Reviewed,
UniProtKB/Swiss-Prot P49913 (CAMP_HUMAN)
Last modified
January 19, 2010.
Version 88.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cathelicidin antimicrobial peptide Alternative name(s): 18 kDa cationic antimicrobial protein Short name=CAP-18 Short name=hCAP-18 Cleaved into the following 2 chains: 1- Recommended name: Antibacterial protein FALL-39 Alternative name(s): FALL-39 peptide antibiotic 2- Recommended name: Antibacterial protein LL-37 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 170 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity. Ref.11 Ref.12 |
| Subcellular location | |
| Tissue specificity | Expressed in bone marrow and testis and neutrophils. |
| Post-translational modification | The N-terminus is blocked. |
| Sequence similarities | Belongs to the cathelicidin family. |
| Caution | Ref.8 sequence was incorrectly assigned to originate from M.mulatta. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Antibiotic Antimicrobial |
| PTM | Cleavage on pair of basic residues Disulfide bond Pyrrolidone carboxylic acid |
| Technical term | 3D-structure Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||
Molecule processing | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 30 | 30 | Potential | ||||||||||
| Propeptide | 31 – 131 | 101 | PRO_0000004722 | ||||||||||
| Chain | 132 – 170 | 39 | Antibacterial protein FALL-39 | PRO_0000004723 | |||||||||
| Chain | 134 – 170 | 37 | Antibacterial protein LL-37 | PRO_0000004724 | |||||||||
Amino acid modifications | |||||||||||||
| Modified residue | 31 | 1 | Pyrrolidone carboxylic acid By similarity | ||||||||||
| Disulfide bond | 86 ↔ 97 | By similarity | |||||||||||
| Disulfide bond | 108 ↔ 125 | By similarity | |||||||||||
Experimental info | |||||||||||||
| Sequence conflict | 6 | 1 | D → N Ref.1 | ||||||||||
| Sequence conflict | 6 | 1 | D → N Ref.6 | ||||||||||
| Sequence conflict | 6 | 1 | D → N Ref.7 | ||||||||||
| Sequence conflict | 6 | 1 | D → N in CAG46759. Ref.9 | ||||||||||
Secondary structure | |||||||||||||
Helix Strand Turn | |||||||||||||
| Helix | 136 – 140 | 5 | |||||||||||
| Helix | 151 – 161 | 11 | |||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis." Agerberth B., Gunne H., Odeberg J., Kogner P., Boman H.G., Gudmundsson G.H. Proc. Natl. Acad. Sci. U.S.A. 92:195-199(1995) [PubMed: 7529412] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 132-170. Tissue: Bone marrow. |
| [2] | "hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules." Cowland J.B., Johnsen A.H., Borregaard N. FEBS Lett. 368:173-176(1995) [PubMed: 7615076] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 42-68 AND 83-100. Tissue: Bone marrow. |
| [3] | "Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein." Larrick J.W., Hirata M., Balint R.F., Lee J., Zhong J., Wright S.C. Infect. Immun. 63:1291-1297(1995) [PubMed: 7890387] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bone marrow. |
| [4] | "Structural, functional analysis and localization of the human CAP18 gene." Larrick J.W., Lee J., Ma S., Li X., Francke U., Wright S.C., Balint R.F. FEBS Lett. 398:74-80(1996) [PubMed: 8946956] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [5] | "The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes." Gudmundsson G.H., Agerberth B., Odeberg J., Bergman T., Olsson B., Salcedo R. Eur. J. Biochem. 238:325-332(1996) [PubMed: 8681941] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [6] | Gao Y., Huang Y.F., Xia X.Y. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Epididymis. |
| [7] | "A new spermatogenesis-related gene." Wu N., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| [8] | "Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules." Bals R., Lang C., Weiner D.J., Vogelmeier C., Welsch U., Wilson J.M. Clin. Diagn. Lab. Immunol. 8:370-375(2001) [PubMed: 11238224] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [9] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [10] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [11] | "Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region." Li X., Li Y., Han H., Miller D.W., Wang G. J. Am. Chem. Soc. 128:5776-5785(2006) [PubMed: 16637646] [Abstract] Cited for: STRUCTURE BY NMR OF 146-170, FUNCTION. |
| [12] | "Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles." Wang G. J. Biol. Chem. 283:32637-32643(2008) [PubMed: 18818205] [Abstract] Cited for: STRUCTURE BY NMR OF 134-170, FUNCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | Z38026 mRNA. Translation: CAA86115.1. X89658 mRNA. Translation: CAA61805.1. U19970 mRNA. Translation: AAA74084.1. U48795 Genomic DNA. Translation: AAC02634.1. X96735 Genomic DNA. No translation available. AY162210 mRNA. Translation: AAN78318.1. AY251531 mRNA. Translation: AAP20054.1. AF288284 mRNA. Translation: AAG40802.1. CR457083 mRNA. Translation: CAG33364.1. CR541961 mRNA. Translation: CAG46759.1. BC055089 mRNA. Translation: AAH55089.1. | ||||||||||||||||||||||||||||||
| IPI | IPI00292532. | ||||||||||||||||||||||||||||||
| PIR | I38932. S74248. | ||||||||||||||||||||||||||||||
| RefSeq | NP_004336.2. | ||||||||||||||||||||||||||||||
| UniGene | Hs.51120 | ||||||||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||||||||
| PDBe RCSB PDB PDBj |
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| SMR | P49913. Positions 31-127. | ||||||||||||||||||||||||||||||
| DisProt | DP00004. | ||||||||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||||||||
| STRING | P49913. | ||||||||||||||||||||||||||||||
Protein family/group databases | |||||||||||||||||||||||||||||||
| TCDB | 1.C.33.1.10. cathelicidin family. | ||||||||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||||||||
| PRIDE | P49913. | ||||||||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||||||||
| Ensembl | ENST00000296435; ENSP00000296435; ENSG00000164047; Homo sapiens. [Genome view] | ||||||||||||||||||||||||||||||
| GeneID | 820. | ||||||||||||||||||||||||||||||
| KEGG | hsa:820. | ||||||||||||||||||||||||||||||
| UCSC | uc003csj.1. human. | ||||||||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||||||||
| CTD | 820. | ||||||||||||||||||||||||||||||
| GeneCards | GC03P048240. | ||||||||||||||||||||||||||||||
| H-InvDB | HIX0024318. | ||||||||||||||||||||||||||||||
| HGNC | HGNC:1472. CAMP. | ||||||||||||||||||||||||||||||
| HPA | CAB015949. CAB016522. | ||||||||||||||||||||||||||||||
| MIM | 600474. gene. | ||||||||||||||||||||||||||||||
| PharmGKB | PA26054. | ||||||||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||||||||
| eggNOG | prNOG07162. | ||||||||||||||||||||||||||||||
| HOGENOM | HBG127142. | ||||||||||||||||||||||||||||||
| HOVERGEN | P49913. | ||||||||||||||||||||||||||||||
| InParanoid | P49913. | ||||||||||||||||||||||||||||||
| OMA | QRSSDAN. | ||||||||||||||||||||||||||||||
| OrthoDB | EOG915JZK. | ||||||||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||||||||
| ArrayExpress | P49913. | ||||||||||||||||||||||||||||||
| Bgee | P49913. | ||||||||||||||||||||||||||||||
| CleanEx | HS_CAMP. | ||||||||||||||||||||||||||||||
| Genevestigator | P49913. | ||||||||||||||||||||||||||||||
| GermOnline | ENSG00000164047. Homo sapiens. | ||||||||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||||||||
| InterPro | IPR001894. Cathelicidin. IPR018216. Cathelicidin_CS. [Graphical view] | ||||||||||||||||||||||||||||||
| PANTHER | PTHR10206. Cathelicidin. 1 hit. | ||||||||||||||||||||||||||||||
| Pfam | PF00666. Cathelicidins. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||
| ProDom | PD001838. Cathelicidin. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||||||||||||||||||||
| PROSITE | PS00946. CATHELICIDINS_1. 1 hit. PS00947. CATHELICIDINS_2. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||||||||
| NextBio | 3356. | ||||||||||||||||||||||||||||||
| PMAP-CutDB | P49913. | ||||||||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||||||||
Entry information
| Entry name | CAMP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P49913 Secondary accession number(s): Q71SN9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


