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P49944

- BFR_BRUME

UniProt

P49944 - BFR_BRUME

Protein

Bacterioferritin

Gene

bfr

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex.By similarity

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Cofactori

    Binds 1 heme B (iron-protoporphyrin IX) group per dimer.By similarity
    Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi18 – 181Iron 1PROSITE-ProRule annotation
    Metal bindingi51 – 511Iron 1PROSITE-ProRule annotation
    Metal bindingi51 – 511Iron 2PROSITE-ProRule annotation
    Metal bindingi52 – 521Iron (heme axial ligand); shared with dimeric partnerPROSITE-ProRule annotation
    Metal bindingi54 – 541Iron 1PROSITE-ProRule annotation
    Metal bindingi94 – 941Iron 2PROSITE-ProRule annotation
    Metal bindingi127 – 1271Iron 1PROSITE-ProRule annotation
    Metal bindingi127 – 1271Iron 2PROSITE-ProRule annotation
    Metal bindingi130 – 1301Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-4193-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bacterioferritin (EC:1.16.3.1)
    Short name:
    BFR
    Gene namesi
    Name:bfr
    Ordered Locus Names:BMEII0704
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161BacterioferritinPRO_0000192589Add
    BLAST

    Interactioni

    Subunit structurei

    Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.By similarity

    Protein-protein interaction databases

    STRINGi224914.BMEII0704.

    Structurei

    3D structure databases

    ProteinModelPortaliP49944.
    SMRiP49944. Positions 1-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 145145Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bacterioferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000262383.
    KOiK03594.
    OMAiAGDYVSM.
    OrthoDBiEOG6WDSKP.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR002024. Bacterioferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002560. Bacterioferritin. 1 hit.
    PRINTSiPR00601. BACFERRITIN.
    SUPFAMiSSF47240. SSF47240. 1 hit.
    TIGRFAMsiTIGR00754. bfr. 1 hit.
    PROSITEiPS00549. BACTERIOFERRITIN. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49944-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGEPKVIER LNDALFLELG AVNQYWLHYR LLNDWGYTRL AKKEREESIE    50
    EMHHADKLIN RIIFFEGFPN LQTVSPLRIG QNVKEVLEAD LKGEYDARAS 100
    YKESREICDK LGDYVSKQLF DELLADEEGH IDFLETQLDL LAKIGEERYG 150
    QLNAAPADEA E 161
    Length:161
    Mass (Da):18,659
    Last modified:October 1, 1996 - v1
    Checksum:i5A92C1759B68BD1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19760 Genomic DNA. Translation: AAC43322.1.
    AE008918 Genomic DNA. Translation: AAL53946.1.
    PIRiAG3597.
    S68771.
    RefSeqiNP_541682.1. NC_003318.1.

    Genome annotation databases

    EnsemblBacteriaiAAL53946; AAL53946; BMEII0704.
    GeneIDi1198476.
    KEGGibme:BMEII0704.
    PATRICi17799658. VBIBruMel146950_2166.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19760 Genomic DNA. Translation: AAC43322.1 .
    AE008918 Genomic DNA. Translation: AAL53946.1 .
    PIRi AG3597.
    S68771.
    RefSeqi NP_541682.1. NC_003318.1.

    3D structure databases

    ProteinModelPortali P49944.
    SMRi P49944. Positions 1-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEII0704.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL53946 ; AAL53946 ; BMEII0704 .
    GeneIDi 1198476.
    KEGGi bme:BMEII0704.
    PATRICi 17799658. VBIBruMel146950_2166.

    Phylogenomic databases

    HOGENOMi HOG000262383.
    KOi K03594.
    OMAi AGDYVSM.
    OrthoDBi EOG6WDSKP.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-4193-MONOMER.

    Miscellaneous databases

    PROi P49944.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR002024. Bacterioferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002560. Bacterioferritin. 1 hit.
    PRINTSi PR00601. BACFERRITIN.
    SUPFAMi SSF47240. SSF47240. 1 hit.
    TIGRFAMsi TIGR00754. bfr. 1 hit.
    PROSITEi PS00549. BACTERIOFERRITIN. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the bacterioferritin gene of Brucella melitensis 16M strain."
      Denoel P.A., Zygmunt M.S., Weynants V.E., Tibor A., Lichtfouse B., Briffeuil P., Limet J.N., Letesson J.J.
      FEBS Lett. 361:238-242(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiBFR_BRUME
    AccessioniPrimary (citable) accession number: P49944
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3