ID   CDN1C_MOUSE             Reviewed;         348 AA.
AC   P49919; G3UW61;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   24-JAN-2024, entry version 155.
DE   RecName: Full=Cyclin-dependent kinase inhibitor 1C;
DE   AltName: Full=Cyclin-dependent kinase inhibitor p57;
DE   AltName: Full=p57Kip2;
GN   Name=Cdkn1c; Synonyms=Kip2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=7729683; DOI=10.1101/gad.9.6.639;
RA   Lee M.-H., Reynisdottir I., Massague J.;
RT   "Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain
RT   structure and tissue distribution.";
RL   Genes Dev. 9:639-649(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 14-348.
RX   PubMed=7729684; DOI=10.1101/gad.9.6.650;
RA   Matsuoka S., Edwards M.C., Bai C., Parker S., Zhang P., Baldini A.,
RA   Harper J.W., Elledge S.J.;
RT   "p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor
RT   family, is a candidate tumor suppressor gene.";
RL   Genes Dev. 9:650-662(1995).
RN   [5]
RP   METHYLATION [LARGE SCALE ANALYSIS] AT ARG-109, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Embryo;
RX   PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA   Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA   Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA   Bedford M.T., Comb M.J.;
RT   "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT   methylation.";
RL   Mol. Cell. Proteomics 13:372-387(2014).
CC   -!- FUNCTION: Potent tight-binding inhibitor of several G1 cyclin/CDK
CC       complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to
CC       lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell
CC       proliferation. May play a role in maintenance of the non-proliferative
CC       state throughout life.
CC   -!- SUBUNIT: Interacts with PCNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=KIP2a; Synonyms=p57a;
CC         IsoId=P49919-1; Sequence=Displayed;
CC       Name=KIP2b; Synonyms=p57b;
CC         IsoId=P49919-2; Sequence=VSP_000868;
CC   -!- TISSUE SPECIFICITY: Expressed in the heart, brain, lung, skeletal
CC       muscle, kidney, pancreas and testis. High levels are seen in the
CC       placenta while low levels are seen in the liver.
CC   -!- SIMILARITY: Belongs to the CDI family. {ECO:0000305}.
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DR   EMBL; U20553; AAC52186.1; -; mRNA.
DR   EMBL; AC023248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466531; EDL18208.1; -; Genomic_DNA.
DR   EMBL; U22399; AAA85096.1; -; mRNA.
DR   CCDS; CCDS22040.1; -. [P49919-2]
DR   CCDS; CCDS52463.1; -. [P49919-1]
DR   PIR; I49262; I49262.
DR   RefSeq; NP_001155096.1; NM_001161624.1. [P49919-1]
DR   RefSeq; NP_034006.3; NM_009876.4. [P49919-2]
DR   RefSeq; XP_006508534.1; XM_006508471.3.
DR   AlphaFoldDB; P49919; -.
DR   BioGRID; 198653; 2.
DR   ELM; P49919; -.
DR   STRING; 10090.ENSMUSP00000128828; -.
DR   iPTMnet; P49919; -.
DR   PhosphoSitePlus; P49919; -.
DR   MaxQB; P49919; -.
DR   PaxDb; 10090-ENSMUSP00000128828; -.
DR   PeptideAtlas; P49919; -.
DR   ProteomicsDB; 281356; -. [P49919-1]
DR   ProteomicsDB; 281357; -. [P49919-2]
DR   Antibodypedia; 972; 1300 antibodies from 41 providers.
DR   DNASU; 12577; -.
DR   Ensembl; ENSMUST00000037287.8; ENSMUSP00000037302.7; ENSMUSG00000037664.14. [P49919-2]
DR   Ensembl; ENSMUST00000167912.9; ENSMUSP00000128828.2; ENSMUSG00000037664.14. [P49919-1]
DR   GeneID; 12577; -.
DR   KEGG; mmu:12577; -.
DR   UCSC; uc009kpd.2; mouse. [P49919-1]
DR   AGR; MGI:104564; -.
DR   CTD; 1028; -.
DR   MGI; MGI:104564; Cdkn1c.
DR   VEuPathDB; HostDB:ENSMUSG00000037664; -.
DR   eggNOG; KOG4743; Eukaryota.
DR   GeneTree; ENSGT00940000162677; -.
DR   HOGENOM; CLU_077692_0_0_1; -.
DR   InParanoid; P49919; -.
DR   OrthoDB; 2900553at2759; -.
DR   TreeFam; TF101111; -.
DR   Reactome; R-MMU-69231; Cyclin D associated events in G1.
DR   BioGRID-ORCS; 12577; 0 hits in 78 CRISPR screens.
DR   ChiTaRS; Cdkn1c; mouse.
DR   PRO; PR:P49919; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; P49919; Protein.
DR   Bgee; ENSMUSG00000037664; Expressed in humerus cartilage element and 266 other cell types or tissues.
DR   ExpressionAtlas; P49919; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:InterPro.
DR   GO; GO:0140678; F:molecular function inhibitor activity; ISO:MGI.
DR   GO; GO:0004860; F:protein kinase inhibitor activity; ISO:MGI.
DR   GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR   GO; GO:0030325; P:adrenal gland development; IMP:MGI.
DR   GO; GO:0043010; P:camera-type eye development; IMP:MGI.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0055123; P:digestive system development; IMP:MGI.
DR   GO; GO:0060669; P:embryonic placenta morphogenesis; IMP:MGI.
DR   GO; GO:0071514; P:genomic imprinting; IMP:MGI.
DR   GO; GO:0001822; P:kidney development; IMP:MGI.
DR   GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
DR   GO; GO:0030099; P:myeloid cell differentiation; IGI:MGI.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISO:MGI.
DR   GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:MGI.
DR   GO; GO:0045930; P:negative regulation of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0042326; P:negative regulation of phosphorylation; IDA:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:MGI.
DR   GO; GO:0042551; P:neuron maturation; IMP:MGI.
DR   GO; GO:0001890; P:placenta development; IMP:MGI.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISO:MGI.
DR   GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; ISO:MGI.
DR   GO; GO:0007096; P:regulation of exit from mitosis; IGI:MGI.
DR   GO; GO:1902746; P:regulation of lens fiber cell differentiation; IGI:MGI.
DR   GO; GO:0001501; P:skeletal system development; IMP:MGI.
DR   GO; GO:0060065; P:uterus development; IMP:MGI.
DR   Gene3D; 4.10.365.10; p27; 1.
DR   InterPro; IPR003175; CDI_dom.
DR   InterPro; IPR044898; CDI_dom_sf.
DR   PANTHER; PTHR10265; CYCLIN-DEPENDENT KINASE INHIBITOR 1; 1.
DR   PANTHER; PTHR10265:SF44; CYCLIN-DEPENDENT KINASE INHIBITOR 1C; 1.
DR   Pfam; PF02234; CDI; 1.
DR   Genevisible; P49919; MM.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell cycle; Methylation; Nucleus;
KW   Protein kinase inhibitor; Reference proteome.
FT   CHAIN           1..348
FT                   /note="Cyclin-dependent kinase inhibitor 1C"
FT                   /id="PRO_0000190088"
FT   REGION          115..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           309..312
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        146..160
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        231..270
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         109
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0007744|PubMed:24129315"
FT   VAR_SEQ         1..13
FT                   /note="Missing (in isoform KIP2b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_000868"
FT   CONFLICT        150..151
FT                   /note="EP -> DA (in Ref. 1; AAC52186)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   348 AA;  37372 MW;  100032B2F76BEC92 CRC64;
     MGMSDVYLRS RTAMERLASS DTFPVIARSS ACRSLFGPVD HEELGRELRM RLAELNAEDQ
     NRWDFNFQQD VPLRGPGRLQ WMEVDSESVP AFYRETVQVG RCRLQLGPRP PPVAVAVIPR
     SGPPAGEAPD GLEEAPEQPP SAPASAVVAE PTPPATPAPA SDLTSDPIPE VTLVATSDPT
     PDPIPDANPD VATRDGEEQV PEQVSEQGEE SGAEPGDELG TEPVSEQGEE QGAEPVEEKD
     EEPEEEQGAE PVEEQGAEPV EEQNGEPVEE QDENQEQRGQ ELKDQPLSGI PGRPAPGTAA
     ANANDFFAKR KRTAQENKAS NDVPPGCPSP NVAPGVGAVE QTPRKRLR
//