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Protein

Antibacterial peptide PMAP-36

Gene

PMAP36

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Exerts antimicrobial activity against both Gram-positive and negative bacteria. Its activity appears to be mediated by its ability to damage bacterial membranes.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Antibacterial peptide PMAP-36
Alternative name(s):
Myeloid antibacterial peptide 36
Gene namesi
Name:PMAP36
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Propeptidei30 – 129100Sequence analysisPRO_0000004734Add
BLAST
Peptidei130 – 16637Antibacterial peptide PMAP-36PRO_0000004735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301Pyrrolidone carboxylic acidBy similarity
Disulfide bondi85 ↔ 96By similarity
Disulfide bondi107 ↔ 124By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Structurei

3D structure databases

ProteinModelPortaliP49931.
SMRiP49931. Positions 30-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006116.
InParanoidiP49931.
KOiK13916.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQRASLCL GRWSLWLLLL GLVVPSASAQ ALSYREAVLR AVDRLNEQSS
60 70 80 90 100
EANLYRLLEL DQPPKADEDP GTPKPVSFTV KETVCPRPTW RPPELCDFKE
110 120 130 140 150
NGRVKQCVGT VTLNPSNDPL DINCDEIQSV GRFRRLRKKT RKRLKKIGKV
160
LKWIPPIVGS IPLGCG
Length:166
Mass (Da):18,647
Last modified:October 1, 1996 - v1
Checksum:i94B13C69709DA64B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29125 mRNA. Translation: AAA31070.1.
PIRiS41731.
RefSeqiNP_001123437.1. NM_001129965.1.
UniGeneiSsc.420.

Genome annotation databases

GeneIDi100170124.
KEGGissc:100170124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29125 mRNA. Translation: AAA31070.1.
PIRiS41731.
RefSeqiNP_001123437.1. NM_001129965.1.
UniGeneiSsc.420.

3D structure databases

ProteinModelPortaliP49931.
SMRiP49931. Positions 30-130.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100170124.
KEGGissc:100170124.

Organism-specific databases

CTDi100170124.

Phylogenomic databases

HOVERGENiHBG006116.
InParanoidiP49931.
KOiK13916.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Chemical synthesis and biological activity of a novel antibacterial peptide deduced from a pig myeloid cDNA."
    Storici P., Scocchi M., Tossi A., Gennaro R., Zanetti M.
    FEBS Lett. 337:303-307(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 130-166.
    Tissue: Bone marrow.

Entry informationi

Entry nameiPMP36_PIG
AccessioniPrimary (citable) accession number: P49931
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.