ID CAMP_HUMAN Reviewed; 170 AA. AC P49913; Q71SN9; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 24-NOV-2009, entry version 86. DE RecName: Full=Cathelicidin antimicrobial peptide; DE AltName: Full=18 kDa cationic antimicrobial protein; DE AltName: Full=CAP-18; DE AltName: Full=hCAP-18; DE Contains: DE RecName: Full=Antibacterial protein FALL-39; DE AltName: Full=FALL-39 peptide antibiotic; DE Contains: DE RecName: Full=Antibacterial protein LL-37; DE Flags: Precursor; GN Name=CAMP; Synonyms=CAP18, FALL39; ORFNames=HSD26; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND SYNTHESIS OF 132-170. RC TISSUE=Bone marrow; RX MEDLINE=95116523; PubMed=7529412; DOI=10.1073/pnas.92.1.195; RA Agerberth B., Gunne H., Odeberg J., Kogner P., Boman H.G., RA Gudmundsson G.H.; RT "FALL-39, a putative human peptide antibiotic, is cysteine-free and RT expressed in bone marrow and testis."; RL Proc. Natl. Acad. Sci. U.S.A. 92:195-199(1995). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 42-68 AND 83-100. RC TISSUE=Bone marrow; RX MEDLINE=95339969; PubMed=7615076; DOI=10.1016/0014-5793(95)00634-L; RA Cowland J.B., Johnsen A.H., Borregaard N.; RT "hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil RT specific granules."; RL FEBS Lett. 368:173-176(1995). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Bone marrow; RX MEDLINE=95197251; PubMed=7890387; RA Larrick J.W., Hirata M., Balint R.F., Lee J., Zhong J., Wright S.C.; RT "Human CAP18: a novel antimicrobial lipopolysaccharide-binding RT protein."; RL Infect. Immun. 63:1291-1297(1995). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=97102716; PubMed=8946956; DOI=10.1016/S0014-5793(96)01199-4; RA Larrick J.W., Lee J., Ma S., Li X., Francke U., Wright S.C., RA Balint R.F.; RT "Structural, functional analysis and localization of the human CAP18 RT gene."; RL FEBS Lett. 398:74-80(1996). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=8681941; DOI=10.1111/j.1432-1033.1996.0325z.x; RA Gudmundsson G.H., Agerberth B., Odeberg J., Bergman T., Olsson B., RA Salcedo R.; RT "The human gene FALL39 and processing of the cathelin precursor to the RT antibacterial peptide LL-37 in granulocytes."; RL Eur. J. Biochem. 238:325-332(1996). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Epididymis; RA Gao Y., Huang Y.F., Xia X.Y.; RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RA Wu N., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.; RT "A new spermatogenesis-related gene."; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=21137962; PubMed=11238224; DOI=10.1128/CDLI.8.2.370-375.2001; RA Bals R., Lang C., Weiner D.J., Vogelmeier C., Welsch U., Wilson J.M.; RT "Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are RT close homologues of human molecules."; RL Clin. Diagn. Lab. Immunol. 8:370-375(2001). RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., RA Korn B., Zuo D., Hu Y., LaBaer J.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [11] RP STRUCTURE BY NMR OF 146-170, AND FUNCTION. RX PubMed=16637646; DOI=10.1021/ja0584875; RA Li X., Li Y., Han H., Miller D.W., Wang G.; RT "Solution structures of human LL-37 fragments and NMR-based RT identification of a minimal membrane-targeting antimicrobial and RT anticancer region."; RL J. Am. Chem. Soc. 128:5776-5785(2006). RN [12] RP STRUCTURE BY NMR OF 134-170, AND FUNCTION. RX PubMed=18818205; DOI=10.1074/jbc.M805533200; RA Wang G.; RT "Structures of human host defense cathelicidin LL-37 and its smallest RT antimicrobial peptide KR-12 in lipid micelles."; RL J. Biol. Chem. 283:32637-32643(2008). CC -!- FUNCTION: Binds to bacterial lipopolysaccharides (LPS), has CC antibacterial activity. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Expressed in bone marrow and testis and CC neutrophils. CC -!- PTM: The N-terminus is blocked. CC -!- SIMILARITY: Belongs to the cathelicidin family. CC -!- CAUTION: PubMed:11238224 sequence was incorrectly assigned to CC originate from M.mulatta. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Z38026; CAA86115.1; -; mRNA. DR EMBL; X89658; CAA61805.1; -; mRNA. DR EMBL; U19970; AAA74084.1; -; mRNA. DR EMBL; U48795; AAC02634.1; -; Genomic_DNA. DR EMBL; X96735; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY162210; AAN78318.1; -; mRNA. DR EMBL; AY251531; AAP20054.1; -; mRNA. DR EMBL; AF288284; AAG40802.1; -; mRNA. DR EMBL; CR457083; CAG33364.1; -; mRNA. DR EMBL; CR541961; CAG46759.1; -; mRNA. DR EMBL; BC055089; AAH55089.1; -; mRNA. DR IPI; IPI00292532; -. DR PIR; I38932; I38932. DR PIR; S74248; S74248. DR RefSeq; NP_004336.2; -. DR UniGene; Hs.51120; -. DR PDB; 2FBS; NMR; -; N=150-162. DR PDB; 2FBU; NMR; -; H=134-145. DR PDB; 2FCG; NMR; -; F=146-170. DR PDB; 2K6O; NMR; -; A=134-170. DR PDBsum; 2FBS; -. DR PDBsum; 2FBU; -. DR PDBsum; 2FCG; -. DR PDBsum; 2K6O; -. DR DisProt; DP00004; -. DR STRING; P49913; -. DR PRIDE; P49913; -. DR Ensembl; ENST00000296435; ENSP00000296435; ENSG00000164047; Homo sapiens. DR GeneID; 820; -. DR KEGG; hsa:820; -. DR UCSC; uc003csj.1; human. DR CTD; 820; -. DR GeneCards; GC03P048240; -. DR H-InvDB; HIX0024318; -. DR HGNC; HGNC:1472; CAMP. DR HPA; CAB015949; -. DR HPA; CAB016522; -. DR MIM; 600474; gene. DR PharmGKB; PA26054; -. DR HOVERGEN; P49913; -. DR OMA; QRSSDAN; -. DR OrthoDB; EOG915JZK; -. DR NextBio; 3356; -. DR PMAP-CutDB; P49913; -. DR ArrayExpress; P49913; -. DR Bgee; P49913; -. DR CleanEx; HS_CAMP; -. DR Genevestigator; P49913; -. DR GermOnline; ENSG00000164047; Homo sapiens. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR InterPro; IPR001894; Cathelicidin. DR InterPro; IPR018216; Cathelicidin_CS. DR PANTHER; PTHR10206; Cathelicidin; 1. DR Pfam; PF00666; Cathelicidins; 1. DR ProDom; PD001838; Cathelicidin; 1. DR PROSITE; PS00946; CATHELICIDINS_1; 1. DR PROSITE; PS00947; CATHELICIDINS_2; 1. PE 1: Evidence at protein level; KW 3D-structure; Antibiotic; Antimicrobial; KW Cleavage on pair of basic residues; Complete proteome; KW Direct protein sequencing; Disulfide bond; KW Pyrrolidone carboxylic acid; Secreted; Signal. FT SIGNAL 1 30 Potential. FT PROPEP 31 131 FT /FTId=PRO_0000004722. FT CHAIN 132 170 Antibacterial protein FALL-39. FT /FTId=PRO_0000004723. FT CHAIN 134 170 Antibacterial protein LL-37. FT /FTId=PRO_0000004724. FT MOD_RES 31 31 Pyrrolidone carboxylic acid (By FT similarity). FT DISULFID 86 97 By similarity. FT DISULFID 108 125 By similarity. FT CONFLICT 6 6 D -> N (in Ref. 1, 6, 7 and 9; CAG46759). FT HELIX 136 140 FT HELIX 151 161 SQ SEQUENCE 170 AA; 19301 MW; 055B07DCA95A7D16 CRC64; MKTQRDGHSL GRWSLVLLLL GLVMPLAIIA QVLSYKEAVL RAIDGINQRS SDANLYRLLD LDPRPTMDGD PDTPKPVSFT VKETVCPRTT QQSPEDCDFK KDGLVKRCMG TVTLNQARGS FDISCDKDNK RFALLGDFFR KSKEKIGKEF KRIVQRIKDF LRNLVPRTES //