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Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member A

Gene

Anp32a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of histone acetylation Source: RGD
  • negative regulation of neuron projection development Source: RGD
  • nucleocytoplasmic transport Source: UniProtKB
  • regulation of apoptotic process Source: GO_Central
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Alternative name(s):
Leucine-rich acidic nuclear protein
Short name:
LANP
Gene namesi
Name:Anp32a
Synonyms:Lanp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi11508551 Anp32a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375941 – 247Acidic leucine-rich nuclear phosphoprotein 32 family member AAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphothreonineBy similarity1
Modified residuei17PhosphoserineBy similarity1
Modified residuei158PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine residues.By similarity
Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP49911
PRIDEiP49911

PTM databases

iPTMnetiP49911
PhosphoSitePlusiP49911
SwissPalmiP49911

Expressioni

Tissue specificityi

Widely distributed in the central nervous system, with an abundant expression in the cerebellum.1 Publication

Developmental stagei

It is moderately expressed in the cerebellum on postnatal day 7 in the external granule and Perkinje cells, increases in the second postnatal week and thereafter decreases to an adult level.1 Publication

Interactioni

Subunit structurei

Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET. Interacts with ATXN1/SCA1. Interacts with MAP1B. Interacts with ELAVL1. Part of the INHAT (inhibitor of histone acetyltransferases) complex. Interacts with E4F1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP49911, 1 interactor
STRINGi10116.ENSRNOP00000066098

Structurei

3D structure databases

ProteinModelPortaliP49911
SMRiP49911
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 41LRR 1Add BLAST24
Repeati43 – 64LRR 2Add BLAST22
Repeati65 – 87LRR 3Add BLAST23
Repeati89 – 110LRR 4Add BLAST22
Domaini123 – 161LRRCTAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 172Necessary for tumor-suppressive functionBy similarityAdd BLAST23
Regioni165 – 247Interaction with E4F1By similarityAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi165 – 247Asp/Glu-rich (highly acidic)Add BLAST83

Sequence similaritiesi

Belongs to the ANP32 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2739 Eukaryota
ENOG4111HZT LUCA
HOGENOMiHOG000007361
HOVERGENiHBG053102
InParanoidiP49911
KOiK18646
PhylomeDBiP49911

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

Sequencei

Sequence statusi: Complete.

P49911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMDKRIYLE LRNRTPSDVK ELVLDNCRSI EGKIEGLTDE FEELEFLSTI
60 70 80 90 100
NVGLTSISNL PKLNKLKKLE LSENRISGDL EVLAEKCPNL KHLNLSGNKI
110 120 130 140 150
KDLSTIEPLK KLENLKSLDL FNCEVTNLNA YRENVFKLLP QVMYLDGYDR
160 170 180 190 200
DNKEAPDSDV EGYVEDDDEE DEDEEEYDEY AQLVEDEEEE DEEEEGEEED
210 220 230 240
VSGEEEEDEE GYNDGEVDDE EDEEDAAEEE GSQKRKREPD DEGQEDD
Length:247
Mass (Da):28,565
Last modified:October 1, 1996 - v1
Checksum:i0919739645557462
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32209 mRNA Translation: BAA06908.1
PIRiI59334
RefSeqiNP_037035.1, NM_012903.1
UniGeneiRn.10123

Genome annotation databases

GeneIDi25379
KEGGirno:25379
UCSCiRGD:2116 rat

Similar proteinsi

Entry informationi

Entry nameiAN32A_RAT
AccessioniPrimary (citable) accession number: P49911
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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