunit A
Alternative name(s):
Ferritin heavy chain 2 (EC:1.16.3.1)
XL2-17
Gene namesi
Name:fth1-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5743368. fth1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 176176Ferritin heavy chain APRO_0000201078Add
BLAST

Interactioni

Subunit structurei

Oligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited By similarity.

Structurei

3D structure databases

ProteinModelPortaliP49948.
SMRiP49948. Positions 3-172.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 156150Ferritin-like diironAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.

Phylogenomic databases

HOVERGENiHBG000410.
KOiK00522.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49948-1 [UniParc]FASTAAdd to Basket

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MQSQVRQNFH SDCEAAINRM VNMEMYASYV YLSMSYYFDR DDVALHHVAK    50
FFKEQSHEER EHAEKFLKYQ NKRGGRVVLQ DIKKPERDEW GNTLEATQAA 100
LQLEKTVNQA LLDLHKLASD KVDAHLCDFL ESEYLEEQVK AMKQLGDYIT 150
NLKRLGVPQN GMGEYLFDKH TLGESS 176
Length:176
Mass (Da):20,526
Last modified:October 1, 1996 - v1
Checksum:iA3C167469B3F3F74
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S64727 mRNA. Translation: AAB20316.1.
RefSeqiNP_001084057.1. NM_001090588.1.
UniGeneiXl.57150.

Genome annotation databases

GeneIDi399281.
KEGGixla:399281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S64727 mRNA. Translation: AAB20316.1 .
RefSeqi NP_001084057.1. NM_001090588.1.
UniGenei Xl.57150.

3D structure databases

ProteinModelPortali P49948.
SMRi P49948. Positions 3-172.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399281.
KEGGi xla:399281.

Organism-specific databases

CTDi 399281.
Xenbasei XB-GENE-5743368. fth1.

Phylogenomic databases

HOVERGENi HBG000410.
KOi K00522.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of ferritin mRNA in heavy metal-poisoned Xenopus laevis cells."
    Muller J.-P., Vedel M., Monnot M.-J., Touzet N., Wegnez M.
    DNA Cell Biol. 10:571-579(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFRIHA_XENLA
AccessioniPrimary (citable) accession number: P49948
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are three types of ferritin subunits in amphibia: L, M and H chains. M and H chains are fast mineralizing; the L chain is very slow mineralizing By similarity.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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