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Protein

Antibacterial peptide PMAP-36

Gene

PMAP36

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Exerts antimicrobial activity against both Gram-positive and negative bacteria. Its activity appears to be mediated by its ability to damage bacterial membranes.

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Antibacterial peptide PMAP-36
Alternative name(s):
Myeloid antibacterial peptide 36
Gene namesi
Name:PMAP36
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000000473430 – 129Sequence analysisAdd BLAST100
PeptideiPRO_0000004735130 – 166Antibacterial peptide PMAP-36Add BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi85 ↔ 96By similarity
Disulfide bondi107 ↔ 124By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PeptideAtlasiP49931.
PRIDEiP49931.

Structurei

3D structure databases

ProteinModelPortaliP49931.
SMRiP49931.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006116.
InParanoidiP49931.
KOiK13916.

Family and domain databases

InterProiView protein in InterPro
IPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
PANTHERiPTHR10206. PTHR10206. 1 hit.
PROSITEiView protein in PROSITE
PS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQRASLCL GRWSLWLLLL GLVVPSASAQ ALSYREAVLR AVDRLNEQSS
60 70 80 90 100
EANLYRLLEL DQPPKADEDP GTPKPVSFTV KETVCPRPTW RPPELCDFKE
110 120 130 140 150
NGRVKQCVGT VTLNPSNDPL DINCDEIQSV GRFRRLRKKT RKRLKKIGKV
160
LKWIPPIVGS IPLGCG
Length:166
Mass (Da):18,647
Last modified:October 1, 1996 - v1
Checksum:i94B13C69709DA64B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29125 mRNA. Translation: AAA31070.1.
PIRiS41731.
RefSeqiNP_001123437.1. NM_001129965.1.
UniGeneiSsc.420.

Genome annotation databases

GeneIDi100170124.
KEGGissc:100170124.

Similar proteinsi

Entry informationi

Entry nameiPMP36_PIG
AccessioniPrimary (citable) accession number: P49931
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 30, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families