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P49947

- FRIM_SALSA

UniProt

P49947 - FRIM_SALSA

Protein

Ferritin, middle subunit

Gene
N/A
Organism
Salmo salar (Atlantic salmon)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi24 – 241Iron 1PROSITE-ProRule annotation
    Metal bindingi59 – 591Iron 1PROSITE-ProRule annotation
    Metal bindingi59 – 591Iron 2PROSITE-ProRule annotation
    Metal bindingi62 – 621Iron 1PROSITE-ProRule annotation
    Metal bindingi104 – 1041Iron 2PROSITE-ProRule annotation
    Metal bindingi138 – 1381Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin, middle subunit (EC:1.16.3.1)
    Short name:
    Ferritin M
    OrganismiSalmo salar (Atlantic salmon)
    Taxonomic identifieri8030 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 176176Ferritin, middle subunitPRO_0000201076Add
    BLAST

    Expressioni

    Tissue specificityi

    Almost exclusively in the gonads.

    Interactioni

    Subunit structurei

    Oligomer of 24 subunits. There are at least two types of subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

    Structurei

    3D structure databases

    ProteinModelPortaliP49947.
    SMRiP49947. Positions 3-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 156150Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG000410.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49947-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESQIRQNYH HDCERAINRM INMEMFASYT YTSMAFYFSR DDVALPGFAH    50
    FFKENSEEER EHADKLLSFQ NKRGGRILLQ DIKKPERDEW GNGLEAMQCA 100
    LQLEKNVNQA LLDLHKIASD KVDPHLCDFL ETHYLNEQVE AIKKLGDHIT 150
    NLTKMDAVKN KMAEYLFDKH TLGGQS 176
    Length:176
    Mass (Da):20,528
    Last modified:October 1, 1996 - v1
    Checksum:i27E8CDC3808F28DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S77386 mRNA. Translation: AAB34576.1.
    RefSeqiNP_001117130.1. NM_001123658.1.
    UniGeneiSsa.23668.

    Genome annotation databases

    GeneIDi100136565.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S77386 mRNA. Translation: AAB34576.1 .
    RefSeqi NP_001117130.1. NM_001123658.1.
    UniGenei Ssa.23668.

    3D structure databases

    ProteinModelPortali P49947.
    SMRi P49947. Positions 3-172.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100136565.

    Phylogenomic databases

    HOVERGENi HBG000410.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two ferritin subunits of Atlantic salmon (Salmo salar): cloning of the liver cDNAs and antibody preparation."
      Andersen O., Dehli A., Standal H., Giskegjerde T.A., Karstensen R., Roervik K.A.
      Mol. Mar. Biol. Biotechnol. 4:164-170(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiFRIM_SALSA
    AccessioniPrimary (citable) accession number: P49947
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3