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Protein

Antibacterial peptide PMAP-23

Gene

PMAP23

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exerts antimicrobial activity against both Gram-positive and negative bacteria at concentrations of 2-16 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes.

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Antibacterial peptide PMAP-23
Alternative name(s):
Myeloid antibacterial peptide 23
Gene namesi
Name:PMAP23
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000000473230 – 130Sequence analysisAdd BLAST101
PeptideiPRO_0000004733131 – 153Antibacterial peptide PMAP-23Add BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi85 ↔ 96By similarity
Disulfide bondi107 ↔ 124By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP49930.
PeptideAtlasiP49930.
PRIDEiP49930.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025756.

Structurei

3D structure databases

ProteinModelPortaliP49930.
SMRiP49930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
HOVERGENiHBG006116.
InParanoidiP49930.

Family and domain databases

InterProiView protein in InterPro
IPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
PANTHERiPTHR10206. PTHR10206. 1 hit.
PROSITEiView protein in PROSITE
PS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQRASLCL GRWSLWLLLL GLVVPSASAQ ALSYREAVLR AVDRLNEQSS
60 70 80 90 100
EANLYRLLEL DQPPKADEDP GTPKPVSFTV KETVCPRPTR QPPELCDFKE
110 120 130 140 150
NGRVKQCVGT VTLKEIRGNF DITCNQLQSV RIIDLLWRVR RPQKPKFVTV

WVR
Length:153
Mass (Da):17,486
Last modified:October 1, 1996 - v1
Checksum:i7ADAA22B6C206000
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26053 mRNA. Translation: AAA31103.1.
Y16624 Genomic DNA. Translation: CAA76328.1.
PIRiA53421.
RefSeqiNP_001123448.1. NM_001129976.1.
UniGeneiSsc.420.

Genome annotation databases

GeneIDi100170138.
KEGGissc:100170138.

Similar proteinsi

Entry informationi

Entry nameiPMP23_PIG
AccessioniPrimary (citable) accession number: P49930
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 30, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome