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Protein

Cyclin-dependent kinase inhibitor 1C

Gene

Cdkn1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: InterPro

GO - Biological processi

  1. adrenal gland development Source: MGI
  2. aging Source: MGI
  3. camera-type eye development Source: MGI
  4. cell cycle arrest Source: InterPro
  5. digestive system development Source: MGI
  6. embryonic placenta morphogenesis Source: MGI
  7. genetic imprinting Source: MGI
  8. kidney development Source: MGI
  9. multicellular organism growth Source: MGI
  10. myeloid cell differentiation Source: MGI
  11. negative regulation of epithelial cell proliferation Source: Ensembl
  12. negative regulation of phosphorylation Source: UniProtKB
  13. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  14. neuron maturation Source: MGI
  15. placenta development Source: MGI
  16. positive regulation of transcription, DNA-templated Source: Ensembl
  17. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  18. regulation of mitotic cell cycle Source: InterPro
  19. skeletal system development Source: MGI
  20. uterus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase inhibitor 1C
Alternative name(s):
Cyclin-dependent kinase inhibitor p57
p57Kip2
Gene namesi
Name:Cdkn1c
Synonyms:Kip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:104564. Cdkn1c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Cyclin-dependent kinase inhibitor 1CPRO_0000190088Add
BLAST

Proteomic databases

MaxQBiP49919.
PaxDbiP49919.
PRIDEiP49919.

PTM databases

PhosphoSiteiP49919.

Expressioni

Tissue specificityi

Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.

Gene expression databases

CleanExiMM_CDKN1C.
ExpressionAtlasiP49919. baseline and differential.
GenevestigatoriP49919.

Interactioni

Subunit structurei

Interacts with PCNA.By similarity

Protein-protein interaction databases

BioGridi198653. 1 interaction.
IntActiP49919. 1 interaction.
MINTiMINT-4090541.
STRINGi10090.ENSMUSP00000037302.

Structurei

3D structure databases

ProteinModelPortaliP49919.
SMRiP49919. Positions 28-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi309 – 3124Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi108 – 18982Pro-richAdd
BLAST
Compositional biasi178 – 284107Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the CDI family.Curated

Phylogenomic databases

eggNOGiNOG245842.
GeneTreeiENSGT00530000063588.
HOGENOMiHOG000294081.
HOVERGENiHBG107407.
InParanoidiP49919.
KOiK09993.
OMAiEQGANQG.
OrthoDBiEOG7GJ6HD.
TreeFamiTF101111.

Family and domain databases

InterProiIPR003175. CDI.
IPR029842. CDKN1C.
[Graphical view]
PANTHERiPTHR10265. PTHR10265. 1 hit.
PTHR10265:SF7. PTHR10265:SF7. 1 hit.
PfamiPF02234. CDI. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform KIP2a (identifier: P49919-1) [UniParc]FASTAAdd to basket

Also known as: p57a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGMSDVYLRS RTAMERLASS DTFPVIARSS ACRSLFGPVD HEELGRELRM
60 70 80 90 100
RLAELNAEDQ NRWDFNFQQD VPLRGPGRLQ WMEVDSESVP AFYRETVQVG
110 120 130 140 150
RCRLQLGPRP PPVAVAVIPR SGPPAGEAPD GLEEAPEQPP SAPASAVVAE
160 170 180 190 200
PTPPATPAPA SDLTSDPIPE VTLVATSDPT PDPIPDANPD VATRDGEEQV
210 220 230 240 250
PEQVSEQGEE SGAEPGDELG TEPVSEQGEE QGAEPVEEKD EEPEEEQGAE
260 270 280 290 300
PVEEQGAEPV EEQNGEPVEE QDENQEQRGQ ELKDQPLSGI PGRPAPGTAA
310 320 330 340
ANANDFFAKR KRTAQENKAS NDVPPGCPSP NVAPGVGAVE QTPRKRLR
Length:348
Mass (Da):37,372
Last modified:October 3, 2012 - v2
Checksum:i100032B2F76BEC92
GO
Isoform KIP2b (identifier: P49919-2) [UniParc]FASTAAdd to basket

Also known as: p57b

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:335
Mass (Da):35,903
Checksum:iE5C40675287FEB3F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1512EP → DA in AAC52186 (PubMed:7729683).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313Missing in isoform KIP2b. CuratedVSP_000868Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20553 mRNA. Translation: AAC52186.1.
AC023248 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL18208.1.
U22399 mRNA. Translation: AAA85096.1.
CCDSiCCDS22040.1. [P49919-2]
CCDS52463.1. [P49919-1]
PIRiI49262.
RefSeqiNP_001155096.1. NM_001161624.1. [P49919-1]
NP_034006.3. NM_009876.4. [P49919-2]
XP_006508534.1. XM_006508471.1. [P49919-2]
UniGeneiMm.168789.

Genome annotation databases

EnsembliENSMUST00000037287; ENSMUSP00000037302; ENSMUSG00000037664. [P49919-2]
ENSMUST00000167912; ENSMUSP00000128828; ENSMUSG00000037664. [P49919-1]
GeneIDi12577.
KEGGimmu:12577.
UCSCiuc009kpe.2. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20553 mRNA. Translation: AAC52186.1.
AC023248 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL18208.1.
U22399 mRNA. Translation: AAA85096.1.
CCDSiCCDS22040.1. [P49919-2]
CCDS52463.1. [P49919-1]
PIRiI49262.
RefSeqiNP_001155096.1. NM_001161624.1. [P49919-1]
NP_034006.3. NM_009876.4. [P49919-2]
XP_006508534.1. XM_006508471.1. [P49919-2]
UniGeneiMm.168789.

3D structure databases

ProteinModelPortaliP49919.
SMRiP49919. Positions 28-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198653. 1 interaction.
IntActiP49919. 1 interaction.
MINTiMINT-4090541.
STRINGi10090.ENSMUSP00000037302.

PTM databases

PhosphoSiteiP49919.

Proteomic databases

MaxQBiP49919.
PaxDbiP49919.
PRIDEiP49919.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037287; ENSMUSP00000037302; ENSMUSG00000037664. [P49919-2]
ENSMUST00000167912; ENSMUSP00000128828; ENSMUSG00000037664. [P49919-1]
GeneIDi12577.
KEGGimmu:12577.
UCSCiuc009kpe.2. mouse.

Organism-specific databases

CTDi1028.
MGIiMGI:104564. Cdkn1c.

Phylogenomic databases

eggNOGiNOG245842.
GeneTreeiENSGT00530000063588.
HOGENOMiHOG000294081.
HOVERGENiHBG107407.
InParanoidiP49919.
KOiK09993.
OMAiEQGANQG.
OrthoDBiEOG7GJ6HD.
TreeFamiTF101111.

Miscellaneous databases

ChiTaRSiCdkn1c. mouse.
NextBioi281694.
PROiP49919.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CDKN1C.
ExpressionAtlasiP49919. baseline and differential.
GenevestigatoriP49919.

Family and domain databases

InterProiIPR003175. CDI.
IPR029842. CDKN1C.
[Graphical view]
PANTHERiPTHR10265. PTHR10265. 1 hit.
PTHR10265:SF7. PTHR10265:SF7. 1 hit.
PfamiPF02234. CDI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution."
    Lee M.-H., Reynisdottir I., Massague J.
    Genes Dev. 9:639-649(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene."
    Matsuoka S., Edwards M.C., Bai C., Parker S., Zhang P., Baldini A., Harper J.W., Elledge S.J.
    Genes Dev. 9:650-662(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-348.

Entry informationi

Entry nameiCDN1C_MOUSE
AccessioniPrimary (citable) accession number: P49919
Secondary accession number(s): G3UW61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2012
Last modified: March 4, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.