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P49946

- FRIH_SALSA

UniProt

P49946 - FRIH_SALSA

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Protein

Ferritin, heavy subunit

Gene
N/A
Organism
Salmo salar (Atlantic salmon)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi24 – 241Iron 1PROSITE-ProRule annotation
Metal bindingi59 – 591Iron 1PROSITE-ProRule annotation
Metal bindingi59 – 591Iron 2PROSITE-ProRule annotation
Metal bindingi62 – 621Iron 1PROSITE-ProRule annotation
Metal bindingi104 – 1041Iron 2PROSITE-ProRule annotation
Metal bindingi138 – 1381Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin, heavy subunit (EC:1.16.3.1)
Short name:
Ferritin H
OrganismiSalmo salar (Atlantic salmon)
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Ferritin, heavy subunitPRO_0000201075Add
BLAST

Expressioni

Tissue specificityi

Liver, gonads, head kidney, heart and spleen.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are at least two types of subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Structurei

3D structure databases

ProteinModelPortaliP49946.
SMRiP49946. Positions 2-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 156150Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG000410.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49946-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSQVRQNFH QDCEAAINRQ INLELYASYV YLSMAYYFDR DDQALHNFAK
60 70 80 90 100
FFKNQSHEER EHAEKLMKVQ NQRGGRIFLQ DVKKPEKDEW GSGVEALESS
110 120 130 140 150
LQLEKSVNQS LLDLHKVCSE HNDPHMCDFI ETHYLDEQVK SIKELGDWVT
160 170
NLRRMGAPQN GMAEYLFDKH TLGKEST
Length:177
Mass (Da):20,730
Last modified:October 1, 1996 - v1
Checksum:i09CDBCE719ADA6F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S77332 mRNA. Translation: AAB34575.1.
RefSeqiNP_001117129.1. NM_001123657.1.
UniGeneiSsa.418.

Genome annotation databases

GeneIDi100136564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S77332 mRNA. Translation: AAB34575.1 .
RefSeqi NP_001117129.1. NM_001123657.1.
UniGenei Ssa.418.

3D structure databases

ProteinModelPortali P49946.
SMRi P49946. Positions 2-173.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100136564.

Phylogenomic databases

HOVERGENi HBG000410.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two ferritin subunits of Atlantic salmon (Salmo salar): cloning of the liver cDNAs and antibody preparation."
    Andersen O., Dehli A., Standal H., Giskegjerde T.A., Karstensen R., Roervik K.A.
    Mol. Mar. Biol. Biotechnol. 4:164-170(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiFRIH_SALSA
AccessioniPrimary (citable) accession number: P49946
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3