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P49919

- CDN1C_MOUSE

UniProt

P49919 - CDN1C_MOUSE

Protein

Cyclin-dependent kinase inhibitor 1C

Gene

Cdkn1c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: InterPro
    2. protein binding Source: MGI

    GO - Biological processi

    1. adrenal gland development Source: MGI
    2. aging Source: MGI
    3. camera-type eye development Source: MGI
    4. cell cycle arrest Source: InterPro
    5. digestive system development Source: MGI
    6. embryonic placenta morphogenesis Source: MGI
    7. genetic imprinting Source: MGI
    8. kidney development Source: MGI
    9. multicellular organism growth Source: MGI
    10. myeloid cell differentiation Source: MGI
    11. negative regulation of epithelial cell proliferation Source: Ensembl
    12. negative regulation of phosphorylation Source: UniProtKB
    13. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    14. neuron maturation Source: MGI
    15. placenta development Source: MGI
    16. positive regulation of transcription, DNA-templated Source: Ensembl
    17. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    18. skeletal system development Source: MGI
    19. uterus development Source: MGI

    Keywords - Molecular functioni

    Protein kinase inhibitor

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase inhibitor 1C
    Alternative name(s):
    Cyclin-dependent kinase inhibitor p57
    p57Kip2
    Gene namesi
    Name:Cdkn1c
    Synonyms:Kip2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:104564. Cdkn1c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Cyclin-dependent kinase inhibitor 1CPRO_0000190088Add
    BLAST

    Proteomic databases

    PaxDbiP49919.
    PRIDEiP49919.

    PTM databases

    PhosphoSiteiP49919.

    Expressioni

    Tissue specificityi

    Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.

    Gene expression databases

    ArrayExpressiP49919.
    CleanExiMM_CDKN1C.
    GenevestigatoriP49919.

    Interactioni

    Subunit structurei

    Interacts with PCNA.By similarity

    Protein-protein interaction databases

    BioGridi198653. 1 interaction.
    IntActiP49919. 1 interaction.
    MINTiMINT-4090541.
    STRINGi10090.ENSMUSP00000037302.

    Structurei

    3D structure databases

    ProteinModelPortaliP49919.
    SMRiP49919. Positions 28-93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi309 – 3124Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi108 – 18982Pro-richAdd
    BLAST
    Compositional biasi178 – 284107Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the CDI family.Curated

    Phylogenomic databases

    eggNOGiNOG245842.
    GeneTreeiENSGT00530000063588.
    HOGENOMiHOG000294081.
    HOVERGENiHBG107407.
    InParanoidiP49919.
    KOiK09993.
    OMAiEQGANQG.
    OrthoDBiEOG7GJ6HD.
    TreeFamiTF101111.

    Family and domain databases

    InterProiIPR003175. CDI.
    [Graphical view]
    PANTHERiPTHR10265. PTHR10265. 1 hit.
    PfamiPF02234. CDI. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform KIP2a (identifier: P49919-1) [UniParc]FASTAAdd to Basket

    Also known as: p57a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGMSDVYLRS RTAMERLASS DTFPVIARSS ACRSLFGPVD HEELGRELRM    50
    RLAELNAEDQ NRWDFNFQQD VPLRGPGRLQ WMEVDSESVP AFYRETVQVG 100
    RCRLQLGPRP PPVAVAVIPR SGPPAGEAPD GLEEAPEQPP SAPASAVVAE 150
    PTPPATPAPA SDLTSDPIPE VTLVATSDPT PDPIPDANPD VATRDGEEQV 200
    PEQVSEQGEE SGAEPGDELG TEPVSEQGEE QGAEPVEEKD EEPEEEQGAE 250
    PVEEQGAEPV EEQNGEPVEE QDENQEQRGQ ELKDQPLSGI PGRPAPGTAA 300
    ANANDFFAKR KRTAQENKAS NDVPPGCPSP NVAPGVGAVE QTPRKRLR 348
    Length:348
    Mass (Da):37,372
    Last modified:October 3, 2012 - v2
    Checksum:i100032B2F76BEC92
    GO
    Isoform KIP2b (identifier: P49919-2) [UniParc]FASTAAdd to Basket

    Also known as: p57b

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: Missing.

    Show »
    Length:335
    Mass (Da):35,903
    Checksum:iE5C40675287FEB3F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti150 – 1512EP → DA in AAC52186. (PubMed:7729683)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1313Missing in isoform KIP2b. CuratedVSP_000868Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20553 mRNA. Translation: AAC52186.1.
    AC023248 Genomic DNA. No translation available.
    CH466531 Genomic DNA. Translation: EDL18208.1.
    U22399 mRNA. Translation: AAA85096.1.
    CCDSiCCDS22040.1. [P49919-2]
    CCDS52463.1. [P49919-1]
    PIRiI49262.
    RefSeqiNP_001155096.1. NM_001161624.1. [P49919-1]
    NP_034006.3. NM_009876.4. [P49919-2]
    XP_006508534.1. XM_006508471.1. [P49919-2]
    UniGeneiMm.168789.

    Genome annotation databases

    EnsembliENSMUST00000037287; ENSMUSP00000037302; ENSMUSG00000037664. [P49919-2]
    ENSMUST00000167912; ENSMUSP00000128828; ENSMUSG00000037664. [P49919-1]
    GeneIDi12577.
    KEGGimmu:12577.
    UCSCiuc009kpe.2. mouse.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20553 mRNA. Translation: AAC52186.1 .
    AC023248 Genomic DNA. No translation available.
    CH466531 Genomic DNA. Translation: EDL18208.1 .
    U22399 mRNA. Translation: AAA85096.1 .
    CCDSi CCDS22040.1. [P49919-2 ]
    CCDS52463.1. [P49919-1 ]
    PIRi I49262.
    RefSeqi NP_001155096.1. NM_001161624.1. [P49919-1 ]
    NP_034006.3. NM_009876.4. [P49919-2 ]
    XP_006508534.1. XM_006508471.1. [P49919-2 ]
    UniGenei Mm.168789.

    3D structure databases

    ProteinModelPortali P49919.
    SMRi P49919. Positions 28-93.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198653. 1 interaction.
    IntActi P49919. 1 interaction.
    MINTi MINT-4090541.
    STRINGi 10090.ENSMUSP00000037302.

    PTM databases

    PhosphoSitei P49919.

    Proteomic databases

    PaxDbi P49919.
    PRIDEi P49919.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037287 ; ENSMUSP00000037302 ; ENSMUSG00000037664 . [P49919-2 ]
    ENSMUST00000167912 ; ENSMUSP00000128828 ; ENSMUSG00000037664 . [P49919-1 ]
    GeneIDi 12577.
    KEGGi mmu:12577.
    UCSCi uc009kpe.2. mouse.

    Organism-specific databases

    CTDi 1028.
    MGIi MGI:104564. Cdkn1c.

    Phylogenomic databases

    eggNOGi NOG245842.
    GeneTreei ENSGT00530000063588.
    HOGENOMi HOG000294081.
    HOVERGENi HBG107407.
    InParanoidi P49919.
    KOi K09993.
    OMAi EQGANQG.
    OrthoDBi EOG7GJ6HD.
    TreeFami TF101111.

    Miscellaneous databases

    NextBioi 281694.
    PROi P49919.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49919.
    CleanExi MM_CDKN1C.
    Genevestigatori P49919.

    Family and domain databases

    InterProi IPR003175. CDI.
    [Graphical view ]
    PANTHERi PTHR10265. PTHR10265. 1 hit.
    Pfami PF02234. CDI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution."
      Lee M.-H., Reynisdottir I., Massague J.
      Genes Dev. 9:639-649(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene."
      Matsuoka S., Edwards M.C., Bai C., Parker S., Zhang P., Baldini A., Harper J.W., Elledge S.J.
      Genes Dev. 9:650-662(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-348.

    Entry informationi

    Entry nameiCDN1C_MOUSE
    AccessioniPrimary (citable) accession number: P49919
    Secondary accession number(s): G3UW61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3