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P49944

- BFR_BRUME

UniProt

P49944 - BFR_BRUME

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Protein
Bacterioferritin
Gene
bfr, BMEII0704
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.
Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181Iron 1 By similarity
Metal bindingi51 – 511Iron 1 By similarity
Metal bindingi51 – 511Iron 2 By similarity
Metal bindingi52 – 521Iron (heme axial ligand); shared with dimeric partner By similarity
Metal bindingi54 – 541Iron 1 By similarity
Metal bindingi94 – 941Iron 2 By similarity
Metal bindingi127 – 1271Iron 1 By similarity
Metal bindingi127 – 1271Iron 2 By similarity
Metal bindingi130 – 1301Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-4193-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterioferritin (EC:1.16.3.1)
Short name:
BFR
Gene namesi
Name:bfr
Ordered Locus Names:BMEII0704
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Bacterioferritin
PRO_0000192589Add
BLAST

Interactioni

Subunit structurei

Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited By similarity.

Protein-protein interaction databases

STRINGi224914.BMEII0704.

Structurei

3D structure databases

ProteinModelPortaliP49944.
SMRiP49944. Positions 1-160.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 145145Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Belongs to the bacterioferritin family.

Phylogenomic databases

HOGENOMiHOG000262383.
KOiK03594.
OMAiAGDYVSM.
OrthoDBiEOG6WDSKP.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF002560. Bacterioferritin. 1 hit.
PRINTSiPR00601. BACFERRITIN.
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR00754. bfr. 1 hit.
PROSITEiPS00549. BACTERIOFERRITIN. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49944-1 [UniParc]FASTAAdd to Basket

« Hide

MKGEPKVIER LNDALFLELG AVNQYWLHYR LLNDWGYTRL AKKEREESIE    50
EMHHADKLIN RIIFFEGFPN LQTVSPLRIG QNVKEVLEAD LKGEYDARAS 100
YKESREICDK LGDYVSKQLF DELLADEEGH IDFLETQLDL LAKIGEERYG 150
QLNAAPADEA E 161
Length:161
Mass (Da):18,659
Last modified:October 1, 1996 - v1
Checksum:i5A92C1759B68BD1B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19760 Genomic DNA. Translation: AAC43322.1.
AE008918 Genomic DNA. Translation: AAL53946.1.
PIRiAG3597.
S68771.
RefSeqiNP_541682.1. NC_003318.1.

Genome annotation databases

EnsemblBacteriaiAAL53946; AAL53946; BMEII0704.
GeneIDi1198476.
KEGGibme:BMEII0704.
PATRICi17799658. VBIBruMel146950_2166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19760 Genomic DNA. Translation: AAC43322.1 .
AE008918 Genomic DNA. Translation: AAL53946.1 .
PIRi AG3597.
S68771.
RefSeqi NP_541682.1. NC_003318.1.

3D structure databases

ProteinModelPortali P49944.
SMRi P49944. Positions 1-160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEII0704.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL53946 ; AAL53946 ; BMEII0704 .
GeneIDi 1198476.
KEGGi bme:BMEII0704.
PATRICi 17799658. VBIBruMel146950_2166.

Phylogenomic databases

HOGENOMi HOG000262383.
KOi K03594.
OMAi AGDYVSM.
OrthoDBi EOG6WDSKP.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-4193-MONOMER.

Miscellaneous databases

PROi P49944.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002560. Bacterioferritin. 1 hit.
PRINTSi PR00601. BACFERRITIN.
SUPFAMi SSF47240. SSF47240. 1 hit.
TIGRFAMsi TIGR00754. bfr. 1 hit.
PROSITEi PS00549. BACTERIOFERRITIN. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of the bacterioferritin gene of Brucella melitensis 16M strain."
    Denoel P.A., Zygmunt M.S., Weynants V.E., Tibor A., Lichtfouse B., Briffeuil P., Limet J.N., Letesson J.J.
    FEBS Lett. 361:238-242(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiBFR_BRUME
AccessioniPrimary (citable) accession number: P49944
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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