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Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member A

Gene

Anp32a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression (By similarity).By similarity

GO - Molecular functioni

  • cell adhesion molecule binding Source: RGD
  • histone binding Source: GO_Central
  • integrin binding Source: RGD
  • protein C-terminus binding Source: RGD

GO - Biological processi

  • negative regulation of histone acetylation Source: RGD
  • negative regulation of neuron projection development Source: RGD
  • nucleocytoplasmic transport Source: UniProtKB
  • regulation of apoptotic process Source: GO_Central
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Alternative name(s):
Leucine-rich acidic nuclear protein
Short name:
LANP
Gene namesi
Name:Anp32a
Synonyms:Lanp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2116. Anp32a.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Endoplasmic reticulum By similarity

  • Note: Translocates to the cytoplasm during the process of neuritogenesis. Shuttles between nucleus and cytoplasm (By similarity).By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: RGD
  • endoplasmic reticulum Source: UniProtKB
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375941 – 247Acidic leucine-rich nuclear phosphoprotein 32 family member AAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphothreonineBy similarity1
Modified residuei17PhosphoserineBy similarity1
Modified residuei158PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine residues.By similarity
Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP49911.
PRIDEiP49911.

PTM databases

iPTMnetiP49911.
PhosphoSitePlusiP49911.

Expressioni

Tissue specificityi

Widely distributed in the central nervous system, with an abundant expression in the cerebellum.1 Publication

Developmental stagei

It is moderately expressed in the cerebellum on postnatal day 7 in the external granule and Perkinje cells, increases in the second postnatal week and thereafter decreases to an adult level.1 Publication

Interactioni

Subunit structurei

Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET. Interacts with ATXN1/SCA1. Interacts with MAP1B. Interacts with ELAVL1. Part of the INHAT (inhibitor of histone acetyltransferases) complex. Interacts with E4F1 (By similarity).By similarity

GO - Molecular functioni

  • cell adhesion molecule binding Source: RGD
  • histone binding Source: GO_Central
  • integrin binding Source: RGD
  • protein C-terminus binding Source: RGD

Protein-protein interaction databases

IntActiP49911. 1 interactor.
STRINGi10116.ENSRNOP00000066098.

Structurei

3D structure databases

ProteinModelPortaliP49911.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 41LRR 1Add BLAST24
Repeati43 – 64LRR 2Add BLAST22
Repeati65 – 87LRR 3Add BLAST23
Repeati89 – 110LRR 4Add BLAST22
Domaini123 – 161LRRCTAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 172Necessary for tumor-suppressive functionBy similarityAdd BLAST23
Regioni165 – 247Interaction with E4F1By similarityAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi165 – 247Asp/Glu-rich (highly acidic)Add BLAST83

Sequence similaritiesi

Belongs to the ANP32 family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2739. Eukaryota.
ENOG4111HZT. LUCA.
HOGENOMiHOG000007361.
HOVERGENiHBG053102.
InParanoidiP49911.
KOiK18646.
PhylomeDBiP49911.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMDKRIYLE LRNRTPSDVK ELVLDNCRSI EGKIEGLTDE FEELEFLSTI
60 70 80 90 100
NVGLTSISNL PKLNKLKKLE LSENRISGDL EVLAEKCPNL KHLNLSGNKI
110 120 130 140 150
KDLSTIEPLK KLENLKSLDL FNCEVTNLNA YRENVFKLLP QVMYLDGYDR
160 170 180 190 200
DNKEAPDSDV EGYVEDDDEE DEDEEEYDEY AQLVEDEEEE DEEEEGEEED
210 220 230 240
VSGEEEEDEE GYNDGEVDDE EDEEDAAEEE GSQKRKREPD DEGQEDD
Length:247
Mass (Da):28,565
Last modified:October 1, 1996 - v1
Checksum:i0919739645557462
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32209 mRNA. Translation: BAA06908.1.
PIRiI59334.
RefSeqiNP_037035.1. NM_012903.1.
UniGeneiRn.10123.

Genome annotation databases

GeneIDi25379.
KEGGirno:25379.
UCSCiRGD:2116. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32209 mRNA. Translation: BAA06908.1.
PIRiI59334.
RefSeqiNP_037035.1. NM_012903.1.
UniGeneiRn.10123.

3D structure databases

ProteinModelPortaliP49911.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP49911. 1 interactor.
STRINGi10116.ENSRNOP00000066098.

PTM databases

iPTMnetiP49911.
PhosphoSitePlusiP49911.

Proteomic databases

PaxDbiP49911.
PRIDEiP49911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25379.
KEGGirno:25379.
UCSCiRGD:2116. rat.

Organism-specific databases

CTDi8125.
RGDi2116. Anp32a.

Phylogenomic databases

eggNOGiKOG2739. Eukaryota.
ENOG4111HZT. LUCA.
HOGENOMiHOG000007361.
HOVERGENiHBG053102.
InParanoidiP49911.
KOiK18646.
PhylomeDBiP49911.

Miscellaneous databases

PROiP49911.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAN32A_RAT
AccessioniPrimary (citable) accession number: P49911
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.