Cyclin-dependent kinase inhibitor 1C

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Molecule processing

Regions

Natural variations

Experimental info

Preferred order of sections

Molecule processing

Regions

Natural variations

Experimental info

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

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P49919 (CDN1C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 88. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Protein names

Recommended name:
Cyclin-dependent kinase inhibitor 1C

Alternative name(s):
Cyclin-dependent kinase inhibitor p57
p57Kip2

Gene names

Name:	Cdkn1c
Synonyms:	Kip2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Function	Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
Subunit structure	Interacts with PCNA By similarity.
Subcellular location	Nucleus.
Tissue specificity	Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.
Sequence similarities	Belongs to the CDI family.

Keywords
Biological process	Cell cycle
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Protein kinase inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle arrest Inferred from electronic annotation. Source: InterPro negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of protein kinase activity Inferred from electronic annotation. Source: GOC negative regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction PubMed 14671317. Source: MGI neuron maturation Inferred from mutant phenotype PubMed 14671317. Source: MGI placenta development Inferred from mutant phenotype PubMed 21729874. Source: MGI positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara positive regulation of transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay PubMed 11737597 PubMed 19228596. Source: MGI
Molecular_function	cyclin-dependent protein serine/threonine kinase inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

1 – 348

348

Cyclin-dependent kinase inhibitor 1C

PRO_0000190088

Motif

309 – 312

Nuclear localization signal Potential

Compositional bias

108 – 189

Pro-rich

Compositional bias

178 – 284

107

Asp/Glu-rich (acidic)

Alternative sequence

1 – 13

Missing in isoform KIP2b.

VSP_000868

Sequence conflict

150 – 151

EP → DA in AAC52186. Ref.1

Sequence		Length	Mass (Da)
Isoform KIP2a (p57a) [UniParc]. Last modified October 3, 2012. Version 2. Checksum: 100032B2F76BEC92 Show »	FASTA	348	37,372
10 20 30 40 50 60 MGMSDVYLRS RTAMERLASS DTFPVIARSS ACRSLFGPVD HEELGRELRM RLAELNAEDQ 70 80 90 100 110 120 NRWDFNFQQD VPLRGPGRLQ WMEVDSESVP AFYRETVQVG RCRLQLGPRP PPVAVAVIPR 130 140 150 160 170 180 SGPPAGEAPD GLEEAPEQPP SAPASAVVAE PTPPATPAPA SDLTSDPIPE VTLVATSDPT 190 200 210 220 230 240 PDPIPDANPD VATRDGEEQV PEQVSEQGEE SGAEPGDELG TEPVSEQGEE QGAEPVEEKD 250 260 270 280 290 300 EEPEEEQGAE PVEEQGAEPV EEQNGEPVEE QDENQEQRGQ ELKDQPLSGI PGRPAPGTAA 310 320 330 340 ANANDFFAKR KRTAQENKAS NDVPPGCPSP NVAPGVGAVE QTPRKRLR « Hide
Isoform KIP2b (p57b) [UniParc]. Checksum: E5C40675287FEB3F Show »	FASTA	335	35,903
10 20 30 40 50 60 MERLASSDTF PVIARSSACR SLFGPVDHEE LGRELRMRLA ELNAEDQNRW DFNFQQDVPL 70 80 90 100 110 120 RGPGRLQWME VDSESVPAFY RETVQVGRCR LQLGPRPPPV AVAVIPRSGP PAGEAPDGLE 130 140 150 160 170 180 EAPEQPPSAP ASAVVAEPTP PATPAPASDL TSDPIPEVTL VATSDPTPDP IPDANPDVAT 190 200 210 220 230 240 RDGEEQVPEQ VSEQGEESGA EPGDELGTEP VSEQGEEQGA EPVEEKDEEP EEEQGAEPVE 250 260 270 280 290 300 EQGAEPVEEQ NGEPVEEQDE NQEQRGQELK DQPLSGIPGR PAPGTAAANA NDFFAKRKRT 310 320 330 AQENKASNDV PPGCPSPNVA PGVGAVEQTP RKRLR « Hide

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution." Lee M.-H., Reynisdottir I., Massague J. Genes Dev. 9:639-649(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene." Matsuoka S., Edwards M.C., Bai C., Parker S., Zhang P., Baldini A., Harper J.W., Elledge S.J. Genes Dev. 9:650-662(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-348.
+	Additional computationally mapped references.

Sequence databases
EMBL GenBank DDBJ	U20553 mRNA. Translation: AAC52186.1. AC023248 Genomic DNA. No translation available. CH466531 Genomic DNA. Translation: EDL18208.1. U22399 mRNA. Translation: AAA85096.1.
IPI	IPI00118931. IPI00224483.
PIR	I49262.
RefSeq	NP_001155096.1. NM_001161624.1. NP_034006.3. NM_009876.4.
UniGene	Mm.168789.
3D structure databases
ProteinModelPortal	P49919.
SMR	P49919. Positions 28-93.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000037302.
PTM databases
PhosphoSite	P49919.
Proteomic databases
PaxDb	P49919.
PRIDE	P49919.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000037287; ENSMUSP00000037302; ENSMUSG00000037664. ENSMUST00000167912; ENSMUSP00000128828; ENSMUSG00000037664.
GeneID	12577.
KEGG	mmu:12577.
Organism-specific databases
CTD	1028.
MGI	MGI:104564. Cdkn1c.
Phylogenomic databases
eggNOG	NOG245842.
GeneTree	ENSGT00530000063588.
HOGENOM	HOG000294081.
HOVERGEN	HBG107407.
InParanoid	P49919.
KO	K09993.
OMA	EQGANQG.
OrthoDB	EOG437RG1.
Gene expression databases
CleanEx	MM_CDKN1C.
Genevestigator	P49919.
GermOnline	ENSMUSG00000037664. Mus musculus.
Family and domain databases
InterPro	IPR003175. CDI. [Graphical view]
PANTHER	PTHR10265. PTHR10265. 1 hit.
Pfam	PF02234. CDI. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	281694.
SOURCE	Search...

Entry name

CDN1C_MOUSE

Accession

Primary (citable) accession number: P49919
Secondary accession number(s): G3UW61

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 3, 2012
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform KIP2a (identifier: P49919-1)

Also known as: p57a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform KIP2b (identifier: P49919-2)

Also known as: p57b;

The sequence of this isoform differs from the canonical sequence as follows:
1-13: Missing.