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P49919 (CDN1C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase inhibitor 1C
Alternative name(s):
Cyclin-dependent kinase inhibitor p57
p57Kip2
Gene names
Name:Cdkn1c
Synonyms:Kip2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

Subunit structure

Interacts with PCNA By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.

Sequence similarities

Belongs to the CDI family.

Ontologies

Keywords
   Biological processCell cycle
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   Molecular functionProtein kinase inhibitor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadrenal gland development

Inferred from mutant phenotype PubMed 19276117. Source: MGI

aging

Inferred from mutant phenotype PubMed 19276117. Source: MGI

camera-type eye development

Inferred from mutant phenotype PubMed 19276117. Source: MGI

cell cycle arrest

Inferred from electronic annotation. Source: InterPro

digestive system development

Inferred from mutant phenotype PubMed 19276117. Source: MGI

embryonic placenta morphogenesis

Inferred from mutant phenotype PubMed 19276117. Source: MGI

genetic imprinting

Inferred from mutant phenotype PubMed 19276117. Source: MGI

kidney development

Inferred from mutant phenotype PubMed 19276117. Source: MGI

multicellular organism growth

Inferred from mutant phenotype PubMed 19276117. Source: MGI

myeloid cell differentiation

Inferred from genetic interaction PubMed 15889154. Source: MGI

negative regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of phosphorylation

Inferred from direct assay PubMed 19170105. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 14671317. Source: MGI

neuron maturation

Inferred from mutant phenotype PubMed 14671317. Source: MGI

placenta development

Inferred from mutant phenotype PubMed 21729874. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

positive regulation of transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

skeletal system development

Inferred from mutant phenotype PubMed 19276117. Source: MGI

uterus development

Inferred from mutant phenotype PubMed 19276117. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 11737597PubMed 19228596. Source: MGI

   Molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 14671317. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform KIP2a (identifier: P49919-1)

Also known as: p57a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform KIP2b (identifier: P49919-2)

Also known as: p57b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Cyclin-dependent kinase inhibitor 1C
PRO_0000190088

Regions

Motif309 – 3124Nuclear localization signal Potential
Compositional bias108 – 18982Pro-rich
Compositional bias178 – 284107Asp/Glu-rich (acidic)

Natural variations

Alternative sequence1 – 1313Missing in isoform KIP2b.
VSP_000868

Experimental info

Sequence conflict150 – 1512EP → DA in AAC52186. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform KIP2a (p57a) [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 100032B2F76BEC92

FASTA34837,372
        10         20         30         40         50         60 
MGMSDVYLRS RTAMERLASS DTFPVIARSS ACRSLFGPVD HEELGRELRM RLAELNAEDQ 

        70         80         90        100        110        120 
NRWDFNFQQD VPLRGPGRLQ WMEVDSESVP AFYRETVQVG RCRLQLGPRP PPVAVAVIPR 

       130        140        150        160        170        180 
SGPPAGEAPD GLEEAPEQPP SAPASAVVAE PTPPATPAPA SDLTSDPIPE VTLVATSDPT 

       190        200        210        220        230        240 
PDPIPDANPD VATRDGEEQV PEQVSEQGEE SGAEPGDELG TEPVSEQGEE QGAEPVEEKD 

       250        260        270        280        290        300 
EEPEEEQGAE PVEEQGAEPV EEQNGEPVEE QDENQEQRGQ ELKDQPLSGI PGRPAPGTAA 

       310        320        330        340 
ANANDFFAKR KRTAQENKAS NDVPPGCPSP NVAPGVGAVE QTPRKRLR 

« Hide

Isoform KIP2b (p57b) [UniParc].

Checksum: E5C40675287FEB3F
Show »

FASTA33535,903

References

« Hide 'large scale' references
[1]"Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution."
Lee M.-H., Reynisdottir I., Massague J.
Genes Dev. 9:639-649(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene."
Matsuoka S., Edwards M.C., Bai C., Parker S., Zhang P., Baldini A., Harper J.W., Elledge S.J.
Genes Dev. 9:650-662(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-348.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U20553 mRNA. Translation: AAC52186.1.
AC023248 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL18208.1.
U22399 mRNA. Translation: AAA85096.1.
CCDSCCDS22040.1. [P49919-2]
CCDS52463.1. [P49919-1]
PIRI49262.
RefSeqNP_001155096.1. NM_001161624.1. [P49919-1]
NP_034006.3. NM_009876.4. [P49919-2]
XP_006508534.1. XM_006508471.1. [P49919-2]
UniGeneMm.168789.

3D structure databases

ProteinModelPortalP49919.
SMRP49919. Positions 28-93.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198653. 1 interaction.
IntActP49919. 1 interaction.
MINTMINT-4090541.
STRING10090.ENSMUSP00000037302.

PTM databases

PhosphoSiteP49919.

Proteomic databases

PaxDbP49919.
PRIDEP49919.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000037287; ENSMUSP00000037302; ENSMUSG00000037664. [P49919-2]
ENSMUST00000167912; ENSMUSP00000128828; ENSMUSG00000037664. [P49919-1]
GeneID12577.
KEGGmmu:12577.
UCSCuc009kpe.2. mouse.

Organism-specific databases

CTD1028.
MGIMGI:104564. Cdkn1c.

Phylogenomic databases

eggNOGNOG245842.
GeneTreeENSGT00530000063588.
HOGENOMHOG000294081.
HOVERGENHBG107407.
InParanoidP49919.
KOK09993.
OMAEQGANQG.
OrthoDBEOG7GJ6HD.
TreeFamTF101111.

Gene expression databases

ArrayExpressP49919.
CleanExMM_CDKN1C.
GenevestigatorP49919.

Family and domain databases

InterProIPR003175. CDI.
[Graphical view]
PANTHERPTHR10265. PTHR10265. 1 hit.
PfamPF02234. CDI. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281694.
PROP49919.
SOURCESearch...

Entry information

Entry nameCDN1C_MOUSE
AccessionPrimary (citable) accession number: P49919
Secondary accession number(s): G3UW61
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot